Abstract: This invention provides a method of treating lung cancer including administering a therapeutically effective amount of a compound of 0089-0022 formula I to a subject in need thereof. The compound activates pyruvate kinase M2 isoform (PKM2) to treat the lung cancer. In one example, the lung cancer is Non-Small Cell Lung Cancer (NSCLC).

Abstract: Systems and methods for tracking shape and orientation of an endoscope employ motion tracking sensors to track locations on the endoscope for use in determining real time shape and distal end orientation for display during navigation of the endoscope. An example system includes sensor units distributed along the endoscope and a control unit. The sensor units track motion of the endoscope locations and transmit resulting tracking data to a control unit. The control unit processes the tracking data to determine shape of the endoscope and orientation of the distal end of the endoscope. The control unit generates output to a display unit that causes the display unit to display one or more representations indicative of the shape of the endoscope and orientation of the distal end of the endoscope for reference by an endoscope operator during an endoscopic procedure.

Abstract: A lift device and a lift system are provided, which comprises: a carrying mechanism including a guiding hole; a lift pin passing through inside the guiding hole; a carrying base, which is connected to the lift pin, wherein when the carrying base is moved upward, the lift pin is moved upward and inside the guiding hole; and a magnetic control device, which is used to send a magnetic control signal, so as to move the lift pin downward. By the lift pin being moved downward and magnetically sucked, a bad process problem and a break risk can be avoided.

Abstract: A lift device and a lift system are provided, which comprises: a carrying mechanism including a guiding hole; a lift pin passing through inside the guiding hole; a carrying base, which is connected to the lift pin, wherein when the carrying base is moved upward, the lift pin is moved upward and inside the guiding hole; and a magnetic control device, which is used to send a magnetic control signal, so as to move the lift pin downward. By the lift pin being moved downward and magnetically sucked, a bad process problem and a break risk can be avoided.

Abstract: The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.

Abstract: An LED illumination structure without a light guide plate (LGP) includes an optical bottom plate, a plurality of LED illumination components arranged at least along one side edge of the optical bottom plate and a plurality of reflecting structures parallel to the LED illumination components formed on the optical bottom plate from two opposite side edges of the optical bottom plate to a center of the optical bottom plate. The reflecting structures are in a shape of tapered embossment and include a first side facing the center of the optical bottom plate and a second side facing the side edges of the optical bottom plate. An optical film is arranged in a raising direction of the reflecting structures of the optical bottom plate. The present invention is applicable to an illumination lamp for generating a uniform light emitting or may further be an illumination structure for projecting a light source of a bare-eyed 3D image.

Abstract: An LED illumination structure without a light guide plate (LGP) includes an optical bottom plate, a plurality of LED illumination components arranged at least along one side edge of the optical bottom plate and a plurality of reflecting structures parallel to the LED illumination components formed on the optical bottom plate from two opposite side edges of the optical bottom plate to a center of the optical bottom plate. The reflecting structures are in a shape of tapered embossment and include a first side facing the center of the optical bottom plate and a second side facing the side edges of the optical bottom plate. An optical film is arranged in a raising direction of the reflecting structures of the optical bottom plate. The present invention is applicable to an illumination lamp for generating a uniform light emitting or may further be an illumination structure for projecting a light source of a bare-eyed 3D image.

Abstract: A filter includes a circuit board, a low-pass filter circuit, and a high-pass filter circuit. The circuit board includes at least one metal layer, and a dielectric layer attached on the at least one metal layer. The low-pass filter circuit is defined in the metal layer, and includes a main line that has two parallel portions, and a modulating circuit serving as a capacitor connected to the main line of the low-pass filter circuit. The high-pass filter circuit defined in the metal layer includes a main line that has two parallel portions and is connected to the low-pass filter circuit, and a modulating circuit serving as a conductor connected to the main line of the high-pass filter circuit.

