Abstract: The invention provides a method for producing embedded contact lenses involving a mold set in a two-curing-step process and a fast-curing SiHy lens formulation. The mold set consists of three mold halves, one of which is used twice, the first time for molding an insert from an insert-forming composition and the second time for an embedded contact lens with the molded insert embedded therein from the fast curing SiHy lens formulation that comprises a N,N-dialkylacrylamide, a hydrophilic (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker and being free of any siloxane-containing vinylic monomer.

Abstract: The invention provides a method for producing delamination-resistant embedded contact lenses involving use of a mold set in two-curing steps and a special lens-forming composition for forming a bulk hydrogel material for embedding a crosslinked polymeric insert. The mold set consists of three mold halves, one of which is used twice, the first time for molding an insert from an insert-forming composition and the second time for an embedded contact lens with the molded insert embedded therein from the special lens-forming composition that a vinylic crosslinking agent and or organic solvent both of which independent of each other can swell an insert by a moderate swelling degree. The resultant embedded hydrogel contact lenses can be free of deformation and delamination.

Abstract: The invention provides a method for producing embedded diffractive contact lenses involving use of a mold set in two-curing steps. The mold set consists of three mold halves, one of which is used twice, the first time for molding a diffractive insert and the second time for an embedded contact lens with the molded diffractive insert embedded therein. The twice-used mold half has been treated with a corona plasma or a vacuum UV in a central circular area having a diameter equal to or smaller than the diameter of the insert to ensure that the molded insert consistently adheres to the twice-used mold half, even though the other mating insert mold half for molding the diffractive insert has a great tendency to bind strongly the molded insert due to the diffractive structure on its molding surface.

Abstract: The invention provides a method for producing embedded contact lenses involving steps of use of a set of 3 mold halves in two-curing steps. One of the 3 mold halves have been used twice, the first time for molding an insert and the second time for molding the embedded hydrogel contact lens. The twice-used mold half has been treated with a corona plasma or a vacuum UV in a central circular area of its molding surface having a diameter equal to or smaller than the diameter of the insert to ensure that the molded insert consistently adhered to the twice-used mold half. The method also comprises a step of forming a reactive polysiloxane coating that is covalently attached onto the back or front surface of a molded insert adhered on the twice-used mold half before molding the embedded contact lens in the 2nd curing step.

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner.

Abstract: Systems and methods for compressing and querying data for real-time analytics. The system can receive log data and generate an intermediate representation by parsing a log template and variables from the log data into a columnar format. The method includes generating a compressed intermediate representation associated with an index type and storing the compressed intermediate representation in the columnar format based on the index type. The method includes receiving a search query and analyzing the search query to identify a user defined function. The method includes parsing the search query to convert the search query into one or more predicates that satisfy the search query. The method includes filtering the compressed log data based on the one or more predicates and providing a query result.

Abstract: The present disclosure is related to methods and network nodes for handling infringement of a background data transfer (BDT) policy. A method at a first network node for handling infringement of one or more conditions associated with a negotiated BDT policy, the method comprising: determining whether a user equipment (UE) infringes any of the one or more conditions other than one or more negotiated time intervals during which BDT is expected to be performed by the UE; and triggering updating of a charging rate applied for the UE in response to determining that the UE infringes at least one of the one or more conditions.

Abstract: A backlight driving method is provided. The method includes: determining a first duration of a first active pulse phase in a backlight driving signal corresponding to a target frame of a to-be displayed picture in a display panel, based on a target duty ratio and a first period corresponding to a target previous frame; wherein the target previous frame is a frame preceding the target frame, and the backlight driving signal is configured to drive a backlight of the display panel; and determining a second duration based on a maximum period corresponding to a frame at a lowest refresh frequency of the display panel and the first period, to delay a start time of the first active pulse phase based on the second duration.

Abstract: A method includes: when performing information transmission with a first access point AP on a first frequency band, determining, whether the terminal equipment needs to establish a connection with a second AP, which is a second frequency band; determining, by the terminal equipment, whether the first AP and the second AP are corresponding to a same dual-band radio access device; sending, by the terminal equipment, a connection request to the second AP when maintaining a protocol layer connection with the first AP; and if establishing, by the terminal equipment, the connection with the second AP when the second AP send feedback.

