Abstract: A low-jitter random clock generation circuit includes: a clock division and pulse generation module connected to an input clock, performing frequency division processing to obtain frequency division clocks, and then detecting some frequency division clocks one by one to obtain frequency division pulses in a one-to-one correspondence; a pseudorandom number generation module connected to one frequency division clock, and generating a pseudorandom number; a status control module connected to all the frequency division clocks and the pseudorandom number to generate status control signals; and a random clock output module connected to the input clock, all the frequency division clocks, all the frequency division pulses, and all the status control signals, randomly sampling the frequency division clocks by using the frequency division pulses under control of the status control signals, and synchronously outputting the randomly sampled frequency division clocks by using the input clock, to obtain random clocks.

Abstract: In a pipelined analog-to-digital converter, at least one pipeline stage includes an N-bit sub-analog-to-digital conversion module, a first sub-digital-to-analog conversion module, a second sub-digital-to-analog conversion module, and a switched capacitor amplification module. The first sub-digital-to-analog conversion module and the second sub-digital-to-analog conversion module respectively receive and process 2N?1 digital signals, which correspondingly require 2*2N?1 switched capacitors. In a pipeline stage based on a structure of “N-bit sub-analog-to-digital conversion module+sub-digital-to-analog conversion module+subtractor+multiplier”, the non-inverting input and the inverting input of the differential input comparison are completely symmetrical, which correspondingly requires 2*2N switched capacitors.

Abstract: An input common-mode compensation circuit includes an energy storage module, a switching selection module, and a feedback compensation module. An end of the energy storage module is connected to an input end of the residual amplifier. An input end of the switching selection module is connected to another end of the energy storage module. Input ends of the feedback compensation module are respectively connected to the end of the energy storage module and to a reset voltage of the residual amplifier, and an output end of the feedback compensation module is connected to an output end of the switching selection module. During the reset stage of a residual amplifier, the energy storage module is charged under the action of a reset voltage. During the working stage of the residual amplifier, feedback compensation is performed on the energy storage module through the feedback compensation module.

Abstract: The present invention relates to the use of a class of 1,4-dihydro-naphthyridine derivatives in the treatment of tumors.

Abstract: Provided are an anti-TROP-2 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising same, and the uses of the anti-TROP-2 antibody or the antigen-binding fragment thereof or the pharmaceutical composition comprising same in the preparation of drugs for cancer treatment.

Abstract: Provided is an anti-HER3 antibody drug conjugate, specifically comprising an antibody moiety, an intermediate linker moiety, and a cytotoxic drug moiety which are linked together. The provided antibody drug conjugate achieves excellent anti-tumor activity or/and better safety. The provided antibody drug conjugate can be used for the treatment of cancer.

Abstract: Provided is a mouse, human, chimeric, or humanized antibody or an antigen-binding fragment thereof specifically binding to CLDN18.2, and also provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, as well an expression vector and host cell used to express the antibody or the antigen-binding fragment thereof. Further provided is a use of the antibody or the antigen-binding fragment thereof, comprising treatment of CLDN18.2-positive diseases.

Abstract: Provided are an anti-CD40 antibody and a use thereof, such as a mouse, human, chimeric, or humanized antibody specifically binding to CD40, and an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, and an expression vector and a host cell for expressing the antibody or the antigen-binding fragment thereof. Further provided are a preparation method and a use method for the antibody or the antigen-binding fragment thereof, comprising treating and preventing immune diseases.

Abstract: The present invention relates to a composition of (S)-3-aminomethyl-5-methylhexanoic acid or a pharmaceutically acceptable salt thereof, and riluzole. The composition has broad application prospects in the manufacture of a medicament for treating neuropathic pain.

Abstract: A comparison method includes: providing a successive approximation register analog-to-digital converter, where the successive approximation register analog-to-digital converter includes n?1 weighted capacitors, a charge transfer capacitor, and a comparator; sampling an differential input signal by using the first weighted capacitor and the charge transfer capacitor; importing the differential input signal stored on the charge transfer capacitor, where the differential input signal is transferred and redistributed on the charge transfer capacitor and n?2 other weighted capacitors than the first weighted capacitor, and completing the first time of comparison; and importing the differential input signal stored on the first weighted capacitor and the differential input signal stored on the charge transfer capacitor, importing a reference voltage by using the second to jth weighted capacitors, where the differential input signal and the reference voltage are transferred and redistributed on a capacitor array, and

Abstract: An adaptive current generation circuit includes an inverter drive chain, a frequency divider, a frequency detector, a low-pass filter, a static comparator group, and a controllable current mirror. An input analog signal of the input buffer is converted into a frequency discrimination voltage in a direct current form sequentially through conversion of the inverter drive chain, frequency division of the frequency divider, frequency detection of the frequency detector, and conversion of the low-pass filter. Then the static comparator group performs a plurality of times of comparison to obtain N bits of digital codes. Finally, the controllable current mirror is controlled by using the N bits of digital codes. The controllable current mirror provides a magnitude-adjustable input current for the input buffer under control of the N bits of digital codes. A magnitude of the input current is positively correlated with a frequency of the input analog signal.

