Patents by Inventor Yukio Oikawa

Yukio Oikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210138482
    Abstract: A field-flow fractionation device includes a separation channel, a carrier fluid supplier, a separation membrane, a waste liquid chamber, a cross-flow flow rate adjuster, and a carrier fluid adder. The carrier fluid adder is configured to add, to a flow of a carrier fluid having passed through the separation membrane, a flow of another carrier fluid at a carrier fluid adding position set on an upstream side of the cross-flow flow rate adjuster so that the flow rate of the carrier fluid flowing into the cross-flow flow rate adjuster is larger than the flow rate of the carrier fluid having passed through the separation membrane.
    Type: Application
    Filed: April 11, 2018
    Publication date: May 13, 2021
    Applicant: SHIMADZU CORPORATION
    Inventors: Shigeyoshi HORIIKE, Jun YANAGIBAYASHI, Yukio OIKAWA, Maiko NAKAYA, Masaki KANAI
  • Publication number: 20200324272
    Abstract: The present invention provides a method for hydrophobization of a hydrophilic material, the method including introducing a hydrophobic group into a hydroxyl group (—OH group) on a surface of the hydrophilic material. A method for hydrophobization of a hydrophilic material, the method comprising reacting a hydrophilic material to be hydrophobized with a hydrophobic group-containing silylating agent in presence of an amino acid as a reaction accelerator, to introduce a hydrophobic group-containing silyl group to a surface of the hydrophilic material. A hydrophobized silica gel column filler is produced by using the method. Further, a hydrophobized silica gel column is produced by filling a column with the hydrophobized silica gel column filler.
    Type: Application
    Filed: March 6, 2020
    Publication date: October 15, 2020
    Applicant: SHIMADZU CORPORATION
    Inventors: Yukio OIKAWA, Shigeyoshi HORIIKE, Hirotaka KOYAMA
  • Publication number: 20200249208
    Abstract: Provided is a field-flow-fractionation apparatus that is configured to supply a carrier fluid to a waste fluid chamber through a fluid supply flow path at a flow rate higher than a set flow rate of a flow rate adjusting part at a timing between an end of analysis of a sample and a start of analysis of a subsequent sample, thereby forming a flow of the carrier fluid from the waste fluid chamber to the separation channel. Accordingly, the sample adhering to a separation membrane is separated from the separation membrane and is discharged from the outlet port.
    Type: Application
    Filed: January 30, 2020
    Publication date: August 6, 2020
    Inventors: Yukio OIKAWA, Shigeyoshi HORIIKE
  • Patent number: 10589191
    Abstract: Provided is a method for separating a substance accommodated in a vessel-shaped structure comprising subjecting a vessel-shaped structure 1, which includes a vessel portion a, a vessel portion b, and a self-fusing material X connecting the both vessel portions, and which accommodates a substance selected from the group consisting of a liquid, a solid a gas, and a dispersion system, to the steps: (i) pulling the vessel portion a and the vessel, portion b away from each other to extend the self-fusing material X; (ii) fusing the extended self-fusing material X together between the vessel portion a and the vessel portion b to separate the accommodated substance; and (iii) cutting a fused part of the self-fusing material X to separate the vessel-shaped structure 1 into a separated structure.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: March 17, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Tetsuo Ohashi, Yukio Oikawa, Kei Shinada
  • Patent number: 10533170
    Abstract: A magnetic particle manipulation method for magnetic particle comprises the steps of; subjecting magnetic particles and a magnetic solid having a larger particle diameter than said magnetic particles to existing together in a liquid layer, and moving said magnetic solid and said magnetic particles in said liquid layer by a magnetic field manipulation. According to one aspect of the present invention; a manipulation method for magnetic particles comprising the steps of; moving magnetic particles in a first liquid layer into a gelled medium layer by a magnetic field manipulation in a device, wherein gelled medium layers and liquid layers are in-place alternately in a container, moving said magnetic particles present in the gelled medium into a second liquid layer by the magnetic field manipulation; and moving said magnetic particles along with said magnetic solid in the second liquid layer.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 14, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Tetsuo Ohashi, Yukio Oikawa
  • Publication number: 20190317057
    Abstract: A field flow fractionation apparatus includes a separation channel provided with an inlet port and an outlet port at both ends and forming a space through which a carrier fluid flows between the inlet port and the outlet port, a separation membrane which is a wall surface that defines the separation channel and is parallel to a channel flow in which a carrier fluid flows in the separation channel from the inlet port toward the outlet port, and has a property of permeating the carrier fluid and not permeating particles to be separated, and a discharge port that discharges the carrier fluid having permeated through the separation membrane to outside. At least a part of the surface of the separation membrane is an ion exchangeable region in which a functional group having ion exchangeability is modified.
