Abstract: Provided is an anti-B7-H4 antibody containing a VH, wherein the VH contains the following CDRs or a mutation thereof: CDR1 as shown in the amino acid sequence of SEQ ID NO: 4 or 5, CDR2 as shown in the amino acid sequence of SEQ ID NO: 15, and CDR3 as shown in the amino acid sequence of SEQ ID NO: 24 or 25, and wherein the mutation is an insertion, deletion or substitution of 3, 2 or 1 amino acid(s) in the amino acid sequences of the CDRs. The antibody has the activity of binding to human B7-H4 and cynomolgus monkey B7-H4. The antibody still retains the activity of binding to human B7-H4 and cynomolgus monkey B7-H4 when prepared into a B7-H4×CD3 bispecific antibody, and has a strong killing effect on tumor cells. The antibody induces a very low expression of nonspecific cytokines such as IL-6 and IFN-?, and exhibits a strong in vivo anti-tumor activity.

Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.

Abstract: An decoding method is disclosed, including: parsing a received bitstream to determine whether a current image block is required to be partitioned; parsing the bitstream to determine a partition direction when the current image block is required to be partitioned, wherein the partition direction is a horizontal direction; partitioning the current image block into four rectangular subblocks when the partition direction is the horizontal direction, wherein a size of the current image block is expressed as 16×H, with H representing a height of the current image block and 16 is a width of the current image block, wherein H is not equal to 16, and wherein a size of each of the four rectangular subblocks is expressed as 16×H/4; and reconstructing the current image block based on the four rectangular subblocks.

Abstract: The present disclosure provides a scanning device, including a laser transmitter and a reflection assembly. The reflection assembly includes a drive member and a first reflector, the drive member being configured to drive the first reflector to rotate; the laser transmitter is configured to emit a laser beam, and an emitting end of the laser transmitter is arranged facing the first reflector, causing the laser beam being emitting toward the first reflector and the first reflector to reflect the laser beam to change a direction of the laser beam.

Abstract: An decoding method is disclosed, including: parsing a bitstream to determine whether a current coding block is required to be partitioned; when the current coding block is required to be partitioned, parsing the bitstream to determine whether the current coding blocks is partitioned in a horizontal direction or a vertical direction; partitioning the current coding block into four first rectangular subblocks in the horizontal direction or four second rectangular subblocks in the vertical direction; and reconstructing the current coding block based on the four first rectangular subblocks or the four second rectangular subblocks.

Abstract: Sample analyzers and a method for controlling the sample analyzer are provided. The sample analyzer includes a reaction device, a detection device, a processor and a display. The reaction device is configured to obtain a reaction product. Multiple types of emitting lights are emitted after the irradiation light from the detection device irradiates the reaction product. An optical signal acquisition component is configured to acquire, in each light acquiring period, optical signals corresponding to a detection wavelength and at least one wavelength other than the detection wavelength for at least one type of emitting light. The processor is configured to calculate, for the at least one type of emitting light, optical data corresponding to the detection wavelength and the at least one wavelength other than the detection wavelength in each light acquiring period. The display is configured to display the optical data in multiple light acquiring periods.

Abstract: A method of providing optimized settings of graphics parameters for a computer gaming application includes: consolidating data related to settings of graphics parameters for different computer hardware equipment and respective performance values; training a machine learning model based on the consolidated data; determining a weight for each setting of a graphics parameter, by the trained machine learning model; for each set of graphics parameters, predicting a performance value achievable by the computer gaining application when it is executed on a specific type of computer, by the trained machine learning model; assigning a priority value to each graphics parameter based on its contribution to the performance value; choosing or generating at least one set of graphics parameters providing an optimized performance value, based on the predicted performance value associated with each set of graphics parameters and the determined weight for each graphics parameter and/or based on the assigned priority value.

Abstract: The disclosure relates to an improved Oil Red O staining solution, which consists of 0.5% of Oil Red O, 50% of ethanol, and 5% to 10% of salicylic acid. The staining solution does not contain organic solvents toxic to human bodies and has good safety and no toxic effect. The disclosure further relates to an Oil Red O staining method for cells or tissues, which is simple in operation, short in staining time, and easy to stain neutral fat in cells or tissues, with good staining effect and clean background. This method does not use isopropanol, which is safe and convenient and is suitable for popularization and application in laboratories.

Abstract: A first set of features associated with a neural network are parameterized. A decision tree is generated from the first set of features. One or more adjustments for the neural network are received at the decision tree. A second set of features associated with the adjustments at the decision tree are parameterized. The parameterized first and second set of features are combined into a plurality of parameters. From the plurality, an adjusted neural network is generated.

