Abstract: A method for defining a metropolitan area based on a regional inter-city flow intensity measurement model includes the following steps: 1. determining an urban agglomeration regional range to be measured and inter-city flow associated cities; 2. measuring, according to the determined associated cities, itemized regional inter-city flow intensities of each group of the associated cities; 3. calculating through weighing, according to the itemized regional inter-city flow intensity values, integrated inter-city flow intensities and membership degrees thereof between a central city and other associated cities; 4. recording the above data into an ArcGIS library, and establishing a regional inter-city flow database through association between spatial data and table data. 5. performing four groups of naturally intermittent type clustering analysis on data in the established regional inter-city flow database, and finally determining the range of a metropolitan area in a narrow sense and in a broad sense.

Abstract: A method for defining a metropolitan area based on a regional inter-city flow intensity measurement model includes the following steps: 1. determining an urban agglomeration regional range to be measured and inter-city flow associated cities; 2. measuring, according to the determined associated cities, itemized regional inter-city flow intensities of each group of the associated cities; 3. calculating through weighing, according to the itemized regional inter-city flow intensity values, integrated inter-city flow intensities and membership degrees thereof between a central city and other associated cities; 4. recording the above data into an ArcGIS library, and establishing a regional inter-city flow database through association between spatial data and table data. 5. performing four groups of naturally intermittent type clustering analysis on data in the established regional inter-city flow database, and finally determining the range of a metropolitan area in a narrow sense and in a broad sense.

Abstract: A hardware encryption housing and a payment device using the hardware encryption housing includes a top shell, a bottom shell, a circuit board and a trigger switch configured to transmit a trigger signal when the top shell is separated from the bottom shell. A security chip, mounted on the circuit board, has a storage module configured to store key information and a detection module configured to clear the key information and lock the security chip after the trigger signal is detected. The trigger signal is transmitted when the top shell is separated from the bottom shell, and the detection module is provided in the security chip to detect whether the trigger switch transmits a trigger signal. When detected, the key information in the storage module is cleared and the security chip is locked.

Abstract: The present application is suitable for the field of payment devices, and provides an integrated payment device including a housing. A near field payment area and a code scanning payment area are provided on the housing. A near field payment module, a code scanning payment module and a circuit board configured for controlling the near field payment module and the code scanning payment module are mounted in the housing. Both the near field payment module and the code scanning payment module are electrically connected with the circuit board. The near field payment module is located at a position corresponding to the near field payment area. The code scanning payment module is located at a position corresponding to the code scanning payment area.

Abstract: Provided herein are compositions, method and uses for modulating MCT4 activity or for the treatment of cancer. The compositions comprise antisense oligonucleotides (ASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of MCT4. The cancer may be selected from one or more of: prostate cancer; renal cell carcinoma; breast cancer; cervical cancer; liver cancer; bladder cancer; and small cell lung cancer pr. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: A sensitive element protection mechanism and a payment device using the sensitive element protection mechanism includes a circuit board; a sensitive element configured for storing, transmitting and/or processing user account information and user transaction information; a shield arranged in parallel with the circuit board; and an elastic member connecting the circuit board and the shield. The sensitive element is located on a side of the circuit board near the shield. The circuit board and the shield are provided and the sensitive element is provided between the circuit board and the shield so as to protect the sensitive element through the shield. The elastic member connects the circuit board and the shield to prevent the circuit board from being separated from the shield, thus preventing the circuit board from being opened to steal sensitive information in the sensitive element.

Abstract: The present invention is applicable to the field of POS machines, and provides a magnetic head protection frame used in a POS machine, a card swiping module using the magnetic head protection frame, and a POS machine using the card swiping module. The magnetic head protection frame comprises a support frame, the support frame is strip-shaped, and the support frame defines a first opening exposing the magnetic head; a circuit board is mounted on an outside surface of the support frame, the circuit board is arranged along the whole length direction of the support frame, and the circuit board avoids a position corresponding to the first opening; connecting wires are connected on the circuit board.

