Abstract: Disclosed are compounds of Formula (I): and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a pharmaceutically acceptable salt.

Abstract: The present invention relates to a process for producing diaryl carbonates, which is to synthesize diaryl carbonates by oxidative carbonylation of phenols with carbon monoxide and oxygen, and in particular, to synthesize diphenyl carbonate from phenol. The present invention is characterized in that a catalytic system comprising a metal halide catalyst and one or more cocatalysts of nitrogenous heterocyclic compounds is used to increase the convertibility, selectivity and yield of this catalytic reaction.

Abstract: A sensor supported by a head transducer has a temperature coefficient of resistance (TCR) and a sensor resistance. The sensor operates at a temperature above ambient and is responsive to changes in sensor-medium spacing. Conductive contacts connected to the sensor have a contact resistance and a cross-sectional area adjacent to the sensor larger than that of the sensor, such that the contact resistance is small relative to the sensor resistance and negligibly contributes to a signal generated by the sensor. A multiplicity of head transducers each support a TCR sensor and a power source can supply bias power to each sensor of each head to maintain each sensor at a fixed temperature above an ambient temperature in the presence of heat transfer changes impacting the sensors. A TCR sensor of a head transducer can include a track-oriented TCR sensor wire for sensing one or both of asperities of the medium.

Abstract: Disclosed are compounds of Formula (I): and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a pharmaceutically acceptable salt.

Abstract: Disclosed are compounds of Formula (I): and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a pharmaceutically acceptable salt.

Abstract: Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed.

Abstract: The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: The present invention provides techniques for splitting bundled inputs and outputs into separated Boolean inputs and outputs for function blocks of automation devices. More specifically, previously-defined bundled inputs and outputs may be used, whereas separated Boolean inputs and outputs may be used as well. In other words, the newly added Boolean inputs and outputs do not replace, but rather compliment, the previously defined bundled inputs and outputs.

Abstract: The present invention provides techniques for automatically binding device parameters to an input and output interface. Doing so enables dynamic parameters to be available to the core firmware engine. More specifically, there is no input and output data in the configuration software domain required for mapping the parameters. Rather, the configuration software may directly access the device parameters during the logic execution. This is achieved in a library by representing the parameter repository and the EPATH pointing to each parameter from the configuration software domain.

Abstract: The present invention provides techniques for encapsulating device-level embedded logic into user-defined instructions using configuration software. More specifically, the disclosed embodiments enable add-on instructions for device configuration embedded logic. Programming interfaces specific to an application or device may be combined into a single instruction as a reusable Macro component that may be reused in the same or different applications or devices.

Abstract: The present invention relates to a process for producing diaryl carbonates, which is to synthesize diaryl carbonates by oxidative carbonylation of phenols with carbon monoxide and oxygen, and in particular, to synthesize diphenyl carbonate from phenol. The present invention is characterized in that a catalytic system comprising a metal halide catalyst and one or more cocatalysts of nitrogenous heterocyclic compounds is used to increase the convertibility, selectivity and yield of this catalytic reaction.

Abstract: The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as cancer by the administration of this compound.

Abstract: Disclosed are compounds of Formula (I): and salts thereof. Also, disclosed are methods of using the compounds in the treatment of proliferative diseases, such as cancer, and to pharmaceutical compositions comprising at least one compound of Formula (I) or a pharmaceutically acceptable salt.

Abstract: The invention is directed to compounds that are useful for the treatment of cancer having the following Formula:

Abstract: The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound; and methods for treating proliferative diseases, such as cancer by the administration of this compound.

Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: An adjustable fixture comprises a clamping board used to mount a workpiece thereon, a hollow telescopic sleeve, a latching assembly, a telescopic shaft, and a fastening seat. The clamping board is fastened to the telescopic sleeve. The telescopic sleeve slidably receives the telescopic shaft therein. The latching assembly is mounted on the telescopic shaft and resists an interior wall of the telescopic sleeve to position the telescopic shaft relative to the telescopic sleeve. The telescopic shaft is rotatably mounted on the fastening seat.

Abstract: The compounds of the instant invention can be used as anticancer agents.

Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.