Abstract: A linker peptide for constructing a fusion protein. The linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units. The rigid peptide consists of one or more rigid units. The flexible unit comprises two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit comprises a human chorionic gonadotropin ?-subunit carboxy-terminal peptide (CTP) bearing a plurality of glycosylation sites. The linker peptide can more effectively eliminate mutual steric hindrance of two fusion molecules, decreasing a reduction/loss of polymerization or activity resulting from improper folding of an active protein or a conformational change. On the other hand, the negatively charged, highly sialylated CTP can resist renal clearance, further prolonging a half-life of a fused molecule and enhancing bioavailability of a fused protein.

Abstract: A high-speed remote landslide simulation test device with a variable angle includes a support adjustment component, slide plates, and loose leaves. The device first transmits the operation paths of adjusting the slide plate at different angles to the controller, and the personnel operates the control panel to control the support jack, the motor, and the electromagnet to start and stop through the controller, the output shaft of the motor drives the stainless steel threaded rod to rotate, the controller first energizes one electromagnet and disconnects the other three electromagnets, which can only make the stainless steel threaded rod rotate in a fixed position inside the inner threaded pipe, and the three inner threaded pipes follow the rotation direction of the stainless steel threaded rod, thus, the position of the support jack can be moved separately.

Abstract: The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using chimeric antigen receptor (CAR) modified cells. Some embodiments of the present disclosure relate to an isolated nucleic acid sequence encoding CAR. The CAR may include an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain. The antigen binding domain may bind to an antigen of a non-essential organ.

Abstract: A method of manufacturing a composite vessel assembly (20) includes the steps of filling a first chamber defined by a first liner (28,30,32) with a first granulated material (96) through a first orifice (98) in the first liner. A vacuum is then applied to the first chamber, and the first orifice is plugged. The first liner may then be enveloped with a first layer (84) for structural rigidity followed by relief of the vacuum.

Abstract: The present disclosure provides a method for distance measurement based on a binocular camera, a system for distance measurement based on a binocular camera, a device and a computer-readable storage medium. The method includes: taking N images of a distance measurement marker placed at each of Z positions in a depth direction of the binocular camera; calculating an average disparity of the distance measurement marker at the middle position, the left side position and the right side position at each of the Z positions; calculating a distance measurement value at each of the Z positions in the depth direction; calculating a distance measurement error value at the middle position, the left side position and the right side position at each of the Z positions, and acquiring a total error cost function; and calculating extrinsic parameters, so as to acquire a distance measurement result in the depth direction.

Abstract: Provided are a compound of Formula (I) and a pharmaceutical composition thereof, as well as a method for using the compounds of Formula (I) to prevent and/or treat immune-related disorders.

Abstract: A turn-up device, comprising a building machine main shaft, an outer sleeve device, a ply down finger assembly, a bladder device, a bead setting device, and a bead locking device. The outer sleeve device, the ply down finger assembly and the bladder device are all sleeved on the building machine main shaft. The outer sleeve device is located on the outer sides of the ply down finger assembly and the bladder device along the radial direction of the building machine main shaft. The bead setting device is located on the outer sleeve device. A tire building method using the turn-up device can improve the building quality of tire beads, improve the service life of capsule, and provide promising precision of carcass.

Abstract: Provided is an Aobject-based short range measurement method, a short range measurement device, a short range measurement system, and a storage medium. The short range measurement method includes: identifying a target object, and acquiring border information about an ROI of the target object; acquiring two groups of geometric constraint points of the target object with respect to a left-eye camera and a right-eye camera respectively; acquiring pixel coordinates of each geometric constraint point and a border pixel size corresponding to the border information, and calculating a monocular distance estimation value of the target object; acquiring an overall disparity of the two groups of geometric constraint points, and calculating a binocular distance estimation value of the target object in accordance with the overall disparity; and acquiring a final measurement value in accordance with the monocular distance estimation value and the binocular distance estimation value.

Abstract: The present disclosure provides a method for calibrating a binocular camera, including: S2 of extracting feature points from an image set 1 and an image set 2 taken at two points separated from each other by a predetermined distance; S3 of fitting Gaussian distribution parameters of each feature point, and extracting a desired value as a theoretical disparity; S4 of selecting a common feature point, and calculating the predetermined quantity of frames at a first theoretical distance and the predetermined quantity of frames at a second theoretical distance; S5 of performing Gaussian fitting on a difference between the theoretical distances of the common feature point, and extracting a variance as an evaluation index; S6 of determining whether the evaluation index is smaller than a threshold, if yes, terminating the calibration, and otherwise, proceeding to S7; and S7 of adjusting posture parameters of the binocular camera, and returning to S3.

Abstract: A tire building method comprises the following steps: step 1, manufacturing a first carcass assembly on a carcass drum, and transferring the first carcass assembly to a building drum through a first carcass transfer device; step 2, manufacturing a second carcass assembly on a belt drum, and transferring the second carcass assembly to the building drum through a second carcass transfer device; step 3, respectively driving a first chuck seat and a second chuck seat to move oppositely by a first nut and a second nut; step 4, sleeving the second carcass assembly on the supported first carcass assembly, and fitting the two carcass assemblies together and rolling the same to form a third carcass assembly; step 5, winding a tread to the outer surface of the third carcass assembly to form a fourth carcass assembly; and step 6, dismounting the fourth carcass assembly from the building drum.

