Patents by Inventor Zachary Shriver

Zachary Shriver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED HEPARINASE III AND METHODS OF SEQUENCING THEREWITH
    Publication number: 20120027744
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: March 30, 2011
    Publication date: February 2, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: DONGFANG LIU, KEVIN POJASEK, ZACHARY SHRIVER, KRISTINE HOLLEY, YOSUF EL-SHABRAWI, GANESH VENKATARAMAN, RAM SASISEKHARAN
  • Methods of evaluating mixtures of polysaccharides
    Patent number: 8101733
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysaccharides in the mixture are chemically modified prior to analysis.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: January 24, 2012
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Cuihua Liu, Nur Sibel Gunay, Ishan Capila, Ganesh Venkataraman
  • METHODS RELATED TO MODIFIED GLYCANS
    Publication number: 20110306075
    Abstract: Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments, methods comprise providing a glycan preparation from which sialic acids have been released; subjecting the sialidase-treated glycan preparation to a separation technique that separates glycans based on charge-to-mass ratio; and quantifying the charged products using at least one quantification standard.
    Type: Application
    Filed: December 18, 2009
    Publication date: December 15, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Carlos J. Bosques, Jennifer Lynn Murphy, Sibel Nur Gunay, Zachary Shriver
  • Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
    Patent number: 8076149
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: December 13, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • ANALYSIS OF SULFATED POLYSACCHRIDES
    Publication number: 20110288046
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Application
    Filed: April 13, 2011
    Publication date: November 24, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: GANESH VENKATARAMAN, ZACHARY SHRIVER, MALIKARJUN SUNDARAM, YI-WEI QI, RAM SASISEKHARAN
  • MODULAR GLYCAN ARRAYS
    Publication number: 20110257032
    Abstract: The present invention provides methods and systems for functionally analyzing glycans and their interaction partners. Among other things, the invention provides modular glycan arrays in which different glycan populations are associated with different discrete solid phase particles. Provided arrays offer many advantages over available systems for assessing glycan binding interactions.
    Type: Application
    Filed: April 14, 2011
    Publication date: October 20, 2011
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Ram Sasisekharan, Karthik Viswanathan, Udayanath Aich, Rahul Raman, Zachary Shriver, Ido Bachelet
  • Evaluating mixtures of low molecular weight heparins by NMR
    Patent number: 7968082
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: June 28, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Jonathan Lansing
  • Delta 4,5 glycuronidase compositions and methods related thereto
    Patent number: 7951560
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: May 31, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: James R. Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland W. McLean
  • Analysis of sulfated polysaccharides
    Patent number: 7947507
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: May 24, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ganesh Venkataraman, Zachary Shriver, Mallikarjun Sundaram, Yi Wei Qi, Ram Sasisekharan
  • Modified heparinase III and methods of sequencing therewith
    Patent number: 7939292
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: May 10, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Analysis of amino acid copolymer compositions
    Patent number: 7884187
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: February 8, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
  • ANALYSIS OF AMINO ACID COPOLYMER COMPOSITIONS
    Publication number: 20100331266
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Application
    Filed: September 15, 2010
    Publication date: December 30, 2010
    Applicant: Momenta Pharmaceuticals, Inc. a Massachusetts corporation
    Inventors: Yanjie Jiang, Peter James Ahern, James Eric Anderson, Corinne Bauer, Xiangping Zhu, Zachary Shriver
  • LOW MOLECULAR WEIGHT HEPARIN COMPOSITION AND USES THEREOF
    Publication number: 20100305022
    Abstract: Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Inventors: Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, Pat Oliver-Shaffer, Yiming Yao, Zainab Sirajbhai Mamuwala, Ian David Fier, Yiwei Qi, Ishan Capila, Nur Sibel Gunay, Daniela Beccati, Cuihua Liu, Corinne Bauer, Ying Li
  • Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
    Patent number: 7816144
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: October 19, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
    Patent number: 7790466
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: September 7, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • METHODS RELATED TO CELL SURFACE GLYCOSYLATION
    Publication number: 20100196940
    Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
    Type: Application
    Filed: April 15, 2008
    Publication date: August 5, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
  • DELTA 4,5 GLYCURONIDASE COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20100129868
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Application
    Filed: November 11, 2009
    Publication date: May 27, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: James R. Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland W. McLean
  • DEFINED GLYCOPROTEIN PRODUCTS AND RELATED METHODS
    Publication number: 20100113294
    Abstract: The invention provides methods, databases and systems for making glycoprotein products having defined properties.
    Type: Application
    Filed: April 15, 2008
    Publication date: May 6, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Ganesh Venkataraman, Brian Edward Collins, Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Dorota A. Bulik, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru
  • ? 4,5 glycuronidase nucleic acid compositions
    Patent number: 7695711
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: April 13, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: James R. Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland W. McLean
  • Methods and producing low molecular weight heparin
    Patent number: 7687479
    Abstract: The invention relates, in part, to methods and products related to producing low molecular weight heparin.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: March 30, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi