Abstract: This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from sources of non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

Abstract: A circuit includes an electronic component package that comprises a first lead, a second lead, and a third lead; and a III-N transistor encased in the electronic component package, the III-N transistor including a drain, a gate, and a source, where the source is coupled to the first lead, the gate is coupled to the second lead, and the drain is coupled to the third lead. The circuit includes a high voltage node and a resistor, the resistor having a first terminal coupled to the high voltage node and a second terminal coupled to the third lead. The circuit further includes a ferrite bead connected in parallel to the resistor and coupled between the third lead and the high voltage node. When switching, the deleterious effects of a parasitic inductance of the circuit's power loop are mitigated by the ferrite bead and the resistor.

Abstract: Provided herein are compositions and methods for identifying one or more targeted nanoparticles suitable for delivery to one or more organs or tissues of a subject.

Abstract: Provided herein are liposomal vesicles comprising at least a first lipid bilayer and a second lipid bilayer, and a plurality of crosslinkages between the first lipid bilayer and the second lipid bilayer, wherein the plurality of crosslinkages comprise boronic ester or thioketal bonds. Also provided are pharmaceutical compositions comprising the liposomal vesicles described herein and a pharmaceutically acceptable excipient. Also provided are methods of making and using the liposomal vesicles. Thus, a method of treating a subject with a disease comprising administering to the subject a pharmaceutical composition comprising the liposomal vesicles is described herein. Methods of making multilamellar liposomal vesicles responsive to reactive oxygen species are also provided.

Abstract: Provided herein are encapsulated liposomes comprising a lipid bilayer, a first polyethylene glycol (PEG) corona, a targeting molecule and a second PEG corona. The second, encapsulating PEG corona can be reversibly linked to the first PEG corona. Also provided are pharmaceutical compositions comprising the encapsulated liposomes and methods of treating a subject with a disease characterized by production of reactive oxygen species (ROS) with the compositions. Also provided are methods of making the encapsulated liposomes disclosed herein.

Abstract: An alloy cast strip includes grains having R2Fe14B-type compound as main phase, where R denotes a rare earth element, Fe denotes iron, and B denotes boron. The grains include non-columnar grains having an aspect ratio in a range from 0.3 to 2 and columnar grains having an aspect ratio equal to or larger than 3. A ratio of an area of the non-columnar grains to a total area of the grains is equal to or larger than 60% and a ratio of a number of the non-columnar grains to a total number of the grains is equal to or larger than 75%. A ratio of an area of the columnar grains to the total area of the grains is equal to or smaller than 15% and a ratio of a number of the columnar grains to the total number of the grains is equal to or smaller than 10%.

Abstract: A fixing apparatus for holding a circuit board in place includes a cover plate, a base for supporting the circuit board thereon, a connecting assembly for hinge-coupling a first end of the cover plate to the base, and a latching assembly for latching a second end of the cover plate to the base. The circuit board is held in place between the base and the cover plate.

Abstract: An arc-preventing fast-breaking surge protection device is disclosed. In one of implement, surge protection device includes an arc-preventing assembly consisted of an arc-preventing catapult and an elastic element, comprising a voltage sensitive assembly, a response switch assembly, a thermosensitive element, an inner shell and an outer cover. The voltage sensitive assembly is tightly coupled with the response switch assembly.

Abstract: Disclosed herein is a particle comprising a first effector element covalently bonded to a nanoparticle via a first orthogonal moiety and a second effector element covalently bonded to the nanoparticle via a second orthogonal moiety, wherein the first orthogonal moiety and the second orthogonal moiety have different chemical structures. The first effector element and the second effector element may be, for example, a targeting agent, a therapeutic agent, and a diagnostic agent. In certain embodiments, the nanoparticle is a liposome. Methods for preparing functionalized nanoparticles, including functionalized liposomes, are also described.

