Abstract: Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R1a, R1b, R1c, R2, R3, R4 and R5 are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (I) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: A method for reducing fuel consumption of a work vehicle may include monitoring one or more loads associated with both a drive power requirement and a hydraulic power requirement for the work vehicle. In addition, the method may include actively adjusting one or more operating parameters of the work vehicle based on the monitored loads in a manner that meets the drive power requirement and the hydraulic power requirement for the work vehicle while reducing the fuel consumption of the vehicle's engine.

Abstract: A method for detecting parasitic power circulation within a work vehicle may include controlling an operation of the work vehicle such that a transmission of the work vehicle has a first output speed and determining a first power value associated with power transmitted through a drive shaft of the work vehicle at the first output speed. The method may also include adjusting the operation of the work vehicle such that the transmission has a second output speed that differs from the first output speed and determining a second power value associated with power transmitted through the drive shaft at the second output speed. In addition, the method may include comparing the first and second power values to a predetermined relationship to determine whether the work vehicle is currently experiencing parasitic power circulation, wherein the predetermined relationship is associated with operation of the work vehicle without parasitic power circulation.

Abstract: Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R1a, R1b, R1c, R2, R3, R4 and R5 are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient.

Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: In one aspect, a method for reducing fuel consumption of a work vehicle is disclosed. The method may generally include determining, with a controller, a load power requirement for the work vehicle, determining a plurality of candidate engine speeds at which the load power requirement is achievable, analyzing stored efficiency data for a transmission and at least one additional component of the work vehicle to determine a power loss value for each candidate engine speed, determining a candidate engine power for each candidate engine speed based on the load power requirement and the power loss values and analyzing stored fuel efficiency data based on the candidate engine powers to determine a target engine speed for the work vehicle.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Disclosed herein are compounds (such as peptides or peptide mimetics) that bind to HIV RRE RNA. In some examples, the compounds inhibit (for example, decrease) binding of Rev to the RRE RNA. In some embodiments, the compounds include two moieties, each of which bind to one of the Rev binding sites in the RRE. In some examples, the moieties include peptides or small molecules. In some examples, the peptides include an arginine-rich motif. The RRE binding compounds may be further linked to a detectable label or cargo moiety. Also disclosed are methods of treating or inhibiting HIV including administering one or more of the disclosed compounds to a subject.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.

Abstract: The invention relates to a method for synthesizing a selectively labeled RNA, and an apparatus for performing the method. Specific segments or discrete residues within the RNA may be selectively labeled, and different segments may include different labels.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

Abstract: In one aspect, a method for reducing fuel consumption of a work vehicle is disclosed. The method may generally include determining, with a controller, a load power requirement for the work vehicle, determining a plurality of candidate engine speeds at which the load power requirement is achievable, analyzing stored efficiency data for a transmission and at least one additional component of the work vehicle to determine a power loss value for each candidate engine speed, determining a candidate engine power for each candidate engine speed based on the load power requirement and the power loss values and analyzing stored fuel efficiency data based on the candidate engine powers to determine a target engine speed for the work vehicle.