Abstract: The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.

Abstract: Embodiments of structure and methods for forming a staircase structure of a memory device are disclosed. In an example, a memory device includes a memory array structure and a staircase structure. The staircase structure includes a plurality of stairs each has a first number of divisions at different depths along a first direction. The plurality of stairs extend along a second direction perpendicular to the first direction. Each of the first number of divisions of a respective stair includes a conductor portion on the top surface of the respective division and a second number of non-conductor portions under the conductor portion. The conductor portion and the non-conductor portions are insulated from one another by one or more dielectric layers.

Abstract: A method for detecting fraud and non-fraud pattern changes can be based on transaction pathway transversal analysis. A decision tree can be built based on a training dataset from a reference dataset. Pathway transversal information can be recorded along each pathway for the reference dataset. A first mean and a first variance of a class probability can be calculated of all samples over each pathway. A pathway distribution for a new transaction dataset under investigation and a second mean and a second variance of all samples of the new transaction dataset can be obtained. The second mean and the second variance can represent a fraud probability. The deviation metrics between one or more feature statistics of a feature along each pathway for the reference dataset and the new dataset can be determined on a local level. Feature contributors to pattern changes can be determined by analyzing the deviation metrics.

Abstract: A wireless channel monitoring and simulation device with multi-input multi-output (MIMO) is provided, which includes: a wireless channel monitor, configured to collect characteristic parameters of wireless channels in typical environments, and establish models based on the characteristic parameters; a model database, configured to store the characteristic parameter models and parameterize; an original signal, configured to input N different original signals; a wireless channel simulator, configured to simulate a typical channel environment according to the model database configuration, so that the original signal is the same as that in a real typical channel environment, and adopts a N-path output; an N-channel oscilloscope, configured to observe specific waveforms of N-path simulated signals; and a master computer software, configured to process, analyze, and store N-path output signals.

Abstract: A display substrate, a display device and a test method of the display substrate are disclosed. The display substrate includes a display region and a peripheral region. The peripheral region includes: a first leading wire extending in a first direction and including a first end and a second end; a first test wire electrically connected with the first leading wire at a first position of the first test wire between the first end and the second end; the display region includes first signal wires of first group extending in a second direction, two first signal wires arranged outermost in the first direction among the first signal wires of first group are respectively connected with the first end and the second end, and remaining first signal wires among the first signal wires of first group are connected with the first leading wire between the first end and the second end.

Abstract: Embodiments of the present disclosure relate to a method for running an application, an electronic device, and a computer program product. The method includes determining, based on historical data associated with running of the application, a target time period and a computing resource to be used for running the application within the target time period, a load rate associated with the computing resource being higher than a threshold load rate in the target time period. The method further includes determining an interruption tolerance of the application based on a type of the application, determining costs for running the application by a plurality of types of virtual machines and determining a target type from the plurality of types based on the costs and the computing resource, to cause the application to be run by a virtual machine of the target type.

Abstract: Embodiments of the present disclosure relate to a multi-node storage system and a data deduplication method thereof. The method includes: determining a similarity hash value of a super block, wherein the similarity hash value indicates similarity between super blocks; comparing the similarity hash value of the super block with a feature similarity hash value of a node of the multi-node storage system to determine whether the super block matches the node; and in response to determining that the super block matches the node, allocating the super block to the node.

Abstract: The invention relates to a polyamide compound and a use thereof. Specifically, the invention relates to a type of polyamide compound (which preferably comprise one or more amide bonds formed by condensation of same or different L-amino acids or D-amino acids), or stereoisomers, crystalline polymorphs, solvates, metabolites, prodrugs or pharmaceutically acceptable salts or esters thereof, or pharmaceutical compositions thereof, as well as a method for preparing the polyamide compound and a use thereof in the prevention or treatment of diseases associated with ?-opioid receptor. The polyamide compound of the invention has excellent ?-opioid receptor agonistic activity and hydrophilicity, thus having a lesser ability of penetrating the blood-brain barrier and a lower capacity for entering the brain.

Abstract: In some embodiments, a method receives one or more segments for content from a first content delivery network during a playback session for the content. The content includes a number of segments. The method evaluates buffer occupancy of a buffer configured to store segments of the content for playback and evaluates a number of times of a failure to download a segment for the content. The buffer occupancy is compared to a first threshold and the number of times of the failure to a second threshold. The method determines a switch from the first content delivery network to a second content delivery network during the playback session based on the comparing.

Abstract: Embodiments of the present disclosure provide a method, a device and a computer program for data backup. A method of backing up data comprises: in response to receiving, from an application system, a request for backing up first data, storing the first data into a first backup node; generating first metadata corresponding to the first data, the first metadata comprising first digest information of the first data; storing the first metadata into a block chain system to which the first backup node belongs; and verifying integrity of the first data stored in the first backup node with the first metadata stored in the block chain system. By utilizing a block chain system, the embodiments of the present disclosure ensure that data backed up are protected from being tampered with.

Abstract: Provided are a live detection method and apparatus for a high-voltage switch cabinet. The live detection apparatus for a high-voltage switch cabinet includes a robot body and a back-end server. The robot body includes a host module, a power module, a detection module and a motion module. The power module is electrically connected to the host module and the motion module. The host module is communicably connected to the motion module and the detection module. The detection module includes a visible light camera, an infrared thermal imager, an non-contacting ultrasonic sensor and an ultrahigh-frequency sensor. The motion module includes a horizontal motion module, a vertical motion module and a rotating motion module. The horizontal motion module includes a motor-driven carrier and a laser navigation system. The vertical motion module is secured to the motor-driven carrier.

Abstract: An assembly system includes a positioning unit adapted to clamp and position a cable, a supply unit adapted to supply a connector, and an insertion unit adapted to insert an end of the cable into the connector by moving the connector. The supply unit includes a conveyor belt having a side to which ends of a plurality of connectors in a row of connectors are connected, a cutting device configured to cut each connector of the row of connectors from the conveyor belt, and a conveyor configured to move the conveyor belt, so as to move the connectors individually to the cutting device.

Abstract: Disclosed are systems, apparatuses and techniques for replicating data between different cloud computing platforms. Examples include storage replicator components operable in different cloud computing platforms. The first storage replicator component may identify the second cloud computing platform as a location to copy a data file in response to an event related to the data file stored in a first cloud computing platform. The first storage replicator component may request a copy of the data file via an application programming interface of the first cloud computing platform. The attributes of the copy of the data file which involve modification to conform to data management conventions of the second cloud computing platform may be determined and modified to comply with conventions of the second cloud computing platform. The modified copy of the data file may be forwarded to the second cloud computing platform for storage.

Abstract: Disclosed herein is a method for maintenance therapy of a PARP inhibitor in treating a subject with gastric cancer (GC) comprising administering to the subject a therapeutic or maintenance effective amount of a PARP inhibitor, wherein the subject had previously received chemotherapy.

Abstract: A cable foil layer processing equipment includes a rack, a knife holder installed on the rack, a plurality of cutters movably installed on the knife holder and arranged in a crisscross manner in a vertical plane, and a linear moving mechanism configured to move linearly in a horizontal direction parallel to an axial direction of a cable. The rack is installed on the linear moving mechanism so as to move linearly in the horizontal direction along with the linear moving mechanism. The cutters clamp a foil layer of the cable in a radial direction of the cable. The linear moving mechanism drives the knife holder to move in the horizontal direction so as to cut the foil layer of the cable into a plurality of equal parts.