Abstract: The present invention features methods and compositions for the generation and use of conformation-specific antibodies or fragments thereof.

Abstract: Techniques are provided for the scheduling of file pre-fetches from a file system into a cache memory, to reduce subsequent latency associated with future accesses to those files. A methodology implementing the techniques according to an embodiment includes monitoring accesses to files of the file system (e.g., file open and file read operations) and maintaining a record for each of the accessed files. The record includes an identifier of the file, the number of accesses of the file, and the number of cache memory misses associated with those accesses. The method also includes storing the record into a file access history database (FAHD). The method further includes generating, in response to an Operating System (OS) shutdown, a frequently used file list (FUFL) based on the FAHD. The method further includes pre-fetching files identified by a selected subset of the FUFL to the cache memory during an OS boot.

Abstract: Technologies for monitoring a health-risk condition of a user include a virtual reality compute device having one or more near infrared (NIR) sensors. The virtual reality compute device presents a virtual reality (VR) presentation to the user. The virtual reality compute device produces sensor data through the one or more NIR sensors that is indicative of a heart rate of the user and a blood pressure of the user while the VR presentation is presented to the user. The virtual reality compute device determines whether the user is in a health-risk condition based on a comparison of the heart rate of the user to a heart rate safety threshold and a comparison of the blood pressure of the user to a blood pressure safety threshold. The virtual reality compute device performs a health-risk condition response in response to a determination that the user is in the health-risk condition.

Abstract: The invention introduces a method for testing a storage unit, performed by a processing unit, including at least the following steps: after receiving a test write command from a host device through a first access interface, directing a second access interface to receive a first test pattern from a test writer and program the first test pattern into a PBA (Physical Block Address) of a storage unit; directing the second access interface to read a second test pattern from the PBA of the storage unit and output the second test pattern to a test reader; receiving a test result from the test reader; and generating a test message according to the test result and replying with the test message to the host device.

Abstract: Systems, apparatuses and methods may provide for compressed virtual memory (CVM) management using CVM arbitration. CVM arbitration may monitor CVM utilization, tune CVM and update CVM settings that may be enabled upon reboot of a system and/or apparatus. The CVM arbitration may improve memory management, thereby improving system performance and user experience.

Abstract: A virtual reality headset system includes a vision correction module. The vision correction system can detect a degree of myopia or other visual ailment of a user of the VR system, and then adjust a vision correction lens to adjust for user myopia. An implementation of the vision correction module can adjust right and left lenses separately.

Abstract: A computer implemented method, computer system and computer program product are provided for lost detection for paired mobile devices. According to the method, a processor receives behavior data of paired mobile devices from one or more sensors of the paired mobile devices, wherein the behavior data comprising one or more parameters that reflect current status of the paired mobile devices. And the processor compares the received behavior data with human behavior data model. And, in response to the received behavior data being not matched with the human behavior data model, the processor determines that at least one of the paired mobile devices is lost.

Abstract: A system for a three-dimensional (“3D”) printed circuit board (“PCB”) to printed circuit board interface is provided. A first PCB includes first landing pads disposed on one or more edges of the first PCB. The first landing pads electrically couple to conductive pins or second landing pads disposed on a second PCB. The second landing pads may be disposed in a slot in the second PCB. The interface between the first landing pads and the second landing pads may provide various advantages over traditional PCB to PCB interfaces, such as, improved signal integrity, improved power integrity, increased contact density, decreased clock jitter, etc.

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering an ATRA-related compound in combination with another therapeutic compound.

Abstract: Methods and apparatus such as a processor platform to manage a process under a memory constraint are disclosed herein. An example method includes detecting that a process is to transition from a foreground mode of operation to a background mode of operation. Without transitioning the process to the background mode of operation, a projected out of memory score is calculated. The projected out of memory score is compared to a score threshold, and the process is terminated when the projected out of memory score is greater than the score threshold. When the projected out of memory score is less than or equal to the score threshold, the process is allowed to transition to the background mode of operation. A priority adjustor may determine a projected adjustment value, for example by determining a default adjustment value, or by performing a lookup of an adjustment value currently associated with a second process operating in the background mode.

