Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: The present invention relates to a liquid composition for a liquid heating-type flavor inhaler. A liquid composition for a liquid heating-type flavor inhaler of the present invention contains (1) propylene glycol and glycerol, (2) nicotine, (3) benzoic acid, and (4) one or more organic acids excluding benzoic acid. Another liquid composition for a liquid heating-type flavor inhaler of the present invention contains (1) propylene glycol and glycerol, (2) nicotine, and (4) one or more organic acids excluding benzoic acid.

Abstract: A surface acoustic wave module (SAW module) includes a piezoelectric element substrate including a piezoelectric body, an IDT disposed on a front surface of the piezoelectric element substrate and including a comb-like electrode pair, and a coating layer covering the piezoelectric element substrate and the IDT. The coating layer is disposed on the front surface of the piezoelectric element substrate, an end surface of the piezoelectric element substrate, and a corner portion between the front surface of the piezoelectric element substrate and the end surface of the piezoelectric element substrate.

Abstract: A robot hand is provided. The robot hand includes a first and second drive gears rotated by first actuator and second actuators; a first interlocked gear interlocked with the second drive gear to rotate in opposite directions; a second interlocked gear interlocked with the first drive gear to rotate in opposite directions; a first inner link engaged with rotation of the first drive gear; a first outer link engaged with rotation of the first interlocked gear; a first end link connected to the first inner link and the first outer link opposite the first actuator; a second inner link engaged with rotation of the second interlocked gear; a second outer link engaged with rotation of the second drive gear; and a second end link connected to the second inner link and the second outer link opposite the second actuator.

Abstract: A seat apparatus includes plural links configured to be attached to a base member, a seat cushion frame supported by the links, and a connecting member. The seat cushion frame includes a pair of side walls connected by the connecting member, and a contact portion on at least one of the pair of side walls. At least one of the links includes a first end portion, a second end portion, and a projecting portion projecting from the second end portion. The first end portion is rotatably connectable to the base member directly or indirectly about a first rotation axis, the second end portion is rotatably connectable to the side wall directly or indirectly about a second rotation axis, and the projecting portion is configured such that at least when the seat cushion frame is moved to the highest position, a predetermined portion of the projecting portion faces the contact portion.

Abstract: A sealing member for machine tools is capable of keeping sealing performance. The sealing member includes a support member and an elastic member formed in a flat plate shape. The elastic member includes an edge portion to slide on a sliding surface of a machine tool. The support member has a support surface facing a part of a front surface of the elastic member. The sealing member is mounted to the machine tool such that the elastic member is sandwiched between a mount portion of the machine tool and the support surface of the support member. The elastic member has a fixed portion sandwiched between the mount portion and the support member. A lip portion not sandwiched between the mount portion and the support member when the sealing member is mounted to the machine tool, the lip portion including the edge portion and configured to be curved.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: An aerosol supply device includes: an accommodating part (cartridge) configured to accommodate a liquid; an atomization unit configured to atomize the liquid to generate an aerosol; a discharge port configured to discharge the generated aerosol to the outside of the aerosol supply device; and a volatilization preventing part (solenoid valve or duckbill valve) capable of opening and closing a passage (first passage or second passage) through which at least one of the liquid or the aerosol flows between the accommodating part and the outside of the aerosol supply device.

Abstract: An aerosol supply device includes: an accommodating part (cartridge) configured to accommodate a liquid; an atomization unit having a storing part to store the liquid, the atomization unit being configured to generate an aerosol by atomizing the liquid; and a temperature control part configured to control the temperature of the liquid at a given location between the accommodating part (cartridge) and the storing part.

Abstract: This aerosol supply device is provided with: an accommodating section (cartridge) that accommodates a liquid; an atomizing unit that atomizes the liquid to generate an aerosol; and an atomizing amount adjusting unit (gyro sensor and control unit) that adjusts the atomizing amount of the atomizing unit. The aerosol supply device is characterized in that the atomizing amount adjusting unit (gyro sensor and control unit) stabilizes the atomizing amount regardless of the inclination of the aerosol supply device within at least a certain range.

