Abstract: An apparatus for waveguides and a method of fabricating a waveguide combiner having at least one grating with trenches gap-filled with variable refractive index materials. At least two trenches of at least one grating includes a first gap-fill material having a first volume and a first refractive index, and a second gap-fill material having a second volume and a second refractive index different than the first refractive index. Control of the deposition of first volume and the deposition of second volume in an inkjet deposition process provide for the formation of the grating with two trenches that have different refractive indices and different gap-fill depths. The first gap-fill material and the second gap-fill material merge to form the gap-filler. Therefore, by controlling the varied refractive indices and different gap-fill depths the waveguide combiner is optimized by efficiency or a color uniformity.

Abstract: Disclosed is the use of a composition containing cilostazol or a pharmaceutically acceptable salt thereof and edaravone in the preparation of a drug for treating cerebrovascular diseases, especially ischemic cerebrovascular diseases. The experiment result shows that the tail vein administration of 1-15 mg/kg of cilostazol or 1.67-8.33 mg/kg of edaravone on rats with a focal cerebral ischemia-reperfusion injury can significantly ameliorate neurological defects in rats with an MCAO and reduce a cerebral infarction area; and performing compound combination within the dosage range (the mass ratio of cilostazol:edaravone is 1:5 to 5:1) can be synergistic. The tail vein administration of 3.33-16.67 mg/kg of cilostazol or 3.33-16.67 mg/kg of edaravone on mice with a focal cerebral ischemia-reperfusion injury can significantly ameliorate neurological defects in mice with an MCAO and reduce a cerebral infarction area.

Abstract: Embodiments of the present disclosure generally relate to methods for forming a waveguide. Methods may include measuring a waveguide substrate, the waveguide having a substrate thickness distribution; and depositing an index-matched layer onto a surface of the waveguide, the index-matched layer having a first surface disposed on the waveguide substrate and a second surface opposing the first surface, wherein the index-matched layer is disposed only over a portion of the waveguide substrate, and a device slope of a second surface of the index-matched layer is substantially the same as the waveguide slope of the first surface of the waveguide.

Abstract: A follow-hold switch circuit comprising: a follower; a sampling sub-circuit for voltage sampling; a bootstrap-control sub-circuit, which provides a bootstrap voltage to the sampling sub-circuit when the circuit is in a following state; a sampling-switch-control sub-circuit, which provides a common-mode voltage to a bootstrap capacitor in the bootstrap-control sub-circuit when the circuit is in a holding state; the follower is connected to an output of the sampling sub-circuit; the sampling sub-circuit is connected to the bootstrap-control sub-circuit and the sampling-switch-control sub-circuit respectively through a sampling switch; the present disclosure can effectively improve the linearity of sampling switches.

Abstract: Provided is a bispecific antibody, comprising a first antigen-binding moiety and a second antigen-binding moiety, wherein a paired domain of the first antigen-binding moiety comprises an amino acid sequence of engineered HLA-I ?3 and an amino acid sequence of engineered ?2M. Also provided are an expression method for the bispecific antibody, a polynucleotide encoding the bispecific antibody, a vector and host cell containing the polynucleotide, a pharmaceutical composition containing the bispecific antibody, a fusion protein, and a conjugate.

Abstract: The present invention belongs to the pharmaceutical field, and relates to an application of a cilostazol and d-borneol composition in preparing a drug for treating cerebrovascular disease, in particular ischemic cerebrovascular disease. The present invention specifically relates to a composition containing cilostazol or a pharmaceutically acceptable salt thereof and d-borneol, and an application of the composition in preparing a drug for treating cerebrovascular disease, in particular ischemic cerebrovascular disease.

Abstract: This application provides a folding assembly and a foldable electronic device. The folding assembly is applied to a foldable electronic device, and is configured to carry a flexible display screen. The folding assembly includes a shaft base, a first housing, and a second housing. The first housing and the second housing are respectively disposed on both sides of the shaft base. A door plate swing arm is located above the shaft base and is disposed on each of both sides of a center line of the shaft base, one end of each door plate swing arm is rotatably connected to the shaft base, and the other end of each door plate swing arm is rotatably connected to the first housing or the second housing.

Abstract: The present disclosure provides a polysilicon resistor, a method for manufacturing the same, and a successive approximation register analog-to-digital converter.

Abstract: Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.

Abstract: Provided is an isolated monoclonal antibody or an antigen-binding portion thereof that specifically binds human CD40. A nucleic acid molecule encoding the antibody or antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding portion thereof are also provided. An immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus and a pharmaceutical composition comprising the antibody or antigen-binding portion thereof, as well as a treatment method using the same are further provided.

Abstract: Provided is an ST2 antigen binding protein, such as a mouse, human, chimeric or humanized antibody or antigen binding fragment thereof that specifically binds to ST2. Also provided are nucleic acid molecules encoding the above-mentioned antibodies and antigen binding fragments thereof, and an expression vector and host cell for expressing the antibodies or antigen binding fragments thereof. Further provided are methods for preparing and using the antibodies and antigen binding fragments thereof. The methods comprise treating and preventing IL33/ST2-mediated related diseases or conditions.

