Patents by Inventor Zhaohui Chen

Zhaohui Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12372539
    Abstract: Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: July 29, 2025
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Zhaohui Chen, Nigel Clarke
  • Publication number: 20250180586
    Abstract: A method for determining the amount of insulin in a sample by high resolution/high accuracy mass spectrometry includes (a) subjecting insulin from said sample to an ionization source under conditions suitable to generate a multiply charged insulin ion, wherein said multiply charged insulin ions are detectable by mass spectrometry; and (b) determining the amount of one or more multiply charged insulin ions by high resolution/high accuracy mass spectrometry; wherein the amount of ions determined in step (b) is related to the amount of insulin in said sample.
    Type: Application
    Filed: January 16, 2025
    Publication date: June 5, 2025
    Inventors: Zhaohui Chen, Nigel Clarke
  • Publication number: 20250112378
    Abstract: A multi-band and multi-functional antenna integrated module and a preparation method thereof are provided. The multi-band and multi-functional antenna integrated module has an electromagnetic wave capture layer, a frequency selection circuit layer, and a signal processing circuit layer stacked vertically in sequence. The frequency selection circuit layer and the frequency selection circuit layer are interconnected through a metallized through hole. The frequency selection circuit layer has a plurality of frequency selection circuit units with different processing bands. The signal processing circuit layer has a plurality of signal processing circuit units with different functions. The plurality of frequency selection circuit units are interconnected to the plurality of signal processing circuit units in a one-to-one correspondence manner through a plurality of metallized through holes.
    Type: Application
    Filed: October 30, 2023
    Publication date: April 3, 2025
    Applicant: INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Haoran WANG, Tao ZHANG, Chongmei PENG, Zhaohui CHEN
  • Publication number: 20250102516
    Abstract: A method for determining the amount of C peptide in a sample by tandem mass spectrometry includes (a) subjecting a sample suspected of containing C peptide to solid phase extraction to obtain a fraction enriched in C peptide; (b) subjecting the enriched C peptide to an ionization source under conditions suitable to generate one or more C peptide ions detectable by mass spectrometry; and (c) determining the amount of one or more C peptide ions by tandem mass spectrometry; where the one or more C peptide ions comprise a precursor ion with a mass to charge ratio of 1007.5±0.5 and one or more fragment ions selected from the group of ions with mass to charge ratios consisting of 927.6±0.5, 785.4±0.5, and 646.1±0.5; and the amount of ions determined in (c) is related to the amount of a C peptide in the sample.
    Type: Application
    Filed: December 10, 2024
    Publication date: March 27, 2025
    Inventors: Nigel Clarke, Zhaohui Chen
  • Patent number: 12188943
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: September 12, 2023
    Date of Patent: January 7, 2025
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Publication number: 20240403047
    Abstract: A vector computation apparatus includes: a register unit including circuitry configured to store a first vector and a second vector respectively and divided into computation channels, each computation channel including a first array including first registers and a second array including second registers; a thread management unit including circuitry configured to determine at least one thread according to the corresponding relationship between at least one first element and at least one second element; and a computation unit including circuitry including a plurality of execution units, each execution unit includes circuitry configured to read a first element and a second element corresponding to each thread in the corresponding computation channel according to at least one thread, execute a modular operation between the first element and second element corresponding to the thread, and write a modular operation result in the first array or second array in the computation channel.
    Type: Application
    Filed: May 22, 2024
    Publication date: December 5, 2024
    Inventor: Zhaohui CHEN
  • Publication number: 20240348422
    Abstract: A privacy calculation unit includes a first calculation subunit, a storage subunit, and a communication subunit. The first calculation subunit includes circuitry to calculate first domain conversion ciphertexts sequentially. The storage subunit is configured to store the calculated first domain conversion ciphertexts received from the first calculation subunit. The first domain conversion ciphertext is an intermediate ciphertext when first to-be-converted data is converted from a first privacy-preserving computation domain to a second privacy-preserving computation domain.
    Type: Application
    Filed: April 16, 2024
    Publication date: October 17, 2024
    Inventors: Zhaohui CHEN, Zhen GU, Yanheng LU, Dimin NIU, Ziyuan LIANG, Qi'ao JIN, Fan ZHANG, Yuan XIE
  • Patent number: 11901579
    Abstract: A polymer battery separator with an interpenetrating network structure and a preparation method thereof are disclosed. A multilayer microporous separator includes a PVDF layer, and a PE-PVDF porous substrate located on a surface of the PVDF layer. Finger-like through holes with a pore size of 100-150 nm are distributed in the PVDF finger-like pore layer. An interpenetrating network structure with a pore size of 50-100 nm is distributed on an interface between the PVDF finger-like pore layer and the PE microporous layer. Micropores with a pore size of 20-50 nm are distributed in the PE microporous layer. The surface of the PVDF layer is covered with the PE-PVDF porous substrate, so that the multilayer microporous separator forms an interpenetrating network structure, which has improved thermal stability and high-temperature resistance.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: February 13, 2024
    Assignee: JIANGSU HORIZON NEW ENERGY TECH CO., LTD.
    Inventors: Peiliang Jia, Mengxi Zhao, Xingxing Weng, Zhaohui Chen
  • Publication number: 20230417760
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: September 12, 2023
    Publication date: December 28, 2023
    Inventors: Nigel Clarke, Zhaohui Chen
  • Publication number: 20230385061
    Abstract: The present application discloses a computing accelerator, a data processor and an associated method for homomorphic encryption. The computing accelerator is configured to perform computations on input polynomials to generate output polynomials. The input polynomials are ciphertexts generated from a plaintext data after ring learning with error encryption, and the output polynomials correspond to a result after performing a linear computation on the plaintext data. The computing accelerator includes a polynomial multiplying unit, a coefficient extraction unit, and ciphertext wrapping unit. The polynomial multiplication unit multiplies a first input polynomial with a second input polynomial to generate an intermediate polynomial. The coefficient extraction unit converts the intermediate polynomial into a target polynomial according to a target coefficient in the intermediate polynomial. The ciphertext wrapping unit generates an output polynomial according to at least the target polynomial.
