Patents by Inventor Yun He

Yun He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230287143
    Abstract: Provided is a binding protein, which comprises a protein functional region A and a protein functional region B, both of which target different antigens or different epitopes of antigens. The protein functional region A is Fab; the protein functional region B is VH; and the binding protein also comprises an Fc homodimer. There are two of both the protein functional region A and the protein functional region B. The binding protein has a left-right symmetrical structure. The binding protein consists of the protein functional region A, the protein functional region B and Fc in sequence from the N-terminus to the C-terminus, wherein the protein functional region A and the protein functional region B are connected by means of L1, and the protein functional region B is connected to the Fc by means of L2. The binding protein has a relatively small molecular mass, few polypeptide chains and a simpler structure. The protein has a versatile structure and may be applied to a variety of different target combinations.
    Type: Application
    Filed: June 29, 2021
    Publication date: September 14, 2023
    Inventors: Yun HE, Lei SHI, Bing HUANG, Chen ZHONG, Qiang LV, Ming WANG
  • Patent number: 11750809
    Abstract: An encoding method with multiple image block division manners is disclosed, including: determining a division manner and a division direction of an image block; dividing the image block to obtain image subblocks sequentially arranged horizontally or vertically; determining whether the image subblocks need subdivision, and if subdivision is not needed, predicting the encoding object in the frame according to the image subblocks, to obtain residual data; performing transformation, quantization, and entropy encoding for the residual data so as to obtain coded residual data; and writing the division manner of the image block, the division direction of the image block, an identifier indicating whether the image subblocks need subdivision, and the coded residual data into a bitstream. By applying the encoding method, better prediction accuracy can be achieved when the image block presents a small change of pixel value in the horizontal or vertical direction.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: September 5, 2023
    Assignees: Huawei Technologies Co., Ltd., Tsinghua University
    Inventors: Changcai Lai, Xiaoran Cao, Yongbing Lin, Lingzhi Liu, Yun He
  • Publication number: 20230262221
    Abstract: A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.
    Type: Application
    Filed: April 18, 2023
    Publication date: August 17, 2023
    Applicants: HUAWEI TECHNOLOGIES CO., LTD., TSINGHUA UNIVERSITY
    Inventors: Xiaozhen Zheng, Zhen Mao, Ziyuan Wang, Yun He, Xiaozhong Xu, Jianhua Zheng
  • Publication number: 20230242658
    Abstract: The present invention discloses a 4-1BB-binding protein and use thereof. The 4-1BB-binding protein comprises a heavy chain variable region, wherein the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, wherein the HCDR1 comprises a sequence as set forth in SEQ ID NO: 15 or a variant 1 thereof, or SEQ ID NO: 16; the HCDR2 comprises a sequence selected from SEQ ID NO: 60 or a variant 2 thereof, and SEQ ID NO: 50 or a variant 4 thereof; the HCDR3 comprises a sequence as set forth in SEQ ID NO: 103 or a variant 3 thereof, SEQ ID NO: 333 or a variant 5 thereof, SEQ ID NO: 110, SEQ ID NO: 111, SEQ ID NO: 116, SEQ ID NO: 326, SEQ ID NO: 331, SEQ ID NO: 334 or SEQ ID NO: 96. The 4-1BB-binding protein of the present invention is a fully human antibody having the binding activity to human 4-1BB and cynomolgus monkey 4-1BB. Some 4-1BB-binding proteins are only half the size of conventional IgG antibodies; they can be well used for bispecific antibodies.
    Type: Application
    Filed: June 29, 2021
    Publication date: August 3, 2023
    Applicant: NONA BIOSCIENCES (SUZHOU) CO., LTD.
    Inventors: Lei SHI, Bing HUANG, Yun HE, Xin GAN, Fei CHEN, Jianxun ZHAO, Bo XIANG
  • Publication number: 20230235090
    Abstract: Provided are a bispecific antibody and use thereof. The bispecific antibody comprises a B7-H4-targeting antigen-binding domain and a 4-1BB-targeting antigen-binding domain. The bispecific antibody has one or two or three sites for binding to 4-1BB, along with a novel fully human B7-H4 antibody. The bispecific antibody specifically binds to tumor cells by targeting B7-H4, reducing toxicity induced by 4-1BB activation. In addition, the bispecific antibody of the present invention comprises a human Fc fragment, and thus retains the binding of Fc to FcRn and has a longer half-life.
    Type: Application
    Filed: June 29, 2021
    Publication date: July 27, 2023
    Applicant: HARBOUR BIOMED US, INC.