    Type: Application
    Filed: April 10, 2019
    Publication date: October 17, 2019
    Applicant: SHIMADZU CORPORATION
    Inventors: Yukio OIKAWA, Shigeyoshi Horiike, Maiko Nakaya, Masaki Kanai
  • Patent number: 10005035
    Abstract: An ion processing device includes, on the side of an anion exchange layer of a bipolar membrane which is formed by stacking an anion exchange layer and a cation exchange layer, an anion-side channel which is filled with an anion exchanger, and an anion removal channel provided via an anion exchange membrane, and also includes an anode for moving anions from the anion-side channel to the anion removal channel through the anion exchange membrane. Further, a cation-side channel which is filled with a cation exchanger and a cation removal channel provided via a cation exchange membrane are included on the side of the cation exchange layer of the bipolar membrane as well as a cathode for moving cations from the cation-side channel to the cation removal channel through the cation exchange membrane.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: June 26, 2018
    Assignee: SHIMADZU CORPORATION
    Inventor: Yukio Oikawa
  • Publication number: 20180136176
    Abstract: The suppressor system is provided with: a suppressor which has an eluent flow path and a suppression solution flow path, the eluent flow path and the suppression solution flow path being separated from each other by an ion exchange membrane; a circulation flow path which connects the inlet and the outlet of the suppression solution flow path of the suppressor, and circulates a suppression solution; an ion exchange resin column which is provided on the circulation flow path, and is equipped with a resin accommodation unit through which the suppression solution flowing out of the suppressor is passed, an acidic or alkaline ion exchange resin being accommodated in the resin accommodation unit; and a life detector which determines the life of the ion exchange resin in the ion exchange resin column.
    Type: Application
    Filed: May 22, 2015
    Publication date: May 17, 2018
    Inventors: Yukio OIKAWA, Hiroshi TANAKA
  • Publication number: 20170073667
    Abstract: A magnetic particle manipulation method for magnetic particle comprises the steps of; subjecting magnetic particles and a magnetic solid having a larger particle diameter than said magnetic particles to existing together in a liquid layer, and moving said magnetic solid and said magnetic particles in said liquid layer by a magnetic field manipulation. According to one aspect of the present invention; a manipulation method for magnetic particles comprising the steps of; moving magnetic particles in a first liquid layer into a gelled medium layer by a magnetic field manipulation in a device, wherein gelled medium layers and liquid layers are in-place alternately in a container, moving said magnetic particles present in the gelled medium into a second liquid layer by the magnetic field manipulation; and moving said magnetic particles along with said magnetic solid in the second liquid layer.