Abstract: The present disclosure provides a method for distance measurement based on a binocular camera, a system for distance measurement based on a binocular camera, a device and a computer-readable storage medium. The method includes: taking N images of a distance measurement marker placed at each of Z positions in a depth direction of the binocular camera; calculating an average disparity of the distance measurement marker at the middle position, the left side position and the right side position at each of the Z positions; calculating a distance measurement value at each of the Z positions in the depth direction; calculating a distance measurement error value at the middle position, the left side position and the right side position at each of the Z positions, and acquiring a total error cost function; and calculating extrinsic parameters, so as to acquire a distance measurement result in the depth direction.

Abstract: The present disclosure provides a method for calibrating a binocular camera, including: S2 of extracting feature points from an image set 1 and an image set 2 taken at two points separated from each other by a predetermined distance; S3 of fitting Gaussian distribution parameters of each feature point, and extracting a desired value as a theoretical disparity; S4 of selecting a common feature point, and calculating the predetermined quantity of frames at a first theoretical distance and the predetermined quantity of frames at a second theoretical distance; S5 of performing Gaussian fitting on a difference between the theoretical distances of the common feature point, and extracting a variance as an evaluation index; S6 of determining whether the evaluation index is smaller than a threshold, if yes, terminating the calibration, and otherwise, proceeding to S7; and S7 of adjusting posture parameters of the binocular camera, and returning to S3.

Abstract: A turn-up device, comprising a building machine main shaft, an outer sleeve device, a ply down finger assy, a bladder device, a bead setting device, and a bead locking device. The outer sleeve device, the ply down finger assy and the bladder device are all sleeved on the building machine main shaft. The outer sleeve device is located on the outer sides of the ply down finger assy and the bladder device along the radial direction of the building machine main shaft. The bead setting device is located on the outer sleeve device. A tire building method using the turn-up device can improve the building quality of tire beads, improve the service life of capsule and provide promising precision of carcass.

Abstract: Provided is an object-based short range measurement method, a short range measurement device, a short range measurement system, and a storage medium. The short range measurement method includes: identifying a target object, and acquiring border information about an ROI of the target object; acquiring two groups of geometric constraint points of the target object with respect to a left-eye camera and a right-eye camera respectively; acquiring pixel coordinates of each geometric constraint point and a border pixel size corresponding to the border information, and calculating a monocular distance estimation value of the target object; acquiring an overall disparity of the two groups of geometric constraint points, and calculating a binocular distance estimation value of the target object in accordance with the overall disparity; and acquiring a final measurement value in accordance with the monocular distance estimation value and the binocular distance estimation value.

Abstract: Provided is a road surface information-based imaging environment evaluation method, an imaging environment evaluation device, an imaging environment evaluation system, and a storage medium. The imaging environment evaluation method includes: acquiring a disparity information matrix and pixel coordinates of a vanishing point in the disparity information matrix; subjecting the disparity information matrix to matrix partition and projection in accordance with the pixel coordinates of the vanishing point so as to acquire a disparity projection image; acquiring a road surface model-based statistic model in accordance with the disparity projection image; and acquiring an evaluation result of a current imaging environment in accordance with a relationship between the statistic model and a predetermined threshold.

Abstract: Provided is a road surface information-based imaging environment evaluation method, an imaging environment evaluation device, an imaging environment evaluation system, and a storage medium. The imaging environment evaluation method includes: acquiring a disparity information matrix and pixel coordinates of a vanishing point in the disparity information matrix; subjecting the disparity information matrix to matrix partition and projection in accordance with the pixel coordinates of the vanishing point so as to acquire a disparity projection image; acquiring a road surface model-based statistic model in accordance with the disparity projection image; and acquiring an evaluation result of a current imaging environment in accordance with a relationship between the statistic model and a predetermined threshold.

Abstract: A lens refractive index detection device is disclosed which has a light source module, a lens center physical thickness detection module and a lens center optical thickness detection module. The light source module includes a first light source component and a second light source component for outputting a collimated light beam, a first light combining component, and a focusing component. The lens center physical thickness detection module includes a first imaging component and a second imaging component. The lens center optical thickness detection module includes a first photodetection component and a second photodetection component, a beam splitting component, a partial reflection mirror, and a movable reflection mirror. The lens refractive index detection device enables simple operation, fast and non-destructive on-line detection, and is also applicable to lenses with irregular surfaces, such as aspherical lenses, cylindrical lenses, and finished lenses.

Abstract: A lens refractive index detection device is disclosed which has a light source module, a lens center physical thickness detection module and a lens center optical thickness detection module. The light source module includes a first light source component and a second light source component for outputting a collimated light beam, a first light combining component, and a focusing component. The lens center physical thickness detection module includes a first imaging component and a second imaging component. The lens center optical thickness detection module includes a first photodetection component and a second photodetection component, a beam splitting component, a partial reflection mirror, and a movable reflection mirror. The lens refractive index detection device enables simple operation, fast and non-destructive on-line detection, and is also applicable to lenses with irregular surfaces, such as aspherical lenses, cylindrical lenses, and finished lenses.