Patents by Inventor Zhen Xu

Zhen Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240048885
    Abstract: A headphone includes a cushion assembly and a slider telescopically coupled to the cushion assembly. The slider includes a proximal end that is disposed within the cushion assembly and a distal end extending outward from the cushion assembly. A pivot support is disposed within an opening at the distal end of the slider. A pivot is supported in the pivot support. The headphone also includes an earphone and a yoke that couples the earphone to the slider. The pivot support is secured to the slider via a fastener, and wherein the yoke is pivotable to a position in which it covers the fastener when the headphones are in use.
    Type: Application
    Filed: August 5, 2022
    Publication date: February 8, 2024
    Inventors: Allen T. Graff, Daniel C. Haferman, Zhen Xu, Daniel P. Baker
  • Publication number: 20240048887
    Abstract: A headphone includes a headband and a yoke that is pivotably coupled to the headband. The yoke includes first and second yoke arms that each extend from a pivot point to respective distal ends. An earphone is pivotably coupled to the yoke. The earphone includes an earcup that defines first and second recesses for receiving the distal ends of the yoke arms. The earcup and the yoke are configured such that the distal ends of the yoke arms can be slid into the recesses in the earcup for assembly without elastic deformation of the yoke arms or the earcup.
    Type: Application
    Filed: August 5, 2022
    Publication date: February 8, 2024
    Inventors: Allen T. Graff, Daniel C. Haferman, Zhen Xu
  • Publication number: 20240048886
    Abstract: A headphone includes a cushion assembly, a slider telescopingly received within the cushion assembly, and an earphone. A yoke couples the earphone to the slider. A pivot is disposed at an open end of the slider and couples the yoke to the slider. The pivot includes a barrel that is received within an opening in the yoke. The barrel is secured within the opening via a pin that is inserted into a hole in the yoke.
    Type: Application
    Filed: August 5, 2022
    Publication date: February 8, 2024
    Inventors: Allen T. Graff, Daniel C. Haferman, Zhen Xu, Daniel P. Baker
  • Publication number: 20240033542
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Application
    Filed: October 12, 2023
    Publication date: February 1, 2024
    Inventors: Charles A. CAIN, Adam D. MAXWELL, Zhen XU, Kuang-Wei LIN
  • Publication number: 20240024705
    Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.
    Type: Application
    Filed: September 29, 2023
    Publication date: January 25, 2024
    Inventors: Zhen XU, Clifford Suhyun CHO
  • Patent number: 11819712
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: November 21, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Charles A. Cain, Adam Maxwell, Zhen Xu, Kuang-Wei Lin
  • Patent number: 11813485
    Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: November 14, 2023
    Assignees: The Regents of the University of Michigan, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Zhen Xu, Clifford Suhyun Cho
  • Patent number: 11806314
    Abstract: Novel dry powder compositions comprising and methods relating thereto are provided. The dry powder compositions comprise PDE5 inhibitors, such as vardenafil, or pharmaceutically acceptable salts or esters thereof. The dry powder compositions may optionally include an carrier/excipient. The concentration of active agent may be at least about 2% by weight. Methods of aerosolizing the dry powder compositions and using them to treat various diseases are also disclosed.
    Type: Grant
    Filed: January 20, 2022
    Date of Patent: November 7, 2023
    Assignee: Respira Therapeutics, Inc.
    Inventors: Zhen Xu, Hugh Smyth, Aileen Gibbons, Revati Shreeniwas, Pravin Soni, Dan Deaton, James Hannon, Stephen Lermer, Robert Curtis, Martin J. Donovan
  • Publication number: 20230338985
    Abstract: An automatic production apparatus for high-thermal-conductivity flocking pad includes a conveyor belt system, a cutting assembly, an electrostatic flocking assembly, a perfusion device and a thermosetting device, wherein the electrostatic flocking assembly is connected to a power supply which is configured for outputting a step-wave voltage through a bottom screen mesh thereof. The polymer matrix is conveyed through the conveyor belt system, and is stretched, flocked in the step-wave electric field, shrunk, poured and dried to form a flocking pad product with high-thermal-conductivity. In this invention, the polymer matrix is stretched and shrunk to make the flocking be dense by regulating and controlling the speed of the conveyor belt system, a step-wave electric field is provided during the flocking process, and meanwhile, the flocking, pouring and curing time is regulated and controlled.
    Type: Application
    Filed: April 24, 2023
    Publication date: October 26, 2023
    Inventors: Yingjun Liu, Chao Gao, Jiahao Lu, Zhen Xu, Bo Wang
  • Publication number: 20230329559
    Abstract: A transcranial magnetic resonance (MR)-guided histotripsy (tcMRgHt) system is provided. Using electronic steering only, the tcMRgHt system is configured to create lesions of 25.5 mm in the transverse plane and 50 mm in the axial plane through the skull of a patient. This disclosure provides the design, fabrication, acoustic characterization, and MR compatibility assessment of tcMRgHt systems for histotripsy.