    Type: Application
    Filed: March 14, 2014
    Publication date: March 16, 2017
    Applicant: SHIMADZU CORPORATION
    Inventors: Tetsuo OHASHI, Yukio OIKAWA
  • Patent number: 9535034
    Abstract: A suppressor is structured by an ion exchange section being structured by an eluate path forming member forming an eluate path and a regenerant path forming member forming a regenerant path being stacked across an ion exchange film, and a heat-conductive heat block covering the outside of the ion exchange section. A separation column, the suppressor, and an electrical conductivity meter are accommodated in a common constant temperature bath. The inside of the constant temperature bath is feedback-controlled by a temperature control section so as to be maintained at constant temperature.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: January 3, 2017
    Assignee: SHIMADZU CORPORATION
    Inventors: Katsumasa Sakamoto, Yukio Oikawa, Shigeyoshi Horiike
  • Publication number: 20160175778
    Abstract: An ion processing device includes, on the side of an anion exchange layer of a bipolar membrane which is formed by stacking an anion exchange layer and a cation exchange layer, an anion-side channel which is filled with an anion exchanger, and an anion removal channel provided via an anion exchange membrane, and also includes an anode for moving anions from the anion-side channel to the anion removal channel through the anion exchange membrane. Further, a cation-side channel which is filled with a cation exchanger and a cation removal channel provided via a cation exchange membrane are included on the side of the cation exchange layer of the bipolar membrane as well as a cathode for moving cations from the cation-side channel to the cation removal channel through the cation exchange membrane.
    Type: Application
    Filed: December 8, 2015
    Publication date: June 23, 2016
    Applicant: SHIMADZU CORPORATION
    Inventor: Yukio Oikawa
  • Publication number: 20140320146
    Abstract: A suppressor is structured by an ion exchange section being structured by an eluate path forming member forming an eluate path and a regenerant path forming member forming a regenerant path being stacked across an ion exchange film, and a heat-conductive heat block covering the outside of the ion exchange section. A separation column, the suppressor, and an electrical conductivity meter are accommodated in a common constant temperature bath. The inside of the constant temperature bath is feedback-controlled by a temperature control section so as to be maintained at constant temperature.
    Type: Application
    Filed: October 15, 2012
    Publication date: October 30, 2014
    Inventors: Katsumasa Sakamoto, Yukio Oikawa, Shigeyoshi Horiike
  • Publication number: 20140124446
    Abstract: Provided is a method capable of reliably separating part (e.g., a collection liquid) of an accommodated substance (e.g., a manipulation medium for performing physical, chemical, and/or biochemical treatment and a collection liquid containing a target substance) accommodated in the same space of a vessel-shaped structure only by simple mechanical operation without any contact with an outside atmosphere.
    Type: Application
    Filed: May 31, 2012
    Publication date: May 8, 2014
    Inventors: Tetsuo Ohashi, Yukio Oikawa, Kei Shinada
  • Patent number: 8551760
    Abstract: [Problems] To immobilize a chain-type biopolymer in an elongated state at a predetermined position on a substrate. [Means for Solving Problems] A substrate (1) for immobilizing a biopolymer, which has a mask layer (2) provided with multiple through-holes at predetermined positions on a flat active face, is brought into contact with a solution containing a chain-type biopolymer (7). After thus immobilizing the nucleic acid molecule (7) on the active face within a through-hole (3) via physical adsorption or chemical binding, the mask layer (2) is dissolved in a solvent and thus removed while leaving the nucleic acid molecule (7a) alone having been immobilized on the active face within the through-hole (3). Subsequently, the nucleic acid molecule (7a) having been immobilized on the active face is elongated.
    Type: Grant
    Filed: September 5, 2005
    Date of Patent: October 8, 2013
    Assignee: Shimadzu Corporation
    Inventors: Shigeyoshi Horiike, Yukio Oikawa, Takahiro Nishimoto
  • Patent number: 7981284
    Abstract: Disclosed herein is a suppressor using one ion-exchange tube which has an inner diameter close to that of a tube connected to a separation column and which is constituted by an ion-exchange membrane. The ion-exchange tube is folded or wound more than once in a plane into a sheet form to provide an ion-exchange tube sheet through which an eluate from a separation column flows. The ion-exchange tube sheet is accommodated in a container. The container provides a regenerant flow channel so that a regenerant is allowed to flow on both sides of the ion-exchange tube sheet.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: July 19, 2011
    Assignee: Shimadzu Corporation
    Inventors: Katsumasa Sakamoto, Yukio Oikawa, Shigeyoshi Horiike, Hiroaki Nakanishi
  • Publication number: 20100320132
    Abstract: Disclosed herein is a suppressor using one ion-exchange tube which has an inner diameter close to that of a tube connected to a separation column and which is constituted by an ion-exchange membrane. The ion-exchange tube is folded or wound more than once in a plane into a sheet form to provide an ion-exchange tube sheet through which an eluate from a separation column flows. The ion-exchange tube sheet is accommodated in a container. The container provides a regenerant flow channel so that a regenerant is allowed to flow on both sides of the ion-exchange tube sheet.
