Abstract: The present disclosure provides a method and apparatus for a route navigation, which relate to the technical fields of computer vision, image processing, augmented reality and the like. An implementation solution is: performing an augmented reality navigation on a current route based on real-time acquired GPS information of a terminal; acquiring SLAM (simultaneous localization and mapping) coordinates of the terminal; converting, in response to determining that the GPS information meets a preset positioning difference condition, the SLAM coordinates into calculated geographic coordinates; and performing an augmented reality navigation on the current route based on the calculated geographic coordinates.

Abstract: Provided is a multi-protein degradation agent having an imide skeleton, which can degrade multiple proteins comprising c-Myc, GSPT1, CK1? and IKZF (1/2/3) proteins, and therefore can be used for treating diseases or disorders related thereto, such as cancer.

Abstract: An optical system includes a lens layer including a plurality of microlenses arranged along orthogonal first and second directions, and at least one optically opaque mask layer spaced apart from the lens layer and defining a plurality of through openings therein arranged along the first and second directions. There is a one-to-one correspondence between the microlenses and the openings, such that for each microlens, the microlens and corresponding openings are substantially centered on a straight line making a same oblique angle with the lens layer. An optical layer can include the lens layer and the optically opaque mask layer embedded in the optical layer.

Abstract: A structured optical surface and an optical imaging system including the structured optical surface is described. The structured optical surface includes a plurality of structures formed by an intersection of at least first and second Fresnel patterns, such that when the structured optical surface is incorporated in an optical imaging system comprising a pixelated display surface with at least one pixel comprising at least two sub-pixels spaced apart by a gap, the structured optical surface images the at least two sub-pixels onto an image surface as at least two corresponding imaged sub-pixels spaced apart by a corresponding imaged gap, and the structured optical surface diffracts light so that the diffracted light at least partially fills the imaged gap without substantially overlapping any of the at least two imaged sub-pixels.

Abstract: An optical construction includes a lens film having an outermost structured first major surface and an opposing outermost substantially planar second major surface. The first major surface includes a plurality of microlenses. A radiation cured optically opaque mask layer is disposed on the second major surface of the lens film. The mask layer has an average thickness of less than about 10 microns and defines a plurality of laser-ablated through openings therein. The through openings are aligned to the microlenses in a one-to-one correspondence, such that for a light incident on the structured first major surface along an incident direction forming an incident angle with the second major surface, an optical transmittance of the optical construction as a function of a transmitted angle includes a first transmitted peak having a first peak transmittance T1?40%. The first transmitted peak can be within about 10 degrees of the incident angle.

Abstract: A crystal form of a compound I and a preparation method thereof, a pharmaceutical composition containing the crystal form, and the use of the crystal form in the preparation of a drug for treating related diseases caused by KRAS G12C gene mutation are provided. The crystal form DCIII of the compound I provided by the present invention has important value for the development of the drug in the future.

Abstract: A real-time abnormity-diagnosing and interpolation method for water regime-monitoring data relates to the technical field of monitoring water regime. This method includes the following steps: acquiring water regime-monitoring data, drawing a box plot, recognizing and diagnosing abnormal data in real time based on the box plot, performing grey correlation analysis on other variables related to a predictor variable, building a BP neural network model and making training, applying the BP neural network model to predict water regime-monitoring data in real time, and performing abnormity diagnosis and data interpolation. Adopting this method, we can effectively enhance predicting and monitoring the water regime-monitoring data in real time, and diagnose abnormal data and make interpolations in time, thereby improving the reliability of data, objectively reflecting water regime changes, and effectively guiding engineering scheduling.

Abstract: The present invention relates to a protein degradation agent, and a preparation method therefor and a use thereof. The protein degradation agent can degrade various proteins comprising c-Myc protein, and can therefore be used for the prevention and treatment of diseases related to dysregulation of various proteins comprising c-Myc protein, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection-related diseases.

Abstract: A light control film includes opposing substantially planar substantially parallel first and second major surfaces spaced apart along a thickness direction of the light control film by less than about 500 microns; and a plurality of substantially parallel optically transparent polymeric columns disposed in, and substantially surrounded by, a light absorbing polymeric material. Each of the polymeric columns has a first column end at the first major surface and an opposite second column end at the second major surface and has an aspect ratio of greater than about 3, such that the first column ends of at least one pair of adjacent polymeric columns include substantially parallel substantially straight sides facing, and substantially coextensive with, each other.

Abstract: A bilayer binary 2D surface relief grating includes a primary grating layer having an array of primary grating elements, and a secondary grating layer having an array of secondary grating elements overlying the primary grating layer, where the secondary grating elements are at least partially laterally offset from the primary grating elements. A method of manufacturing such a surface relief grating includes forming a low refractive index layer over a substrate, the low refractive index layer including a primary sub-layer having an array of primary openings and a secondary sub-layer overlying the primary sub-layer and having an array of secondary openings, where the secondary openings are at least partially laterally offset from the primary openings, and forming a high refractive index layer within the primary and secondary openings.

Abstract: An integral optical stack includes a lens film having first and second major surfaces. The first major surface includes microlenses having an average peak-to-valley height PV1. A light absorbing layer is disposed on the lens film and defines a plurality of openings. A substantially planarizing optically diffusive layer is disposed on the first major surface of the lens film, conforming to the microlenses. The optically diffusive layer includes a plurality of nanoparticles. A polymeric material bonds the nanoparticles to each other to form a plurality of nanoparticle aggregates defining a plurality of voids therebetween. The optically diffusive layer has an average thickness greater than about 8 microns, and an index of refraction of less than about 1.25. Any non-planarity of a major surface of the optically diffusive layer due to the microlenses of the first major surface has an average peak-to-valley height PV2, PV2?0.7 PV1.

