Patents by Inventor Yun Lu

Yun Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190022065
    Abstract: Disclosed is a pharmaceutical composition containing a bicyclo-substituted pyrazolone azo derivative or a salt thereof and a preparation method thereof. In particular, the pharmaceutical composition disclosed in the present invention contains (Z)-5-(2-hydroxyl-3-(2-(3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalene-2-yl)-1H-pyr azol-4(5H)-ylidene)hydrazino)phenyl)furan-2-carboxylic acid or a pharmaceutically acceptable salt thereof, and at least one filler optionally selected from cellulose, microcrystalline cellulose, lactose and starch. The composition has a good stability, dissolution rate and bioavailability, and the preparation process is simple, economical and quick.
    Type: Application
    Filed: January 16, 2017
    Publication date: January 24, 2019
    Inventors: Yun LU, Xinhua ZHANG, Daimei ZHANG
  • Publication number: 20190010161
    Abstract: The present invention relates to a crystalline form of a BTK kinase inhibitor and the preparation method thereof. In particular, the present invention relates to a crystal form I of (R)-4-amino-1-(1-(but-2-ynoyl)pyrrolidin-3-yl)-3-(4-(2,6-difluorophenoxy)phenyl)-1H-pyrrolo[2,3-d]pyridazin-7(6H)-one (the compound of formula (I)) and the preparation method thereof. The crystal form I of the compound of formula (I) obtained by the present invention has a good crystalline stability and chemical stability, and the crystallization solvent used has a low toxicity and low residue, thus making it more suitable for use in clinical treatment.
    Type: Application
    Filed: December 20, 2016
    Publication date: January 10, 2019
    Applicant: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Guaili WU, Zhenjun QIU, Xi LU, Yun LU
  • Patent number: 10150739
    Abstract: A crystalline form of an androgen receptor inhibitor and its preparation method are provided. In particular, provided are crystal form I of (S)-4-(3-(4-(2,3-dihydroxypropoxy)phenyl)-4,4-dimethyl-5-carbonyl-2-thioimidazolin-2-yl)-2-(trifluoromethyl)benzonitrile (a compound of formula (I)) and its preparation method. The method includes (a) adding any crystal form or amorphous form of the compound of formula (I) to an organic solvent to obtain a solution and heating the solution until it is clear, followed by cooling the solution to precipitate a crystal; and (b) filtering, washing, and drying the crystal. The obtained crystal form I of the compound of formula (I) has good chemical stability and crystal form stability, and the crystallization solvent used has low toxicity and residue, and is thus better for use in clinical treatment.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: December 11, 2018
    Assignee: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Guaili Wu, Changshan Guo, Liang Zhong, Yun Lu
  • Publication number: 20180322038
    Abstract: In some embodiments, the disclosed subject matter involves a system and method relating to segmenting user population to test the quality of different software states. In at least one embodiment, the software states may be exposed dynamically to users who receive a software build, because features may be turned on/off via the server, at runtime. In an embodiment, if the server is unavailable, feature information may be retrieved from the local client storage. New features may be dynamically exposed to segments of a population to assist in verification and test of the new features. Other embodiments are described and claimed.
    Type: Application
    Filed: May 4, 2017
    Publication date: November 8, 2018
    Inventors: Krishnan Thazhathekalam, Khalid Mahmood, Sebastian Kohlmeier, Anjali Muralidhar, Chaitanya Gogineni, Yun Lu, Jorge H. Banuelos
  • Publication number: 20180322032
    Abstract: A machine may be configured to test an application based on an in-app impersonating of an audience profile. For example, the machine receives a selection of an audience identifier via a user interface. The machine maps the audience identifier to a configuration file that includes identifiers of features of the application available for use by the audience. The machine, based on the audience identifier and the configuration file, causes a display, in the user interface, of the identifiers of the features. The machine receives, via the user interface, a request to modify an operational state of a feature of the application in the software context associated with the audience. The machine configures, at run-time, the application based on the audience identifier, the configuration file, and the request to modify the operational state of the feature. The configuring results in the application including the feature in a modified operational state.
    Type: Application
    Filed: May 4, 2017
    Publication date: November 8, 2018
    Inventors: Krishnan Thazhathekalam, Khalid Mahmood, Sebastin Kohlmeier, Anjali Muralidhar, Yun Lu, Krish Ramineni, Akshay Gandhi
  • Publication number: 20180244628
    Abstract: A crystalline form of an androgen receptor inhibitor and its preparation method are provided. In particular, provided are crystal form I of (S)-4-(3-(4-(2,3-dihydroxypropoxy)phenyl)-4,4-dimethyl-5-carbonyl-2-thioimidazolin-2-yl)-2-(trifluoromethyl)benzonitrile (a compound of formula (I)) and its preparation method. The method includes (a) adding any crystal form or amorphous form of the compound of formula (I) to an organic solvent to obtain a solution and heating the solution until it is clear, followed by cooling the solution to precipitate a crystal; and (b) filtering, washing, and drying the crystal. The obtained crystal form I of the compound of formula (I) has good chemical stability and crystal form stability, and the crystallization solvent used has low toxicity and residue, and is thus better for use in clinical treatment.
