Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: Various embodiments disclose a method for operating a printer apparatus that includes a print head. The method includes causing a media hub to retract a media in a retract direction along a media path. Further, the method includes causing a first media sensor to generate a first signal during retraction of the media. Furthermore, the method includes monitoring the first signal to detect at least one of a leading edge or a trailing edge of a label of the plurality of labels. Upon detecting the at least one of the leading edge or the trailing edge of the label, causing the media hub to retract the media by at least a predetermined distance, wherein the predetermined distance is a distance between the print head and the first media sensor.

Abstract: Disclosed is a cleaning robot. The cleaning robot includes a body, a traveling assembly, a rolling brush assembly, a dust suction assembly, a mopping assembly, and a universal wheel. The traveling assembly, the rolling brush assembly, the dust suction assembly, the mopping assembly, and the universal wheel are all arranged on the body. The dust suction assembly includes a dust box. The rolling brush assembly is configured for sweeping garbage on a ground. The dust box is configured for receiving garbage swept by the rolling brush assembly. In an advancing direction of the cleaning robot, the dust box is arranged in front of the rolling brush assembly, and the mopping assembly and/or the universal wheel is arranged behind the rolling brush assembly.

Abstract: The present application relates to a pregabalin sustained release composition, comprising: (a) an active ingredient; (b) a matrix-forming agent; (c) a swelling agent; (d) a gelling agent; and optionally a filler. The pregabalin sustained release composition provided in the present application can rapidly swell in volume when exposed to aqueous medium until exceeding the dimeter of human gastric pyloric (13 mm). It thereby prolongs the gastric emptying time to increase the retention time of pregabalin in the stomach and enhances absorption of pregabalin in the small intestine and ascending colon. Moreover, the pregabalin sustained release composition provided herein achieves a sustained release for 24 h, which allows QD (once a day) administration, reduces administration number, and improves patient compliance.

Abstract: An image diagnosis supporting device includes a model reader that reads an image diagnostic model that outputs a diagnostic result for a diagnostic image that is an input medical image, a storage unit that stores facility data that is a plurality of medical images associated with diagnostic results held in a facility, and an adjuster that adjusts, based on the facility data, the image diagnostic model or the diagnostic image input to the image diagnostic model.

Abstract: The present disclosure discloses a grid supply load predicting method, a system, and a storage medium. The method includes: determining a characteristic historical data set of a grid supply load; obtaining a grid supply load characteristic trend prediction result by inputting the characteristic data set of the historical grid supply load and the daily characteristic data of target influencing factor into a preset trend prediction model for grid supply load characteristic trend prediction; determining a grid supply load curve type; obtaining a grid supply load prediction model corresponding to the grid supply load curve type to take as a target prediction model; and obtaining a target grid supply load prediction result by inputting the historical data set of the grid supply load, the grid supply load characteristic trend prediction result and the daily characteristic data of target influencing factor into the target prediction model for grid supply load prediction.

Abstract: A system and method of selecting genes for a gene panel, includes retrieving gene-disease associations of genes associated with diseases at a given level in the disease hierarchy from a disease association database. The disease association database stores disease information, gene information, phenotype information, associations between diseases in the disease hierarchy, gene-disease associations and strength parameters related to the gene-disease associations. For each gene associated with the diseases at the given level, the strength parameters are weighted and combined to determine a rank score for the each gene. The genes are ranked based on the rank scores to provide ranked gene information. The ranked gene information is linked with diseases at the higher levels of the disease hierarchy based on hierarchical relationships. The ranked gene information for gene-disease associations can be used to select genes for a gene panel design.

Abstract: The present invention provides an edible blended vegetable oil for reducing blood lipids and cholesterol. The trace elements in the edible blended vegetable oil include 15-300 mg/kg of polyphenols, 290-1700 mg/kg of ?-sitosterol, 260-1500 mg/kg of campesterol, 150-1000 mg/kg of stigmasterol, 140-600 mg/kg of squalene, 50-160 mg/kg of parkerol, 40-120 mg/kg of ?-tocotrienol. The prepared edible blended vegetable oil of the present invention can achieve the effect of reducing blood lipids and cholesterol through a synergistic effect within the trace elements and a reasonable ratio within fatty acids. It is suitable for people with different health needs and has a broad market prospect and application value.

Abstract: Disclosed is an optimal power flow acquiring method for regional distribution network of small hydropower groups based on deep learning, which specifically includes the following steps: generating required data sets by adopting continuous power flow and power flow equation calculation methods; the data set is randomly divided into training data (80 percent) and test data (20 percent); training the built convolutional neural network model with training data to learn the mapping relationship between load and generator output power; inputting test data, and directly obtaining PG and QG from the trained convolutional neural network; and solving residual variables Vi and ?i with traditional power flow solver. The application can accelerate the solving speed of the optimal power flow problem with higher prediction accuracy.