Abstract: The present invention provides a dual-arm type robotic arm and its method of transporting panels, and mainly has a first robotic arm and a second robotic arm which simultaneously extend into a processing equipment. When the second robotic arm takes out a second panel from the processing equipment, the first robotic arm simultaneously executes a stabilization operation and executes a fastening-suction release operation of a carried first panel. Then, the first robotic arm is lowered for placing the first panel in the processing equipment. Thus, the present invention can prevent from occurring a breakage risk of the first panel during being placed, and save the operation time during the first robotic arm waits to be stable and then release the fastening-suction.

Abstract: A power-on reset circuit, connected to an external direct current (DC) power source, to receive DC power signals and generate a reset signal, includes a delay circuit, a combination circuit and a shaping circuit. The delay circuit comprises a plurality of delay units, to delay the received DC power signals and output a plurality of delayed DC power signals. The combination circuit is connected to the delay circuit, to combine the delayed DC power signals into a combination signal, and output the combination signal. The shaping circuit is connected to and turns the combination circuit on and off according to the combination signal and outputs the reset signal.

Abstract: A filter includes a circuit board, a low-pass filter circuit, and a high-pass filter circuit. The circuit board includes at least one metal layer, and a dielectric layer attached on the at least one metal layer. The low-pass filter circuit is defined in the metal layer, and includes a main line that has two parallel portions, and a modulating circuit serving as a capacitor connected to the main line of the low-pass filter circuit. The high-pass filter circuit defined in the metal layer includes a main line that has two parallel portions and is connected to the low-pass filter circuit, and a modulating circuit serving as a conductor connected to the main line of the high-pass filter circuit.

Abstract: A power-on reset circuit, connected to an external direct current (DC) power source, to receive DC power signals and generate a reset signal, includes a delay circuit, a combination circuit and a shaping circuit. The delay circuit comprises a plurality of delay units, to delay the received DC power signals and output a plurality of delayed DC power signals. The combination circuit is connected to the delay circuit, to combine the delayed DC power signals into a combination signal, and output the combination signal. The shaping circuit is connected to and turns the combination circuit on and off according to the combination signal and outputs the reset signal.

Abstract: The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.

Abstract: The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the samples and a second set of nucleic acid fragments derived from a plurality of references immobilized thereon. The invention also provides a microarray comprising a set of nucleic acid fragments immobilized on the surface of the microarray, wherein the nucleic acid fragments are derived from the samples by amplifying a region in the sample containing the polymorphism through asymmetric PCR amplification. Methods of using and making the microarrays are also provided.

Abstract: A method of forming an integrated circuit device structure having a design rule of less than 0.13 micron. The method includes providing a substrate and forming a pad oxide layer overlying the substrate. The method includes forming a nitride layer overlying the pad oxide layer and patterning the nitride layer and pad oxide layer. A trench structure is formed within a thickness of the substrate using the patterned nitride layer and pad oxide layer as hard mask. The method forms a first thickness of liner oxide within the trench structure using at least thermal oxidation of an exposed region of the trench structure to cover the trench structure. Such thermal oxidation causes a rounding region near corners of the trench structure. The method selectively removes the thickness of liner oxide within the trench structure. The method forms a second thickness of liner oxide within the trench structure using at least thermal oxidation to cover the trench structure.

Abstract: This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotides sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.

Abstract: This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotide sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.

Abstract: A ball feeder for ball serving machine includes a seat consisting of a hollow transfer frame and a shaft bear, a rotating unit mounted to one side of the seat and having a ball scoop extended from an end thereof, and a plurality of guide sections sequentially rotatably connected at an end to the shaft bearing. The guide sections may be turned about the shaft bearing in the same direction to form a nonlinearly inclined spiral ball guide path. A ball put in the top guide section automatically rolls down along the ball guide path and falls into the transfer frame to be caught by the ball scoop. When the ball scoop is turned by the rotating unit to face downward, the-ball on the ball scoop falls into a feeding mouth on a body of the ball serving machine and is automatically served.

Abstract: The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus bovienii strain ILM104.