Abstract: An alumina-based ceramic tool material with low thermal expansion and a preparation process thereof, accordingly, the ceramic tool material may have both the high hardness of alumina ceramics after the hot pressing sintering, and reduces the thermal expansion coefficient of the overall ceramic material by adding the Sc2W3O12 as the negative thermal expansion phase, which improves the thermal shock resistance of ceramic tools in high-speed cutting engineering and meets the requirements of large temperature range during the machining of nickel-based superalloys. Moreover, the composite material does not use metal binder and has strong thermal stability even in the high-speed machining under extreme heat-force-chemistry coupling, so it has a high machining compatibility for nickel-based superalloys.

Abstract: Novel dry powder compositions comprising and methods relating thereto are provided. The dry powder compositions comprise PDE5 inhibitors, such as vardenafil, or pharmaceutically acceptable salts or esters thereof. The dry powder compositions may optionally include an carrier/excipient. The concentration of active agent may be at least about 2% by weight. Methods of aerosolizing the dry powder compositions and using them to treat various diseases are also disclosed.

Abstract: A headphone includes a cushion assembly and a slider telescopically coupled to the cushion assembly. The slider includes a proximal end that is disposed within the cushion assembly and a distal end extending outward from the cushion assembly. A pivot support is disposed within an opening at the distal end of the slider. A pivot is supported in the pivot support. The headphone also includes an earphone and a yoke that couples the earphone to the slider. The pivot support is secured to the slider via a fastener, and wherein the yoke is pivotable to a position in which it covers the fastener when the headphones are in use.

Abstract: A headphone includes a headband and a yoke that is pivotably coupled to the headband. The yoke includes first and second yoke arms that each extend from a pivot point to respective distal ends. An earphone is pivotably coupled to the yoke. The earphone includes an earcup that defines first and second recesses for receiving the distal ends of the yoke arms. The earcup and the yoke are configured such that the distal ends of the yoke arms can be slid into the recesses in the earcup for assembly without elastic deformation of the yoke arms or the earcup.

Abstract: A headphone includes a cushion assembly, a slider telescopingly received within the cushion assembly, and an earphone. A yoke couples the earphone to the slider. A pivot is disposed at an open end of the slider and couples the yoke to the slider. The pivot includes a barrel that is received within an opening in the yoke. The barrel is secured within the opening via a pin that is inserted into a hole in the yoke.

Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.

Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.

Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.

Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.

Abstract: Novel dry powder compositions comprising and methods relating thereto are provided. The dry powder compositions comprise PDE5 inhibitors, such as vardenafil, or pharmaceutically acceptable salts or esters thereof. The dry powder compositions may optionally include an carrier/excipient. The concentration of active agent may be at least about 2% by weight. Methods of aerosolizing the dry powder compositions and using them to treat various diseases are also disclosed.

Abstract: An automatic production apparatus for high-thermal-conductivity flocking pad includes a conveyor belt system, a cutting assembly, an electrostatic flocking assembly, a perfusion device and a thermosetting device, wherein the electrostatic flocking assembly is connected to a power supply which is configured for outputting a step-wave voltage through a bottom screen mesh thereof. The polymer matrix is conveyed through the conveyor belt system, and is stretched, flocked in the step-wave electric field, shrunk, poured and dried to form a flocking pad product with high-thermal-conductivity. In this invention, the polymer matrix is stretched and shrunk to make the flocking be dense by regulating and controlling the speed of the conveyor belt system, a step-wave electric field is provided during the flocking process, and meanwhile, the flocking, pouring and curing time is regulated and controlled.

Abstract: A transcranial magnetic resonance (MR)-guided histotripsy (tcMRgHt) system is provided. Using electronic steering only, the tcMRgHt system is configured to create lesions of 25.5 mm in the transverse plane and 50 mm in the axial plane through the skull of a patient. This disclosure provides the design, fabrication, acoustic characterization, and MR compatibility assessment of tcMRgHt systems for histotripsy.

Abstract: A power tool includes a housing, a brushless motor disposed inside the housing, and a controller. The controller is configured to receive power-off signals and power-on signals. Upon receiving a power-on signal, the controller is further configured to receive a time signal indicative of a time interval from the last power-off signal to the current power-on signal. The controller is further configured to determine whether the time interval is greater than or equal to a first time threshold and less than a second time threshold, and brake the motor before start-up if the time interval is greater than or equal to the first time threshold and less than the second time threshold.

Abstract: A method and system for predicting post-earthquake repair of building groups in community are provided. The method includes: obtaining seismic damage states, building functions, and building areas of building groups in the community; determining a repair priority of each building based on functional classifications of the buildings; calculating a building repair workload considering the seismic damage states and building areas of the building groups in the community, and developing an individual-building repair model for simulating the repair process of an individual building under certain resource conditions; and developing a community building group repair resource allocation model and a community building group repair system dynamics model to predict the repair process of the building groups in the community at different levels of resource availability. The technical solution of the present invention can simulate the post-earthquake repair process of the building groups in the community.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for searching for an architecture for a neural network that performs a multi-modal task that requires operating on inputs that each include data from multiple different modalities.

Abstract: A fiber pre-dispersing device for fiber reinforced concrete, comprising: a dispersing chamber, a feed inlet is installed on the upper side of a dispersing chamber, a hopper is installed in the feed inlet, a first dispersing device is installed in the dispersing chamber, a discharge outlet is installed at the bottom of the dispersing chamber, and connected with a second dispersing device, grooves are arranged at both sides of dispersing chamber, supporting legs are installed in the grooves.

Abstract: A fiber pre-dispersing device for fiber reinforced concrete, comprising: a dispersing chamber, a feed inlet is installed on the upper side of a dispersing chamber, a hopper is installed in the feed inlet, a first dispersing device is installed in the dispersing chamber, a discharge outlet is installed at the bottom of the dispersing chamber, and connected with a second dispersing device, grooves are arranged at both sides of dispersing chamber, supporting legs are installed in the grooves.

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.