Abstract: A seat apparatus includes plural links configured to be attached to a base member, a seat cushion frame supported by the links, and a connecting member. The seat cushion frame includes a pair of side walls connected by the connecting member, and a contact portion on at least one of the pair of side walls. At least one of the links includes a first end portion, a second end portion, and a projecting portion projecting from the second end portion. The first end portion is rotatably connectable to the base member directly or indirectly about a first rotation axis, the second end portion is rotatably connectable to the side wall directly or indirectly about a second rotation axis, and the projecting portion is configured such that at least when the seat cushion frame is moved to the highest position, a predetermined portion of the projecting portion faces the contact portion.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the formula: L1-L2-LP-NH—(CH2)n1-La-Lb-Lc or -L1-L2-LP- wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the terminal Lc or LP with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: A vehicle seat lifting apparatus includes: a cushion base of a vehicle seat; a link member rotatably provided on the cushion base and raising and lowering at least a part of the vehicle seat; a front limiter provided on a front portion in front of a rotation center of the link member and limiting rotation of the link member; and a rear limiter provided on a rear portion behind the rotation center of the link member and limiting the rotation of the link member.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: An inhaler includes a first liquid storage unit; a second liquid storage unit; an atomizing unit which includes a piezoelectric element substrate having an IDT constructed by use of a pair of interlocking comb-shaped metallic electrodes and is constructed to atomize liquid by a surface acoustic wave generated by applying a high-frequency voltage to the pair of interlocking comb-shaped metallic electrodes; and a mouthpiece for guiding aerosol which is generated by atomizing the liquid in the atomizing unit. The atomizing unit is constructed to atomize first liquid supplied from the first liquid storage unit and second liquid supplied from the second liquid storage unit, respectively.

Abstract: A controller for controlling an atomizing unit, wherein the atomizing unit includes a piezoelectric element substrate including an IDT including a pair of interlocking comb-shaped metallic electrodes, and a liquid supplier configured to supply liquid, which is to be atomized, to the piezoelectric element substrate; wherein the piezoelectric element substrate is configured to atomize the liquid by use of a surface acoustic wave generated by applying a high-frequency voltage to the pair of interlocking comb-shaped metallic electrodes; and the controller is configured to periodically change amplitude and/or a frequency of the high-frequency voltage applied to the pair of interlocking comb-shaped metallic electrodes.

Abstract: A inhaler includes a piezoelectric element substrate having an IDT constructed by use of a pair of interlocking comb-shaped metallic electrodes, a liquid supplier for supplying liquid, which is to be atomized, to a front surface of the piezoelectric element substrate on which the pair of interlocking comb-shaped metallic electrodes is positioned, a sensor, which includes at least a pair of detection parts which are opposite to each other, for detecting liquid supplied to the front surface of the piezoelectric element substrate, and a controller for controlling, based on result of detection by the sensor, the liquid supplier in such a manner that the liquid supplier supplies a certain quantity of the liquid to the front surface of the piezoelectric element substrate.

Abstract: An inhaler includes an atomizing unit including a piezoelectric element substrate having a first IDT including a pair of interlocking comb-shaped electrodes. The atomizing unit is configured to atomize liquid by a surface acoustic wave generated by applying a high-frequency voltage to the pair of interlocking comb-shaped electrodes, and a controller is configured to monitor a resonant frequency of the pair of interlocking comb-shaped electrodes and apply a voltage to the pair of interlocking comb-shaped electrodes at a frequency determined based on the monitored resonant frequency.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: A vehicle lock device includes a base member, a latch, and a release lever. The base member includes a base groove, into which a striker is inserted. The latch includes a latch groove into which the striker is inserted. The latch is pivotal between a lock position, where the striker is fixed to the base groove, and an unlock position, where the striker is released from the base groove. The release lever is pivotal between a lock release position, where pivoting of the latch is permitted from the lock position to the unlock position, and a restriction position, where pivoting of the latch is restricted from the lock position to the unlock position. The release lever includes an engagement release member that contacts the latch when pivoted from the restriction position to the lock release position to pivot the latch from the lock position to the unlock position.