Abstract: Embodiments of this application relate to the video coding and compression field, and disclose an encoding method and apparatus, and a decoding method and apparatus, to resolve a problem that an existing split mode cannot satisfy a relatively complex texture requirement. The decoding method specifically includes: parsing a bitstream to determine a basic split mode for a current to-be-decoded picture block and a target derivation mode for a subpicture block of the current to-be-decoded picture block; splitting the current to-be-decoded picture block into N subpicture blocks in the basic split mode, where N is an integer greater than or equal to 2; deriving one derived picture block from at least two adjacent subpicture blocks in the N subpicture blocks in the target derivation mode; and decoding the derived picture block.

Abstract: The present application relates to a protein-drug conjugate, containing an antigen binding protein portion and a drug conjugate portion. The antigen binding protein portion comprises one or more antigen binding fragments, and at least two linker peptides are directly or indirectly connected to the antigen binding fragments. The two linker peptides can each independently contain a first cysteine Cys1 and a second cysteine Cys2. The drug conjugate portion is covalently bonded on Cys1. The present application further relates to a preparation method for the protein-drug conjugate, and a use for the protein-drug conjugate in preventing or treating tumors or other diseases.

Abstract: An decoding method is disclosed, including: parsing a bitstream to obtain a first flag, wherein the first flag specifies whether a current coding block is required to be partitioned; when the first flag specifies that the current coding block is required to be partitioned, parsing the bitstream to obtain a second flag, wherein the second flag specifies whether the current coding blocks is partitioned in a horizontal direction or a vertical direction; partitioning the current coding block into four first rectangular subblocks in the horizontal direction or four second rectangular subblocks in the vertical direction; and reconstructing the current coding block based on the four first rectangular subblocks or the four second rectangular subblocks.

Abstract: Provided an isolated antigen binding protein having one or more of the following properties: a. capable of binding to both human CD73 and Cynomolgus monkey CD73; b. capable of inhibiting 5?ectonucleotidase activity of CD73; c. capable of mediating CD73 internalization; d. capable of promoting T cell proliferation; e. with a relatively stable concentration in serum; and f. capable of inhibiting tumor growth and/or tumor cell proliferation. In addition, provided a method for producing the isolated antigen binding protein as well as pharmaceutical uses of the isolated antigen binding protein in preventing, alleviating and/or treating tumor.

Abstract: The present disclosure relates to a laser coupling device, which includes a plurality of laser units, configured to emit laser beams; and at least one first convex lens, arranged on optical paths of the laser beams and configured to converge the laser beam. The laser coupling device can emit laser beam with a high power.

Abstract: The present invention provides a method for improving the stability of pramipexole or its salt preparation, and further provides a pramipexole hydrochloride oral liquid with excellent stability and oral absorption effect. The pramipexole hydrochloride oral liquid of the present invention is prepared through a simple process, and shows bioequivalence with the tablet containing pramipexole hydrochloride. The invention perfectly realizes multi-dose administration of pramipexole hydrochloride and improves the compliance and accessibility of medication for patients.

Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.

Abstract: The present invention provides a binding protein and use thereof, wherein the binding protein comprises a first protein functional region binding to a targeting moiety of an antigen on a target cell, and a second protein functional region binding to an effector moiety of an antigen on an immune effector cell; and the binding protein is selected from the following structure: the first protein functional region is of a Fab structure, the second protein functional region is of a VH structure or a Fab structure, and the first protein functional region and the second protein functional region are arranged sequentially from the N-terminus to the C-terminus of the binding protein. The binding protein can bring the immune effector cell and the specific target cell together, efficiently and selectively activate the immune effector cell in a microenvironment of the specific target cell, further enhance immune responses, and reduce toxic and side effects caused by non-specific activation of peripheral immune cells.

Abstract: Provided is a binding protein, which comprises a protein functional region A and a protein functional region B, both of which target different antigens or different epitopes of antigens. The protein functional region A is Fab; the protein functional region B is VH; and the binding protein also comprises an Fc homodimer. There are two of both the protein functional region A and the protein functional region B. The binding protein has a left-right symmetrical structure. The binding protein consists of the protein functional region A, the protein functional region B and Fc in sequence from the N-terminus to the C-terminus, wherein the protein functional region A and the protein functional region B are connected by means of L1, and the protein functional region B is connected to the Fc by means of L2. The binding protein has a relatively small molecular mass, few polypeptide chains and a simpler structure. The protein has a versatile structure and may be applied to a variety of different target combinations.