    Inventors: Lei SHI, Chen ZHONG, Xiaodong WU, Yun HE, Fei CHEN, Xiaocheng LV, Jinli XIE, Yiping RONG, Bing HUANG, Fangfang DU, Jianxun ZHAO
  • Publication number: 20230235011
    Abstract: A Fc-CD80 fusion protein has a CD80 extracellular domain (ECD) linked to a C-terminal of an immunoglobulin Fc domain. The Fc-CD80 fusion protein can be used for the preparation of a conjugate, the conjugate including the Fc-CD80 fusion protein as a first component, and a second component containing a second effector molecule, the second component being located at an N-terminal of the first component. In addition, a conjugate including the Fc-CD80 fusion protein, a pharmaceutical composition including the Fc-CD80 fusion protein and/or the conjugate are effective for the treatment or prevention of cancerous diseases in individuals.
    Type: Application
    Filed: May 25, 2021
    Publication date: July 27, 2023
    Inventors: Pinliang HU, Jing ZOU, Weidong HONG, Yun HE, Lingyun SONG, Wendi YANG
  • Publication number: 20230193343
    Abstract: Apparatus and methods for determining the blood glucose concentration of a patient are disclosed A saliva glucose measurement strip is used in conjunction with a glucose measurement device to measure an electrochemical signal of a saliva sample and the measured electrochemical signal is correlated to a blood glucose convention.
    Type: Application
    Filed: December 20, 2022
    Publication date: June 22, 2023
    Inventors: PRIYANKA AGRAWAL, VLADIMIR BASHKIROV, STEPHEN F. DREYER, YUN HE, IGOR IVANOV, CHING JINN LIN, LANXIN SHEN, HUI TIAN
  • Patent number: 11667704
    Abstract: The invention relates to the field of medical biotechnology. Specifically, the present invention relates to a fusion protein containing an anti-interleukin-17 antibody and a tumor necrosis factor receptor extracellular region, a polynucleotide encoding the fusion protein, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, and the use of the fusion protein for the treatment, prevention, and/or diagnosis of a related disease in an individual.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: June 6, 2023
    Assignees: BEIJING BEYOND BIOTECHNOLOGY CO., LTD, HANGZHOU POLYMED BIOPHARMACEUTICALS, INC.
    Inventors: Pinliang Hu, Jing Zou, Weidong Hong, Yun He, Jie Bai, Lingyun Song, Wendi Yang, Zhijian Lv, Shaoyun Xiang
  • Patent number: 11659184
    Abstract: A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: May 23, 2023
    Assignees: HUAWEI TECHNOLOGIES CO., LTD., TSINGHUA UNIVERSITY
    Inventors: Xiaozhen Zheng, Zhen Mao, Ziyuan Wang, Yun He, Xiaozhong Xu, Jianhua Zheng
  • Publication number: 20230061159
    Abstract: The present invention provides a method for improving the stability of pramipexole or its salt preparation, and further provides a pramipexole hydrochloride oral liquid with excellent stability and oral absorption effect. The pramipexole hydrochloride oral liquid of the present invention is prepared through a simple process, and shows bioequivalence with the tablet containing pramipexole hydrochloride. The invention perfectly realizes multi-dose administration of pramipexole hydrochloride and improves the compliance and accessibility of medication for patients.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 2, 2023
    Inventors: Xinhua FAN, Yanyuan ZHANG, Yun HE, Pengfei LI, Xiang ZHANG, Longhao WU, Peng PENG, Sujing ZHUANG, Li XIAO, Yongrui TU
  • Publication number: 20220411513
    Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.
    Type: Application
    Filed: September 29, 2020
    Publication date: December 29, 2022
    Applicant: Harbour BioMed (Shanghai) Co., Ltd
    Inventors: Yun HE, Shuwen REN, Bin LIU, Xin GAN, Donghai LI, Fei CHEN, Ling WANG, Jin LI, Yiping RONG
  • Publication number: 20220363781
    Abstract: Related are an anti-TSLP antibody or an antigen-binding fragment thereof, nucleic acid molecules coding the same, and a method for preparing the same. The anti-TSLP antibody or the antigen-binding fragment thereof have high affinity to TSLP, capable of effectively binding with TSLP and blocking the proliferative effect of TSLP with respect to Ba/F3-hTSLPR-hIL7R? cells, and blocking the capability of TSLP in activating and secreting cytokines with respect to PBMC. At the same time, further related are a medicinal composition comprising the antibody or the antigen-binding fragment thereof, and uses of the composition in preparing a medicament for preventing and/or treating asthma, allergic inflammation, an allergic reaction or autoimmune disease.
    Type: Application
    Filed: December 8, 2020
    Publication date: November 17, 2022
    Applicants: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Harbour Biomed (Suzhou) Co., Ltd.
