Abstract: A composition containing a docetaxel albumin nanoparticle. The composition contains docetaxel and an acid-denatured albumin, wherein the acid-denatured albumin is obtained by means of adding an acid to human serum albumin to adjust the pH value. The composition can be prepared into an injection or a freeze-dried powder injection. A composition with satisfactory physical and chemical stability is obtained by means of controlling the content of sodium octanoate in human serum albumin, preferably in an acid denaturation condition.

Abstract: A system for processing and presenting a conversation includes a sensor, a processor, and a presenter. The sensor is configured to capture an audio-form conversation. The processor is configured to automatically transform the audio-form conversation into a transformed conversation. The transformed conversation includes a synchronized text, wherein the synchronized text is synchronized with the audio-form conversation. The presenter is configured to present the transformed conversation including the synchronized text and the audio-form conversation. The presenter is further configured to present the transformed conversation to be navigable, searchable, assignable, editable, and shareable.

Abstract: Detecting fine-grained similarity in image includes determining a core area of a search image by generating an image salient map from a plurality of layers of the search image and determining a connected area based on the image salient map. Feature descriptors are generated from the core area of the search image. A plurality of capsule vectors are generated from different ones of a plurality of keypoints of the feature descriptors. Capsule vectors of the search image are compared with capsule vectors of each image of the dataset to generate a top-K matrix. Similarity scores for the top-K matrix are calculated. One or more image of the dataset having fine-grained similarity with the search image are selected based a bundled similarity score for each image of the dataset. The bundled similarity score is a summation of the similarity scores of the image.

Abstract: A battery pack, comprising a first cell and a second cell connected in series, the first cell having a current cut-off device and having a first failure voltage, the current cut-off device being configured to be able to break a circuit in response to a voltage value of the first cell reaching or exceeding the first failure voltage, and the second cell having no current cut-off device. The battery pack may use a soft pack battery as the second cell, having advantages such as high energy density, low impedance, high discharge power, a low rate of temperature rise during high-rate discharge, and flexibility in dimensions.

Abstract: One or more systems, devices, computer program products and/or computer-implemented methods of use provided herein relate to detecting a closed ring in a three-dimensional (3D) point cloud via cycle basis. A system can comprise a memory configured to store computer executable components; and a processor configured to execute the computer executable components stored in the memory, wherein the computer executable components can comprise a filtering component that can filter a first undirected graph of a three-dimensional (3D) point cloud, by eliminating one or more edges of the first undirected graph that are longer than an adaptive threshold, wherein filtering the first undirected graph can produce a second undirected graph; and a detection component that can detect a minimum cycle basis of the second undirected graph to determine a cycle path that can traverse an irregular annular shape that is represented by the 3D point cloud.

Abstract: Computer-implemented method and system for receiving and processing one or more moment-associating elements. For example, the computer-implemented method includes receiving the one or more moment-associating elements, transforming the one or more moment-associating elements into one or more pieces of moment-associating information, and transmitting at least one piece of the one or more pieces of moment-associating information.

Abstract: A method for recommending fuel filling stations based on water in fuel content is disclosed. In one example, a data structure is generated to house data from a plurality of fuel filling stations. The data structure may include data that is indicative of water in fuel. A recommendation for refilling a fuel tank may be provided according to data that is held in the data structure.

Abstract: An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.

Abstract: Methods and systems are provided for a vehicle engine fuel system. In one embodiment the method comprises indicating degradation of each of a low-pressure fuel pump and a fuel filter based on a comparison of a pressure differential between a high-pressure pump pressure setting to an actual pressure and a demanded fuel flow to an engine, the indication distinguishing between pump ageing and filter degradation. The method may include adjusting operation of the low-pressure fuel pump in response to the comparison of the high-pressure pump pressure setting and pressure of fuel entering a high-pressure pump. In one example, the fuel filter may be positioned to filter fuel drawn from a fuel tank before entering the low-pressure fuel pump.

Abstract: Provided is an engineered immune cell. The engineered immune cell expresses (i) a chimeric receptor, and (ii) exogenous CCL3, CCL4 and/or CCL5, has improved tumor killing activity, and can be used to treat cancer, infection or autoimmune diseases.

Abstract: Methods and apparatus to sense brake pad wear are disclosed. An example apparatus includes at least one memory device and at least one processor to execute instructions to determine whether a braking event corresponds to an anti-lock braking event or a non-anti-lock braking event, in response to the braking event corresponding to the anti-lock braking event, determine at least one of a thickness of a brake pad or a wear of the brake pad based on at least operating parameters of a motor associated with pumping a brake fluid, and in response to the braking event corresponding to the non-anti-lock braking event, determine at least one of the thickness or the wear based on at least a first measurement from a rotary sensor operatively coupled to a brake rotor and a second measurement from a pressure sensor operatively coupled to a flow path of the brake fluid.

Abstract: A method for determining the presence of water and diesel exhaust fluid mixed with diesel fuel is disclosed. In one example, output pressure of a fuel pump may be indicative of the presence or absence of water in diesel fuel. The presence or absence of water in fuel may be evaluated in response to filling a fuel tank.

Abstract: Methods and systems are provided for a vehicle engine fuel system. In one embodiment the method comprises indicating degradation of each of a low-pressure fuel pump and a fuel filter based on a comparison of a pressure differential between a high-pressure pump pressure setting to an actual pressure and a demanded fuel flow to an engine, the indication distinguishing between pump ageing and filter degradation. The method may include adjusting operation of the low-pressure fuel pump in response to the comparison of the high-pressure pump pressure setting and pressure of fuel entering a high-pressure pump. In one example, the fuel filter may be positioned to filter fuel drawn from a fuel tank before entering the low-pressure fuel pump.

Abstract: Methods and apparatus to sense brake pad wear are disclosed. An example apparatus includes at least one memory device and at least one processor to execute instructions to, in response to an anti-lock braking system event, determine a volume of brake fluid in a brake piston chamber based on a flow rate of the brake fluid and a pressure within the brake piston chamber, and determine at least one of a thickness of a brake pad or a wear of the brake pad based on the volume of the brake fluid in the brake piston chamber and a volume of the brake piston chamber.

Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA are provided. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also provided are methods of treating or inhibiting HIV including administering one or more of the RRE binding compounds to a subject.

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.