Patents by Inventor Yuntao Wu

Yuntao Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11474264
    Abstract: Eutectic lithium chloride-cerium chloride (LiCl—CeCl3) compositions are described. An exemplary eutectic composition has about 75 mole % LiCl and about 25 mole % CeCl3. The eutectic compositions can have optical and/or scintillation properties. Also described are methods of preparing the eutectic compositions as well as methods of using radiation detectors including the eutectic compositions in the detection of radiation, including thermal neutrons.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: October 18, 2022
    Assignee: University of Tennessee Research Foundation
    Inventors: Mariya Zhuravleva, Yuntao Wu, Charles L. Melcher
  • Patent number: 11473064
    Abstract: Timely development of vaccines and antiviral drugs is critical to control the COVID-19 pandemic. Current methods for quantifying vaccine-induced neutralizing antibodies involve the use of pseudoviruses, such as the SARS-CoV-2 spike protein (S) pseudotyped lentivirus. However, these pseudoviruses contain structural proteins foreign to SARS-CoV-2, and require days to infect and express reporter genes. Here, the present application discloses composition and methodology for making and using a new hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) particle for rapid and accurate quantification of neutralization antibodies and viral variants.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: October 18, 2022
    Assignee: George Mason Research Foundation, Inc.
    Inventors: Brian Hetrick, Yuntao Wu
  • Patent number: 11437808
    Abstract: A wind turbine includes a superconducting generator having an armature and a superconducting field winding set. The armature includes at least one multiphase armature winding set having a plurality of armature windings. The superconducting field winding set is separated by a gap from the armature. The superconducting field winding set includes a plurality of field windings, wherein one of the armature winding set and superconducting field winding set is connectable to rotate with a rotating component of the wind turbine and another of the armature and the superconducting field winding set being non-rotating. The wind turbine also includes a controllable power converter coupled to the at least one multiphase armature winding set and a controller configured to control switching operations of the controllable power converter to effect a phase shift among the plurality of armature windings.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: September 6, 2022
    Assignee: General Electric Company
    Inventors: Nathaniel Benedict Hawes, Yuntao Xu, Nidhishri Tapadia, David Allan Torrey, Anbo Wu
  • Patent number: 11382967
    Abstract: Embodiments relate to methods comprising expressing or overexpressing P-selectin glycoprotein ligand-1 (PSGL-1) in human immunodeficiency virus (HIV) producing cells; isolating HIV particles from the HIV producing cells; and preparing the isolated HIV particles as a HIV vaccine. Embodiments relate to systems comprising a HIV vaccine comprising live attenuated, inactivated, or non-infectious HIV particles. Embodiments relate to systems capable of performing a method comprising administering a vaccine comprising live attenuated, inactivated, or non-infectious HIV particles to a subject in need of the vaccine; and treating or preventing one or more disease states in the subject resulting from HIV infection.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: July 12, 2022
    Assignee: George Mason University
    Inventors: Yuntao Wu, Yajing Fu, Deemah Dabbagh, Zheng Zhou
  • Patent number: 11377499
    Abstract: The present disclosure provides a method of restoring immune reconstitution, immune control of viremia, and one or more T cell functions in a subject infected with HIV. The method includes administering to the subject infected with HIV an agent that targets the cofilin pathway.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: July 5, 2022
    Assignee: George Mason University
    Inventor: Yuntao Wu
  • Publication number: 20220119776
    Abstract: Timely development of vaccines and antiviral drugs is critical to control the COVID-19 pandemic. Current methods for quantifying vaccine-induced neutralizing antibodies involve the use of pseudoviruses, such as the SARS-CoV-2 spike protein (S) pseudotyped lentivirus. However, these pseudoviruses contain structural proteins foreign to SARS-CoV-2, and require days to infect and express reporter genes. Here, the present application discloses composition and methodology for making and using a new hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) particle for rapid and accurate quantification of neutralization antibodies and viral variants.