    Inventors: Liang XIAO, Jinqiu HE, Tongtong XUE, Hongshui LIU, Jingyi WANG, Hongzhuan GU, Shuntao LUO, Yiping RONG, Dengnian LIU, Yun HE
  • Publication number: 20220347583
    Abstract: A method of providing optimized settings of graphics parameters for a computer gaming application includes: consolidating data related to settings of graphics parameters for different computer hardware equipment and respective performance values; training a machine learning model based on the consolidated data; determining a weight for each setting of a graphics parameter, by the trained machine learning model; for each set of graphics parameters, predicting a performance value achievable by the computer gaining application when it is executed on a specific type of computer, by the trained machine learning model; assigning a priority value to each graphics parameter based on its contribution to the performance value; choosing or generating at least one set of graphics parameters providing an optimized performance value, based on the predicted performance value associated with each set of graphics parameters and the determined weight for each graphics parameter and/or based on the assigned priority value.
    Type: Application
    Filed: September 27, 2019
    Publication date: November 3, 2022
    Inventors: Yun HE, Xu ZHU, Dejun CHEN
  • Publication number: 20220348661
    Abstract: Disclosed are a CD3-targeting antibody, a bispecific antibody and the use thereof. The CD3-targeting antibody comprises a light chain variable region (VL) and a heavy chain variable region (VH). The VL has the amino acid sequence as shown in SEQ ID NO: 56 or a mutation thereof. The VH has mutations on the amino acid sequence as shown in SEQ ID NO: 42, and the mutations occur at one or more of the sites of amino acid residues selected from positions 30, 73, 76, 78, 93 and 94. The bispecific antibody comprises a first protein functional region and a second protein functional region, wherein the first protein functional region comprises the CD3-targeting antibody as described above. The CD3-targeting antibody reduces the toxicity caused by cytokine release syndrome, and the bispecific antibody prepared therefrom is stable and has the ability to bind to T cells, and also reduces the difficulty of producing.
    Type: Application
    Filed: September 29, 2020
    Publication date: November 3, 2022
    Inventors: Yun HE, Lei SHI
  • Publication number: 20220340673
    Abstract: Provided are an antibody targeting BCMA, a bispecific antibody targeting BCMA and CD3, and applications thereof. The antibody targeting BCMA comprises two heavy chain variable regions, the heavy chain variable regions comprising HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 22, SEQ ID NO: 33 and SEQ ID NO: 42, or HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 37 and SEQ ID NO: 41. The antibody effectively targets human BCMA and binds to cynomolgus BCMA; the bispecific antibody effectively targets both human BCMA and human CD3, and can bind to cynomolgus BCMA and cynomolgus CD3.
    Type: Application
    Filed: September 29, 2020
    Publication date: October 27, 2022
    Inventors: Lei SHI, Xuekun ZHANG, Yun HE, Jianxun ZHAO, Wei ZHOU, Fei CHEN, Xiangyang TAN, Yiping RONG
  • Patent number: 11483561
    Abstract: The present disclosure provide a transform method in picture block encoding, an inverse transform method in picture block decoding, and an apparatus. The inverse transform method includes: determining, in a target transform set, a corresponding transform pair of each region of at least two regions that constitute a to-be-decoded current block; inverse transforming each region based on the corresponding transform pair of each region to obtain an inverse transform result of each region; and obtaining an inverse transform result of the current block based on the inverse transform result of each region and a position of each region in the current block, where the at least two regions do not overlap each other, the target transform set includes a correspondence between a transform pair and a position of a region in the current block, and the transform pair includes a horizontal transform core and a vertical transform core.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: October 25, 2022
    Assignees: Huawei Technologies Co., Ltd., TSINGHUA UNIVERSITY
    Inventors: Liqiang Wang, Jianhua Zheng, Quanhe Yu, Yongbing Lin, Yun He
  • Patent number: D980295
    Type: Grant
    Filed: May 16, 2021
    Date of Patent: March 7, 2023
    Assignee: SHENZHEN ATOMSTACK TECHNOLOGIES CO., LTD.
    Inventors: Yun He, Huigang Lin
  • Patent number: D986932
    Type: Grant
    Filed: November 26, 2021
    Date of Patent: May 23, 2023
    Assignee: SHENZHEN ATOMSTACK TECHNOLOGIES CO., LTD
    Inventors: Huigang Lin, Yun He, Zebin Li
  • Patent number: D992505
    Type: Grant
    Filed: November 26, 2021
    Date of Patent: July 18, 2023
    Assignee: SHENZHEN ATOMSTACK TECHNOLOGIES CO., LTD
    Inventors: Huigang Lin, Yun He, Zebin Li
  • Patent number: D992518
    Type: Grant
    Filed: November 26, 2021
    Date of Patent: July 18, 2023
    Assignee: SHENZHEN ATOMSTACK TECHNOLOGIES CO., LTD
    Inventors: Huigang Lin, Yun He, Zebin Li