Publication number: 20260135023
Abstract: A high-coercivity and high-remanence NdFeB magnet includes R, M, B, and Fe, R includes RL and RH, RL includes at least one of Pr, Nd, La, Ce, or Y, RH includes at least one of Dy, Tb, Gd, or Ho, M includes Co, Cu, and M?, and M? includes at least one of Cr, Ni, Ga, Al, Zr, Nb, or Ti. The NdFeB magnet includes R2 T14B main phase grains and grain boundary phase A, R content in the grain boundary phase A is in a range of 29 at % to 55 at %, Co content in the grain boundary phase A is in a range of 3 at % to 7 at %, Cu content in the grain boundary phase A is in a range of 7 at % to 20 at %.
Type:
Application
Filed:
September 24, 2025
Publication date:
May 14, 2026
Inventors:
Zhixue LI, Shaofang LI, Yi CHENG, Lijun CAO, Fei DU, Zhan WANG
Patent number: 12270029
Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.
Type:
Grant
Filed:
September 20, 2023
Date of Patent:
April 8, 2025
Assignee:
Flagship Pioneering Innovations VI, LLC
Inventors:
Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Aamir Mir, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, Robert James Citorik, William Edward Salomon, William Querbes, Luciano Henrique Apponi, Zhan Wang
Publication number: 20240093186
Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.
Type:
Application
Filed:
September 20, 2023
Publication date:
March 21, 2024
Inventors:
Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Aamir Mir, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, Robert James Citorik, William Edward Salomon, William Querbes, Luciano Henrique Apponi, Zhan Wang