Patents by Inventor Zheng Xia
Zheng Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10333018Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.Type: GrantFiled: August 6, 2018Date of Patent: June 25, 2019Assignee: Premium Genetics (UK) LTDInventors: Frederick Hershel Savage, Glenn J. Szejna, Zheng Xia
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Publication number: 20190187044Abstract: A method of inseminating an animal including flowing a stream of a population of sperm cells through a channel, differentiating the sperm cells into two subpopulations of X-chromosome containing sperm cells and Y-chromosome containing sperm cells, selecting a desired subpopulation, ablating an undesired subpopulation, and collecting both the subpopulations of sperm cells including the desired subpopulation and the ablated undesired subpopulation together, wherein the collected population of sperm cells is used to fertilize an egg.Type: ApplicationFiled: February 19, 2019Publication date: June 20, 2019Inventors: David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
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Publication number: 20190088813Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.Type: ApplicationFiled: August 6, 2018Publication date: March 21, 2019Inventors: Frederick Hershel Savage, Glenn J. Szejna, Zheng Xia
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Patent number: 10069027Abstract: A cytometer includes an avalanche photodiode, a switching power supply, a filter, and voltage adjustment circuitry. The switching power supply includes a feedback loop. The filter is electrically connected between the switching power supply and the avalanche photodiode. The voltage adjustment circuitry adjusts a voltage on the feedback loop based at least in part on a voltage measured between the filter and the avalanche photodiode.Type: GrantFiled: December 12, 2017Date of Patent: September 4, 2018Assignee: PREMIUM GENETICS (UK) LTDInventors: Frederick Hershel Savage, Glenn J. Szejna, Zheng Xia
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Publication number: 20180126376Abstract: This disclosure concerns a method of providing a hydrophobic coating on a microfluidic chip that promotes the discrete flow of at least one liquid. It includes applying the hydrophobic coating onto an area of the microfluidic chip. The disclosure further includes a microfluidic chip that provides discrete flow of at least one liquid.Type: ApplicationFiled: September 12, 2017Publication date: May 10, 2018Inventors: John Larsen, Yu Zhou, Zheng Xia
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Patent number: 9781759Abstract: A method, corresponding apparatuses, and a non-transitory computer readable medium for operating a companion device and a companion device are provided. A method comprises detecting, at a companion device, presence of a primary device that is paired with the companion device according to at least one short-range radio communication technique. The method additionally comprises connecting the companion device to a cellular network upon detecting that the primary device is not present. With the claimed inventions, the battery life of the companion device can be extended.Type: GrantFiled: February 17, 2014Date of Patent: October 3, 2017Assignee: Nokia Technologies OyInventors: Simo Pekka Veikkolainen, Vladimir Khokhlov, Zheng Xia, Christian Rossing Kraft
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Publication number: 20170167966Abstract: An apparatus and method of identifying objects includes: a microfluidic chip in which are disposed a plurality of channels, the micro-fluidic chip including: a main fluid channel into which a sample fluid mixture of objects to be identified is introduced; a plurality of sheath fluid channels into which sheath fluids are introduced, the sheath fluids which orient the objects in the main fluid channel in a predetermined direction while still maintaining laminar flow in the main fluid channel; an interrogation apparatus which detects and interrogates the oriented objects in the main fluid channel; and a focused energy apparatus which performs an action on the objects.Type: ApplicationFiled: December 21, 2016Publication date: June 15, 2017Inventors: David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
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Patent number: 9588100Abstract: An apparatus and method of identifying objects includes: a microfluidic chip in which are disposed a plurality of channels, the microfluidic chip including: a main fluid channel into which a sample fluid mixture of objects to be identified is introduced; a plurality of sheath fluid channels into which sheath fluids are introduced, the sheath fluids which orient the objects in the main fluid channel in a predetermined direction while still maintaining laminar flow in the main fluid channel; an interrogation apparatus which detects and interrogates the oriented objects in the main fluid channel; and a focused energy apparatus which performs an action on the objects.Type: GrantFiled: June 18, 2014Date of Patent: March 7, 2017Assignee: PREMIUM GENETICS (UK) LTDInventors: David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
