Abstract: The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.

Abstract: A door opening and closing device for a vehicle that can remove an object attached to operation surface of a door handle with a simpler structure is provided. The device includes a door handle 41. The door handle 41 includes a grip 44 and a deflective portion 47. The grip 44 protrudes outward and defines a space 32 between the outer surface of the door outer panel 3 and the grip 44 to allow gripping by a user. The grip includes an outer surface and an operation surface opposing to the outer surface of the door outer panel 3. The deflective portion is located at an end of the grip 44 and extends from the outer surface of the grip 44 along the outer surface of the door outer panel 13 in a direction crossing front and rear directions of the vehicle to direct air flow flowing along the outer surface of the door outer panel 3 to flow through at least the space 32 of the grip 44 to the operation surface 44a.

Abstract: The present invention relates to a benzazepinone compound represented by the following formula (I): wherein R1 represents a C1-C6 alkyl group or halogeno C1-C6 alkyl group, R2 represents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or a nitrogen atom, or a pharmaceutically acceptable salt thereof.

Abstract: An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. In the formulae, R represents a protecting group for a hydroxyl group. A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.

Abstract: The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.