    Type: Application
    Filed: October 19, 2021
    Publication date: April 21, 2022
    Inventors: Brian HETRICK, Yuntao WU
  • Patent number: 11230667
    Abstract: Codoped rare earth garnet-type oxide scintillators are described. More particularly, the scintillators include lutetium yttrium aluminum garnet (LuYAG)-type materials that are doped with an activator, such as praseodymium, and codoped with a monovalent cation, such as lithium. Radiation detectors comprising the scintillators, methods of detecting higher energy radiation using the scintillators, and methods of preparing the scintillators and altering scintillator properties are also described.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: January 25, 2022
    Assignee: University of Tennessee Research Foundation
    Inventors: Camera Janelle Foster, Yuntao Wu, Merry A. Koschan, Charles L. Melcher
  • Patent number: 11116833
    Abstract: Embodiments relate to expressing or overexpressing P-selectin glycoprotein ligand-1 (PSGL-1) in human immunodeficiency virus (HIV) producing cells; isolating HIV particles from the HIV producing cells; and preparing the isolated HIV particles as a HIV vaccine. Embodiments relate to a HIV vaccine comprising live attenuated, inactivated, or non-infectious HIV particles. Embodiments relate to systems performing a method comprising administering a vaccine comprising live attenuated, inactivated, or non-infectious HIV particles to a subject in need of the vaccine; and treating or preventing one or more disease states in the subject resulting from HIV infection.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: September 14, 2021
    Assignee: George Mason University
    Inventors: Yuntao Wu, Yajing Fu, Deemah Dabbagh, Zheng Zhou
  • Publication number: 20210270980
    Abstract: Eutectic lithium chloride-cerium chloride (LiCl—CeCl3) compositions are described. An exemplary eutectic composition has about 75 mole % LiCl and about 25 mole % CeCl3. The eutectic compositions can have optical and/or scintillation properties. Also described are methods of preparing the eutectic compositions as well as methods of using radiation detectors including the eutectic compositions in the detection of radiation, including thermal neutrons.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 2, 2021
    Inventors: Mariya Zhuravleva, Yuntao Wu, Charles L. Melcher
  • Publication number: 20210261635
    Abstract: Compositions and methods for using actin-based peptides to modulate cellular bioactivity, including modulation of cellular susceptibility to intracellular pathogens, such as bacteria and viruses.
    Type: Application
    Filed: May 11, 2021
    Publication date: August 26, 2021
    Inventor: Yuntao Wu
  • Publication number: 20210236583
    Abstract: The present disclosure relates to the design and method for targeting the renin-angiotensin system (RAS) for therapeutics of lung diseases, particularly environment- and pathogen-induced lung injury. Provided herein are design, methodology, compositions, and the like for such for restoring the regulatory balance the RAS system for the management of lung diseases.
    Type: Application
    Filed: February 1, 2021
    Publication date: August 5, 2021
    Inventor: Yuntao WU
  • Publication number: 20210179712
    Abstract: The present disclosure relates to composition and methodology for using the CD2 receptor to block viral replication, such as HIV-1 infection. In one embodiment, viral target cells such as blood CD4 T cells can be rendered resistant to HIV through stimulation of the CD2 receptor with either an antibody, a ligand, or a small molecule that binds to the CD2 receptor. Pre-stimulation of CD2 can be used to enhance the anti-HIV immunity and used to promote immune response from HIV infection or from an anti-HIV vaccine.
    Type: Application
    Filed: October 10, 2018
    Publication date: June 17, 2021
    Inventors: Yuntao WU, Hong SHANG
  • Patent number: 11028138
    Abstract: Compositions and methods for using actin-based peptides to modulate cellular bioactivity, including modulation of cellular susceptibility to intracellular pathogens, such as bacteria and viruses.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: June 8, 2021
    Inventor: Yuntao Wu
  • Publication number: 20210093709
    Abstract: Live attenuated viruses are provided. The viruses, when assembled, include one or more SHREK proteins and are thereby rendered non-infective and attenuated, and can be safely used in vaccines, e.g. to treat or prevent infections and to eliminate e.g. latent virus reservoirs.
    Type: Application
    Filed: September 24, 2020
    Publication date: April 1, 2021
    Inventors: Yuntao Wu, Deemah Dabbagh, Sijia He, Brian Hetrick
  • Publication number: 20210041437
    Abstract: A major immune dysfunction persisting in chronic diseases such as HIV infection and cancer is the impairment of T cell motility and migration to tissues. Therapeutics such as antiretroviral therapy or cancer therapy frequently do not fully restore T cell motility for tissue migration and infiltration. Cofilin is an actin-depolymerizing factor that regulates actin dynamics for T cell migration. Here we demonstrate that the levels of cofilin phosphorylation in blood T cells (CD4 or CD8), macrophages, B cells, natural killer (NK) cells, and/or cancer cells can be used to quantify the immune damages caused by chronic viral infection and cancer, and to predict the recovery of T cells following treatment.