Abstract: A follow-hold switch circuit comprising: a follower; a sampling sub-circuit for voltage sampling; a bootstrap-control sub-circuit, which provides a bootstrap voltage to the sampling sub-circuit when the circuit is in a following state; a sampling-switch-control sub-circuit, which provides a common-mode voltage to a bootstrap capacitor in the bootstrap-control sub-circuit when the circuit is in a holding state; the follower is connected to an output of the sampling sub-circuit; the sampling sub-circuit is connected to the bootstrap-control sub-circuit and the sampling-switch-control sub-circuit respectively through a sampling switch; the present disclosure can effectively improve the linearity of sampling switches.

Abstract: A differential-follower control circuit has been provided, comprising: a follower; an output-voltage following module, which controls a voltage at a control terminal of the follower to vary with an output voltage; a substrate-voltage following module, which controls a substrate voltage of an output transistor of the follower to vary with an input voltage; an output terminal of the follower is connected to a first terminal of the output-voltage following module; a second terminal of the output-voltage following module is connected to the control terminal of the follower; a first terminal of the substrate-voltage following module is connected to an input terminal of the follower and a second terminal of the substrate-voltage following module is connected to a substrate of the output transistor; the invention effectively improves the overall linearity of the follower.

Abstract: An isolated monoclonal antibody that specifically binds human IL4R?, or an antigen-binding portion thereof. A nucleic acid molecule encoding the antibody or the antigen-binding portion thereof, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding portion thereof are also provided. The present disclosure further provides a bispecific molecule, an oncolytic virus and a pharmaceutical composition comprising the antibody or the antigen-binding portion thereof, as well as a treatment method using an Anti-IL4R? antibody or the antigen-binding portion thereof of the disclosure.

Abstract: Disclosed is an isolated monoclonal antibody that specifically binds human TSLP, or the antigen-binding portion thereof. A nucleic acid molecule encoding the antibody, an expression vector, a host cell and a method for expressing the antibody are also provided. The present disclosure further provides a bispecific molecule, an immunoconjugate, a CAR-immune cell, an oncolytic virus and a pharmaceutical composition comprising the antibody, as well as a treatment method using an anti-TSLP antibody of the disclosure.

Abstract: A digital temperature sensor circuit is disclosed. The digital temperature sensor circuit includes a proportional to the absolute temperature (PTAT) current source, generating a PTAT current proportional to absolute temperature; a sigma-delta modulation module, including an integrator, an analog-to-digital conversion unit, and a feedback digital-to-analog conversion unit; the integrator converts the PTAT current into temperature voltage; the analog-to-digital conversion unit compares the temperature voltage with a band gap reference voltage to generate a digital modulation signal with a duty ratio proportional to the temperature; the feedback digital-to-analog conversion unit adjusts the voltage input by the analog-to-digital conversion unit and controls the charging and discharging speed of the integrator; a digital filter, quantizing the digital modulation signal into a digital signal, and outputting the digital signal.

Abstract: The present disclosure provides a low-jitter frequency division clock circuit, including: a clock control signal generation circuit, to generate clock signals having different phases; a low-level narrow pulse width clock control signal generation circuit, to generate a low-level narrow pulse width clock control signal; a high-level narrow pulse width clock control signal generation circuit, to generate a high-level narrow pulse width clock control signal; and a frequency division clock generation circuit, to generate a frequency division clock signal according to low-level narrow pulse width clock control signal and high-level narrow pulse width clock control signal. The delay from a clock input end to an output end of low-jitter frequency division clock circuit is up to three logic gates.

Abstract: The present disclosure provides a circuit for generating a multi-phase clock having random disturbance added thereto. The circuit for generating a clock includes a main clock module, a random signal generation module and a buffer matrix switch module. The main clock module generates N multi-phase clock signals; and the buffer matrix switch module randomly switches, under the control of a random control signal output by the random signal generation module, transmission paths of the input N multi-phase clock signals, and outputs N multi-phase clock signals with random disturbance. In the present disclosure, the clock phase error is whitened by adding random disturbance. Only with a small loss of signal-to-noise ratio, the influence of a multi-phase clock phase error on the performance of a high-precision TI ADC can be eliminated in real time, and the influence of the fluctuation of a clock phase error can be tracked and eliminated.

Abstract: The present disclosure provides a low-jitter frequency division clock circuit, including: a clock control signal generation circuit, to generate clock signals having different phases; a low-level narrow pulse width clock control signal generation circuit, to generate a low-level narrow pulse width clock control signal; a high-level narrow pulse width clock control signal generation circuit, to generate a high-level narrow pulse width clock control signal; and a frequency division clock generation circuit, to generate a frequency division clock signal according to low-level narrow pulse width clock control signal and high-level narrow pulse width clock control signal. The delay from a clock input end to an output end of low-jitter frequency division clock circuit is up to three logic gates.

Abstract: The present disclosure provides a circuit for generating a multi-phase clock having random disturbance added thereto. The circuit for generating a clock includes a main clock module, a random signal generation module and a buffer matrix switch module. The main clock module generates N multi-phase clock signals; and the buffer matrix switch module randomly switches, under the control of a random control signal output by the random signal generation module, transmission paths of the input N multi-phase clock signals, and outputs N multi-phase clock signals with random disturbance. In the present disclosure, the clock phase error is whitened by adding random disturbance. Only with a small loss of signal-to-noise ratio, the influence of a multi-phase clock phase error on the performance of a high-precision TI ADC can be eliminated in real time, and the influence of the fluctuation of a clock phase error can be tracked and eliminated.