Patents by Inventor Zhenhua Huang

Zhenhua Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220378938
    Abstract: The present disclosure belongs to the technical field of gene therapy, and specifically relates to a series of lipid compounds as well as lipid vectors, nucleic acid lipid nanoparticle compositions, and pharmaceutical preparations containing the same. The compound having the structure of formula (I) provided by the present disclosure may be used in combination with other lipid compounds to prepare a lipid vector, which exhibits pH responsiveness, has high encapsulation efficiency for nucleic acid drugs, and greatly enhances the in-vivo delivery efficiency of nucleic acid drugs. Moreover, it is possible to select lipid compounds with different structures as lipid vectors to adjust the enrichment of nucleic acid drugs in different organs, thereby having good market application prospect.
    Type: Application
    Filed: July 26, 2022
    Publication date: December 1, 2022
    Inventors: Ke HUANG, Chaoxuan JING, Yingwen LI, Yinjia GAO, Yuping LIU, Zhenhua SUN
  • Patent number: 11507276
    Abstract: Techniques for submitting unaligned IO data to an alignment-required IO stack of a storage system. The techniques include determining that IO data specified by an IO command contains unaligned IO data, and generating an IOCB and a tunneling IOCB. The IOCB includes information pertaining to the tunneling IOCB and the tunneling IOCB includes information pertaining to a sector-unaligned buffer for storing the IO data. The tunneling IOCB satisfies a sector-alignment requirement of an IO stack. The techniques include, in response to submitting the IO command and the information included in the IOCB to the IO stack, determining that the tunneling IOCB satisfies the sector-alignment requirement of the IO stack; having satisfied the sector-alignment requirement, building a driver command based on the IO command and the information included in the tunneling IOCB; and, transferring, by executing the driver command, the unaligned IO data from the sector-unaligned buffer to a storage device.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: November 22, 2022
    Assignee: EMC IP Holding Company LLC
    Inventors: Zhonghua Zhu, Wai C. Yim, Peter J. McCann, Guifeng Tang, Yechen Huang, Honggang Li, Zhenhua Dong
  • Patent number: 11498909
    Abstract: The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: November 15, 2022
    Assignee: KBP BIOSCIENCES CO., LTD.
    Inventors: Zhenhua Huang, Li Li, Min Zhang
  • Patent number: 11500717
    Abstract: Techniques involve: acquiring, through a first downstream port of a first switch of a data storage system, information indicating an error of a storage device array from a second switch of the data storage system, wherein the first switch and the second switch are connected to the storage device array and the first downstream port is connected to a second downstream port of the second switch; executing, based on the acquired information, actual actions intended for solving the error; and in response to the executed actual actions failing to match with expected actions for the error, issuing an alarm indicating failure of processing the error.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: November 15, 2022
    Assignee: EMC IP Holding Company LLC
    Inventors: Min Zhang, Zhonghua Zhu, Guifeng Tang, Qiulin Cheng, Yechen Huang, Zhenhua Dong, Thomas Dibb
  • Patent number: 11489351
    Abstract: The present disclosure provides a wireless earphone device and method for using the wireless earphone device. The wireless earphone device comprises a processing unit, a switch unit, a wireless transceiving unit, a language input unit, and a speaker unit. The switch unit is electrically connected to the processing unit. The wireless transceiving unit is electrically connected to the processing unit, transmitting wirelessly with the earphone. The language input unit is electrically connected to the processing unit. The speaker unit is electrically connected to the processing unit. While the earphone charging case is activated and switched to a translation mode by the switch unit, a first voice signal is inputted into the processing unit through the earphone, the processing unit processes the first voice signal into a second voice signal, and the second voice signal is emitted by the speaker unit.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: November 1, 2022
    Assignee: LUXSHARE PRECISION INDUSTRY COMPANY LIMITED
    Inventors: Yun Feng, ZhenHua Liu, Yong Huang
  • Patent number: 11484335
    Abstract: A skin surface indwelling device for guiding punctures includes: an indwelling tube (13) having an inside tunnel (P) substantially extending along the longitudinal direction of the indwelling tube (13), the tunnel (P) is used for guiding needle (N), the indwelling tube (13) has a proximal end positioned above the skin surface (S) and a distal end positioned under the skin surface (S) in indwelling state; a support (11) having a bottom surface on its bottom that directly or indirectly contacts with the skin surface (S), the support (11) supports and fixates the indwelling tube (13); and a sealing elements (141,142) configured to seal the tunnel (P). The skin surface indwelling device for guiding punctures can shorten the time of establishing a puncture tunnel in the buttonhole puncture method, and help to build the puncture tunnel. In addition, the skin surface indwelling device can also guide the puncture needle (N) when puncturing, and protect the immature puncture tunnel.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: November 1, 2022
    Assignee: MEDTRONIC, INC.
