Abstract: A tissue puncture closure device includes a vessel locator and a sealing plug delivery member. The vessel locator includes an expandable member. The sealing plug delivery member includes a carrier tube, a sealing plug, and a locking member. The carrier tube includes a distal end and a side opening, the side opening extending proximally from the distal end along at least a portion of a length of the carrier tube to provide lateral insertion of the vessel locator into an interior of the carrier tube. The sealing plug includes a lumen and a slot extending from a distal end to a proximal end of the sealing plug, wherein the slot provides lateral access of the vessel locator into the lumen. The locking member is operable to retain the vessel locator within the sealing plug delivery member.

Abstract: A tissue puncture closure device includes an anchor, a sealing plug, a filament, a compaction member assembly, a spool, a stop feature, a driving plate, and a release member. The filament attaches the sealing plug to the anchor. The compaction member assembly applies an axially directed compressive force to compact the sealing plug toward the anchor. The spool has a portion of the filament wound thereon. The stop feature is coupled to the spool. The driving plate is connected to the spool and arranged to apply a force to a proximal end of the compaction member assembly upon rotation of the driving plate to advance the compaction member assembly. The release member is operable from a first position contacting the stop feature to limit rotation of the spool, and a second position out of contact with the stop feature to permit rotation of the spool.

Abstract: A tissue puncture closure device includes an anchor, a sealing plug, a compaction member, a suture, a handle portion, a sheath attachment member, and a sheath adapter. The compaction member is configured to compress the sealing plug towards the anchor. The suture is coupled to the sealing plug and anchored. The handle portion is arranged proximal of the sealing plug and anchor. The sheath attachment member extends from the handle portion. The sheath adapter has a first end portion configured to mount to the sheath attachment member, and a second end portion configured to mount to a procedural sheath that is inserted into a tissue puncture.

Abstract: A bioadhesive mixing assembly includes first and second syringes and an adapter. The first syringe includes first and second chambers holding a first sealant component and an activator, respectively. The second syringe includes third and fourth chambers holding a second sealant component and one of an activator or a third sealant component, respectively. The adapter is mounted to the first syringe and includes first and second channels in flow communication with the first and second chambers, a first seal member providing sealed access to the first and second channels, first and second needles connected in flow communication with the third and fourth chambers, and a second seal member enclosing the first and second needles. Connecting the adapter to the second syringe punctures the first and second seal members with the first and second syringes to create flow communication between the first and third chambers and the second and fourth chambers.

Abstract: A tissue closure system includes a sheath and a tissue closure device. The sheath includes a tensioner assembly. The tissue closure device is insertable through and connected to the sheath, and includes an expandable member positionable distal of a distal end of the sheath. Operating the tensioner assembly applies a biasing force to the tissue closure device that withdraws the expandable member.

Abstract: A manifold for the delivery of bioadhesive sealant may comprise an inlet, a first outlet, a second outlet, and at least one valve positioned and configured to facilitate selective fluid communication between the inlet and the first outlet and the inlet and the second outlet. A syringe for delivering a bioadhesive sealant may comprise at least one barrel, at least one plunger, and at least one feature positioned and configured to prevent movement of the at least one plunger relative to the at least one barrel after a first predetermined quantity of bioadhesive sealant has been delivered. A bioadhesive sealant delivery system may comprise a manifold, a syringe, and a catheter, wherein a first lumen of the catheter is coupled to a first outlet of the manifold and a second lumen of the catheter coupled to a second outlet of the manifold.

Abstract: A closure assembly includes an insertion sheath insertable into a tissue puncture and a tissue puncture closure device insertable through the insertion sheath and into the tissue puncture. The tissue puncture closure device includes a dual lumen delivery tube, a first sealing sleeve, and a second sealing sleeve. The dual lumen delivery tube has a first lumen configured to deliver a volume of sealing material to the tissue puncture, and a second lumen sized for insertion of a balloon location device. The first sealing sleeve is positioned between an outer surface of the dual lumen delivery tube and an inner surface of the insertion sheath to limit backflow of the sealing material into the insertion sheath. The second sealing sleeve is positioned between an outer surface of the balloon location device and an inner surface of the second lumen to limit backflow of the sealing material into the second lumen.

Abstract: A vascular closure device includes an inflation balloon and a delivery tube. The delivery tube includes an inflation lumen configured to deliver inflation fluid to the inflation balloon, a sealant lumen configured to deliver a sealant to a vessel puncture, and a delivery tip in flow communication with the sealant lumen and having a plurality of outlet openings.

Abstract: A vessel puncture closure device includes a balloon catheter and a sealant delivery device. The balloon catheter has an inflatable balloon positioned at a distal end thereof. The sealant delivery catheter has a sealant lumen configured to delivery a volume of sealant to a vessel puncture. The sealant delivery catheter is configured to move axially relative to the balloon between a first position in which the sealant delivery catheter delivers a first volume of sealant to the vessel puncture, and a second position spaced proximal of the first position to deliver a second volume of sealant to the vessel puncture.

Abstract: A catheter assembly and related methods directed to stent edge protection for an edge of a stent. One example stent edge protect member is positioned with a distal end portion of the stent edge protect member arranged proximal of and adjacent to a proximal end of the stent. The stent edge protect member defines an outer surface that transitions from an outer surface of the stent at the proximal end of the stent to an outer surface of the catheter branch on which the stent edge protect member is positioned. The stent edge protect member can be positioned on a single catheter branch or multiple catheter branches.

