Abstract: A neodymium-iron-boron flexible magnet includes 93.5 wt % to 94.6 wt % of neodymium-iron-boron magnetic powder, 0.3 wt % to 0.5 wt % of surface treatment agent for magnetic powder, 2.7 wt % to 3.7 wt % of binder, 0.3 wt % to 1.0 wt % of antioxidant, and 0.5 wt % to 1.8 wt % of plasticizer. The binder includes type I thermoplastic elastomer and type II thermoplastic elastomer, with a mass ratio of the type I thermoplastic elastomer to the type II thermoplastic elastomer being 1:9 to 4:6. The type I thermoplastic elastomer is selected from one or more of thermoplastic polyamide elastomer and thermoplastic polyurethane elastomer; and the type II thermoplastic elastomer is selected from one or more of styrenic block copolymers, dynamically vulcanized thermoplastic elastomers, thermoplastic polyolefin elastomers, and thermoplastic polyester elastomers.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: Ionizable lipids and lipid nanoparticles comprising ionizable lipids are provided herein. Also provided are methods for making and using the lipid nanoparticles for delivery to a cell one or more payload agents, including polypeptides, mRNAs such as mRNA encoding Cas9 nuclease, and guide RNAs comprising backbone, sugar or base modifications.

Abstract: This invention relates to a method for entire removal of a space truss, and an assistive support mechanism therefor. The assistive support mechanism is arranged on a vertical support rod of a truss structure, the assistive support mechanism comprises an assistive support assembly, a lattice support member, and a conversion platform. The lifting assembly is arranged at a top of the conversion platform and comprises a stranded wire, a lifting member, and a control member. The method for entire removal of a space truss comprises mounting the assistive support mechanism, and performing initial removal of the truss structure; lowering the truss structure; and then performing secondary removal of the entire space truss. The major removal work is done on the ground, thereby reducing the requirement for removal-assisting measures and the operational risks, and improving the working efficiency.

Abstract: An improvement in the telemedicine-based diagnosis of acute otitis media is discussed. The improvement including a system and method for merging an otoscope video stream into a telemedicine session. Operations for merging the otoscope video stream can being with initiating a telemedicine session. Subsequently, the system can determine, from within the telemedicine session, whether a connection to an otoscope providing the otoscope video stream is available. If the video stream is available, the system can access the otoscope video stream within the telemedicine session.

Abstract: A NdFeB rare earth magnet includes a main phase and a grain boundary phase including a white grain boundary phase and a gray grain boundary phase. In a microstructure observation area of the rare earth magnet, an area of the white grain accounts for 1˜3% of a total area of the microstructure observation area, and an area of the gray grain boundary phase accounts for 2˜10% of the total area of the microstructure observation area.

Abstract: Provided herein are encapsulated liposomes comprising a lipid bilayer, a first polyethylene glycol (PEG) corona, a targeting molecule and a second PEG corona. The second, encapsulating PEG corona can be reversibly linked to the first PEG corona. Also provided are pharmaceutical compositions comprising the encapsulated liposomes and methods of treating a subject with a disease characterized by production of reactive oxygen species (ROS) with the compositions. Also provided are methods of making the encapsulated liposomes disclosed herein.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating sickle cell disease (SCD) are described.

Abstract: An absorption type near-infrared filter comprising a first multilayer film, a second multilayer film, and an absorption film, wherein in the ultraviolet band, the difference of between the wavelength with the transmittance at 80% of the absorbing film and the wavelength with the reflectivity at 80% of the first multilayer film falls in the range between 25 nm and 37 nm, the difference of between the wavelength with the transmittance at 50% of the absorbing film and the wavelength with the reflectivity at 50% of the first multilayer film falls in the range between 6 nm and 14 nm, and the difference of between the wavelength with the transmittance at 20% of the absorbing film and the wavelength with the reflectivity at 20% of the first multilayer film falls in the range between ?6 nm and 2.5 nm.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: A C-arm imaging system includes a C-arm, and a sliding support assembly. The C-arm includes a first end portion and a second end portion which are oppositely disposed. The first end portion is used to connect to the X-ray tube assembly, while the second end portion is used to connect to the detector assembly, and the X-ray tube assembly and the detector assembly are aligned. The sliding support assembly is connected to the C-arm, and the C-arm can slide relative to the sliding support assembly, wherein the C-arm rotates at a rotational angle of not less than 90 degrees relative to the sliding support assembly from a first position to the first end portion or the second end portion, the first position being a position where the line connecting the center of the detector assembly and the center of the X-ray tube assembly is in a vertical direction.

Abstract: The invention proposes an intelligent underwriting risk management method, and system, device, medium thereof, relating the technical field of medical risk management.

Abstract: Apparatus, systems, computer-readable storage media, and methods for computer-based games and matches are disclosed. An example computer system for managing a prize that can be awarded based on an outcome of a game includes a data processing arrangement. The example data processing arrangement is arranged to: access historical game data, wherein the historical game data represents information about historical outcomes of the game; process the historical game data to generate probability data, wherein the probability data represents information about a plurality of discrete probabilities each of which is associated with a different future outcome of the game; and process the probability data to generate prize data, wherein the prize data represents at least one characteristic associated with the prize.

Abstract: Provided in the present application are a C-arm imaging system and a tube assembly mounting method. The C-arm imaging system includes a C-arm, a tube assembly, a detector assembly, and a rotation assembly. The C-arm includes an inner surface and an outer surface disposed opposite to each other. The tube assembly is located at a first end of the C-arm, and is mounted on the inner surface of the C-arm. The detector assembly is located at a second end of the C-arm opposite to the first end. The rotation assembly is mounted on the outer surface of the C-arm. The C-arm is movable relative to the rotation assembly, and an outer surface opposite to an inner surface on which the tube assembly is located is slidable relative to the rotation assembly.

Abstract: An analyte-sensitive substance is provided that has an optical property related to the concentration of an analyte. The analyte-sensitive substance includes an ionophore or other substance configured to provide a local pH, within the analyte-sensitive substance, that is related to the concentration of the analyte proximate the analyte-sensitive substance. The analyte-sensitive substance further includes a pH-sensitive fluorophore that increases or decreases its intrinsic fluorescence intensity with the local pH across a specified range of pH values. The analyte-sensitive substance further includes a pH-sensitive quencher configured to increase the slope of the change of fluorescence intensity of the pH-sensitive fluorophore across the specified range of pH values. The analyte-sensitive substance may further include an ionic additive configured to adjust the local pH such that the specified range of pH values corresponds to a range of analyte concentration values of interest.

Abstract: This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

Abstract: The water channel structure for connecting a controller to a motor includes a controller main housing and a motor body that are connected and fastened to each other. A water-cooling plate is fastened in the controller main housing. A water inlet and a water outlet are respectively provided at two ends of the controller main housing. A heat dissipation water channel communicating the water inlet with the water outlet inside the controller main housing is formed in the water-cooling plate. A motor water channel is provided inside the motor body. A transition water joint is provided at the water outlet of the controller main housing. The transition water joint is directly connected to a water inlet of the motor water channel.

Abstract: This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.