    Type: Application
    Filed: August 23, 2016
    Publication date: August 30, 2018
    Inventors: Guaili WU, Changshan GUO, Liang ZHONG, Yun LU
  • Publication number: 20170298087
    Abstract: Provided are an L-proline complex of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline complex. Specifically, provided are 1,6-dehydrated-1—C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5—C-(hydroxymethyl)-?-L-idopyranose L-proline (a compound of formula (I)), a monohydrate and a type A crystal thereof, and a preparation method therefor. The obtained type A crystal of the compound of formula (I) has good chemical stability and crystal stability, and the crystallization solvent used has low toxicity and low residue, so the type A crystal can be better used in clinical treatment.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 19, 2017
    Inventors: Piaoyang SUN, Guaili WU, Changshan GUO, Yun LU, Yuxia WU, Lingjia SHEN
  • Publication number: 20170239203
    Abstract: Disclosed is a pregabalin sustained-release preparation, wherein the sustained-release tablet contains a pharmaceutically active ingredient containing pregabalin or a salt or hydrate thereof, a gel framework material containing alginic acid, and a swellable material containing polyoxyethylene.
    Type: Application
    Filed: September 24, 2015
    Publication date: August 24, 2017
    Inventors: Yun LU, Jiajia XU, Hao CHEN
  • Publication number: 20170240328
    Abstract: A straw closing sleeve for closing a drinking end of a straw includes a foldable blank that is converted into a sleeve body. The sleeve body includes a top end wall, two surrounding wall halves that extend downwardly from a peripheral end of the top end wall and that cooperate to define a bottom opening opposite to the top end wall, and a receiving space between the top end wall and the bottom opening, and two adhesively bonded joint portions that are respectively connected to two opposite sides of each of the surrounding wall halves. A foldable blank supplying sheet and a roll of foldable blank supplying tape for providing the straw closing sleeve are also disclosed.
    Type: Application
    Filed: September 13, 2016
    Publication date: August 24, 2017
    Inventor: Chih-Yun LU
  • Patent number: 9545603
    Abstract: Composite membranes, methods or processes for producing composite membranes, and systems utilizing composite membranes are generally described. In some examples, a composite membrane includes a porous halogenated polymer and a conductive polymer coupled to the porous halogenated polymer. In some examples, a process for producing a composite membrane includes coupling a conductive polymer and a porous halogenated polymer.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: January 17, 2017
    Assignee: NANJING UNIVERSITY
    Inventors: Yun Lu, Zhiquan Shi, Hui Zhou, Tingyang Dai
  • Patent number: 9296086
    Abstract: An improved destructive and visual measurement automation system and a method for measuring a web thickness of a microdrill are provided. When a dual-axis motion platform module moves the microdrill to a first position, a reflection module reflects a first image in a first direction toward a second direction. A vision module receives the reflected first image in the second direction and outputs the received first image to a computer. According to the first image, the computer performs a positioning procedure and a grinding procedure to drive a drill grinding module to grind the microdrill to a sectional position to be measured of the microdrill. When the microdrill is moved to a second position, the vision module outputs a second image to the computer. According to the second image, the computer performs an image computing procedure to obtain the web thickness at the sectional position to be measured.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: March 29, 2016
    Assignee: National Taiwan Ocean University
    Inventors: Wen-Tung Chang, Yu-Yun Lu
  • Publication number: 20150324879
    Abstract: A challenge-based system is provided for end users or website administrators to confirm the validity of an online listing by initiating requests for photographs of an item in various contexts, preferably contexts that would be difficult to reproduce without possession of the item listed.