    Inventors: Yong Feng, Yueqiang Xue, Jian Song, Kai Huang, Chengrui Pan, Xin Tang, Jianming Zhou, Zhenhua Yuan, Jing Zhang, Wei Hu
  • Publication number: 20220334732
    Abstract: Techniques for managing a storage system involve cleaning up a persistent storage disk in a backup mode to increase a writing rate of the persistent storage disk. The techniques further involve creating a library partition in the cleaned persistent storage disk. The techniques further involve writing cache data in a volatile storage device into the library partition. Accordingly, in a storage device with only a single persistent storage disk, cache data in a volatile storage device can be written into the persistent storage disk at a relatively high writing rate, thereby achieving efficient memory persistence.
    Type: Application
    Filed: November 3, 2021
    Publication date: October 20, 2022
    Inventors: Yechen Huang, Honggang Li, Zhonghua Zhu, Zhenhua Dong
  • Publication number: 20220326854
    Abstract: Techniques for submitting unaligned IO data to an alignment-required IO stack of a storage system. The techniques include determining that IO data specified by an IO command contains unaligned IO data, and generating an IOCB and a tunneling IOCB. The IOCB includes information pertaining to the tunneling IOCB and the tunneling IOCB includes information pertaining to a sector-unaligned buffer for storing the IO data. The tunneling IOCB satisfies a sector-alignment requirement of an IO stack. The techniques include, in response to submitting the IO command and the information included in the IOCB to the IO stack, determining that the tunneling IOCB satisfies the sector-alignment requirement of the IO stack; having satisfied the sector-alignment requirement, building a driver command based on the IO command and the information included in the tunneling IOCB; and, transferring, by executing the driver command, the unaligned IO data from the sector-unaligned buffer to a storage device.
    Type: Application
    Filed: April 13, 2021
    Publication date: October 13, 2022
    Inventors: Zhonghua Zhu, Wai C. Yim, Peter J. McCann, Guifeng Tang, Yechen Huang, Honggang Li, Zhenhua Dong
  • Publication number: 20220319374
    Abstract: The present disclosure provides a shift register unit, a driving method, a driving circuit and a display device. The shift register unit includes a first node potential adjustment circuit, a first tank circuit, a second node control circuit, a second tank circuit, a third node control circuit, a first node control circuit, and an output circuit; the first node potential adjustment circuit changes the potential of the first node according to the adjustment clock signal under the control of the potential of the first node; the first tank circuit is used to maintain the potential of the first node; the third node control circuit controls the potential of the third isolation node and the potential of the fourth node; the second node control circuit controls the potential of the second isolation node.
    Type: Application
    Filed: October 23, 2020
    Publication date: October 6, 2022
    Inventors: Yingsong XU, Zhenhua ZHANG, Qian MA, Xilei CAO, Changlong YUAN, Jingyi FENG, Weiyun HUANG, Benlian WANG
  • Patent number: 11452737
    Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: September 27, 2022
    Assignees: The Johns Hopkins University, Duke University, Kennedy Krieger Institute, Inc.
