Abstract: The invention provides a settling device comprising an acoustic wave generator and an inclined settling chamber. The angle ? between the acoustic wave direction and the inclined settling chamber is greater than 0 and less than 90°. The invention also provides a concentration method and a separation method using the device. The invention can be used to concentrate or separate particles such as inorganic particles, organic particles, and biological particles, for example, mammalian cells, bacteria, yeast, algae, and plant cells. The invention exhibits technical merits such as higher efficiency, cost-effectiveness, and large-scale production.

Abstract: The invention provides a simple, inexpensive, accurate, and rapid method of measuring particle settling velocity comprising: (i) providing a gravity settler such as a column; (ii) filling the column with a first homogenous particle suspension, wherein the particle concentration in the first homogenous particle suspension is X, (iii) separating the column into an upper sub-column and a lower sub-column with a height h after settling the first homogenous particle suspension for a period of time t, wherein some particles remain in the upper sub-column; (iv) removing the particle suspension in the upper sub-column and mixing the particle suspension confined in the lower sub-column with a height h to prepare a second homogenous particle suspension; (v) measuring the particle concentration in the second homogenous particle suspension X; and (vi) determining the particle settling velocity v with the formula: v=h(X?X)ltX. Also provided are device and system for carrying out the method.

Abstract: The invention provides a settling device comprising an acoustic wave generator and an inclined settling chamber. The angle ? between the acoustic wave direction and the inclined settling chamber is greater than 0 and less than 90°. The invention also provides a concentration method and a separation method using the device. The invention can be used to concentrate or separate particles such as inorganic particles, organic particles, and biological particles, for example, mammalian cells, bacteria, yeast, algae, and plant cells. The invention exhibits technical merits such as higher efficiency, cost-effectiveness, and large-scale production.

Abstract: The invention provides a simple, inexpensive, accurate, and rapid method of measuring particle settling velocity comprising: (i) providing a gravity settler such as a column; (ii) filling the column with a first homogenous particle suspension, wherein the particle concentration in the first homogenous particle suspension is X, (iii) separating the column into an upper sub-column and a lower sub-column with a height h after settling the first homogenous particle suspension for a period of time t, wherein some particles remain in the upper sub-column; (iv) removing the particle suspension in the upper sub-column and mixing the particle suspension confined in the lower sub-column with a height h to prepare a second homogenous particle suspension; (v) measuring the particle concentration in the second homogenous particle suspension X; and (vi) determining the particle settling velocity v with the formula: v=h(X?X)ltX. Also provided are device and system for carrying out the method.

Abstract: The invention provides a device for separating a first entity and a second entity by flowing them downwardly in an inclined settling chamber. Each entity has its own outlet located at approximately the lowest end of the inclined settling chamber. The device may be used in industrial fields such as pharmaceutics, biologics, and biofuels, for the purposes of large-scale growth and separation of algae biomass, bacteria and yeast cultures; algae metabolite production; and cell separation, among others. The invention exhibits technical merits such as effective particle separation or concentration capacity, robust structure, easy operation, cost-effective manufacturability, disposability, and high productivity in e.g. perfusion photobioreactor systems.