Abstract: An analysis element for use in a blood test method enabling easy and simple operations that are performed quickly up to measurement, an analysis element for use in a blood test method that operations up to the measurement for many components can be quickly performed, and that is safe and has a sufficient measurement accuracy thereof, and an analysis element for use in a test method using body fluids and urines of humans and animals, plain water, seawater, soil extract, agricultural products, marine products, processed-food extracts, and liquid for use in scientific research as specimens, are provided, the present invention relates to a multi-component measurement dry analysis element for use in a method for testing a specimen, the method using an area sensor as a detector to obtain a result of measurement according to information represented by 1000 pixels or more per one component, and to perform simultaneous measurements of plural components.

Abstract: The present invention provides a reactive microreactor wherein a group of the following formula (1) which can bind to a member of specifically binding partner, is bound to a part or entirety of a wall surface of a channel: -L-SO2—X1??(1) wherein X1 represents —CR1?CR2R3 or —CHR1—CR2R3Y; R1, R2 and R3 independently represent an atom or a group selected from the group consisting of a hydrogen atom, a C1-6 alkyl group, a C6-20 aryl group, and a C7-20 aralkyl group having a C1-6 alkyl chain; Y represents a group which can be substitutable by a nucleophilic reagent or a group which is released as “HY” by a base; and L represents a linking group. The microreactor according to the present invention has advantages that it requires a less amount of a reagent and achieves a higher S/N ratio.

Abstract: An object of the present invention is to provide a microchip whereby, when chemical analysis is conducted, a specimen liquid can be directly collected and weighed without using any collecting and weighing devices. The present invention provides a microchip for analyzing liquid samples, which has a measuring structure for weighing and collecting a given amount of a specimen liquid within a range of 0.05 to 10 ?l from an an excessive amount of the specimen liquid which was introduced in the chip, wherein the measuring structure is located at the upstream side of an analysis element for analyzing a target substance in the specimen liquid inside the microchip.

Abstract: According to the present invention, there is provided a fluorescent nucleotide represented by the formula: A-B-C, wherein A represents a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue; B represents a divalent linking group or a single bond; and C represents a monovalent group derived from a fluorescent dye having 0 or 1 sulfonic acid group or phosphoric acid group in a molecule. The present invention provides useful fluorescent nucleotides for labeling nucleic acids, specifically, fluorescent nucleotides of which uptake ratio is high in synthetic reaction of nucleic acids.

Abstract: A power steering system for a vehicle. The system includes a hydraulic power cylinder, first and second hydraulic lines, a bypass passage through which the first and second hydraulic lines are connected with each other, and a flow passage change-over device adapted to close the bypass passage during steering assisting. A supply passage and a return passage are disposed in parallel with each other to form part of each of the first and second hydraulic lines. The flow passage change-over device is disposed in each of the first and second hydraulic lines. A differential pressure regulating valve is disposed in each of the return passages and adapted to allow hydraulic fluid to flow toward the hydraulic pressure source in a condition where pressure on side of the hydraulic power cylinder becomes higher than a set pressure or higher than pressure on side of the hydraulic pressure source.

Abstract: A reactive solid carrier favorably employable for manufacturing DNA chip is composed of a solid carrier and a plurality of vinylsulfonyl groups or their reactive precursors each of which is fixed onto a surface of the solid carrier by covalent bonding via a linking group, and a method for producing a DNA chip is performed by bringing the reactive solid carrier into contact with nucleotide derivatives or their analogues having a reactive group which is reactive with the vinylsulfonyl group or reactive precursor fixed to the solid carrier.

Abstract: An object of the present invention is to provide a method for detecting a protein using a nonradioactive label which is prevented to a smaller extent than in the case of the interaction of biotin/(strepto)avidin, and which achieves higher detection sensitivity than that of the detection system using DIG. The present invention provides a method for detecting a target substance, which comprises steps of: (A) allowing a target substance to come into contact with a protein labeled with a compound having a 6-membered ring, so as to carry out a binding reaction; and (B) detecting the protein labeled with the compound having a 6-membered ring, which was bound to the target substance, by using an antibody against the above compound having a 6-membered ring.

Abstract: Revolving rollers, each provided on an outer peripheral surface thereof with revolving roller grooves extending therearound, are caused to mesh with a rack rod thread of a central rack rod with an axial angle over a lead angle of the rack rod thread and arranged for rotation on a holder member to be twisted. The holder member is rotated round the rack rod by a motor to translate the rack rod. A large thrust can be generated while ensuring a high reliability since a high efficiency is achieved by realizing rolling contact in set points of mesh of the rack rod thread and the revolving roller grooves, points of mesh are made planar, and interference in other points than the points of mesh can be suppressed. Also, play can be restricted by assembling the revolving rollers to the rack rod thread while applying torque in a direction, in which the axial angle is increased.

Abstract: A microdevice for performing a method for separating and purifying a nucleic acid, the microdevice comprising: at least one opening; and at least one channel for passing a sample solution, wherein the method comprises: (A) a step of bringing a nucleic acid-containing sample solution into contact with a nucleic acid-adsorbing support having a function of adsorbing a nucleic acid; (B) a step of washing the nucleic acid-adsorbing support with a washing solution in a state of a nucleic acid being adsorbed to the support; and (C) a step of desorbing the nucleic acid from the nucleic acid-adsorbing support by a recovering solution, thereby purifying the nucleic acid; an apparatus for utilizing the microdevice; and a reagent kit for use in the microdevice.

