Abstract: A system for monitoring glucose blood level of a user is disclosed. The system comprising an illumination unit configured for providing coherent optical illumination on a selected inspection region on the user body, a collection unit configured for collecting light returning from the inspection region and generating a plurality of image data pieces associated with speckle patterns in the collected light, and a control unit comprising a processing utility and storage utility comprising pre-stored calibration data, the processing utility is configured for receiving input data on a plurality of image data pieces from the collection unit and for processing said input data for determining correlation functions between different image data pieces and using said correlation functions and said pre-stored calibration data for determining data on glucose blood level of the user.

Abstract: An ophthalmic lens is presented. The lens includes a toric optical zone and a phase-affecting, non-diffractive optical element for extending depth of focus of imaging.

Abstract: A microscopy system which includes a light source for illuminating a sample; an objective lens for capturing light emitted from the illuminated sample to form a signal beam; and a dispersive optical element through which the signal beam is directed, wherein the dispersive optical element converts the signal beam to a spatially coherent signal beam.

Abstract: A system for use in monitoring parameters of an object is described. The system comprising an illumination unit configured for providing coherent illumination of a predetermined wavelength range and for directing said coherent illumination onto an inspection region of the object, and a collection unit comprising a lens arrangement and a detector array and configured for collecting light returning from the inspection region and for generating one or more image data pieces associated with speckle patterns generated at an intermediate plane between the inspection region and said detector array. The detector array is configured as a rolling shutter type detector unit and said collection unit comprises at least one light splitting element configured for splitting collected light to thereby form a plurality of image replications corresponding to said speckle patterns on said detector array.

Abstract: Endoscopes, multicore endoscope fibers and configuration and operation methods are provided. The fibers may have hundreds or thousands of cores and possibly incorporate working channel(s) and additional fibers. The fiber may be used at different optical configurations to capture images of tissue and objects at the distal tip and to enhance a wide range of optical characteristics of the images such as resolution, field of view, depth of field, wavelength ranges etc. Near-field imaging as well as far-field imaging may be implemented in the endoscopes and the respective optical features may be utilized to optimize imaging. Optical elements may be used at the distal fiber tip, or the distal fiber tip may be lens-less. Diagnostics and optical treatment feedback loops may be implemented and illumination may be adapted to yield full color images, depth estimation, enhanced field of views and/or depths of field, and additional diagnostic data.

Abstract: An integrated optical module is provided. The optical module comprises multi optically-coupled channels, and enables the use thereof in an Artificial Neural Network (ANN). According to some embodiments the integrated optical module comprises a multi-core optical fiber, wherein the cores are optically coupled.

Abstract: A system and technique for monitoring of one or more parameters of a sample are presented. The system comprising: an illumination unit configured for providing coherent illumination of at least two wavelength ranges and for directing said coherent illumination onto an inspection region, and a collection unit configured for collecting light returning from the inspection region and generate one or more image data pieces associated with speckle pattern generated at an intermediate plane between said inspection region and said collection unit. The use of illumination having at least two different wavelength ranges provides generation of speckles associated with mutual- interference of light of the different wavelength ranges, enabling higher efficiency and stability with respect to movement of the inspection region.

Abstract: A system for use in monitoring application is described. The system comprises a light detection unit and an illumination arrangement. The detection unit is configured for collecting light returning from a selected inspection region for determining variations in collected light intensity. The illumination arrangement comprises one or more light sources configured for providing illumination of a selected wavelength range directed toward said inspection region. Wherein the illumination arrangement is arranged around the detection unit to provide symmetrical illumination conditions with respect to an axis connecting said detection unit and said inspection region.

Abstract: A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions.

Abstract: A system for monitoring parameters of an object is described. The system comprising: a monitoring unit configured for performing one or more monitoring sessions on an object and collecting data from an inspection region on the object over time and generating monitored data indicative of the inspected region, a stimulation unit configured and operable for applying at least one selected external stimulation field on the object during said one or more monitoring sessions, and a control unit configured for receiving the monitored data from the monitoring unit and determining one or more selected parameters. The stimulation unit is configured for providing said at least one selected external stimulation field directed toward said inspection region from two or more different directions.

Abstract: A system for object reconstruction includes an illuminating unit, comprising a light source and a generator of a non-periodic pattern. A diffractive optical element (DOE) is disposed in an optical path of illuminating light propagating from the illuminating unit toward an object, thereby projecting the non-periodic pattern onto an object. An imaging unit detects a light response of an illuminated region and generating image data indicative of the object within the projected pattern. A processor reconstructs a three-dimensional (3D) map of the object responsively to a shift of the pattern in the image data relative to a reference image of the pattern.