    Type: Application
    Filed: February 21, 2008
    Publication date: December 23, 2010
    Inventors: Katsumasa Sakamoto, Yukio Oikawa, Shigeyoshi Horiike, Hiroaki Nakanishi
  • Publication number: 20090269742
    Abstract: [Problems] To immobilize a chain-type biopolymer in an elongated state at a predetermined position on a substrate. [Means for Solving Problems] A substrate (1) for immobilizing a biopolymer, which has a mask layer (2) provided with multiple through-holes at predetermined positions on a flat active face, is brought into contact with a solution containing a chain-type biopolymer (7). After thus immobilizing the nucleic acid molecule (7) on the active face within a through-hole (3) via physical adsorption or chemical binding, the mask layer (2) is dissolved in a solvent and thus removed while leaving the nucleic acid molecule (7a) alone having been immobilized on the active face within the through-hole (3). Subsequently, the nucleic acid molecule (7a) having been immobilized on the active face is elongated.
    Type: Application
    Filed: September 5, 2005
    Publication date: October 29, 2009
    Inventors: Shigeyoshi Horiike, Yukio Oikawa, Takahiro Nishimoto
  • Patent number: 5324434
    Abstract: A filter of a water purifying apparatus main body which is housed in a sink is made as a positive electrode, and a DC voltage is applied, by a dry battery cell, between the filter and a negative electrode in a purified water passage. Thus, microbes are prevented from proliferating in tap water which remains in the water purifying apparatus main body. A discharge pipe of the water faucet used exclusively for purified water is made as a negative electrode, and a DC voltage is applied, by the dry battery cell, between the positive electrode in the outlet of a cartridge and the discharge pipe. Thus, microbes are prevented from proliferating in tap water which remains in the water faucet used exclusively for purified water.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: June 28, 1994
    Assignees: Nippondenso Co., Ltd., Inax Corporation
    Inventors: Yukio Oikawa, Isamu Shigeta, Shiro Saito, Mitsuhiro Hayamizu
  • Patent number: 5281330
    Abstract: A water purifying apparatus of compact construction. The water purifying apparatus has a water channel for receiving water via an inflow passage and discharging water via an outflow passage. An electrically conductive filter is disposed in and fully occupies a portion of the water channel for purifying water flowing through the filter. A first electrode is electrically connected to the filter, and a second electrode, disposed in the filter, is electrically connected to the filter via water flowing through the filter. A battery supplies voltage between the first and second electrodes. A switch controls application of the voltage from the batteries to the first and second electrodes. A circuit board having a control circuit is disposed above the first electrode, the second electrode and the switch. The circuit board is electrically connected to the various electronic components.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: January 25, 1994
    Assignees: Nippondenso Co., Ltd., Inax Corporation
    Inventors: Yukio Oikawa, Isamu Shigeta, Shiro Saito
  • Patent number: 4831011
    Abstract: A carbon-based adsorbent comprising active carbon provided with electron-donative surface functional groups which are bonded directly and chemically to graphite constructing the surface of the active carbon and are coordinated with metallic ions to form chelate structures, which has adsorbing power similar to that of common active carbon and additionally the ability to remove specific harmful gas molecules and smelling gas molecules from air, thus being especially effective for gas filters.
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: May 16, 1989
    Assignee: Nippondenso Co., Ltd.
    Inventors: Yukio Oikawa, Kunio Okamoto, Takahiro Shibakawa