Abstract: A comparator based on a pre-amplifier stage structure and an analog-to-digital converter are provided. The comparator includes: a first pre-amplifier stage, where an input terminal of the first pre-amplifier stage is connected to a differential input signal, to amplify and output the differential input signal so as to output a first differential output signal; a second pre-amplifier stage, where an input terminal of the second pre-amplifier stage is connected to the first differential output signal, to amplify and output the first differential output signal so as to output a second differential output signal, and a positive feedback unit is disposed between an output terminal of the second pre-amplifier stage and the input terminal of the second pre-amplifier stage, to increase a voltage gain of the second pre-amplifier stage by using the positive feedback unit; and a latch, an input terminal thereof connected to the second differential output signal.

Abstract: A digital temperature sensor circuit is disclosed. The digital temperature sensor circuit includes a proportional to the absolute temperature (PTAT) current source, generating a PTAT current proportional to absolute temperature; a sigma-delta modulation module, including an integrator, an analog-to-digital conversion unit, and a feedback digital-to-analog conversion unit; the integrator converts the PTAT current into temperature voltage; the analog-to-digital conversion unit compares the temperature voltage with a band gap reference voltage to generate a digital modulation signal with a duty ratio proportional to the temperature; the feedback digital-to-analog conversion unit adjusts the voltage input by the analog-to-digital conversion unit and controls the charging and discharging speed of the integrator; a digital filter, quantizing the digital modulation signal into a digital signal, and outputting the digital signal.

Abstract: A circuit for channel randomization based on time-interleaved ADC includes: a channel selection module for outputting M clock reception control signals and encoded N data reception control signals based on a main clock and a generated random number; a multi-phase clock distribution module for generating N multi-phase clocks according to a sampling main clock, redistributing the multi-phase clocks according to the clock reception control signals, and outputting M redistributed clock signals; a time-interleaved ADC module for outputting M output data and a corresponding number of channel quantization completion signals according to the redistributed clock signals; an adjustable delay module for setting a delay length for the data reception control signals; and a timing distribution control module for controlling, according to delayed data reception control signals and the channel quantization completion signals, the output data to be output sequentially in chronological order.

Abstract: Reference voltage circuits and methods for designing the same are provided. The reference voltage circuit includes: a reference core unit configured to output a reference voltage; a main amplification unit connected to the reference core unit and configured to form feedback to the reference core unit; and a feedforward amplification unit connected to the main amplification unit and configured to form feedforward to the main amplification unit. The reference core unit, the main amplification unit, and the feedforward amplification unit form a third-order negative feedback loop to improve a power supply rejection ratio of the reference voltage.

Abstract: A composition applied to preparation of a medicament for treating cerebrovascular diseases, in particular ischemic cerebrovascular diseases. The composition contains 2-amino-6-trifluoromethoxybenzothiazole or a pharmaceutically acceptable salt thereof and borneol. By means of the compatibility between 2-amino-6-trifluoromethoxybenzothiazole and d-borneol, according to non-clinical cell test and animal efficacy test results, for cerebrovascular diseases, 2-amino-6-trifluoromethoxybenzothiazole and d-borneol have the effect of synergistically increasing efficacy.

Abstract: Disclosed is the use of a composition containing cilostazol or a pharmaceutically acceptable salt thereof and edaravone in the preparation of a drug for treating cerebrovascular diseases, especially ischemic cerebrovascular diseases. The experiment result shows that the tail vein administration of 1-15 mg/kg of cilostazol or 1.67-8.33 mg/kg of edaravone on rats with a focal cerebral ischemia-reperfusion injury can significantly ameliorate neurological defects in rats with an MCAO and reduce a cerebral infarction area; and performing compound combination within the dosage range (the mass ratio of cilostazol:edaravone is 1:5 to 5:1) can be synergistic. The tail vein administration of 3.33-16.67 mg/kg of cilostazol or 3.33-16.67 mg/kg of edaravone on mice with a focal cerebral ischemia-reperfusion injury can significantly ameliorate neurological defects in mice with an MCAO and reduce a cerebral infarction area.

Abstract: A follow-hold switch circuit comprising: a follower; a sampling sub-circuit for voltage sampling; a bootstrap-control sub-circuit, which provides a bootstrap voltage to the sampling sub-circuit when the circuit is in a following state; a sampling-switch-control sub-circuit, which provides a common-mode voltage to a bootstrap capacitor in the bootstrap-control sub-circuit when the circuit is in a holding state; the follower is connected to an output of the sampling sub-circuit; the sampling sub-circuit is connected to the bootstrap-control sub-circuit and the sampling-switch-control sub-circuit respectively through a sampling switch; the present disclosure can effectively improve the linearity of sampling switches.

Abstract: Provided is a bispecific antibody, comprising a first antigen-binding moiety and a second antigen-binding moiety, wherein a paired domain of the first antigen-binding moiety comprises an amino acid sequence of engineered HLA-I ?3 and an amino acid sequence of engineered ?2M. Also provided are an expression method for the bispecific antibody, a polynucleotide encoding the bispecific antibody, a vector and host cell containing the polynucleotide, a pharmaceutical composition containing the bispecific antibody, a fusion protein, and a conjugate.

Abstract: The present invention belongs to the pharmaceutical field, and relates to an application of a cilostazol and d-borneol composition in preparing a drug for treating cerebrovascular disease, in particular ischemic cerebrovascular disease. The present invention specifically relates to a composition containing cilostazol or a pharmaceutically acceptable salt thereof and d-borneol, and an application of the composition in preparing a drug for treating cerebrovascular disease, in particular ischemic cerebrovascular disease.