    Type: Application
    Filed: September 13, 2021
    Publication date: October 19, 2023
    Inventors: Zhen XU, Douglas NOLL, Timothy L. HALL
  • Patent number: 11791750
    Abstract: A power tool includes a housing, a brushless motor disposed inside the housing, and a controller. The controller is configured to receive power-off signals and power-on signals. Upon receiving a power-on signal, the controller is further configured to receive a time signal indicative of a time interval from the last power-off signal to the current power-on signal. The controller is further configured to determine whether the time interval is greater than or equal to a first time threshold and less than a second time threshold, and brake the motor before start-up if the time interval is greater than or equal to the first time threshold and less than the second time threshold.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: October 17, 2023
    Assignee: Nanjing Chervon Industry Co., Ltd.
    Inventors: Zhen Xu, Junya Duan, Jifeng Feng
  • Publication number: 20230325737
    Abstract: A method and system for predicting post-earthquake repair of building groups in community are provided. The method includes: obtaining seismic damage states, building functions, and building areas of building groups in the community; determining a repair priority of each building based on functional classifications of the buildings; calculating a building repair workload considering the seismic damage states and building areas of the building groups in the community, and developing an individual-building repair model for simulating the repair process of an individual building under certain resource conditions; and developing a community building group repair resource allocation model and a community building group repair system dynamics model to predict the repair process of the building groups in the community at different levels of resource availability. The technical solution of the present invention can simulate the post-earthquake repair process of the building groups in the community.
    Type: Application
    Filed: September 28, 2022
    Publication date: October 12, 2023
    Applicant: University of Science and Technology Beijing
    Inventors: Zhen XU, Furong ZHANG, Xintian HAO
  • Publication number: 20230310899
    Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.
    Type: Application
    Filed: August 27, 2021
    Publication date: October 5, 2023
    Inventors: Timothy Lewis HALL, Jonathan Robert SUKOVICH, Zhen XU, Jonathan Jenner MACOSKEY
  • Publication number: 20230270715
    Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.
    Type: Application
    Filed: May 25, 2022
    Publication date: August 31, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Yanning Rui, Zhen Xu, John Hagan
  • Publication number: 20230274151
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for searching for an architecture for a neural network that performs a multi-modal task that requires operating on inputs that each include data from multiple different modalities.
    Type: Application
    Filed: March 30, 2021
    Publication date: August 31, 2023
    Inventors: Zhen Xu, David Richard So, Andrew M. Dai
  • Patent number: 11731314
    Abstract: A fiber pre-dispersing device for fiber reinforced concrete, comprising: a dispersing chamber, a feed inlet is installed on the upper side of a dispersing chamber, a hopper is installed in the feed inlet, a first dispersing device is installed in the dispersing chamber, a discharge outlet is installed at the bottom of the dispersing chamber, and connected with a second dispersing device, grooves are arranged at both sides of dispersing chamber, supporting legs are installed in the grooves.
    Type: Grant
    Filed: December 12, 2022
    Date of Patent: August 22, 2023
    Assignee: QINGDAO UNIVERSITY OF TECHNOLOGY
    Inventors: Jianqiang Chen, Yutian Wang, Wei Zhou, Enbo Fan, Taiyan Liu, Lingbo Meng, Xun Wang, Zhen Xu, Junwei Liu, Xiaoyu Bai
  • Publication number: 20230234260
    Abstract: A fiber pre-dispersing device for fiber reinforced concrete, comprising: a dispersing chamber, a feed inlet is installed on the upper side of a dispersing chamber, a hopper is installed in the feed inlet, a first dispersing device is installed in the dispersing chamber, a discharge outlet is installed at the bottom of the dispersing chamber, and connected with a second dispersing device, grooves are arranged at both sides of dispersing chamber, supporting legs are installed in the grooves.
    Type: Application
    Filed: December 12, 2022
    Publication date: July 27, 2023
    Inventors: Jianqiang Chen, Yutian Wang, Wei Zhou, Enbo Fan, Taiyan Liu, Lingbo Meng, Xun Wang, Zhen Xu, Junwei Liu, Xiaoyu Bai
  • Patent number: 11701134
    Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: July 18, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Adam D. Maxwell, Zhen Xu, Hitinder S. Gurm, Charles A. Cain
  • Publication number: 20230212522
    Abstract: The disclosure describes global transcriptome profiling in human vascular endothelial cells upon THSD1 knockdown and identification from these studies of specific genes and pathways that are THSD1. The analysis highlights a role for THSD1 in regulating endothelial to mesenchymal transition and other pathways. The analysis also demonstrates that endothelial cell injury is the first event of an intracranial aneurysm. The disclosure provides novel cell lines and reagents used for better understanding the molecular mechanism of THSD1 biology.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 6, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Yuanqing Yan, Yanning Rui, Zhen Xu, John Hagan
  • Publication number: 20230210858
    Abstract: Disclosed here are uses of anti-podosome therapies for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that endothelial podosomes plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 6, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dong H. Kim, Zhen Xu, Yanning Rui, John Hagan