Patents by Inventor Yun He

Yun He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200165246
    Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 28, 2020
    Applicant: Xiamen University
    Inventors: Xianming Deng, Wei Huang, Xihuan Sun, Ting Zhang, Zhixiang He, Yan Liu, Xinrui Wu, Baoding Zhang, Xiaoyang Li, Jingfang Zhang, Yun Chen, Li Li, Qingyan Xu, Zhiyu Hu
  • Publication number: 20200157661
    Abstract: A Ni—Al-RE ternary eutectic alloy and a preparation method thereof are provided. The alloy is composed of the following elements by weight percent, aluminum (Al) of 2.50% to 19.50%, rare earth (RE) of 1.30% to 20.0%, other impurity elements being less than or equal to 0.10%, and the rest being nickel (Ni). The microstructure of the alloy is in a completely eutectic form, and the density is 6.8 to 7.1 g/cm3. Raw materials are prepared according to the ratio, and are placed into a vacuum induction smelting furnace; the smelting furnace is vacuumized to 10?5 Pa, power is increased to ensure complete melting of the raw materials, and the molten alloy melt is poured into an iron mold to obtain alloy ingots. The eutectic phase in the microstructure of the alloy in the disclosure has high hardness.
    Type: Application
    Filed: October 25, 2017
    Publication date: May 21, 2020
    Applicants: SHANGHAI JIAO TONG UNIVERSITY, ZHONGCHAO HANGYU INVESTMENT CASTING S&T CO.
    Inventors: Jun WANG, Yun WU, Maodong KANG, Haiyan GAO, Shuxian HE, Yahui LIU
  • Publication number: 20200131185
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 30, 2020
    Inventors: Yun-Long Li, Xiaozhao Wang, Chunhong He
  • Patent number: 10637636
    Abstract: In accordance with embodiments disclosed herein, there is provided systems and methods for jitter sensing and adaptive control of parameters of clock and data recovery (CDR) circuits. A receiver component includes an adaptive CDR loop dynamic control circuit. The adaptive CDR loop dynamic control circuit is to detect first sinusoidal jitter at a first frequency and a first amplitude and update parameters of the CDR circuit to a first plurality of values based on the first frequency and the first amplitude. The adaptive CDR loop dynamic control circuit is further to detect second sinusoidal jitter at a second frequency and a second amplitude and update the parameters of the CDR circuit to a second plurality of values based on the second frequency and the second amplitude. The first sinusoidal jitter is in a first incoming data signal and the second sinusoidal jitter is in a second incoming data signal.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: April 28, 2020
    Assignee: Intel Corporation
    Inventors: Yun He, Adhiveeraraghavan Srikanth, Sanjib Sarkar
  • Publication number: 20200103364
    Abstract: Disclosed are compositions and methods for the electrochemical detection of enzymes, such as enzymes that are indicative of disease, disorders, or pathogens, such as viruses, bacteria, and fungi, or other disorders. These methods can be used in point-of-care diagnostic assays for the detection of disease, disorder, or pathogen (e.g., to identify the strain of pathogen infecting a patient in a healthcare setting). The electrochemical methods described herein can also be used to assess the susceptibility of a pathogen to an antipathogen drug. Also provided are probes suitable for use in conjunction with the methods described herein.
    Type: Application
    Filed: September 9, 2019
    Publication date: April 2, 2020
    Inventors: Suri Saranathan Iyer, Abasaheb Dhawane, Yun He, Xiaohu Zhang, Hieu Dinh, Mugdha Vasireddi, Joyce Sweeney
  • Publication number: 20200095576
    Abstract: In an embodiment, a device for modulating intracellular gene expression, the device having a calcium actuator component and a transcription reprogramming component. In another embodiment, a method for modulating intracellular gene expression, where the method includes inducing a system having a calcium actuator component and a transcription reprogramming component with at least one of light and a chemical, causing an increase in Ca2+, and translocating the transcription reprogramming component from cytosol to the nucleus.
    Type: Application
    Filed: September 24, 2019
    Publication date: March 26, 2020
    Inventors: Yubin Zhou, Yun Huang, Nhung T. Nguyen, Lian He
  • Publication number: 20200074301
    Abstract: A method for knowledge base completion includes encoding a knowledge base comprising entities and relations between the entities into embeddings for the entities and embeddings for the relations. The embeddings for the entities are encoded based on a Graph Convolutional Network (GCN) with different weights for at least some different types of the relations, which GCN is called a Weighted GCN (WGCN). The method further includes decoding the embeddings by a convolutional network for relation prediction. The convolutional network is configured to apply one dimensional (1D) convolutional filters on the embeddings, which convolutional network is called Conv-TransE. The method further includes at least partially complete the knowledge base based on the relation prediction.
