Patents by Inventor Zhanling Cheng

Zhanling Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL HETEROCYCLIC COMPOUNDS
    Publication number: 20230257354
    Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R9 and p are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: March 6, 2023
    Publication date: August 17, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
    Publication number: 20230165865
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 1, 2023
    Inventors: Yanping XU, Yimin JIANG, Gang DENG, Zhanling CHENG, Chao LIANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230141403
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), or pharmaceutically acceptable salts thereof, wherein X, m, n, and R1 to R3 are as described herein: Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: December 6, 2022
    Publication date: May 11, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Xingchun HAN, Christian KRAMER, Holger KUEHNE, Christian LERNER, Mingming LI, Matthias NETTEKOVEN, Theodor STOLL, Min WANG, Song YANG
  • IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230141600
    Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein: or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: December 6, 2022
    Publication date: May 11, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Christian KRAMER, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Sébastien SCHMITT, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
    Publication number: 20230083012
    Abstract: Provided are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Application
    Filed: July 30, 2020
    Publication date: March 16, 2023
    Inventors: Yimin JIANG, Zhanling CHENG, Gang DENG, Zhiguo LIU, Chao LIANG, Jianping WU, Linglong KONG, Xiangjun DENG, Yanping XU
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230022724
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 26, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230017532
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 19, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sebastien SCHMITT, Theodor STOLL, Jianhua WANG, Song YANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230012368
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 12, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Baptiste BLANC, Zhanling CHENG, Xingchun HAN, Nawaz KHAN, Christian KRAMER, Holger KUEHNE, Christian LERNER, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Sebastien SCHMITT, Theodor STOLL, Jianhua WANG, Yongguang WANG, Song YANG
  • NOVEL IMIDAZOPYRAZINE DERIVATIVES
    Publication number: 20230011869
    Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: June 16, 2021
    Publication date: January 12, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Nawaz KHAN, Christian KRAMER, Christian LERNER, Philippe PFLIEGER, Theodor STOLL, Jianhua WANG, Min WANG, Yongguang WANG, Song YANG
  • HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
    Publication number: 20230002408
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: December 18, 2020
    Publication date: January 5, 2023
    Inventors: Gang DENG, Zhanling CHENG, Zhiguo LIU, Chao LIANG, Jianping WU, Linglong KONG, Xiangjun DENG, Yimin JIANG, Yanping XU
  • NOVEL HETEROCYCLIC COMPOUNDS
    Publication number: 20220396565
    Abstract: Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
    Type: Application
    Filed: July 20, 2022
    Publication date: December 15, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Xingchun HAN, Christian KRAMER, Christian LERNER, Yongqiang LIU, Matthias NETTEKOVEN, Philippe PFLIEGER, Bernd PUELLMANN, Jianhua WANG, Lisha WANG, Min WANG, Yongguang WANG, Song YANG, Chengang ZHOU
  • DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
    Publication number: 20220348571
    Abstract: The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Application
    Filed: June 25, 2019
    Publication date: November 3, 2022
    Inventors: Gang DENG, Yimin JIANG, Qian LIU, Chao LIANG, Zhao-Kui WAN, Wing Shun CHEUNG, Zhanling CHENG, Yanping XU
  • DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
    Publication number: 20220281865
    Abstract: Provided herein are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 8, 2022
    Inventors: Yimin JIANG, Zhanling CHENG, Gang DENG, Zhiguo LIU, Chao LIANG, Jianping WU, Linglong KONG, Xiangjun DENG, Yanping XU
  • DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
    Publication number: 20220267313
    Abstract: Provided herein are dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Application
    Filed: July 30, 2020
    Publication date: August 25, 2022
    Inventors: Yimin JIANG, Zhanling CHENG, Gang DENG, Zhiguo LIU, Chao LIANG, Jianping WU, Linglong KONG, Xiangjun DENG, Yanping XU
  • HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
    Publication number: 20220048919
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Application
    Filed: December 19, 2019
    Publication date: February 17, 2022
    Inventors: Yanping XU, Yimin JIANG, Wangyang TU, Gang DENG, Zhanling CHENG, Chao LIANG
  • Dihydropyrrolopyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 11225482
    Abstract: The present invention provides novel compounds having the general formula: wherein R1, R2, A and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: January 18, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Min Jiang, Song Yang
  • Tetrahydroisoquinolines and terahydronaphthyridines for the treatment of hepatitis B virus infection
    Patent number: 11124495
    Abstract: The present invention provides novel compounds having the general formula (I): wherein R1, R2, R3, U, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: September 21, 2021
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Zhanling Cheng, Jianhua Wang, Min Wang, Song Yang
  • Tetrahydropyridopyrimidines for the treatment of HBV infection
    Patent number: 11104674
    Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: August 31, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Min Jiang, Jianhua Wang, Yongguang Wang, Song Yang
  • Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
    Patent number: 11053235
    Abstract: The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: July 6, 2021
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Gang Deng, Yimin Jiang, Qian Liu, Chao Liang, Zhao-Kui Wan, Wing Shun Cheung, Zhanling Cheng, Yanping Xu
  • Tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10968218
    Abstract: The present invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: April 6, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Yongguang Wang, Song Yang