Abstract: A method for increasing the number of analyte/assay combinations in a single chip or cartridge of an in vitro diagnostic system may include: prioritizing a set of analyte/assay combinations based on characteristics of each analyte in the set of analyte/assay combinations, wherein the characteristics comprise one selected from the group consisting of a prevalence of each analyte, a clinical relevance of each analyte, a clinical actionability of each analyte, a patient benefit, a cost savings, and any combination thereof; deriving an analyte/analyte interactivity for two or more analytes in the set of analyte/assay combinations; designing a plurality of candidate panel layouts based on panel layout rules, the prioritization of the set of analyte/assay combinations, and the analyte/analyte interactivity, wherein the panel layout comprises one or more chips each comprising a chamber with two or more analytes; and validating the plurality of candidate panel layouts to produce panel layout solutions.

Abstract: Borehole logging methods for estimating a parameter of interest using nuclear radiation. Methods include estimating a water saturation of the formation from gamma radiation from at least the formation detected in the borehole using a radiation detector, the gamma radiation responsive to a pulsed neutron source and resulting from at least one of: (i) decay of nitrogen-16 formed by activation of oxygen-16, and ii) inelastic scattering of neutrons from oxygen. This may include using at least one processor to: obtain a gamma ray count measurement, representing gamma rays from one of: (i) the decay of nitrogen-16 (ii) and the inelastic scattering, and estimate the water saturation using the gamma ray count measurement and a model comprising a relationship between measured gamma ray counts and modeled gamma ray counts from each of a fully water saturated formation and a minimally water saturated formation.

Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.

Abstract: An assay device (10) is provided. The device comprises an integrated circuit (IC) (16) comprising a plurality of ISFETs (18); an over-moulded layer (17) which partially covers the IC, such that the plurality of ISFETs remain uncovered; and a film (20) provided across substantially the entire IC. The film acts as a passivation and/or sensing layer for each of the ISFETs. In addition, the film acts as a barrier layer to encase the over-moulded layer.

Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.

Abstract: An assay device (10) is provided. The device comprises an integrated circuit (IC) (16) comprising a plurality of ISFETs (18); an over-moulded layer (17) which partially covers the IC, such that the plurality of ISFETs remain uncovered; and a film (20) provided across substantially the entire IC. The film acts as a passivation and/or sensing layer for each of the ISFETs. In addition, the film acts as a barrier layer to encase the over-moulded layer.

Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.

Abstract: The present disclosure relates to borehole logging methods and apparatuses for estimating formation properties using nuclear radiation, particularly an apparatus and method for estimating amounts of silicon and/or oxygen in the formation. The method may include using nuclear radiation information from at least one nuclear radiation detector to estimate at least one parameter of interest. The method may include separating a gross nuclear radiation count into separate nuclear radiation components. The method may also include reducing an error in the estimated formation properties due to speed variations of a nuclear radiation source that activates the silicon and oxygen in the formation. The apparatus may include at least one nuclear radiation detector. The apparatuses may include an information processing device to perform the methods.

Abstract: Borehole logging methods for estimating a parameter of interest using nuclear radiation. Methods include estimating a water saturation of the formation from gamma radiation from at least the formation detected in the borehole using a radiation detector, the gamma radiation responsive to a pulsed neutron source and resulting from at least one of: (i) decay of nitrogen-16 formed by activation of oxygen-16, and ii) inelastic scattering of neutrons from oxygen. This may include using at least one processor to: obtain a gamma ray count measurement, representing gamma rays from one of (i) the decay of nitrogen-16 (ii) and the inelastic scattering, and estimate the water saturation using the gamma ray count measurement and a model comprising a relationship between measured gamma ray counts and modeled gamma ray counts from each of a fully water saturated formation and a minimally water saturated formation.

Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.

Abstract: Borehole logging methods for estimating a parameter of interest using nuclear radiation. Methods include estimating a water saturation of the formation from gamma radiation from at least the formation detected in the borehole using a radiation detector, the gamma radiation responsive to a pulsed neutron source and resulting from at least one of: (i) decay of nitrogen-16 formed by activation of oxygen-16, and ii) inelastic scattering of neutrons from oxygen. This may include using at least one processor to: obtain a gamma ray count measurement, representing gamma rays from one of: (i) the decay of nitrogen-16 (ii) and the inelastic scattering, and estimate the water saturation using the gamma ray count measurement and a model comprising a relationship between measured gamma ray counts and modeled gamma ray counts from each of a fully water saturated formation and a minimally water saturated formation.

