Abstract: The present disclosure belongs to the technical field of gene therapy, and specifically relates to a series of lipid compounds as well as lipid vectors, nucleic acid lipid nanoparticle compositions, and pharmaceutical preparations containing the same. The compound having the structure of formula (I) provided by the present disclosure may be used in combination with other lipid compounds to prepare a lipid vector, which exhibits pH responsiveness, has high encapsulation efficiency for nucleic acid drugs, and greatly enhances the in-vivo delivery efficiency of nucleic acid drugs. Moreover, it is possible to select lipid compounds with different structures as lipid vectors to adjust the enrichment of nucleic acid drugs in different organs, thereby having good market application prospect.

Abstract: Techniques for submitting unaligned IO data to an alignment-required IO stack of a storage system. The techniques include determining that IO data specified by an IO command contains unaligned IO data, and generating an IOCB and a tunneling IOCB. The IOCB includes information pertaining to the tunneling IOCB and the tunneling IOCB includes information pertaining to a sector-unaligned buffer for storing the IO data. The tunneling IOCB satisfies a sector-alignment requirement of an IO stack. The techniques include, in response to submitting the IO command and the information included in the IOCB to the IO stack, determining that the tunneling IOCB satisfies the sector-alignment requirement of the IO stack; having satisfied the sector-alignment requirement, building a driver command based on the IO command and the information included in the tunneling IOCB; and, transferring, by executing the driver command, the unaligned IO data from the sector-unaligned buffer to a storage device.

Abstract: The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.

Abstract: Techniques involve: acquiring, through a first downstream port of a first switch of a data storage system, information indicating an error of a storage device array from a second switch of the data storage system, wherein the first switch and the second switch are connected to the storage device array and the first downstream port is connected to a second downstream port of the second switch; executing, based on the acquired information, actual actions intended for solving the error; and in response to the executed actual actions failing to match with expected actions for the error, issuing an alarm indicating failure of processing the error.

Abstract: The present disclosure provides a wireless earphone device and method for using the wireless earphone device. The wireless earphone device comprises a processing unit, a switch unit, a wireless transceiving unit, a language input unit, and a speaker unit. The switch unit is electrically connected to the processing unit. The wireless transceiving unit is electrically connected to the processing unit, transmitting wirelessly with the earphone. The language input unit is electrically connected to the processing unit. The speaker unit is electrically connected to the processing unit. While the earphone charging case is activated and switched to a translation mode by the switch unit, a first voice signal is inputted into the processing unit through the earphone, the processing unit processes the first voice signal into a second voice signal, and the second voice signal is emitted by the speaker unit.

Abstract: A skin surface indwelling device for guiding punctures includes: an indwelling tube (13) having an inside tunnel (P) substantially extending along the longitudinal direction of the indwelling tube (13), the tunnel (P) is used for guiding needle (N), the indwelling tube (13) has a proximal end positioned above the skin surface (S) and a distal end positioned under the skin surface (S) in indwelling state; a support (11) having a bottom surface on its bottom that directly or indirectly contacts with the skin surface (S), the support (11) supports and fixates the indwelling tube (13); and a sealing elements (141,142) configured to seal the tunnel (P). The skin surface indwelling device for guiding punctures can shorten the time of establishing a puncture tunnel in the buttonhole puncture method, and help to build the puncture tunnel. In addition, the skin surface indwelling device can also guide the puncture needle (N) when puncturing, and protect the immature puncture tunnel.

Abstract: Techniques for managing a storage system involve cleaning up a persistent storage disk in a backup mode to increase a writing rate of the persistent storage disk. The techniques further involve creating a library partition in the cleaned persistent storage disk. The techniques further involve writing cache data in a volatile storage device into the library partition. Accordingly, in a storage device with only a single persistent storage disk, cache data in a volatile storage device can be written into the persistent storage disk at a relatively high writing rate, thereby achieving efficient memory persistence.

Abstract: Techniques for submitting unaligned IO data to an alignment-required IO stack of a storage system. The techniques include determining that IO data specified by an IO command contains unaligned IO data, and generating an IOCB and a tunneling IOCB. The IOCB includes information pertaining to the tunneling IOCB and the tunneling IOCB includes information pertaining to a sector-unaligned buffer for storing the IO data. The tunneling IOCB satisfies a sector-alignment requirement of an IO stack. The techniques include, in response to submitting the IO command and the information included in the IOCB to the IO stack, determining that the tunneling IOCB satisfies the sector-alignment requirement of the IO stack; having satisfied the sector-alignment requirement, building a driver command based on the IO command and the information included in the tunneling IOCB; and, transferring, by executing the driver command, the unaligned IO data from the sector-unaligned buffer to a storage device.