Abstract: A vascular closure system (10) includes a dual lumen tube (14), an inflatable balloon (16), and a distal sealing assembly (18). The dual lumen tube includes a proximal end portion, a distal end portion, a first lumen, and a second lumen. The first lumen is coupled in fluid communication with an inflation fluid and has a first distal opening at a distal end of the dual lumen tube. The second lumen extends from the proximal end portion to the distal end portion. The inflatable balloon is mounted to the dual lumen tube in fluid communication with the first lumen, and is inflatable within a vessel to temporarily seal closed a tissue puncture. The distal sealing assembly includes a distal sealing member (74) positioned distal of the inflatable balloon, and is detachable from the distal sealing assembly at a location exterior and adjacent to the vessel.

Abstract: A vascular closure assembly is configured to seal a vascular puncture in a vessel. The vascular closure assembly includes a balloon location device and a sealant delivery device. The balloon location device includes an inflation tube and an inflatable balloon positioned at a distal end of the inflation tube and operable, when inflated, between a first position blocking blood flow through the vessel and a second position sealing the puncture from within the vessel. The sealant delivery device includes a sealant delivery tube having a first lumen sized to advance over the inflation tube to the puncture, and a second lumen configured to deliver a volume of sealant to the puncture. The first lumen may include a rapid exchange feature.

Abstract: A tissue puncture access assembly that includes a sheath and a dilator. The sheath is operable between an expanded position with a first maximum outer diameter, and a collapsed position with a second maximum outer diameter that is less than the first maximum outer diameter. The dilator is insertable through the sheath and has a leading end positionable distal of a distal end of the sheath. The sheath is operated into the collapsed position prior to and during insertion with the dilator into a tissue puncture. The sheath is operated into the expanded position once positioned in the tissue puncture.

Abstract: A deployment device having a carrier tube, for bringing a sealing plug into position within a puncture tract or incision and deploying the sealing plug within the incision or puncture tract, towards the outer surface of a tissue puncture, is provided. The carrier tube is designed to facilitate easier deployment and improved compaction of the sealing plug, the sealing plug often made of collagen. The carrier tube is adapted to prevent the premature hydration of the sealing plug, where premature hydration of the sealing plug may result in difficulty in deploying the sealing plug. The carrier tube is designed to facilitate easier loading of puncture tract closing elements into the distal end of the carrier tube.

Abstract: A tissue puncture closure device includes a delivery member, a handle assembly, and a sealant cartridge. The delivery member includes a sealant lumen and is insertable into a tissue puncture. The handle assembly is mounted to a proximal end of the delivery member and includes a cartridge chamber and a plunger member. The sealant cartridge is insertable into the cartridge chamber. The sealant cartridge has at least first and second sealant chambers carrying at least first and second sealant components, respectively. Operation of the handle assembly ejects the first and second sealant components into the sealant lumen for delivery to the tissue puncture.

Abstract: A bioadhesive sealant storage and preparation system may comprise a plurality of containers and an adapter. The plurality of containers may comprise a first container having a first bioadhesive sealant component therein, and a second container having a second bioadhesive sealant component therein. The adapter may comprise a manifold comprising a plurality of channels formed therein, an inlet region sized and configured to receive the plurality of containers and facilitate fluid communication between each container of the plurality of containers and a respective channel of the plurality of channels, and an outlet region sized and configured to receive a syringe and provide fluid communication between the syringe and the plurality of channels.

Abstract: A bioresorbable anchor for deployment in a live body, in one embodiment the anchor comprises an inner anchor made of a first bioresorbable material and an outer anchor made of a second bioresorbable material, wherein the outer anchor envelops the inner anchor. In another embodiment, the anchor comprises a base anchor made of a first bioresorbable material and a second bioresorbable material overlays at least a portion of the base anchor. The first bioresorbable material has a faster resorption rate than the second bioresorbable material. Further, the second bioresorbable material can provide additional strength to the anchor structure. A tissue puncture closure device comprising a filament extending from a first end of the closure device to a second end of the closure device; an anchor comprising a plurality of bioresorbable materials; a sealing plug slidingly attached to the filament adjacent to the anchor; and a tamping assembly.

Abstract: Methods and apparatus are disclosed for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug. The methods and apparatus provide for a compaction device or a tamping device that improves control of the amount of force exerted upon the sealing plug. Further, the compaction tube or tamping device can deform upon application of excessive compaction force, thereby reducing the possibility of damage to the sealing plug, anchor, or artery.

Abstract: A vascular closure device (200) includes a carrier tube (202), an anchor (208), a sealing pad (210), and a suture (204). The carrier tube defines a first lumen (268) and comprises a distal portion (260) and a proximal portion (262). The carrier tube is insertable through an insertion sheath (216). The anchor is positioned outside of the carrier tube. The sealing pad is positioned inside the first lumen. The suture couples the sealing pad to the anchor. The distal portion of the carrier tube has a different material composition from the proximal portion.

Abstract: A closure device operable to seal a vessel puncture and including a delivery member and a sealant material applicator. The delivery member is insertable through a tissue tract to the vessel puncture. The sealant material applicator is configured to supply a volume of sealant material to the delivery member and includes a housing, a plunger assembly, and at least one container. The housing includes at least first and second chambers, wherein the first chamber carries a first sealant component and the second chamber carries a second sealant component. The container is insertable into the first or second chamber and carries a third sealant component of the sealant material. The sealant material applicator creates flow communication between the container and at least one of the first and second chambers to mix the third sealant component with the first and second sealant components.