Patents by Inventor Zhanling Cheng

Zhanling Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10968217
    Abstract: The present invention provides novel compounds having the general formula (I) wherein R1, R2 and Z are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: April 6, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Jianhua Wang, Min Wang, Song Yang
  • NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20200062747
    Abstract: The present invention provides novel compounds having the general formula (I) wherein R1, R2 and Z are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 1, 2017
    Publication date: February 27, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Jianhua WANG, Min WANG, Song YANG
  • NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20200062748
    Abstract: The present invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 31, 2017
    Publication date: February 27, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Yongguang Wang, Song Yang
  • DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
    Publication number: 20200048242
    Abstract: The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
    Type: Application
    Filed: August 9, 2019
    Publication date: February 13, 2020
    Inventors: Gang DENG, Yimin JIANG, Qian LIU, Chao LIANG, Zhao-Kui WAN, Wing Shun CHEUNG, Zhanling CHENG, Yanping XU
  • NOVEL TETRAHYDROISOQUINOLINES AND TERAHYDRONAPHTHYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20190276433
    Abstract: The present invention provides novel compounds having the general formula (I): wherein R1, R2, R3, U, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 2, 2017
    Publication date: September 12, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Jianhua WANG, Min WANG, Song YANG
  • NOVEL DIHYDROPYRROLOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20190241570
    Abstract: The present invention provides novel compounds having the general formula: wherein R1, R2, A and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 20, 2018
    Publication date: August 8, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Min Jiang, Song Yang
  • NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION
    Publication number: 20190241559
    Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 20, 2018
    Publication date: August 8, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Min Jiang, Jianhua Wang, Yongguang Wang, Song Yang
  • Tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10336751
    Abstract: The invention provides novel compounds having the general formula: wherein R1 to R7 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: July 2, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Chungen Liang, Song Yang
  • Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10196391
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, Q, U, W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: February 5, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Min Wang, Song Yang
  • 6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10150740
    Abstract: The invention provides novel compounds having the general formula: wherein R1 to R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: December 11, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Yongguang Wang, Song Yang
  • NOVEL TRICYCLIC 4-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20180134705
    Abstract: The invention provides novel compounds having the general formula: wherein R1 to R7 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 10, 2018
    Publication date: May 17, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Xingchun HAN, Chungen LIANG, Song YANG
  • NOVEL 6,7-DIHYDROPYRIDO[2,1-A]PHTHALAZIN-2-ONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20180127381
    Abstract: The invention provides novel compounds having the general formula: wherein R1 to R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 9, 2018
    Publication date: May 10, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling CHENG, Xingchun HAN, Yongguang WANG, Song YANG
  • Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9845322
    Abstract: The present invention provides novel compounds having the general formula: wherein R1, R2, U, W, X, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: December 19, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Min Jiang, Jianhua Wang, Min Wang, Yongguang Wang, Song Yang
  • NOVEL TETRAHYDROPYRIDOPYIMIDINES AND TETRAHYDROPRIDOPYRIDOPYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20170298067
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, Q, U,W, Z, X and Y are as described herein, compositions including the compounds and methods of using the compounds. These compounds are HbsAg inhibitors and are useful as medicaments for the treatment or prophylaxis of HBV infection.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 19, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Min Wang, Song Yang
  • Novel Tetrahydropyridopyrimidines and Tetrahydropyridopyridines for the Treatment and Prophylaxis of Hepatitis B Virus Infection
    Publication number: 20160326167
    Abstract: The present invention provides novel compounds having the general formula: wherein R1, R2, U, W, X, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 3, 2016
    Publication date: November 10, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zhanling Cheng, Xingchun Han, Min Jiang, Jianhua Wang, Min Wang, Yongguang Wang, Song Yang
  • NOVEL BI-RING PHENYL-PYRIDINES/PYRAZINES FOR THE TREATMENT OF CANCER
    Publication number: 20150266878
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 10, 2015
    Publication date: September 24, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Song Yang, Zhanling Cheng, Chengang Zhou, Min Jiang, Jianhua Wang, Min Wang, Xingchun Han