Abstract: A liquid filtering instrument 10 according to the present invention achieves filtered liquid by pressure-reduced filtration, and it comprises a filter member 12 in which a liquid filter 15 is accommodated, and a holder member 14 for stocking filtered liquid passed through the liquid filter 15, wherein the filter member 12 and the holder member 14 are formed in capable of being fitted so as to be kept substantially air-tight and water-tight under pressure reduced state.

Abstract: A microchemical device capable of promoting mixing of a specimen and a reagent particularly in analyzing trace constituents of liquid such as blood or body fluid, and a microchemical device that can rapidly and easily analyze one or more constituents from a small amount of specimen, are provided, which is an integrated microchemical device for analyzing one or more constituents of a specimen, the microchemical device comprising at least the two elements of (a) one or more flow channels through which a specimen passes and (b) a multilayer dry analysis element that can come in contact with at least one of the flow channels and analyze the constituents of the specimen.

Abstract: An object of the present invention is to provide a method for detecting a protein using a nonradioactive label which is prevented to a smaller extent than in the case of the interaction of biotin/(strepto)avidin, and which achieves higher detection sensitivity than that of the detection system using DIG. The present invention provides a method for detecting a target substance, which comprises steps of: (A) allowing a target substance to come into contact with a protein labeled with a compound having a 6-membered ring, so as to carry out a binding reaction; and (B) detecting the protein labeled with the compound having a 6-membered ring, which was bound to the target substance, by using an antibody against the above compound having a 6-membered ring.

Abstract: A power steering system for a vehicle, comprises a steering shaft connected to a steering mechanism. A hydraulic power cylinder is provided for assisting a steering effort of the steering mechanism. A reversible pump is provided having first and second discharge ports which are respectively connected through first and second hydraulic lines with two hydraulic pressure chambers of the hydraulic power cylinder so that the two hydraulic pressure chambers are respectively provided with hydraulic pressures. A driving device is provided for driving the reversible pump to rightly and reversely rotate. A differential pressure regulating valve is disposed in the hydraulic circuit to maintain pressure at least in the first and second hydraulic lines at a level of atmospheric pressure or higher in an inoperative condition of the reversible pump.

Abstract: The object of the present invention is to provide a method for analyzing double stranded DNA directly without denaturation. According to the present invention, there is provided a method of analyzing double stranded DNA present in an analyte, which comprises the steps of: (1) contacting the analyte with a double stranded DNA recognizing substance immobilized on a support, and (2) measuring double stranded DNA bound to the double stranded DNA recognizing substance.

Abstract: A power steering system for a vehicle, comprises a steering shaft connected to a steering mechanism. A hydraulic power cylinder is provided for assisting a steering effort of the steering mechanism. A reversible pump is provided having first and second discharge ports which are respectively connected through first and second hydraulic lines with two hydraulic pressure chambers of the hydraulic power cylinder so that the two hydraulic pressure chambers are respectively provided with hydraulic pressures. A driving device is provided for driving the reversible pump to rightly and reversely rotate. A differential pressure regulating valve is disposed in the hydraulic circuit to maintain pressure at least in the first and second hydraulic lines at a level of atmospheric pressure or higher in an inoperative condition of the reversible pump.

Abstract: A modified solid carrier composed of a solid carrier and a group of compounds having a vinylsulfonyl group which are fixed to the solid carrier with non-covalent bonding is favorably employed for preparing a device for detection of oligonucleotide or polynucleotide.

Abstract: The present invention provides a reactive microreactor wherein a group of the following formula (1) which can bind to a member of specifically binding partner, is bound to a part or entirety of a wall surface of a channel:

Abstract: A DNA chip or its analogue composed of nucleotide derivatives attached to a solid carrier is prepared by method of bringing nucleotide derivatives having a reactive group at each one terminal into contact with a solid carrier having thereon reactive groups in an aqueous phase in the presence of a transferase which is capable of producing a covalent bond by rearrangement of the reactive group of the nucleotide derivative and the reactive group of the solid carrier.

Abstract: The present invention provides a fluorescent substance which is represented by a formula: A-B-C wherein A is a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue, or A is a residue of avidin or streptavidin; B is a divalent linking group or a single bond; and C is a monovalent group derived from a general formula (I) and binds to B at a reactive group present in R1 or R2: wherein R1 and R2 each independently represent an alkyl group that may be substituted with a reactive group capable of covalently bonding to A-B-; R3, R4, R5, and R6 each independently represent an alkyl group, and R3 and R4, and/or R5 and R6 may bind to each other to form a saturated carbon-ring together with a carbon atom(s) to which they bind; V1, V2, V3, V4, V5, V6, V7, V8, V9 and V10 each independently represent a hydrogen atom or a monovalent substituent, and two adjacent groups thereof may bind to form a ring; L1, L2,

Abstract: A power steering system for a vehicle, comprises a steering shaft connected to a steering mechanism. A hydraulic power cylinder is provided for assisting a steering effort of the steering mechanism. A reversible pump is provided having first and second discharge ports which are respectively connected through first and second hydraulic lines with two hydraulic pressure chambers of the hydraulic power cylinder so that the two hydraulic pressure chambers are respectively provided with hydraulic pressures. A driving device is provided for driving the reversible pump to rightly and reversely rotate. A differential pressure regulating valve is disposed in the hydraulic circuit to maintain pressure at least in the first and second hydraulic lines at a level of atmospheric pressure or higher in an inoperative condition of the reversible pump.