Abstract: Disclosed are a method, an apparatus, and a device for predicting adverse drug-drug interactions, and a readable storage medium, and relates to the technical field of pharmaceutical research and development. An objective of the present application is to provide the method, apparatus, and device for predicting adverse drug-drug interactions, and the readable storage medium for solving the above problems. To achieve the above objective, a technical solution adopted by the present application is as follows: acquiring first information; constructing an adverse drug-drug interaction prediction model according to the first information; acquiring second information, where the second information is molecular structure information of two drugs to be predicted; and outputting predicted adverse drug-drug interactions with the second information as an input into the adverse drug-drug interaction prediction model.

Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. The method of the invention involves using a silicone fluid (or so-called silicone oil) as non-reactive diluent in SiHy lens formulation for making SiHy contact lenses. Resultant SiHy contact lenses cast-molded from such a SiHy lens formulation can have a significantly reduced adhesion force with the molding surfaces of a lens mold and consequently a higher efficiency and consistency in removing unprocessed molded SiHy contact lenses from mold halves can be achieved. This method of the invention can be easily implemented in a production environment for enhancing the production yield.

Abstract: Described herein is a method for producing a contact lens comprising a central photochromic zone that has a diameter of about 13 mm or less and is concentric with the central axis of the contact lens. The method comprises: applying a first polymerizable fluid composition containing at least one photochromic compound on a central portion of the molding surface of a female mold half to form a circular layer; partially photocuring, in situ, the circular layer in the female mold half by using a visible light; dispensing a second polymerizable fluid composition over the partially-cured circular layer on the molding surface of the female mold half; and a step of thermally curing the second polymerizable fluid composition and the partially-cured circular layer immersed therein in the mold cavity formed between the molding surfaces of the female mold half and a male mold half.

Abstract: A method of electroplating a stress-free copper film on a substrate includes: providing the substrate; providing an electroplating bath that includes a copper salt, an acid, a leveler, a chlorine compound, an accelerator, a suppressor; and water; heating the electroplating bath to 25 to 60° C.; and electroplating the substrate in the electroplating bath to form the stress-free copper film while maintaining the electroplating bath at 25 to 60° C. The leveler is an organic compound containing an amine group. The method further includes annealing the stress-free copper film at 60-260° C. for 0.5 to 2 hours, or at 60-120° C. for 0.5 to 2 hours. A stress-free electroplated copper film is also disclosed.

Abstract: A virtual device management system for creating and implementing virtual devices and associated methods are provided herein. The system presents to a user a list of devices available for combining to create the virtual device. When the system receives from the user a selection of two or more devices that the user wishes to combine to create the virtual device, the system presents to the user a list of available functions that can be performed by the virtual device based on the selected devices. The system then receives from the user a selection of one or more functions and configures the virtual device to perform the selected functions. The system can also be configured to present, via a user interface via a mobile application running on a user device, a plurality of virtual devices with predetermined functionalities that are created by detecting the various connected devices within an IoT network.

Abstract: A bullet-screen comment processing method and apparatus are provided. The bullet-screen comment processing method includes: obtaining a to-be-displayed bullet-screen comment of a target video; determining preset bullet-screen comment tracks of a video playing interface based on a playing mode of the target video on the video playing interface, where the preset bullet-screen comment tracks are generated based on at least two playing modes; and rendering the to-be-displayed bullet-screen comment to the video playing interface based on the preset bullet-screen comment tracks and a bullet-screen comment display effect.

Abstract: Provided are single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises treating the molding surfaces of polypropylene lens molds (or other hydrophobic plastic molds) with a vacuum UV or a corona plasma to increase the surface energies of the molding surfaces of the lens molds, cast-molding a silicone hydrogel lens formulation containing a relatively small amount of at least one carboxyl-containing vinylic monomer in the treated lens molds, and heating resultant cast-molded silicone hydrogel contact lenses in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel layer covalently attached onto the bulk silicone hydrogel material.

Abstract: The present invention includes compositions and methods for detecting the presence of: a coronavirus or an immune response relevant to a coronavirus infection including T cells responsive to one or more coronavirus peptides or proteins comprising, consisting of, or consisting essentially of: one or more amino acid sequences selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166), or a subsequence, portion, homologue, variant or derivative thereof; a fusion protein comprising one or more amino acid sequences selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166); a pool of 2 or more peptides selected from the amino acid sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166); or a polynucleotide that encodes one or more peptides or proteins, comprising, consisting of, or consisting essentially of an amino acid sequence selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166), or a subsequence, portion, homologue, variant or derivative

Abstract: In an example method, after an electronic device sends a first request to a first server, the first server may obtain an advertisement from an advertisement server and send the advertisement to the electronic device, and the electronic device displays the advertisement.