Abstract: Provided herein are compositions, method and uses for modulating MCT4 activity or for the treatment of cancer. The compositions comprise antisense oligonucleotides (ASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of MCT4. The cancer may be selected from one or more of: prostate cancer; renal cell carcinoma; breast cancer; cervical cancer; liver cancer; bladder cancer; and small cell lung cancer pr. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: Provided herein are compositions, method and uses for modulating MCT4 activity or for the treatment of cancer. The compositions comprise antisense oligonucleotides (ASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of MCT4. The cancer may be selected from one or more of: prostate cancer; renal cell carcinoma; breast cancer; cervical cancer; liver cancer; bladder cancer; and small cell lung cancer pr. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: Provided herein are compositions, method and uses for modulating MCT4 activity or for the treatment of cancer. The compositions comprise antisense oligonucleotides (ASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of MCT4. The cancer may be selected from one or more of: prostate cancer; renal cell carcinoma; breast cancer; cervical cancer; liver cancer; bladder cancer; and small cell lung cancer pr. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: A sensitive element protection mechanism and a payment device using the sensitive element protection mechanism includes a circuit board; a sensitive element configured for storing, transmitting and/or processing user account information and user transaction information; a shield arranged in parallel with the circuit board; and an elastic member connecting the circuit board and the shield. The sensitive element is located on a side of the circuit board near the shield. The circuit board and the shield are provided and the sensitive element is provided between the circuit board and the shield so as to protect the sensitive element through the shield. The elastic member connects the circuit board and the shield to prevent the circuit board from being separated from the shield, thus preventing the circuit board from being opened to steal sensitive information in the sensitive element.

Abstract: A hardware encryption housing and a payment device using the hardware encryption housing includes a top shell, a bottom shell, a circuit board and a trigger switch configured to transmit a trigger signal when the top shell is separated from the bottom shell. A security chip, mounted on the circuit board, has a storage module configured to store key information and a detection module configured to clear the key information and lock the security chip after the trigger signal is detected. The trigger signal is transmitted when the top shell is separated from the bottom shell, and the detection module is provided in the security chip to detect whether the trigger switch transmits a trigger signal. When detected, the key information in the storage module is cleared and the security chip is locked.

Abstract: A method for defining a metropolitan area based on a regional inter-city flow intensity measurement model includes the following steps: 1. determining an urban agglomeration regional range to be measured and inter-city flow associated cities; 2. measuring, according to the determined associated cities, itemized regional inter-city flow intensities of each group of the associated cities; 3. calculating through weighing, according to the itemized regional inter-city flow intensity values, integrated inter-city flow intensities and membership degrees thereof between a central city and other associated cities; 4. recording the above data into an ArcGIS library, and establishing a regional inter-city flow database through association between spatial data and table data. 5. performing four groups of naturally intermittent type clustering analysis on data in the established regional inter-city flow database, and finally determining the range of a metropolitan area in a narrow sense and in a broad sense.

Abstract: A method for defining a metropolitan area based on a regional inter-city flow intensity measurement model includes the following steps: 1. determining an urban agglomeration regional range to be measured and inter-city flow associated cities; 2. measuring, according to the determined associated cities, itemized regional inter-city flow intensities of each group of the associated cities; 3. calculating through weighing, according to the itemized regional inter-city flow intensity values, integrated inter-city flow intensities and membership degrees thereof between a central city and other associated cities; 4. recording the above data into an ArcGIS library, and establishing a regional inter-city flow database through association between spatial data and table data. 5. performing four groups of naturally intermittent type clustering analysis on data in the established regional inter-city flow database, and finally determining the range of a metropolitan area in a narrow sense and in a broad sense.

Abstract: A hardware encryption housing and a payment device using the hardware encryption housing includes a top shell, a bottom shell, a circuit board and a trigger switch configured to transmit a trigger signal when the top shell is separated from the bottom shell. A security chip, mounted on the circuit board, has a storage module configured to store key information and a detection module configured to clear the key information and lock the security chip after the trigger signal is detected. The trigger signal is transmitted when the top shell is separated from the bottom shell, and the detection module is provided in the security chip to detect whether the trigger switch transmits a trigger signal. When detected, the key information in the storage module is cleared and the security chip is locked.