Abstract: Borehole logging methods for estimating a parameter of interest using nuclear radiation. Methods include estimating a water saturation of the formation from gamma radiation from at least the formation detected in the borehole using a radiation detector, the gamma radiation responsive to a pulsed neutron source and resulting from at least one of: (i) decay of nitrogen-16 formed by activation of oxygen-16, and ii) inelastic scattering of neutrons from oxygen. This may include using at least one processor to: obtain a gamma ray count measurement, representing gamma rays from one of: (i) the decay of nitrogen-16 (ii) and the inelastic scattering, and estimate the water saturation using the gamma ray count measurement and a model comprising a relationship between measured gamma ray counts and modeled gamma ray counts from each of a fully water saturated formation and a minimally water saturated formation.

Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.

Abstract: Borehole logging methods for estimating a parameter of interest using nuclear radiation. Methods include estimating a water saturation of the formation from gamma radiation from at least the formation detected in the borehole using a radiation detector, the gamma radiation responsive to a pulsed neutron source and resulting from at least one of: (i) decay of nitrogen-16 formed by activation of oxygen-16, and ii) inelastic scattering of neutrons from oxygen. This may include using at least one processor to: obtain a gamma ray count measurement, representing gamma rays from one of (i) the decay of nitrogen-16 (ii) and the inelastic scattering, and estimate the water saturation using the gamma ray count measurement and a model comprising a relationship between measured gamma ray counts and modeled gamma ray counts from each of a fully water saturated formation and a minimally water saturated formation.

Abstract: Borehole logging methods and apparatuses for estimating formation properties using nuclear radiation, particularly an apparatus and method for estimating amounts of silicon and/or oxygen in the formation. Methods include estimating a formation property using an oxygen estimate and at least a formation lithology. The method may include using nuclear radiation information from at least one nuclear radiation detector generate the oxygen estimate. The apparatus may include at least one nuclear radiation detector. The apparatuses may include an information processing device to perform the methods.

Abstract: The present disclosure relates to borehole logging methods and apparatuses for estimating formation properties using nuclear radiation, particularly an apparatus and method for estimating amounts of silicon and/or oxygen in the formation using exposure time information. The method may include using nuclear radiation information from at least one nuclear radiation detector to estimate at least one parameter of interest. The method may also include reducing an error in the estimated formation properties due to speed variations of a nuclear radiation source that activates the silicon and oxygen in the formation. The apparatus may include at least one nuclear radiation detector. The apparatuses may include an information processing device to perform the methods.

Abstract: Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.

Abstract: A startup circuit delivers regulated startup current to a control IC in a switched-mode power supply (SMPS) system, and automatically disconnects the startup current when the SMPS Control IC starts switching the transformer or inductor used as the energy storage element in the SMPS system. Disconnection of the startup current may be triggered by detecting a time-varying voltage waveform on an accessible node in the SMPS system, or by detecting an increased current consumption by the SMPS Control IC, without requiring any ground reference to the SMPS Control IC, nor without requiring any logic signals generated by the SMPS Control IC. This provides for rapid and predictable startup of an SMPS Control IC and reduced power loss once the SMPS Control IC is operational, and is independent of the operating voltages of the SMPS control IC, and independent of the particular control scheme and switch topology of the SMPS system.

Abstract: A startup circuit delivers regulated startup current to a control IC in a switched-mode power supply (SMPS) system, and automatically disconnects the startup current when the SMPS Control IC starts switching the transformer or inductor used as the energy storage element in the SMPS system. Disconnection of the startup current may be triggered by detecting a time-varying voltage waveform on an accessible node in the SMPS system, or by detecting an increased current consumption by the SMPS Control IC, without requiring any ground reference to the SMPS Control IC, nor without requiring any logic signals generated by the SMPS Control IC. This provides for rapid and predictable startup of an SMPS Control IC and reduced power loss once the SMPS Control IC is operational, and is independent of the operating voltages of the SMPS control IC, and independent of the particular control scheme and switch topology of the SMPS system.

Abstract: The present disclosure relates to borehole logging methods and apparatuses for estimating formation properties using nuclear radiation, particularly an apparatus and method for estimating amounts of silicon and/or oxygen in the formation. The method may include using nuclear radiation information from at least one nuclear radiation detector to estimate at least one parameter of interest. The method may include separating a gross nuclear radiation count into separate nuclear radiation components. The method may also include reducing an error in the estimated formation properties due to speed variations of a nuclear radiation source that activates the silicon and oxygen in the formation. The apparatus may include at least one nuclear radiation detector. The apparatuses may include an information processing device to perform the methods.