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Publication number: 20170064752Abstract: A method, corresponding apparatuses, and a non-transitory computer readable medium for operating a companion device and a companion device are provided. A method comprises detecting, at a companion device, presence of a primary device that is paired with the companion device according to at least one short-range radio communication technique. The method additionally comprises connecting the companion device to a cellular network upon detecting that the primary device is not present. With the claimed inventions, the battery life of the companion device can be extended.Type: ApplicationFiled: February 17, 2014Publication date: March 2, 2017Inventors: Simo Pekka Veikkolainen, Vladimir Khokhlov, Zheng Xia, Christian Rossing Kraft
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Publication number: 20170052105Abstract: An apparatus and method of identifying objects includes: a microfluidic chip in which are disposed a plurality of channels, the microfluidic chip including: a main fluid channel into which a sample fluid mixture of objects to be identified is introduced; a plurality of sheath fluid channels into which sheath fluids are introduced, the sheath fluids which orient the objects in the main fluid channel in a predetermined direction while still maintaining laminar flow in the main fluid channel; an interrogation apparatus which detects and interrogates the oriented objects in the main fluid channel; and a focused energy apparatus which performs an action on the objects.Type: ApplicationFiled: June 18, 2014Publication date: February 23, 2017Inventors: David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
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Publication number: 20150355725Abstract: In accordance with an example embodiment of the present invention, an apparatus is disclosed with: a touch surface having one or more key tops configured to identify one or more keys to a user; a key sensing circuitry configured to detect a key press of any one or more of the key tops; a network of electromagnetic touch detectors configured to continually detect touching of the touch surface; and an elastic layer between the key sensing circuitry and the key tops configured to relay pressing forces from the key tops to the key sensing circuitry.Type: ApplicationFiled: January 15, 2013Publication date: December 10, 2015Inventors: Zhigang Chen, Yong Li, Zheng Xia, Ligang Shang
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Publication number: 20150114093Abstract: An apparatus and method of identifying objects includes: a microfluidic chip in which are disposed a plurality of channels, the microfluidic chip including: a main fluid channel into which a sample fluid mixture of objects to be identified is introduced; a plurality of sheath fluid channels into which sheath fluids are introduced, the sheath fluids which orient the objects in the main fluid channel in a predetermined direction while still maintaining laminar flow in the main fluid channel; an interrogation apparatus which detects and interrogates the oriented objects in the main fluid channel; and a focused energy apparatus which performs an action on the objects.Type: ApplicationFiled: June 18, 2014Publication date: April 30, 2015Applicant: PREMIUM GENETICS (UK) LTD.Inventors: David APPLEYARD, Jeff BETTHAUSER, Marjorie FAUST, John LARSEN, Guocheng SHAO, Zheng XIA, Yu ZHOU
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Publication number: 20150111196Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.Type: ApplicationFiled: December 22, 2014Publication date: April 23, 2015Applicant: PREMIUM GENETICS (UK) LTD.Inventors: Zheng XIA, Yu ZHOU, John LARSEN, Guocheng SHAO, Shane PETERSON, Marjorie FAUST
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Patent number: 8961904Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.Type: GrantFiled: July 16, 2013Date of Patent: February 24, 2015Assignee: Premium Genetics (UK) Ltd.Inventors: Zheng Xia, Yu Zhou, John Larsen, Guocheng Shao, Shane Peterson, Marjorie Faust
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Publication number: 20150024373Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.Type: ApplicationFiled: July 16, 2013Publication date: January 22, 2015Inventors: Zheng XIA, Yu ZHOU, John LARSEN, Guocheng SHAO, Shane PETERSON, Marjorie FAUST