Abstract: Apparatus, method and storage medium associated with UAV position estimation are disclosed herein. In embodiments, an UAV may comprise a transmitter-receiver arrangement to transmit and receive communication signals, including receipt of absolute positioning system (APS) signals from one or more APS sensors, and wireless signals from one or more proximately located other UAVs; one or more motors or engines to provide propulsive force for the UAV; and a flight controller coupled to the transmitter-receiver arrangement and the one or more motors or engines to control at least the one or more motors or engines to provide propulsive force to navigate the UAV, based at least in part on the APS and relative positioning signals. Other embodiments may be disclosed or claimed.

Abstract: A data storage device capable of just partially executing a read/write command issued by a host is disclosed. The data storage device uses a controller to perform a partial execution of a first read/write command issued by the host, and returns a breakpoint of the first read/write command to the host and returns information that the first read/write command is in a partial completion status to the host to drive the host to further issue a second read/write command. In this manner, fewer computational resources are required in determining read/write command granularity.

Abstract: The present invention features methods and compositions for the generation of conformation-specific antibodies.

Abstract: The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.

Abstract: A real time and quantitative method of measuring traction force of living cells include the following procedures. Place AT-cut and BT-cut quartz crystals of the same frequency, surface morphology and/or modified with the same cell adhesion molecules in petri dishes or detection cells; add the cells to the petri dishes or detection cells, the cell traction force at arbitrary time t during adhesion of the cells or under different internal/external environmental stimulations is estimated by the following equation: ?St=(KAT?KBT)?1[tqAT?ftAT/frAT?tqBT?ftBT/frBT]. The method can be used to track the dynamic changes of cells generated force during the adhesion of cells and under different internal/external environmental stimulations, such as the effects of drugs. The drugs can be added before or after the adhesion of the cells. This method is suitable for all adherent cells, including primary cells and passage cells.

Abstract: A method and system provide for storage device metadata management. The storage device metadata management method comprises: a superblock is formed of at least one erase block; the superblock reserves a space for storing metadata related to the superblock; the metadata related to the superblock comprises a serial number distributed to the superblock and address mapping information in the superblock; the address mapping information stores a mapping relationship of a physical block address to a logic block address (S1); when data is written into the superblock, the address mapping information corresponding to the data is also written into the superblock (S2); when a system is recovered, a page table of the storage system is recovered according to the address mapping information of the superblock; the page table marks a mapping relationship of a logic block address to a physical block address (S3).

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: The invention introduces a method for atomic writes in an SSD (Solid State Disk) system, performed by a processing unit, including at least the following steps. An atomic-write command instructing the processing unit to write first data whose length is less than a page length in a storage unit is received. When it is determined that the atomic-write command will trigger a cross-page buffering of a buffer, dummy data is filled into all available sub-regions of a first region of the buffer, and the first data is stored in a second region of the buffer. After the first data is successfully stored in the second region of the buffer, a safe pointer is modified to point to the end address of the last sub-region of the second region, which stores the first data.

Abstract: Biomarkers and driver mutations for diagnosis and prognosis of Pin 1-associated diseases are disclosed. In one embodiment, the methods for diagnosis of Pin 1-associated diseases may include detecting the level of Pin1 to stage abnormal cell growth, such as breast or prostate cancer. In another embodiment, the methods include evaluating the efficacy of a treatment of abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the methods include using driver mutations to determine the pharmacogenetics of abnormal cell growth, such as cancer. In the present disclosure, elevated active monomeric Pin1 levels may be detected by Pin1 biomarkers, which may include Pin1 Q33K or E100D driver mutations, Pin1 protein or transcript overexpression, dephosphorylation of Pin1 on Ser71, dephosphorylation of S16, phosphorylation of S65, phosphorylation of S138, deacetylation of Pin1 on K13 and deacetylation of K46, and/or desumoylation of Pin1 on K6 and desumolation of K63, among others.