Patents by Inventor Yuhpyng L. Chen

Yuhpyng L. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Corticotropin releasing factor antagonists
    Patent number: 6844351
    Abstract: Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: January 18, 2005
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Corticotropin releasing factor antagonists
    Patent number: 6833378
    Abstract: Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: December 21, 2004
    Assignee: Pfizer Inc
    Inventor: Yuhpyng L. Chen
  • Thiazole compounds for treatment of neurodegenerative disorders
    Publication number: 20040152747
    Abstract: The invention provides compounds of Formula I: 1
    Type: Application
    Filed: October 8, 2003
    Publication date: August 5, 2004
    Applicant: Pfizer Inc
    Inventors: Yuhpyng L. Chen, Michael L. Corman
  • Pyrazole compounds for treatment of neurodegenerative disorders
    Publication number: 20040142997
    Abstract: The invention provides compounds of Formula I: 1
    Type: Application
    Filed: October 7, 2003
    Publication date: July 22, 2004
    Inventors: Yuhpyng L. Chen, Spiros Liras, Robert L. Rosati, Martin P. Allen
  • Use of CRF antagonists and related compositions
    Publication number: 20040082597
    Abstract: A corticotropin releasing factor (CRF) antagonist is administered to treat a condition selected from the group consisting of:
    Type: Application
    Filed: October 1, 2003
    Publication date: April 29, 2004
    Applicant: Pfizer Inc
    Inventor: Yuhpyng L. Chen
  • Substituted6,6-hetero-bicyclicderivatives
    Publication number: 20030114671
    Abstract: This invention relates to compounds of the formula 1
    Type: Application
    Filed: January 6, 2003
    Publication date: June 19, 2003
    Inventor: Yuhpyng L. Chen
  • Heterocyclic-cyclic amine derivatives as cholinesterase inhibitors
    Patent number: 6498255
    Abstract: Compounds of the formula wherein R1 R2, R7, R8, X, Y, M and L are defined as below. The compounds of formula I are cholinesterase inhibitors and are useful in enhancing memory in patients suffering from. dementia and Alzheimer's disease.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 24, 2002
    Assignee: Pfizer Inc.
    Inventors: Anabella Villalobos, Arthur A. Nagel, Yuhpyng L. Chen
  • Substituted pyrido-or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
    Patent number: 6492520
    Abstract: This invention relates to compounds of formula (I), wherein A, B, D, E, K, G, Z, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds. Compounds (I) are corticotropin releasing factor (hormone) CRF (CRH) antagonists.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: December 10, 2002
    Assignee: Pfizer Inc
    Inventor: Yuhpyng L. Chen
  • Use of CRF antagonists and related compositions
    Publication number: 20020156089
    Abstract: A corticotropin releasing factor (CRF) antagonist is administered to treat a condition selected from the group consisting of:
    Type: Application
    Filed: June 4, 2002
    Publication date: October 24, 2002
    Applicant: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Substituted 6,5-hetero-bicyclic derivatives
    Publication number: 20020151713
    Abstract: This invention relates to compounds of the formula 1
    Type: Application
    Filed: May 30, 2002
    Publication date: October 17, 2002
    Applicant: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Use of CRF antagonists to treat circadian rhythm disorders
    Patent number: 6432989
    Abstract: A corticotropin releasing factor (CRF) antagonist is administered to treat disorders that can be treated by altering circadian rhythm.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: August 13, 2002
    Assignee: Pfizer Inc
    Inventor: Yuhpyng L. Chen
  • Corticotropin releasing factor antagonists
    Patent number: 6403599
    Abstract: A method of treating, preventing or inhibiting a disorder selected from the group consisting of cardiovascular or heart related diseases such as stroke, hypertension, tachycardia, and congestive heart failure, osteoporosis, premature birth, psychosocial dwarfism, stress-induced fever, ulcer, diarrhea, post-operative ileus, and colonic hypersensitivity associated with psychopathological disturbance and stress, comprising administering to a mammal, including a human, in need of such treatment a therapeutically effective amount of a compound of the formula or a pharmaceutically acceptable salt thereof, wherein A, B, D, E, Y, Z, R3, R4, and R5 are as defined herein.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: June 11, 2002
    Assignee: Pfizer Inc
    Inventors: Yuhpyng L. Chen, Anthony A. Fossa
  • Heteroaryl amines as novel acetylcholinesterase inhibitors
    Publication number: 20020049210
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: August 23, 2001
    Publication date: April 25, 2002
    Inventors: Yuhpyng L. Chen, Arthur A. Nagel
  • Heterocyclic-cyclic amine derivatives
    Publication number: 20020028834
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: September 19, 2001
    Publication date: March 7, 2002
    Inventors: Anabella Villalobos, Arthur A. Nagel, Yuhpyng L. Chen
  • Corticotropin releasing factor antagonists
    Publication number: 20020016328
    Abstract: Corticotropin-releasing factor (CRF) antagonists having the formulae 1
    Type: Application
    Filed: January 17, 2001
    Publication date: February 7, 2002
    Inventor: Yuhpyng L. Chen
  • Heterocyclic-cyclic amine derivatives
    Patent number: 6326382
    Abstract: Compounds of the formula wherein R1 R2, R7, R8, X, Y, M and L are defined as below. The compounds of formula I are cholinesterase inhibitors and are useful in enhancing memory in patients suffering from dementia and Alzheimer's disease.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: December 4, 2001
    Assignee: Eisai Co., LTD
    Inventors: Anabella Villalobos, Arthur A. Nagel, Yuhpyng L. Chen
  • Process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines
    Patent number: 6316631
    Abstract: This invention relates to a process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines, comprising reacting a compound of formula (I), wherein R1 is (C1-C4)alkyl; R2 is methyl or ethyl; and R3, R4 and R5 are selected, independently, from (C1-C4)alkyl and (C1-C4)alkoxy; or a pharmaceutically acceptable salt thereof; comprising reacting a compound of formula (II), wherein R1 and R2 are defined as above, with a compound of formula (III), wherein R3, R4 and R5 are defined as above, in the presence of a base that is capable of deprotonating the compound of formula (III), optionally in the presence of an organometallic halide or oxide and a suitable solvent, and then optionally converting the resulting compound of formula (I) into a pharmaceutically acceptable salt of such compound.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: November 13, 2001
    Assignee: Pfizer Inc.
    Inventors: Yuhpyng L. Chen, Sally Gut Ruggeri
  • Heteroaryl amines as novel acetylcholinesterase inhibitors
    Patent number: 6303633
    Abstract: Compounds of the formula wherein ring A, ring B, ring D, R2, R3, R4, R5, R6, R11, R12, R13, E, G, X and P are as defined below. The compounds of formula I are cholinesterase inhibitors and are useful in enhancing memory in patients suffering from dementia and Alzheimer's disease.
    Type: Grant
    Filed: November 11, 1999
    Date of Patent: October 16, 2001
    Assignee: Pfizer Inc
    Inventors: Yuhpyng L. Chen, Arthur A. Nagel
  • SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES
    Publication number: 20010007867
    Abstract: This invention relates to compounds of the formula 1
    Type: Application
    Filed: December 13, 1999
    Publication date: July 12, 2001
    Inventor: YUHPYNG L. CHEN
  • Bicyclic compounds
    Patent number: 6248753
    Abstract: This invention relates to compounds of the formula wherein A, B, R3, R4, R5 and R7 are as defined herein, and to their use in the treatment of stress-related diseases.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: June 19, 2001
    Assignee: Pfizer Inc
    Inventor: Yuhpyng L. Chen