Abstract: An integrated optical module is provided. The optical module includes multi optically-coupled channels, and enables the use thereof in an Artificial Neural Network (ANN). According to some embodiments the integrated optical module includes a multi-core optical fiber, wherein the cores are optically coupled.

Abstract: A monitoring system is presented, configured for use in monitoring heart condition of a subject. The system comprises: a receiver utility for receiving input data comprising data corresponding to signals continuously collected from the subject over time N and being indicative of a sequence of heart sounds; and a processing utility configured and operable for processing said input data to determine data indicative of heart condition of the subject. The processing comprises: identifying within said input data a sequence of acoustic signals corresponding to heart sounds comprising S1 signals corresponding to ventricular contraction and S2 signals corresponding to end of ventricular systole; analyzing the sequence of acoustic signals in accordance with parameters including signal periodicity, amplitude of S1 and S2 sounds, and intervals between S1 and S2 sounds within the collected sequence; and generating data indicative of cardiac condition of the subject in accordance with the analyzed data.

Abstract: Nucleic acid origami devices are provided that are non-immunogenic and/or resistant to nucleases, which may be activated by one or more external cues, such as ligands, glucose concentration or electromagnetic fields; or used for attenuation or prevention of internalization of cell-surface receptors or prolongation of shelf-life of active agents. Further provided are methods for treating diabetes and methods for preparing the devices.

Abstract: Disclosed are a method for achieving ultrahigh spectral resolution and a photonic spectral processor, which is designed to carry out the method. The disclosed photonic spectral processor overcomes the current 0.8 GHz spectral resolution limitation. The new spectral processor uses a Fabry-Perot interferometer array located before the dispersive element of the system, thus significantly improving the spectral separation resolution, which is now limited by the full width at half maximum of the Fabry-Perot interferometer rather than the spectral resolution of the dispersive element spectral as is the current situation. A proof of concept experiment utilizing two Fabry-Perot interferometers and a diffractive optical grating with spectral resolution of 6.45 GHz achieving high spectral resolution of 577 MHz is described.

Abstract: A method and system for use in detection of a periodic signal are described. The method comprising: providing data about periodicity of the periodic signal; sampling said periodic signal at a sampling rate along a plurality of periods of said signal, said sampling rate being selected as having temporal location of at least one sampling event along a corresponding period thereof varies for each period for a desired number of the periods; arranging sampled data pieces in accordance with sample time thereof with respect to time within a period of said periodic signal; and reconstructing a profile of said periodic signal from said plurality of periods being sampled at a desired resolution being greater than resolution associated with said sampling rate. The variation in temporal location of sampling event may be provided by proper selection of sampling rate, or by varying time of sampling rate in accordance with the period of the periodic signal.

Abstract: A system for use in monitoring one or more parameters of a subject's body is described. The system comprising: an illumination unit configured for providing pulsed coherent illumination and directing said illumination onto an inspected region on said subject's body; a collection unit configured for collecting light returning from said inspection region and generate a plurality of data pieces associated with secondary speckle patterns in said light; an external field stimulation unit configured for selectively generating external field stimulation onto the subject's body; and a control unit. The control unit is configured and operable for operating said illumination unit said collection unit and said external field stimulation unit and for receiving said plurality of data pieces from said collection unit to thereby determine said one or more conditions of the subject's body.

Abstract: A system and method monitoring conditions of a subject's body including a control unit receiving image data and data indicative of an external stimulation applied to the body during collection of the image data therefrom, a memory utility, and a processor utility. The image data is indicative of a sequence of speckle patterns generated by the body according to a certain sampling time pattern.

Abstract: Endoscopes, multicore endoscope fibers and configuration and operation methods are provided. The fibers may have hundreds or thousands of cores and possibly incorporate working channel(s) and additional fibers. The fiber may be used at different optical configurations to capture images of tissue and objects at the distal tip and to enhance a wide range of optical characteristics of the images such as resolution, field of view, depth of field, wavelength ranges etc. Near-field imaging as well as far-field imaging may be implemented in the endoscopes and the respective optical features may be utilized to optimize imaging. Optical elements may be used at the distal fiber tip, or the distal fiber tip may be lens-less. Diagnostics and optical treatment feedback loops may be implemented and illumination may be adapted to yield full color images, depth estimation, enhanced field of views and/or depths of field, and additional diagnostic data.

Abstract: An ophthalmic lens is presented. The lens includes a toric optical zone and a phase-affecting, non-diffractive optical element for extending depth of focus of imaging.