Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.

Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

Abstract: A data enhancement method includes obtaining first data including sub-data of a plurality of modalities. The sub-data of one modality corresponds to one data type and the data types of different modalities are different. The method further includes determining, in the sub-data of each modality, an entity object matching the data type of the sub-data, and performing inference on the entity objects corresponding to different modalities based on entity relationship information in a knowledge graph to obtain second data different from the first data.

Abstract: A method for recommending fuel filling stations based on water in fuel content is disclosed. In one example, a data structure is generated to house data from a plurality of fuel filling stations. The data structure may include data that is indicative of water in fuel. A recommendation for refilling a fuel tank may be provided according to data that is held in the data structure.

Abstract: Methods and systems are provided for a vehicle engine fuel system. In one embodiment the method comprises indicating degradation of each of a low-pressure fuel pump and a fuel filter based on a comparison of a pressure differential between a high-pressure pump pressure setting to an actual pressure and a demanded fuel flow to an engine, the indication distinguishing between pump ageing and filter degradation. The method may include adjusting operation of the low-pressure fuel pump in response to the comparison of the high-pressure pump pressure setting and pressure of fuel entering a high-pressure pump. In one example, the fuel filter may be positioned to filter fuel drawn from a fuel tank before entering the low-pressure fuel pump.

Abstract: An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.

Abstract: Provided is an engineered immune cell. The engineered immune cell expresses (i) a chimeric receptor, and (ii) exogenous CCL3, CCL4 and/or CCL5, has improved tumor killing activity, and can be used to treat cancer, infection or autoimmune diseases.

Abstract: Methods and apparatus to sense brake pad wear are disclosed. An example apparatus includes at least one memory device and at least one processor to execute instructions to determine whether a braking event corresponds to an anti-lock braking event or a non-anti-lock braking event, in response to the braking event corresponding to the anti-lock braking event, determine at least one of a thickness of a brake pad or a wear of the brake pad based on at least operating parameters of a motor associated with pumping a brake fluid, and in response to the braking event corresponding to the non-anti-lock braking event, determine at least one of the thickness or the wear based on at least a first measurement from a rotary sensor operatively coupled to a brake rotor and a second measurement from a pressure sensor operatively coupled to a flow path of the brake fluid.

Abstract: A method for determining the presence of water and diesel exhaust fluid mixed with diesel fuel is disclosed. In one example, output pressure of a fuel pump may be indicative of the presence or absence of water in diesel fuel. The presence or absence of water in fuel may be evaluated in response to filling a fuel tank.

Abstract: Methods and systems are provided for a vehicle engine fuel system. In one embodiment the method comprises indicating degradation of each of a low-pressure fuel pump and a fuel filter based on a comparison of a pressure differential between a high-pressure pump pressure setting to an actual pressure and a demanded fuel flow to an engine, the indication distinguishing between pump ageing and filter degradation. The method may include adjusting operation of the low-pressure fuel pump in response to the comparison of the high-pressure pump pressure setting and pressure of fuel entering a high-pressure pump. In one example, the fuel filter may be positioned to filter fuel drawn from a fuel tank before entering the low-pressure fuel pump.

Abstract: Methods and apparatus to sense brake pad wear are disclosed. An example apparatus includes at least one memory device and at least one processor to execute instructions to, in response to an anti-lock braking system event, determine a volume of brake fluid in a brake piston chamber based on a flow rate of the brake fluid and a pressure within the brake piston chamber, and determine at least one of a thickness of a brake pad or a wear of the brake pad based on the volume of the brake fluid in the brake piston chamber and a volume of the brake piston chamber.

Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA are provided. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also provided are methods of treating or inhibiting HIV including administering one or more of the RRE binding compounds to a subject.

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.

Abstract: A method for recommending fuel filling stations based on water in fuel content is disclosed. In one example, a data structure is generated to house data from a plurality of fuel filling stations. The data structure may include data that is indicative of water in fuel. A recommendation for refilling a fuel tank may be provided according to data that is held in the data structure.

Abstract: A method for determining the presence of water and diesel exhaust fluid mixed with diesel fuel is disclosed. In one example, output pressure of a fuel pump may be indicative of the presence or absence of water in diesel fuel. The presence or absence of water in fuel may be evaluated in response to filling a fuel tank.