    Type: Application
    Filed: May 23, 2023
    Publication date: November 30, 2023
    Inventors: XUANLE REN, YANHENG LU, JIANSONG ZHANG, ZHAOHUI CHEN
  • Publication number: 20230385373
    Abstract: The present application discloses a calculator and a method thereof. The calculator is configured to accelerate the number-theoretic transformation of a 2N-dimensional polynomial. The calculator includes a first coefficient memory, a second coefficient memory, a twiddle factor memory, a plurality of processing units and a data flow controller. In the odd-number rounds of coefficient computation operations, the processing units perform first calculation procedures to read coefficients from the first coefficient memory for modulo calculation, and perform first writing procedures to write output coefficients to the second coefficient memory. In even-number rounds of coefficient computation operations, the processing units performs second calculation procedures to read coefficients from the second coefficient memory for modulo calculations, and perform second writing procedures to write output coefficients to the first coefficient memory.
    Type: Application
    Filed: November 8, 2022
    Publication date: November 30, 2023
    Inventors: ZHAOHUI CHEN, XUANLE REN, YANHENG LU, JIANSONG ZHANG
  • Patent number: 11789026
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: October 17, 2023
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Patent number: 11753056
    Abstract: Provided are a cloud platform-based comprehensive line network monitoring method and system. Device state data of each line is acquired, and stored in a monitoring platform and a data platform that are built on a cloud platform. The monitoring platform can only store only the latest device state data, perform data monitoring processing on the device state data to obtain real-time monitoring data, and transmit corresponding real-time monitoring data to a client at an application layer based on a data subscription demand of the client, to allow the client to perform real-time device monitoring processing based on the real-time monitoring data. Also, the data platform can provide, in response to a historical data application request sent by the client, the device state data to the client as historical statistical analysis data, to allow the client to perform historical state monitoring processing based on the historical statistical analysis data.
    Type: Grant
    Filed: March 16, 2023
    Date of Patent: September 12, 2023
    Assignees: PCI TECHNOLOGY & SERVICE CO., LTD., GUANGHOU HUAJIA SOFTWARE CO., LTD., GUANGDONG HUAZHIYUAN TECHNOLOGY CO., LTD., GUANGZHOU PCI URBAN RAIL TRANSIT SMART OPERATION & MAINTENANCE SERVICE CO., LTD.
    Inventors: Xiong Xiao, Jianping Jia, Zhaohui Chen
  • Publication number: 20230219605
    Abstract: Provided are a cloud platform-based comprehensive line network monitoring method and system. Device state data of each line is acquired, and stored in a monitoring platform and a data platform that are built on a cloud platform. The monitoring platform can only store only the latest device state data, perform data monitoring processing on the device state data to obtain real-time monitoring data, and transmit corresponding real-time monitoring data to a client at an application layer based on a data subscription demand of the client, to allow the client to perform real-time device monitoring processing based on the real-time monitoring data. Also, the data platform can provide, in response to a historical data application request sent by the client, the device state data to the client as historical statistical analysis data, to allow the client to perform historical state monitoring processing based on the historical statistical analysis data.
    Type: Application
    Filed: March 16, 2023
    Publication date: July 13, 2023
    Inventors: Xiong XIAO, Jianping JIA, Zhaohui CHEN
  • Publication number: 20230184740
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: October 31, 2022
    Publication date: June 15, 2023
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Steven W. TAYLOR, Michael McPHAUL, Richard E. REITZ, Zhaohui CHEN, Nigel J. CLARKE
  • Patent number: 11486874
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: November 1, 2022
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Steven W. Taylor, Michael McPhaul, Richard E. Reitz, Zhaohui Chen, Nigel Clarke
  • Publication number: 20220291228
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 15, 2022
    Inventors: Nigel CLARKE, Zhaohui CHEN
  • Patent number: 11346845
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: May 31, 2022
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen
  • Patent number: 11276853
    Abstract: Electrodes, energy storage devices using such electrodes, and associated methods are disclosed. In an example, an electrode for use in an energy storage device can comprise porous disks comprising a porous material, the porous disks having a plurality of channels and a surface, the plurality of channels opening to the surface; and a structural material encapsulating the porous disks; where the structural material provides structural stability to the electrode during use.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: March 15, 2022
    Assignee: Intel Corporation
    Inventors: Donald S. Gardner, Charles W. Holzwarth, Bum Ki Moon, Yang Liu, Priyanka Pande, Shanthi Murali, Nicolas Cirigliano, Zhaohui Chen
  • Publication number: 20220044545
    Abstract: The present invention discloses an air-sea buoy monitoring system towards mid-latitude ocean including a meteorological data acquisition system, an underwater data acquisition system and a central processor. It collects data through different sensors via both meteorology and underwater data acquisition systems, and then transmits data to a central processor. The data collected by meteorology and underwater data acquisition systems will be analyzed and visualized via an information processing system and an image processing system. An alarm module is provided to alarm when meteorological data/value exceeds a certain threshold. This buoy monitoring system ensures the long term, continuous and simultaneous observation of multi-level/multi-factors for the air-sea interface and underwater oceanic environment at a fixed point, with the data being transmitted to shore-based data center in real time via communication satellites.
    Type: Application
    Filed: March 1, 2021
    Publication date: February 10, 2022
    Inventors: Xin MA, Zhaohui Chen, Lixin Wu, Weicheng Wang