Abstract: Provided is a polypeptide, a production method therefor and a use thereof. The polypeptide includes 63 to 1496 continuous amino acid residues of SEQ ID NO: 9, and includes a sequence represented by (A)m or is composed of the sequence represented by (A)m, wherein each A is an amino acid sequence selected from any one of those represented by SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3, or a modified amino acid sequence or a sequence variant thereof; m is an integer between 1 and 10; and each A is the same or different and two adjacent As are directly connected by peptide bonds or connected by at least one amino acid residue, wherein the polypeptide has a cell adhesion activity, and a method of producing said polypeptide and use of said polypeptide.

Abstract: A method for distilling one or more trained teacher automatic speech recognition (ASR) models into a multilingual student model includes receiving a plurality of teacher training examples and a plurality of student training examples. The method also includes training one or more teacher automatic speech recognition (ASR) models using the plurality of teacher training examples. Each teacher ASR model is configured to output a respective textual representation of a respective audio input. The method further includes generating a multi-lingual student ASR model by training the multi-lingual student ASR model using the plurality of student training examples and distilling the trained one or more teacher ASR models into the multilingual student ASR model using a tunable distillation loss weight. Each student ASR model is configured to receive an audio input and output a corresponding textual representation of the received audio input.

Abstract: After a first broadband access server (BAS) receives a connection request of a first terminal, when a quantity of remaining session resources of the first BAS is less than or equal to a first threshold, the first BAS sends the connection request to a second BAS, so that the first terminal accesses a network via the second BAS, wherein the second BAS is determined by the first BAS by using a BAS pool communication protocol.

Abstract: The present disclosure provides a polar code coding method, a polar code decoding method, apparatus and device. The polar code coding method includes: obtaining a plurality of CRC check bits; determining interleaved padding positions in a to-be-coded sequence; filling a first predetermined number of CRC check bits of the plurality of CRC check bits into the interleaved padding positions in the to-be-coded sequence in an interleaving manner; and performing polar coding on the to-be-coded sequence that is filled with the predetermined number of CRC check bits in interleaving manner, and transmitting a coded sequence to a receiving end. The first predetermined number is less than or equal to a total number of the plurality of CRC check bits.

Abstract: The present invention provides an edible blended vegetable oil for reducing blood lipids and cholesterol. The trace elements in the edible blended vegetable oil include 15-300 mg/kg of polyphenols, 290-1700 mg/kg of ?-sitosterol, 260-1500 mg/kg of campesterol, 150-1000 mg/kg of stigmasterol, 140-600 mg/kg of squalene, 50-160 mg/kg of parkerol, 40-120 mg/kg of ?-tocotrienol. The prepared edible blended vegetable oil of the present invention can achieve the effect of reducing blood lipids and cholesterol through a synergistic effect within the trace elements and a reasonable ratio within fatty acids. It is suitable for people with different health needs and has a broad market prospect and application value.

Abstract: A sensor module includes a sensor module main body having a rectangular board provided with a radio radar sensor function, and a metallic case having a rectangular parallelepiped box shape in which an opening part opened at one face in a thickness direction is formed and a cut-out opening for drawing out a cable connecting the sensor module main body is formed on a side face, the opening part being closed by the board inserted through the opening part with a component disposed on a front face of the board facing toward a bottom part on the inner side, and the cable is inserted into at least a part of the cut-out opening, and the cut-out opening is formed to be symmetrical with respect to a plane passing through the center of the metallic case and perpendicular to a plane of the cut-out opening.

Abstract: The present disclosure provides a polar code coding method, a polar code decoding method, apparatus and device. The polar code coding method includes: obtaining a plurality of CRC check bits; determining interleaved padding positions in a to-be-coded sequence; filling a first predetermined number of CRC check bits of the plurality of CRC check bits into the interleaved padding positions in the to-be-coded sequence in an interleaving manner; and performing polar coding on the to-be-coded sequence that is filled with the predetermined number of CRC check bits in interleaving manner, and transmitting a coded sequence to a receiving end. The first predetermined number is less than or equal to a total number of the plurality of CRC check bits.

Abstract: Method and apparatus are disclosed for estimating job and career transition capabilities of candidates in a database. An example system for processing a search query indicative of a candidate to hire includes a database including records of a plurality of profiles, a network connector to provide access to the database via an application programming interface, and a computing device. The computing device periodically generates a first score representing a likelihood that a person associated with the respective profile will respond to a communication regarding a job in a particular category. The computing device also, in response to receiving a search query (a) generates a second score representing a probabilistic measurement of a likelihood that the person associated with the retrieved profile will change jobs, (b) generates a third score representative of a percentile level of activity associated with searching for a new job.

Abstract: Coating systems for a cooled turbine blade tip, such as a metal turbine blade tip, are provided. The coating system includes an abrasive layer overlying the surface of the turbine blade tip. One or more buffer layers may additionally be disposed between an outer surface of the blade tip and the abrasive layer. The coated blade tip can be used with a ceramic matrix composite (CMC) shroud coated with an environmental barrier coating (EBC) to provide improved cooling to the tip so as to lengthen oxidation time of the abrasive layer and reduce blade tip wear. Methods are also provided for forming the cooled blade tip and applying the coating system onto the cooled turbine blade tip.