Patents by Inventor Zaneta Nikolovska-Coleska

Zaneta Nikolovska-Coleska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STAT3 LIGANDS AND THERAPEUTIC USES THEREOF
    Publication number: 20110319362
    Abstract: Inhibitors of STAT3 are disclosed. Methods of using the STAT3 inhibitors in the treatment of diseases and conditions wherein inhibition of STAT3 provides a benefit, like cancers, also are disclosed.
    Type: Application
    Filed: December 7, 2009
    Publication date: December 29, 2011
    Inventors: Shaomeng Wang, Jianyong Chen, Cindy Gomez, Longchuan Bai, Zaneta Nikolovska-Coleska, Yu-Jun Zhao
  • Bivalent Smac mimetics and the uses thereof
    Patent number: 7960372
    Abstract: The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: June 14, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Dongguang Qin, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu, Yuefeng Peng, Qian Cai
  • Conformationally constrained Smac mimetics and the uses thereof
    Patent number: 7932382
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: April 26, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu
  • Small molecule antagonists of XIAP family proteins
    Patent number: 7910621
    Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: March 22, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Jianyong Chen, Zaneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang, Haiying Sun, Liang Xu, Zengjian Hu
  • HETEROARYL-SUBSTITUTED BICYCLIC SMAC MIMETICS AND THE USES THEREOF
    Publication number: 20110046189
    Abstract: The invention relates to heteroaryl-substituted bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: April 13, 2009
    Publication date: February 24, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska
  • SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF
    Publication number: 20100273799
    Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
    Type: Application
    Filed: June 24, 2010
    Publication date: October 28, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Ke Ding, Yipin Lu, Zaneta Nikolovska-Coleska, Su Qiu, Guoping Wang, Dongguang Qin, Sanjeev Kumar
  • DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF
    Publication number: 20100273812
    Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: April 14, 2008
    Publication date: October 28, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Yuefeng Peng, Haiying Sun, Qian Cai, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu
  • Small molecule inhibitors of MDM2 and the uses thereof
    Patent number: 7759383
    Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: July 20, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Ke Ding, Yipin Lu, Zaneta Nikolovska-Coleska, Su Qiu, Guoping Wang, Dongguang Qin, Sanjeev Kumar
  • SMAC Peptidomimetics and the Uses Thereof
    Publication number: 20100093645
    Abstract: The invention relates to peptidomimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these peptidomimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: January 18, 2005
    Publication date: April 15, 2010
    Inventors: Shaomeng Wang, Halying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, Jlanyong Chen
  • Conformationally constrained Smac mimetics and the uses thereof
    Patent number: 7674787
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: March 9, 2010
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu, Naoyuki G. Saito, Jianyong Chen
  • BIVALENT SMAC MIMETICS AND THE USES THEREOF
    Publication number: 20090123480
    Abstract: The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 14, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Haiying Sun, Dongguang Qin, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu, Yuefeng Peng, Qian Cai
  • APOGOSSYPOLONE AND THE USES THEREOF
    Publication number: 20090118377
    Abstract: The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: January 12, 2009
    Publication date: May 7, 2009
    Applicant: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Jianyong Chen, Zaneta Nikolovska-Coleska, Dajun Yang
  • Conformationally Constrained Smac Mimetics and the Uses Thereof
    Publication number: 20080269140
    Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: January 18, 2005
    Publication date: October 30, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Haiying Sun, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Liang Xu
  • Bivalent SMAC mimetics and the uses thereof
    Publication number: 20080089896
    Abstract: The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
    Type: Application
    Filed: May 4, 2007
    Publication date: April 17, 2008
    Applicant: Regents of the University of Michigan
    Inventors: Shaomeng Wang, Haiying Sun, Dongguang Qin, Zaneta Nikolovska-Coleska, Jianfeng Lu, Su Qiu, Yuefeng Peng
  • Small Molecule Antagonists of Xiap Family Proteins
    Publication number: 20080021095
    Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
    Type: Application
    Filed: March 22, 2005
    Publication date: January 24, 2008
    Inventors: Jianyong Chen, Zaneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang, Haiying Sun, Liang Xu, Zengjian Hu
  • Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof
    Publication number: 20060247305
    Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: March 13, 2006
    Publication date: November 2, 2006
    Applicant: Regents of the University of Michigan
    Inventors: Shaomeng Wang, Ke Ding, Guozhi Tang, Zaneta Nikolovska-Coleska, Renxio Wang, Chao-Yie Yang
  • Small molecule inhibitors of MDM2 and the uses thereof
    Publication number: 20060211757
    Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
    Type: Application
    Filed: February 22, 2006
    Publication date: September 21, 2006
    Applicant: Regents of the University of Michigan
    Inventors: Shaomeng Wang, Ke Ding, Yipin Lu, Zaneta Nikolovska-Coleska, Su Qiu, Guoping Wang, Dongguang Qin, Sanjeev Kumar
  • Apogossypolone and the uses thereof
    Publication number: 20060178435
    Abstract: The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: November 2, 2005
    Publication date: August 10, 2006
    Applicant: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Jianyong Chen, Zaneta Nikolovska-Coleska, Dajun Yang
  • Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
    Publication number: 20060084647
    Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
    Type: Application
    Filed: August 22, 2005
    Publication date: April 20, 2006
    Applicant: Regents of the University of Michigan
    Inventors: Shaomeng Wang, Guoping Wang, Guozhi Tang, Renxiao Wang, Zaneta Nikolovska-Coleska, Dajun Yang, Liang Xu