Abstract: The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

Abstract: An absorption type near-infrared filter comprising a first multilayer film, a second multilayer film, and an absorption film comprising an infrared absorbing dye with a weight percentage between 1% and 3%, wherein in the infrared band, the difference between the wavelength with the transmittance at 80% of the absorption film and the wavelength with the reflectivity at 80% of the first multilayer film ranges between 130 nm and 145 nm; the difference between the wavelength with the transmittance at 50% of the absorption film and the wavelength with the reflectivity at 50% of the first multilayer film ranges between 75 nm and 90 nm; the difference between the wavelength with the transmittance at 20% of the absorption film and the wavelength with the reflectivity at 20% of the first multilayer film ranges between 25 nm and 45 nm.

Abstract: A three-port bidirectional DC-DC converter for grid-interactive renewable energy source system applications. The three-phase topology is suitable for residential power requirements. The control of the backup battery system and the renewable energy source system are naturally decoupled. In addition, the port interface with the renewable energy is current type, which can implement maximum power point tracking (MPPT) and soft switching under wide variations in the renewable energy source terminal voltage.

Abstract: A fixing apparatus for holding a circuit board in place includes a cover plate, a base for supporting the circuit board thereon, a connecting assembly for hinge-coupling a first end of the cover plate to the base, and a latching assembly for latching a second end of the cover plate to the base. The circuit board is held in place between the base and the cover plate.

Abstract: Embodiments of the disclosure provide methods and systems for providing transportation service. The method can include receiving, from a remote passenger terminal, a transportation service request in a district. The method can further include detecting that the transportation service request is within a first queuing zone, the first queuing zone associated with at least one first queuing condition. The method can also include placing the transportation service request in a first request queue associated with the first queuing zone based on a determination that the transportation service request meets the first queuing condition.

Abstract: Embodiments of the disclosure provide methods and systems for predicting wait time of a transportation service request. The method includes receiving, from a terminal device, the transportation service request. The method further includes determining, by a processor, a first queue position of the transportation service request at a first time point. The method also includes determining, by the processor, a second queue position of the transportation service request at a second time point. The method also includes determining, by the processor, a request processing speed based on the first and second queue positions and the first and second time points. The method also includes determining, based on the request processing speed and the second queue position of the transportation service request, the predicted wait time. The method also includes providing, to the terminal device, the predicted wait time of the transportation service request.

Abstract: Embodiments of the disclosure provide methods and systems for processing transportation requests. The method can include receiving, from a terminal device, a transportation request in a district. The method can also include determining a first queue associated with a queuing zone for placing the transportation request, the transportation request having a first estimated waiting time before being processed in the first queue. The method can further include determining a second queue associated with the queuing zone, the transportation request having a second estimated waiting time before being processed in the second queue, wherein the second estimated waiting time is shorter than the first estimated waiting time. The method can also include providing to the terminal device information related to the second queue.

Abstract: Methods and systems for providing transportation service are provided. The method can include detecting, by at least one processor, a request queue associated with an area. The method can further include receiving transportation service requests, from remote terminal devices, to be placed in the request queue. The method can also include determining, by the at least one processor, a number of the transportation service requests for the request queue. The method can further include activating, by the at least one processor, the request queue in response to the determined number being greater than an activation threshold; and providing transportation service according to respective positions of the transportation service requests in the activated request queue.

Abstract: The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

Abstract: A circuit includes first and second half bridges, a first inductor, a second inductor, and a main inductor. The half bridges each include a high side switch, a low side switch, and a gate driver configured to apply switching signals to the high side switch and the low side switch. The first inductor has one side electrically connected to an output node of the first half bridge between the high side switch and the low side switch. The second inductor has one side electrically connected to an output node of the second half bridge between the high side switch and the low side switch. The main inductor is coupled to a node between the other sides of the first and second inductors. The main inductor has a greater inductance than each of the first and second inductors, and the first and second inductors are inversely coupled to one another.