Abstract: A coil component includes a coil having inner and outer circumferential surfaces, a pair of end surfaces, and a core surrounding at least a part of a periphery of the core. A cross section is where the coil component is cut by a plane, when each of coil sections is divided into eight regions by four straight lines extending along the inner circumferential surface, the outer circumferential surface and the end surfaces. In the cross section, first core members positioned at four corner regions, second core members positioned at an inner side of the inner circumferential surface and an outer side of the outer circumferential surface, and third core members, positioned at outer sides of the end surfaces form the core. At least one of the second and third core members has a magnetic permeability lower than that of the first core member in a zero magnetic field.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LF-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A sealing member for machine tools is capable of keeping sealing performance. The sealing member includes a support member and an elastic member formed in a flat plate shape. The elastic member includes an edge portion to slide on a sliding surface of a machine tool. The support member has a support surface facing a part of a front surface of the elastic member. The sealing member is mounted to the machine tool such that the elastic member is sandwiched between a mount portion of the machine tool and the support surface of the support member. The elastic member has a fixed portion sandwiched between the mount portion and the support member. A lip portion not sandwiched between the mount portion and the support member when the sealing member is mounted to the machine tool, the lip portion including the edge portion and configured to be curved.

Abstract: A vehicle seat lifting apparatus includes: a cushion base of a vehicle seat; a link member rotatably provided on the cushion base and raising and lowering at least a part of the vehicle seat; a front limiter provided on a front portion in front of a rotation center of the link member and limiting rotation of the link member; and a rear limiter provided on a rear portion behind the rotation center of the link member and limiting the rotation of the link member.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula (I) is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- or -L1-L2-LP- wherein the antibody is connected to the terminal of L1, the antitumor compound is connected to the terminal of Lc or LP, and any one or two or more of linkers of L1, L2, and LP has a hydrophilic structure.

Abstract: A sealing member for machine tools includes a plate-shaped supporting member and a plate-shaped elastic member. The elastic member is attached to the machine tool so as to be sandwiched between an attachment portion of the machine tool and the supporting member. The elastic member is in sliding contact with a sliding surface of the machine tool. The elastic member includes a projecting portion which projects from an edge portion of the supporting member toward a side of the sliding surface of the machine tool such that one surface side of the projecting portion comes into sliding contact with the sliding surface of the machine tool. The projecting portion has a distal edge including a plurality of linear portions. A corner portion is sandwiched between two adjacent linear portions among the linear portions, and is provided with an incision extending from the corner portion toward the supporting member side.

Abstract: A vehicle lock device includes a base member, a latch, and a release lever. The base member includes a base groove, into which a striker is inserted. The latch includes a latch groove into which the striker is inserted. The latch is pivotal between a lock position, where the striker is fixed to the base groove, and an unlock position, where the striker is released from the base groove. The release lever is pivotal between a lock release position, where pivoting of the latch is permitted from the lock position to the unlock position, and a restriction position, where pivoting of the latch is restricted from the lock position to the unlock position. The release lever includes an engagement release member that contacts the latch when pivoted from the restriction position to the lock release position to pivot the latch from the lock position to the unlock position.

Abstract: A reactor comprises a first coil, a second coil and a core. Each of the first coil and the second coil is embedded in the core. The core has an outer core part, an inner core part, an upper core part, a lower core part and a middle core part. The upper core part is positioned above an upper end of a cross-section of the first coil in an up-down direction. The lower core part is positioned below a lower end of a cross-section of a second coil in the up-down direction. The core is made of a first member and a second member. The second member has a relative permeability which is greater than a relative permeability of the first member. Each of the upper core part and the lower core part is made of the second member.

Abstract: A reactor comprises a first coil, a second coil and a core. Each of the first coil and the second coil is embedded in the core. The core has an outer core part, an inner core part, an upper core part, a lower core part and a middle core part. The upper core part is positioned above an upper end of a cross-section of the first coil in an up-down direction. The lower core part is positioned below a lower end of a cross-section of a second coil in the up-down direction. The core is made of a first member and a second member. The second member has a relative permeability which is greater than a relative permeability of the first member. Each of the upper core part and the lower core part is made of the second member.

Abstract: An object of the present invention is to provide a sealing member for machine tools which has excellent reliability because excellent sealability can be maintained for a long period of time and which can be manufactured efficiently at low cost. The sealing member for machine tools of the present invention includes a supporting member; a plate-shaped elastic member; and an adhesive layer which bonds the elastic member to the supporting member. The supporting member has a shape of a bent plate-like body, the elastic member is bonded to the supporting member via the adhesive layer laminated on a part of a front face of the elastic member so as to be curved along the bent shape of the supporting member, and a corner portion formed by a back face and one side face of the elastic member is assumed to be an edge portion in contact with an opposite material, and the one side face is formed by cutting.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: A composite silica glass made light diffusion member includes a dense silica glass, and a porous silica glass which has been layered on the surface of the dense silica glass. The porous silica glass is a porous body and has a homogeneous pore distribution. The porous body has a framework including a plurality of spherical silica glasses, contains a communicating pore part formed by spaces among them, and has a central pore size of 10 to 20 ?m and a porosity of 25 to 40%. The spherical silica glasses have an average diameter of 30 to 100 ?m. An average value of a specific arithmetic average roughness Ra in each of the spherical silica glass exposed on an outer surface of the porous silica glass is 0.8 to 4.0 nm.

Abstract: A sensor device includes a sensor element, a converter, and an output unit. The sensor element includes a sheet-like dielectric layer including an elastomer composition and a top electrode layer and a bottom electrode layer each including an electroconductive composition containing carbon nanotubes. The top and the bottom electrode layers are formed on a top surface and a bottom surface of the dielectric layer, respectively, and are at least partially opposed to each other across the dielectric layer. The at least partially opposed portions of the top and the bottom electrode layers constitute a detection portion, and the dielectric layer reversibly deforms to change an area of a main surface of the dielectric layer. The converter electrically is connected to the sensor element and converts capacitance at the detection portion that varies in accordance with the deformation of the dielectric layer to electric characteristics.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A coil component includes a coil having inner and outer circumferential surfaces, a pair of end surfaces, and a core surrounding at least a part of a periphery of the core. A cross section is where the coil component is cut by a plane, when each of coil sections is divided into eight regions by four straight lines extending along the inner circumferential surface, the outer circumferential surface and the end surfaces. In the cross section, first core members positioned at four corner regions, second core members positioned at an inner side of the inner circumferential surface and an outer side of the outer circumferential surface, and third core members, positioned at outer sides of the end surfaces form the core. At least one of the second and third core members has a magnetic permeability lower than that of the first core member in a zero magnetic field.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.