Abstract: A method of processing nano- and micro-pores includes washing a substrate and cleaning a surface of the substrate; spin-coating photoresist, exposing the substrate and developing to form the substrate with a pattern; 3. depositing micro-nano metal particles on the surface of the substrate; wherein the micro-nano metal particles are centered on a magnetic core; and the surface of the magnetic core is plated with a metal nano-particle coating composed of a plurality of gold, silver or aluminum nanoparticles; removing the photoresist, and maintaining dot arrays of the micro-nano metal particles; applying laser irradiation and a strong uniform magnetic field on the substrate, so that the substrate is processed to form processed structures; and after the processed structures being formed into nano-/micro-pores with targeted pore size, shape and depth, stopping the laser irradiation and removing the strong uniform magnetic field.

Abstract: Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions enhance the therapeutic window of peptide epoxyketone compounds by improving in vivo half-life relative to non-liposomal compositions comprising peptide epoxyketone compounds, providing desirable pharmacodynamic profiles, and providing anti-tumor activity in a human tumor xenograft model, greater than or equal to non-liposomal compositions comprising peptide epoxyketone compounds. Further, experiments performed in support of the present invention demonstrated improved tolerability of liposomal compositions comprising peptide epoxyketone compounds.

Abstract: Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions provide prolonged drug exposure (relative to non-liposomal compositions comprising peptide epoxyketone compounds) without significantly affecting biodistribution of the drug. Tolerability of peptide epoxyketone compounds was also enhanced when formulated in the liposomal compositions.

Abstract: Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions enhance the therapeutic window of peptide epoxyketone compounds by improving in vivo half-life relative to non-liposomal compositions comprising peptide epoxyketone compounds, providing desirable pharmacodynamic profiles, and providing anti-tumor activity in a human tumor xenograft model, greater than or equal to non-liposomal compositions comprising peptide epoxyketone compounds. Further, experiments performed in support of the present invention demonstrated improved tolerability of liposomal compositions comprising peptide epoxyketone compounds.

Abstract: A screw thread driving polyhedral ultrasonic motor includes a stator, a rotor and multiple piezoelectric plates being bonded to the stator or the rotor. The stator and the rotor have screw threads matched with each other. The stator and the rotor are connected via the screw threads.

Abstract: A screw thread driving polyhedral ultrasonic motor includes a stator, a rotor and multiple piezoelectric plates being bonded to the stator or the rotor. The stator and the rotor have screw threads matched with each other. The stator and the rotor are connected via the screw threads.

Abstract: The peak potential values of each cardioelectric wave components detected from the body surface are uniquely presented as a few iso-potential and isochronous contour maps by the electrocardiac peak mapping (EPM) method and apparatus described. The change in the size and the contour of the relevant EPM maps provides a simple, non-invasive, yet sensitive means for clinical diagnosis of at least the following heart diseases:1) the locations and sizes of myocardial infarction (hereafter, MI),2) primary and second cardiomyopathies,3) locations and sizes of "non-Q-wave MI", which can not be diagnosed by conventional electrocardiography, and4) various intracardiac conduction blocks and Wolff-Parkinson-White syndrome,5) various repolarization abnormalities and their quantitative analysis.The EPM apparatus comprises an elastic Waistcoat with embodied special electrodes, signal preprocessors, a multiplexer, a main differential amplifier, and a general purpose computer with appropriate software.