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Publication number: 20140080903Abstract: The invention discloses a new use of ?-Mangostin in medicine, which is application of ?-Mangostin in preparation of medicaments for Alzheimer's disease. Under the new working concentration, ?-Mangostin showed the capability to inhibit the aggregation and deposition of A?. Moreover, it displayed the neuroprotective effect against neurotoxicity caused by A? oligomer, which maintained normal morphology of mammalian neuron cells, enhanced their normal physiological function, and realized the intervention in pathological process of Alzheimer's disease. The invention provided a new approach to treat Alzheimer's disease.Type: ApplicationFiled: February 14, 2012Publication date: March 20, 2014Applicant: BOMAI LIMITEDInventor: Zheng Xia
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Patent number: 8232270Abstract: The present invention belongs to pharmaceutical field. It relates to a novel family of bivalent (?)-meptazinol compounds and/or their salts, as well as the preparation and utilization of the compounds in the treatment of neurodegenerative disorders and dementias such as Alzheimer's Disease (AD). In the present invention, bivalent (?)-meptazinol compounds were synthesized, from the starting material (?)-meptazinol, successively by N-demethylation forming (?)-nor-meptazinol and then by acylation with ?,?-alkanediacyl dihalides or alkylation with ?,?-dihaloalkanes. Results from in vitro cholinesterase inhibiting test and AChE-induced A? aggregation test demonstrated that the bivalent (?)-meptazinol compounds and/or their salts were novel bivalent inhibitors of both AChE and A? aggregation. The most potent compound inhibited both AChE and BChE at nM level, which was 10000 and 1500 times more potent than (?)-MEP hydrochloride, respectively.Type: GrantFiled: July 24, 2007Date of Patent: July 31, 2012Inventors: Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Hao Wang, Zheng Xia, Meiyan Lu, Xinghai Wang
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Publication number: 20110177547Abstract: A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a motive force such as optical trapping into a collection channel. Once in the collection channel, particles can be collected, including by trapping in a porous matrix.Type: ApplicationFiled: January 14, 2011Publication date: July 21, 2011Applicant: ARRYX, INC.Inventors: Zheng Xia, Tania Chakrabarty, Haojun Fu, Dan Mueth
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Publication number: 20100104518Abstract: A method for producing a chewing gum with a controlled release traditional Chinese medicine active agent, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the traditional Chinese medicine active agent by coating and drying. The traditional Chinese medicine active agent is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated traditional Chinese medicine active agent is preferably then co-dried and particle sized to produce a release-modified traditional Chinese medicine active agent for use in chewing gum. The traditional Chinese medicine active agent may also be used in a coating on a chewing gum product, as part of a rolling compound applied to the chewing gum product, or as a part of the liquid in a liquid-center chewing gum product.Type: ApplicationFiled: January 16, 2007Publication date: April 29, 2010Inventors: Jianwei J. Cai, Minmin Tian, Michael J. Greenberg, Scott W. Marske, Biao Che, Albert H. Chapdelaine, Zheng Xia Han, Wen Xiong Huang
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Publication number: 20100035861Abstract: The present invention belongs to pharmaceutical field. It relates to a novel family of bivalent (?)-meptazinol compounds and/or their salts, as well as the preparation and utilization of the compounds in the treatment of neurodegenerative disorders and dementias such as Alzheimer's Disease (AD). In the present invention, bivalent (?)-meptazinol compounds were synthesized, from the starting material (?)-meptazinol, successively by N-demethylation forming (?)-nor-meptazinol and then by acylation with ?,?-alkanediacyl dihalides or alkylation with ?,?-dihaloalkanes. Results from in vitro cholinesterase inhibiting test and AChE-induced A? aggregation test demonstrated that the bivalent (?)-meptazinol compounds and/or their salts were novel bivalent inhibitors of both ACHE and A? aggregation. The most potent compound inhibited both ACHE and BCHE at nM level, which was 10000 and 1500 times more potent than (?)-MEP hydrochloride, respectively.Type: ApplicationFiled: July 24, 2007Publication date: February 11, 2010Inventors: Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Hao Wang, Zheng Xia, Meiyan Lu