    Type: Application
    Filed: May 9, 2014
    Publication date: November 12, 2015
    Inventors: Yun Lu, Oliver I. Chrzan
  • Patent number: 9164062
    Abstract: A method of early detection of scaling on internal surfaces of conduits of water processing equipment, is provided herein. The method includes: transmitting ultrasonic signals through the wall of the conduits; deriving data samples from received ultrasonic signals or reflections thereof; calculating a moving average of the scatter of the ultrasonic signals, over time, based on the data samples; applying a statistical operand to the moving average, to yield a statistical distribution metric; determining a dynamic window defined by: (i) an upper boundary being the moving average plus at least a fraction of the statistical distribution metric and (ii) a lower boundary being the moving average minus the at least a fraction of the statistical distribution metric; generating a trend line being a smooth fitting of the derived samples; and monitoring the trend line within the window to detect a crossover of the trend line at either of the boundaries.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: October 20, 2015
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Alan R Greenberg, Jack Gilron, Keith D Cobry, Elmira Kujundzic, Xiao Yun Lu, Guy Mizrahi, Michael Peterson
  • Patent number: 9124551
    Abstract: A method for providing multi-touch, multi-user interactive control system using mobile devices. The method includes establishing socket connections with the mobile devices and receiving messages representing multi-touch user actions from the mobile devices through the socket connections. The messages are translated into predetermined parameters, and transmitted to an application for performing actions corresponding to the multi-touch user actions. Related apparatus, systems, techniques and articles are also described.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: September 1, 2015
    Assignee: SAP SE
    Inventors: Hai Yun Lu, Kar Leong Tew
  • Patent number: 9075311
    Abstract: A manufacturing method of microstructure comprises steps of: a motion determination step which determines the motion of a substrate relative to at least a photomask; a microlens determination step which determines the profile of a microlens unit on the substrate; an analysis step which calculates the feature of the photomask according to the motion of the substrate and the profile of the microlens unit by using a numerical analysis method; a production step which produces the photomask according to the feature of the photomask; driving the substrate to do the motion determined in the motion determination step, and meanwhile making a laser light illuminate the substrate through the photomask to manufacture the microlens unit on the substrate by the superposition effect of the laser light; and performing a photolithography process by using the microlens unit to produce a microstructure on a photoresist substrate.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: July 7, 2015
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Yung-Chun Lee, Chi-Cheng Chiu, Chih-Hao Chang, Ching-Yun Lu
  • Publication number: 20150017879
    Abstract: An improved destructive and visual measurement automation system and a method for measuring a web thickness of a microdrill are provided. When a dual-axis motion platform module moves the microdrill to a first position, a reflection module reflects a first image in a first direction toward a second direction. A vision module receives the reflected first image in the second direction and outputs the received first image to a computer. According to the first image, the computer performs a positioning procedure and a grinding procedure to drive a drill grinding module to grind the microdrill to a sectional position to be measured of the microdrill. When the microdrill is moved to a second position, the vision module outputs a second image to the computer. According to the second image, the computer performs an image computing procedure to obtain the web thickness at the sectional position to be measured.
    Type: Application
    Filed: April 16, 2014
    Publication date: January 15, 2015
    Applicant: National Taiwan Ocean University
    Inventors: Wen-Tung CHANG, Yu-Yun LU
  • Publication number: 20140380182
    Abstract: A method for providing multi-touch, multi-user interactive control system using mobile devices. The method includes establishing socket connections with the mobile devices and receiving messages representing multi-touch user actions from the mobile devices through the socket connections. The messages are translated into predetermined parameters, and transmitted to an application for performing actions corresponding to the multi-touch user actions. Related apparatus, systems, techniques and articles are also described.
    Type: Application
    Filed: June 25, 2013
    Publication date: December 25, 2014
    Applicant: SAP AG
    Inventors: Hai Yun Lu, Kar Leong Tew
  • Patent number: 8859689
    Abstract: Polymer compositions based on polyaniline and carbonyl-functionalized polysilicones, and methods for making these polymer compositions are disclosed in the present application. The polymer compositions have, for example, good solubility, processability, mechanical performance and conductivity.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: October 14, 2014
    Assignee: Nanjing University
    Inventors: Yun Lu, Hongjuan Wang
  • Publication number: 20140295354
    Abstract: A manufacturing method of microstructure comprises steps of: a motion determination step which determines the motion of a substrate relative to at least a photomask; a microlens determination step which determines the profile of a microlens unit on the substrate; an analysis step which calculates the feature of the photomask according to the motion of the substrate and the profile of the microlens unit by using a numerical analysis method; a production step which produces the photomask according to the feature of the photomask; driving the substrate to do the motion determined in the motion determination step, and meanwhile making a laser light illuminate the substrate through the photomask to manufacture the microlens unit on the substrate by the superposition effect of the laser light; and performing a photolithography process by using the microlens unit to produce a microstructure on a photoresist substrate.
    Type: Application
    Filed: March 26, 2013
    Publication date: October 2, 2014
    Applicant: National Cheng Kung University
    Inventors: Yung-Chun LEE, Chi-Cheng CHIU, Chih-Hao CHANG, Ching-Yun LU
  • Patent number: 8753546
    Abstract: Techniques are generally described related to a composite material with dielectric properties and the preparation method thereof. One example composite material may include a core having a first polymer and an ionic salt and a shell having a second polymer, where the core is electrically conductive and the shell electrically insulates and substantially surrounds the core, wherein the first polymer has a first polarity and the second polymer has a second polarity, and the first polarity is greater than the second polarity.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: June 17, 2014
    Assignee: Nanjing University
    Inventors: Yun Lu, Tingyang Dai, Xutang Qing