Abstract: An integral optical construction includes a lens layer including a structured first major surface having a plurality of microlenses. An optically opaque mask layer is disposed on the lens layer and defines a plurality of openings. Each of the openings extends from a first major surface of the mask layer facing the lens layer to an opposite second major surface of the mask layer. The openings are in a one-to-one correspondence with the microlenses. Regions of the mask layer between the openings have an optical density of greater than about 2 for at least a first visible wavelength in a visible wavelength range. An optical adhesive layer is disposed on, and makes physical contact with, the second major surface of the mask layer. The optical adhesive layer defines a recess at each of the openings. The recess includes a closed bottom and an opposite open top open to the opening.

Abstract: A device includes a pair of electrodes and a dynamic material disposed between the pair of electrodes, the dynamic material including a crystalline microstructure configured to change between at least two states in response to a change in an electric field between the two electrodes. A material includes tetragonal lead magnesium niobate-lead titanate (PMN-PT) and at least one lanthanide series element. A method includes doping a lead magnesium niobate-lead titanate material with at least one lanthanide series element, and processing the PMN-PT material to form tetragonal PMN-PT. A further method includes forming a low refractive index nanostructured grating over a carrier substrate, forming a high refractive index layer over the low refractive index grating to produce a nanostructured coupling element, forming an adhesive layer over the nanostructured coupling element, and affixing the nanostructured coupling element to a high index waveguide.

Abstract: An organic light emitting diode (OLED) display includes a pixelated OLED display panel and a color-correction component disposed on the pixelated OLED display panel. The pixelated OLED display panel has a ratio of blue-to-red color mixing weights at 30 degrees of ?030, and a ratio of blue-to-red color mixing weights at 45 degrees of ?045, where ?045??030?1.05 and 1.5??045?1.1. The color-correction component is configured such that a ratio of blue-to-red color mixing weights at 45 degrees of the display is ?45 and a ratio of blue-to-red color mixing weights at 30 degrees of the display is ?30, where ?045?0.1??45?2.1??045 and ?030?0.05??30?2.05??030. Methods of making OLED displays are described.

Abstract: An optical system includes a lens layer having a first major surface including first and second microlenses and a first light absorbing layer. The light absorbing layer defines first and second through openings with a one-to-one correspondence between the first and second microlenses and respective first and second through openings. Each pair of first microlens and first through opening centered on a first optical axis makes a first angle with a normal to the first light absorbing layer. Each pair of second microlens and second through opening centered on a second optical axis makes a second angle, different than the first angle, with the normal to the first light absorbing layer. A light source emits light incident on the first major surface side. The emitted light includes first and second light beams carrying respective first and second information and propagating substantially parallel to the first and second optical axes, respectively.

Abstract: An optical device is disclosed and includes an optical sensor, a plurality of photosensitive pixels disposed on the optical sensor, a wavelength-selective optical filter in optical communication with the photosensitive pixels, and a plurality of spatially-variant written regions disposed in the optical filter, the written regions having a transmission spectrum and each of the written regions being larger than each of the pixels.

Abstract: An integral optical stack includes a lens film having first and second major surfaces. The first major surface includes microlenses having an average peak-to-valley height PV1. A light absorbing layer is disposed on the lens film and defines a plurality of openings. A substantially planarizing optically diffusive layer is disposed on the first major surface of the lens film, conforming to the microlenses. The optically diffusive layer includes a plurality of nanoparticles. A polymeric material bonds the nanoparticles to each other to form a plurality of nanoparticle aggregates defining a plurality of voids therebetween. The optically diffusive layer has an average thickness greater than about 8 microns, and an index of refraction of less than about 1.25. Any non-planarity of a major surface of the optically diffusive layer due to the microlenses of the first major surface has an average peak-to-valley height PV2, PV2?0.7 PV1.

Abstract: Phase separated articles that include a matrix phase including an acrylate copolymer; and a silicone elastomer phase stably dispersed in the matrix phase are described. The matrix phase may be derived from precursors comprising from 60 to 95 parts by weight of an alkyl acrylate having an alkyl group having 1 to 14 carbon atoms. Methods of forming phase separated articles, and articles including phase separated articles are also described.

Abstract: An opening method and opening device are provided. The opening device can perform opening according to the following steps: controlling a first laser processing device to process an object to be opened to form a first opening area; controlling a second laser processing device to process the object to be opened to form a second opening area; the power of the first laser processing device is greater than that of the second laser processing device, and the light spot of the first laser processing device is larger than that of the second laser processing device. The second opening area surrounds the edge of the first opening area and connects to the first opening area.

Abstract: An optical construction includes a lens film having a structured first major surface having a plurality of microlenses and an opposing second major surface. A light absorbing layer is disposed on the second major surface and has an average thickness of greater than about 0.5 microns and an optical density of greater than about 3. A plurality of openings are provided in the light absorbing layer. A major surface of the light absorbing layer includes a plurality of irregular features imparting an average mean square height Sq of greater than about 0.05 microns. In a cross-section, the opening includes opposing first and second sidewalls having respective first and second best linear fits with respective r-squared values R1 and R2 and respective linear slope magnitudes S1 and S2, each of R1 and R2 greater than about 0.8. S1 and S2 within 30% of each other.