Abstract: The present invention is applicable to the field of POS machines, and provides a peep-proof input keyboard and a POS machine using the peep-proof input keyboard. The peep-proof input keyboard comprises a circuit board, a keyboard, and a peep-proof cover, the keyboard includes a plurality of keys configured to input information, a portion of the circuit board corresponding to the keys is provided with a first connecting finger configured for the pressing operations of the keys, the circuit board is provided with a second connecting finger configured to control the keyboard to work and be turned off, and a bottom of the peep-proof cover is provided with at least one support post configured to abut against the second connecting finger so as to enable the keyboard to work.

Abstract: In an aspect, the invention provides methods and uses of PCAT18 for diagnosing, prognosing, and treatment monitoring of prostate cancer (PCa) in a subject. In another aspect, methods of treating PCa in a subject by administering an inhibiting agent of PCAT18 are provided. Uses of PCAT18 in treating PCa in a subject, and pharmaceutical compositions comprising a therapeutic agent effective to reduce the amount of PCAT18 in cancerous prostate cells and a pharmaceutically acceptable carrier, are also provided. The transcript of PCAT18 is a long non-coding RNA (lncRNA), whose expression is significantly altered in biological samples obtained from subjects with PCa or at risk of developing PCa compared to normal individuals. Expression of PCAT18 is specific to prostate tissue and is elevated in both cancerous prostate tissue and blood plasma of subjects with PCa relative to subjects without PCa or patients with other forms of cancer.

Abstract: Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract: The present invention is applicable to the field of POS machines, and provides a magnetic head protection frame used in a POS machine, a card swiping module using the magnetic head protection frame, and a POS machine using the card swiping module. The magnetic head protection frame comprises a support frame, the support frame is strip-shaped, and the support frame defines a first opening exposing the magnetic head; a circuit board is mounted on an outside surface of the support frame, the circuit board is arranged along the whole length direction of the support frame, and the circuit board avoids a position corresponding to the first opening; connecting wires are connected on the circuit board.

Abstract: The present invention is applicable to the field of POS machines, and provides a hidden wireless swiping device used in a POS machine and a POS machine using the hidden wireless swiping device. The hidden wireless swiping device comprises a circuit board, a wireless module, a light transmission plate configured to cover the wireless module, and an indicator light mounted on the circuit board; at least one surface of the light transmission plate is a frosted surface, and the circuit board is provided thereon with a control circuit configured to control the wireless module and the indicator light to operate. In the hidden wireless swiping device, the light transmission plate of which one surface is arranged to be a frosted surface covers on the wireless module, the indicator light is arranged on the circuit board, and the control circuit is arranged on the circuit board to control the wireless module and the indicator light to be turned on/off and to operate.

Abstract: The present invention provides a system and a method for reducing the space charge effect in a linear ion trap. The system includes a linear ion trap, a first AC power supply, a second AC power supply, and a RF power supply. The linear ion trap includes four identical electrode rods, where two poles of the first AC power supply are respectively connected to two of the electrode rods, and two poles of the second AC power supply are respectively connected to the other two electrode rods. Two poles of the RF power supply are respectively connected to the first AC power supply and the second AC power supply. The first AC power supply and the second AC power supply provide sinusoidal AC signals. The present invention reduces the resolution decrease caused by the space charge effect, thereby improving analytical performance in mass spectroscopy.

Abstract: The present invention is applicable to the field of POS machines, and provides a peep-proof input keyboard and a POS machine using the peep-proof input keyboard. The peep-proof input keyboard comprises a circuit board, a keyboard, and a peep-proof cover, the keyboard includes a plurality of keys configured to input information, a portion of the circuit board corresponding to the keys is provided with a first connecting finger configured for the pressing operations of the keys, the circuit board is provided with a second connecting finger configured to control the keyboard to work and be turned off, and a bottom of the peep-proof cover is provided with at least one support post configured to abut against the second connecting finger so as to enable the keyboard to work.