    Type: Application
    Filed: August 16, 2019
    Publication date: March 5, 2020
    Inventors: Chao Shang, Yun Tang, Jing Huang, Xiaodong He, Bowen Zhou
  • Publication number: 20200040682
    Abstract: The present invention discloses a method for lowering an oil pipe in a gas well without well-killing, a soluble bridge plug and a material preparation method thereof, wherein, the method comprises the steps of: lowering a bridge plug in a wellbore such that the bridge plug blocks the wellbore at a predetermined location in the wellbore; injecting water in the wellbore after the pressure in the wellbore has been relieved so as to replace gases in the wellbore; and lowering an oil pipe in the wellbore to the location of the bridge plug. The method for lowering an oil pipe in a gas well without well-killing, the soluble bridge plug and the material preparation method thereof provided in the present invention successfully solve the problem of high cost for lowering an oil pipe under pressure after a fracturing fluid has been injected into the casing.
    Type: Application
    Filed: April 4, 2018
    Publication date: February 6, 2020
    Inventors: Xianwen Li, Qiaorong Han, Yanming Zhang, Xu Ma, Zhanguo Ma, Yangming Hu, Changjing Zhou, Yuanxiang Xiao, Huaqiang Shi, Baochun Chen, Yonghong Gu, Xiaoyong Wen, Xuan'ang Lai, Yong Ding, Liang Ye, Qianyun Zhao, Xinxing Ma, Yajuan Wang, Man Bi, Hua Shi, Mingfang He, Xiaorui Liu, Wei Gao, Hongying Li, Yun Ling, Ruifen Hao, Lei Shen, Guohui Su, Shaowei Zhou, Shusheng Li, Zhe Li
  • Publication number: 20200043138
    Abstract: An electronic device may include enhancement circuitry to enhance high resolution image data to improve perceived quality of an image corresponding to the high resolution image data. The enhancement circuitry may include tone detection circuitry to determine one or more tones within the image and apply changes to the high resolution image data based on the one or more tones. The enhancement circuitry may also include example-based improvement circuitry to compare the high resolution image data to low resolution image data and apply changes to the high resolution image data based on differences between sections of the high resolution image data and sections of the low resolution image data. The enhancement circuitry may also include channel processing circuitry to apply the first and second changes to one or more channels of the high resolution image data.
    Type: Application
    Filed: August 2, 2018
    Publication date: February 6, 2020
    Inventors: Jim C. Chou, Haiyan He, Yun Gong
  • Patent number: 10542256
    Abstract: Embodiments of the present invention provide a method and a device for determining a transform block size, and can improve image compression efficiency. The method includes: obtaining, according to image block information and a splitting manner of an image block, a parameter of a transform block corresponding to the image block; and obtaining a transform block size according to the parameter of the transform block and the splitting manner of the image block. In the embodiments of the present invention, during determination of a transform block size, the transform block size is obtained according to a splitting manner of an image block and a parameter of a transform block corresponding to the image block. Therefore, a transform block matching the splitting manner of the image block can be used, improving image compression efficiency.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 21, 2020
    Assignees: Huawei Technologies Co., Ltd., Tsinghua University
    Inventors: Yuan Yuan, Xiaozhen Zheng, Yun He
  • Publication number: 20200021850
    Abstract: The present disclosure disclose a video data decoding method. The method includes: receiving a bitstream; parsing the bitstream to obtain residual data of a current to-be-decoded image block, prediction information of the current to-be-decoded image block, and a pixel value transformation mode identifier of the current to-be-decoded block; obtaining predictors of the current to-be-decoded image block; obtaining reconstructed pixel values of pixels of the current to-be-decoded image block; and performing spatial transformation on the reconstructed pixel values of the pixels of the current to-be-decoded image block according to a pixel value transformation mode corresponding to the transformation mode identifier of the current to-be-decoded image block, to obtain transformed pixel values of the pixels of the current to-be-decoded image block. The embodiments of the present disclosure further disclose a video data encoding method, a decoding apparatus, and an encoding apparatus.
    Type: Application
    Filed: September 23, 2019
    Publication date: January 16, 2020
    Inventors: Benben NIU, Quanhe YU, Junyou CHEN, Jianhua ZHENG, Yun HE
  • Publication number: 20200014927
    Abstract: A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.