    Type: Application
    Filed: January 23, 2019
    Publication date: February 11, 2021
    Inventors: Yuntao WU, Hong SHANG, Yajing FU
  • Publication number: 20200362238
    Abstract: Codoped rare earth garnet-type oxide scintillators are described. More particularly, the scintillators include lutetium yttrium aluminum garnet (LuYAG)-type materials that are doped with an activator, such as praseodymium, and codoped with a monovalent cation, such as lithium. Radiation detectors comprising the scintillators, methods of detecting higher energy radiation using the scintillators, and methods of preparing the scintillators and altering scintillator properties are also described.
    Type: Application
    Filed: February 7, 2019
    Publication date: November 19, 2020
    Inventors: Camera Janelle Foster, Yuntao Wu, Merry A. Koschan, Charles L. Melcher
  • Patent number: 10838083
    Abstract: Codoped alkali and alkaline earth halide scintillators are described. More particularly, the scintillators are codoped with tetravalent ions, such as Ti4+, Zr4+, Hf4+, Ge4+. The codoping can alter one or more optical and/or scintillation property of the scintillator material. For example, the codoping can improve energy resolution. Radiation detectors comprising the scintillators and methods of detecting high energy radiation using the radiation detectors are also described.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: November 17, 2020
    Assignee: University of Tennessee Research Foundation
    Inventors: Yuntao Wu, Charles L. Melcher
  • Publication number: 20200345833
    Abstract: Persistence of HIV in anatomic sanctuary sites such as the brain prevents viral eradication. Although combination antiretroviral therapy (cART) inhibits viral replication to undetectable level by standard clinical assay, it does not selectively eliminate virus reservoirs. To target HIV reservoirs, the present inventor developed an HIV Rev-dependent lentiviral vector carrying a series of therapeutic genes, such as diphtheria toxin, anthrolysin O from Bacillus anthracis, human TRAF6, or the herpes simplex 1 virus thymidine kinase gene (HSV-tk). The present disclosure provides the Rev-dependent vectors for targeting viral reservoir in a SIV/rhesus macaque model. SIV-infected rhesus macaques were first treated with cART for over 6 months starting 12 weeks post infection, followed by injections with viral particles assembled from a SIV Rev-dependent vector carrying HSV-tk.
    Type: Application
    Filed: October 23, 2018
    Publication date: November 5, 2020
    Inventor: Yuntao WU
  • Publication number: 20200340055
    Abstract: The present disclosure discloses use of TM9SF1 gene as a target in vascular diseases, which relates to the field of biotechnology. In the present disclosure, by means of RNA interference strategy, it is found that after endogenous TM9SF1 gene is interfered with, the expression of two important genes IL1? and IL8 related to the inflammation of HUVEC and the expression of the gene ACE1 closely related to vasoconstriction are remarkably downregulated, suggesting that TM9SF1 gene has positive regulation effect on the expression of IL1?, IL8 and ACE1 genes. By inhibiting or silencing the expression of the TM9SF1 gene, it is possible to inhibit or silence the expression of IL1?, IL8, and ACE1 genes, and further achieve the object of treating or preventing vascular diseases associated with the expression level of IL1?, IL8 and ACE1 genes.
    Type: Application
    Filed: July 16, 2018
    Publication date: October 29, 2020
    Inventors: Juan XIAO, Yanli HUANG, Chun MAO, Lin YANG, Jiao YIN, Xiaoming HE, Xiaofang SHEN, Wenbin DENG, Yuntao WU
  • Publication number: 20200318006
    Abstract: Codoped lutetium-based oxyorthosilicate scintillators (e.g., lutetium oxyorthosilicase (LSO) and lutetium-ytrrium oxyorthosilicate (LYSO) scintillators) codoped with transition metal ions (e.g., Cu2+) are described. The codoping can alter one or more optical and/or scintillation property of the scintillator material. For example, the codoping can increase scintillation light yield and/or decrease scintillation decay time. Radiation detectors comprising the scintillators, methods of detecting high energy radiation using the radiation detectors, and methods of altering one or more scintillation and/or optical properties of a lutetium-based oxyorthosilicate scintillator are also described.
    Type: Application
    Filed: April 3, 2020
    Publication date: October 8, 2020
    Inventors: Yuntao Wu, Merry A. Koschan, Charles L. Melcher