Patents by Inventor Yuichi Hirata

Yuichi Hirata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reshaped human antibody to human interleukin-6
    Patent number: 5856135
    Abstract: A reshaped antibody comprising:(A) L chains comprising:(1) a human C region, and(2) an L chain V region comprising human L chain FRs and L chain CDRs of a mouse monoclonal antibody; and(B) H chains comprising:(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and H chain cDRs of a mouse monoclonal antibody to human IL-6. Since the major portions of the reshaped human antibody are derived from human, and the mouse CDRs are less immunogenic, then the present reshaped human antibody is less immunogenic, and therefore inhibits information transfer by IL-6, and is promising as a therapeutic agent for diseases caused by IL-6.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: January 5, 1999
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masayuki Tsuchiya, Koh Sato, Yuichi Hirata