Abstract: The present disclosure provides a shift register unit, a driving method, a driving circuit and a display device. The shift register unit includes a first node potential adjustment circuit, a first tank circuit, a second node control circuit, a second tank circuit, a third node control circuit, a first node control circuit, and an output circuit; the first node potential adjustment circuit changes the potential of the first node according to the adjustment clock signal under the control of the potential of the first node; the first tank circuit is used to maintain the potential of the first node; the third node control circuit controls the potential of the third isolation node and the potential of the fourth node; the second node control circuit controls the potential of the second isolation node.

Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.

Abstract: The present disclosure provides an earphone charging case including a case body, a case cover, and a sliding mechanism. The case body includes an earphone charging slot. The case cover is disposed on the case body to cover the earphone charging slot. The sliding mechanism is disposed between the case body and the case cover. The sliding mechanism includes a first sliding part and a second sliding part corresponding to the first sliding part. The case cover is slidably connected to the case body through the sliding mechanism. The earphone charging case can be opened and closed through linear sliding movement between the case cover and the case body.

Abstract: Water outlet valve structure and a humidifier having the same. Opening or closing of the water outlet valve structure is controlled by a control structure. The water outlet valve structure includes a flow channel including an inlet and an outlet. The control structure is capable of sealing or opening the outlet of the flow channel. The outlet of the flow channel is capable of being sealed or opened by the control structure of the water outlet valve structure, to control the open and close of the flow channel, thereby simplifying the water outlet valve structure. In a further aspect, since only the outlet is sealed, specific requirements for the structure of the control structure are relatively low, thereby allowing the control structure to be simplified.

Abstract: A data processing method includes the following steps: a processor receives a symmetric wrapping key, and when an application needs to use a user private key, the processor executes an encryption and decryption instruction in a hardware-acceleration instruction-set. The encryption and decryption instruction is configured to apply the symmetric wrapping key to decrypt a wrapped private key that corresponds to the application to obtain the user private key. In addition, the symmetric wrapping key is stored in a model specific register of the processor.

Abstract: The present application discloses a process for preparing a fused tricyclic compound and an intermediate thereof, specifically relates to a process for preparing a (3S,3aR)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline compound, intermediates in said process, and methods for preparing said intermediates.

Abstract: An electronic device comprises a first processor, a second processor and a communication interface. The first processor operates according to a first clock, and comprises a first time-stamp counter to count the first clock to obtain a first count value. The second processor operates according to a second clock, and comprises a second time-stamp counter to count the second clock to obtain a second count value. The communication interface is coupled between the first processor and the second processor. The first processor periodically sends the first count value to the second processor through the communication interface. When the second processor receives the first count value, the second processor adds a preset deviation value to the first count value to obtain a synchronization value, resets the second count value, and the sum of the synchronization value and the second count value is read by the second processor.

Abstract: A microprocessor for neural network computing having a mapping table, a microcode memory, and a microcode decoding finite-state machine (FSM) is disclosed. According to the mapping table, a macroinstruction is mapped to an address on the microcode memory. The microcode decoding FSM decodes contents which are retrieved from the microcode memory according to the address, to get microinstructions involving at least one microinstruction loop that is repeated to operate a datapath to complete the macroinstruction.

Abstract: The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.

Abstract: A data processing method includes the following steps: a processor receives a symmetric wrapping key, and when an application needs to use a user private key, the processor executes an encryption and decryption instruction in a hardware-acceleration instruction-set. The encryption and decryption instruction is configured to apply the symmetric wrapping key to decrypt a wrapped private key that corresponds to the application to obtain the user private key. In addition, the symmetric wrapping key is stored in a model specific register of the processor.

Abstract: A microprocessor with dynamically adjustable bit width is provided, which has a bit width register, a datapath, a statistical register, and a bit width adjuster. The bit width register stores at least one bit width. The datapath operates according to the bit width stored in the bit width register to acquire input operands from received data and process input operands. The statistical register collects calculation results of the datapath. The bit width adjuster adjusts the bit width stored in the bit width register based on the calculation results collected in the statistical register.