    Type: Application
    Filed: September 17, 2019
    Publication date: January 9, 2020
    Inventors: Xiaozhen ZHENG, Zhen MAO, Ziyuan WANG, Yun HE, Xiaozhong XU, Jianhua ZHENG
  • Patent number: 10526668
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7522 and a method for preparing milbemycin A4 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7522 of the present invention is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9671 on Sep. 16, 2014.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: January 7, 2020
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai
  • Patent number: 10519163
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: December 31, 2019
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, David M. Burns, Hao Feng, Joseph Glenn, Chunhong He, Song Mei, Jun Pan, Xiaozhao Wang, Yingda Ye
  • Publication number: 20190370416
    Abstract: A building-information management (BIM) system receives a set of wind vectors that identify wind speeds and directions at the surfaces of physical structures within a volume of air. The system stratifies the volume into vertically stacked layers that each contains similar wind vectors. Each layer is then divided horizontally into rectangular cells that each at least partially encloses a cluster of the structures. The system infers cell-specific relationships that relate physical attributes of the enclosed structures with the cell's incoming and outgoing airflows, from which the system builds a wind-propagation model for each cell. These cell-specific models are combined into a regional wind-propagation model that predicts how winds entering the volume will be propagated as outgoing wind vectors. The regional model is used by downstream modules of the BIM system to account for airflow effects when designing a planned building.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 5, 2019
    Inventors: Yun He Gao, Yang Zhang
  • Patent number: 10499086
    Abstract: The present application discloses video data encoding and decoding methods and apparatuses, so as to conveniently perform data encoding and decoding on video data. The method includes: arithmetic encoding, where the arithmetic encoding includes: obtaining a binary symbol of image data; and if the binary symbol is a most probable symbol (MPS), updating a first encoding interval corresponding to the MPS in a logarithm domain, and if the first updated encoding interval is less than a preset range of an arithmetic encoding interval, performing normalization processing on the first encoding interval in the logarithm domain; or if the binary symbol is a least probable symbol (LPS), updating a second encoding interval corresponding to the LPS in an original number domain, and performing normalization processing on the second encoding interval in the original number domain.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: December 3, 2019
    Assignees: Tsinghua University, Huawei Technologies Co., Ltd.
    Inventors: Quanhe Yu, Xiaozhen Zheng, Jianhua Zheng, Yun He
  • Publication number: 20190349184
    Abstract: In accordance with embodiments disclosed herein, there is provided systems and methods for jitter sensing and adaptive control of parameters of clock and data recovery (CDR) circuits. A receiver component includes an adaptive CDR loop dynamic control circuit. The adaptive CDR loop dynamic control circuit is to detect first sinusoidal jitter at a first frequency and a first amplitude and update parameters of the CDR circuit to a first plurality of values based on the first frequency and the first amplitude. The adaptive CDR loop dynamic control circuit is further to detect second sinusoidal jitter at a second frequency and a second amplitude and update the parameters of the CDR circuit to a second plurality of values based on the second frequency and the second amplitude. The first sinusoidal jitter is in a first incoming data signal and the second sinusoidal jitter is in a second incoming data signal.
    Type: Application
    Filed: March 18, 2019
    Publication date: November 14, 2019
    Inventors: Yun HE, Adhiveeraraghavan SRIKANTH, Sanjib SARKAR
  • Publication number: 20190340930
    Abstract: The invention provides a signal redundancy control system. The system includes multiple first signal collecting devices, second signal collecting devices and a controller, wherein the multiple first signal collecting devices are configured to collect the dynamic information of default devices where the first signal collecting devices are located in real time; one second signal collecting device corresponding to each of the first signal collecting devices is disposed on each default device, and is configured to collect the dynamic information of the default device where the second signal collecting device is located in real time; the controller is configured to determine whether the first signal collecting devices include fault information or not, and positions each default device according to the dynamic information acquired by the first signal collecting devices or the second signal collecting devices.
    Type: Application
    Filed: December 26, 2017
    Publication date: November 7, 2019
    Inventors: Hongtao WANG, Yun CHEN, Jianbo WU, Yue FANG, Peng HE, Xianhua LIU
  • Publication number: 20190329805
    Abstract: The present disclosure discloses an interlocking protection device for turnout switching. The interlocking protection device for turnout switching comprises a receiving module, a confirmation module, a processing module, and a centralized control interlocking module, wherein the receiving module is configured to receive a turnout switching instruction; the confirmation module is configured to receive a confirmation instruction; the processing module is configured to determine a target turnout position according to the turnout switching instruction and output a driving confirmation signal according to the confirmation instruction; and the centralized control interlocking module comprises a confirmation unit and a position switch unit. Under a centralized control mode, the confirmation unit carries out separate turnout locking according to the target turnout position and carries out locking confirmation according to the driving confirmation signal.
    Type: Application
    Filed: December 26, 2017
    Publication date: October 31, 2019
    Inventors: Yue FANG, Hongtao WANG, Jianbo WU, Yun CHEN, Peng HE, Xianhua LIU
  • Patent number: 10458823
    Abstract: The present disclosure relates to a system and method for health monitoring and early warning for an electronic device. A sensor is used to monitor a physical parameter of a circuit board of a host electronic system of the electronic device to acquire sensor data, and transmit the acquired sensor data to an embedded control device. The sensor data includes at least one of current data, vibration data, temperature data and voltage data. The embedded control device is used to extract a feature from the sensor data to acquire feature data, and perform real-time analysis and prediction based on the feature data to obtain and display a prediction result. In this way, the user can be provided with real-time health monitoring and real-time prediction information for the host electronic system circuit board.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: October 29, 2019
    Assignee: Fifth Electronics Research Institute of Ministry of Industry and Information Technology
    Inventors: Yiqiang Chen, Yun Huang, Dengyun Lei, Yudong Lu, Yunfei En, Chunhua He, Liwei Wang