Patents by Inventor Zachary Shriver

Zachary Shriver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and products related to evaluating the quality of a polysaccharide
    Publication number: 20070161073
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: November 30, 2006
    Publication date: July 12, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Rationally designed heparinases derived from heparinase II
    Publication number: 20070148158
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Application
    Filed: December 20, 2006
    Publication date: June 28, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
  • Methods and products related to producing low molecular weight heparin
    Publication number: 20070065921
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: September 8, 2006
    Publication date: March 22, 2007
    Applicant: Massachusetts Institute Of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Method for identifying or characterizing properties of polymeric units
    Publication number: 20070066769
    Abstract: The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
    Type: Application
    Filed: September 8, 2006
    Publication date: March 22, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ganesh Venkataraman, Zachary Shriver, Rahul Raman, Ram Sasisekharan, Nishla Keiser
  • 2-O sulfatase compositions and methods of hydrolyzing therewith
    Publication number: 20070004012
    Abstract: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
    Type: Application
    Filed: May 11, 2006
    Publication date: January 4, 2007
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, James Myette, Zachary Shriver, Ganesh Venkataraman
  • 2-O sulfatase compositions and methods of degradation therewith
    Publication number: 20060292673
    Abstract: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
    Type: Application
    Filed: May 11, 2006
    Publication date: December 28, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, James Myette, Zachary Shriver, Ganesh Venkataraman
  • 2-O sulfatase nucleic acid compositions
    Publication number: 20060292130
    Abstract: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
    Type: Application
    Filed: May 11, 2006
    Publication date: December 28, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, James Myette, Zachary Shriver, Ganesh Venkataraman
  • 2-O sulfatase compositions and methods of analyzing therewith
    Publication number: 20060292655
    Abstract: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
    Type: Application
    Filed: May 11, 2006
    Publication date: December 28, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, James Myette, Zachary Shriver, Ganesh Venkataraman
  • Method for identifying or characterizing properties of polymeric units
    Patent number: 7139666
    Abstract: The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: November 21, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Ganesh Venkataraman, Zachary Shriver, Rahul Raman, Ram Sasisekharan, Nishla Keiser
  • Method for the compositional analysis of polymers
    Patent number: 7117100
    Abstract: The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: October 3, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Ganesh Venkataraman, Zachary Shriver, Rahul Raman, Ram Sasisekharan, Nishla Keiser
  • Method for identifying or characterizing properties of polymeric units
    Patent number: 7110889
    Abstract: The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: September 19, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Ganesh Venkataraman, Zachary Shriver, Rahul Raman, Ram Sasisekharan, Nishla Keiser
  • Methods for preparing low molecular weight heparin with modified heparinase III
    Publication number: 20060182734
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: April 18, 2006
    Publication date: August 17, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Delta 4,5 glycuronidase nucleic acid compositions
    Publication number: 20060183891
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Application
    Filed: April 11, 2006
    Publication date: August 17, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: James Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland McLean
  • Compositions of low molecular weight heparin produced with modified heparinase III
    Publication number: 20060183713
    Abstract: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
    Type: Application
    Filed: April 18, 2006
    Publication date: August 17, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Dongfang Liu, Kevin Pojasek, Zachary Shriver, Kristine Holley, Yosuf El-Shabrawi, Ganesh Venkataraman, Ram Sasisekharan
  • Delta 4,5 glycuronidase and methods of hydrolyzing therewith
    Publication number: 20060177910
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Application
    Filed: April 11, 2006
    Publication date: August 10, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: James Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland McLean
  • Delta 4,5 glycuronidase and methods of analyzing therewith
    Publication number: 20060177885
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Application
    Filed: April 11, 2006
    Publication date: August 10, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: James Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland McLean
  • Delta 4,5 glycuronidase and methods of cleaving therewith
    Publication number: 20060177911
    Abstract: The invention relates to ?4,5 glycuronidase, related compositions, and methods of use thereof.
    Type: Application
    Filed: April 11, 2006
    Publication date: August 10, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: James Myette, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Maitland McLean
  • Methods and products related to the analysis of polysaccarides
    Patent number: 7083937
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: August 1, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Rationally designed heparinases derived from heparinase I and II
    Patent number: 7056504
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: June 6, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman
  • Rationally designed heparinases derived from heparinase I and II and methods of sequencing therewith
    Publication number: 20060105430
    Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
    Type: Application
    Filed: July 27, 2005
    Publication date: May 18, 2006
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Zachary Shriver, Dongfang Liu, Ganesh Venkataraman