    Inventors: Anne Comi, Jonathan Pevsner, Zhenhua Huang, Doug Marchuk
  • Patent number: 11451896
    Abstract: The present disclosure provides an earphone charging case including a case body, a case cover, and a sliding mechanism. The case body includes an earphone charging slot. The case cover is disposed on the case body to cover the earphone charging slot. The sliding mechanism is disposed between the case body and the case cover. The sliding mechanism includes a first sliding part and a second sliding part corresponding to the first sliding part. The case cover is slidably connected to the case body through the sliding mechanism. The earphone charging case can be opened and closed through linear sliding movement between the case cover and the case body.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: September 20, 2022
    Assignee: LUXSHARE PRECISION INDUSTRY CO., LTD.
    Inventors: Yun Feng, ZhenHua Liu, Yong Huang
  • Patent number: 11415228
    Abstract: Water outlet valve structure and a humidifier having the same. Opening or closing of the water outlet valve structure is controlled by a control structure. The water outlet valve structure includes a flow channel including an inlet and an outlet. The control structure is capable of sealing or opening the outlet of the flow channel. The outlet of the flow channel is capable of being sealed or opened by the control structure of the water outlet valve structure, to control the open and close of the flow channel, thereby simplifying the water outlet valve structure. In a further aspect, since only the outlet is sealed, specific requirements for the structure of the control structure are relatively low, thereby allowing the control structure to be simplified.
    Type: Grant
    Filed: December 25, 2018
    Date of Patent: August 16, 2022
    Assignee: GREE ELECTRIC APPLIANCES, INC. OF ZHUHAI
    Inventors: Zhongping Huang, Yihong Zhang, Zhenhua Lin, Zhicong Chen, Gang Liang, Jiandong Bai, Yuliang Xu, Jianhua Zhang
  • Patent number: 11398899
    Abstract: A data processing method includes the following steps: a processor receives a symmetric wrapping key, and when an application needs to use a user private key, the processor executes an encryption and decryption instruction in a hardware-acceleration instruction-set. The encryption and decryption instruction is configured to apply the symmetric wrapping key to decrypt a wrapped private key that corresponds to the application to obtain the user private key. In addition, the symmetric wrapping key is stored in a model specific register of the processor.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: July 26, 2022
    Assignee: SHANGHAI ZHAOXIN SEMICONDUCTOR CO., LTD.
    Inventors: Gangru Xue, Zhenhua Huang, Yun Shen
  • Publication number: 20220144824
    Abstract: The present application discloses a process for preparing a fused tricyclic compound and an intermediate thereof, specifically relates to a process for preparing a (3S,3aR)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline compound, intermediates in said process, and methods for preparing said intermediates.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 12, 2022
    Inventors: Zhenhua HUANG, Pengfei GUO, Cheng LI
  • Publication number: 20220137661
    Abstract: An electronic device comprises a first processor, a second processor and a communication interface. The first processor operates according to a first clock, and comprises a first time-stamp counter to count the first clock to obtain a first count value. The second processor operates according to a second clock, and comprises a second time-stamp counter to count the second clock to obtain a second count value. The communication interface is coupled between the first processor and the second processor. The first processor periodically sends the first count value to the second processor through the communication interface. When the second processor receives the first count value, the second processor adds a preset deviation value to the first count value to obtain a synchronization value, resets the second count value, and the sum of the synchronization value and the second count value is read by the second processor.
    Type: Application
    Filed: October 25, 2021
    Publication date: May 5, 2022
    Inventors: Jiamin SITU, Zhenhua HUANG, Yang SHI, Jun WU
  • Patent number: 11003445
    Abstract: A microprocessor for neural network computing having a mapping table, a microcode memory, and a microcode decoding finite-state machine (FSM) is disclosed. According to the mapping table, a macroinstruction is mapped to an address on the microcode memory. The microcode decoding FSM decodes contents which are retrieved from the microcode memory according to the address, to get microinstructions involving at least one microinstruction loop that is repeated to operate a datapath to complete the macroinstruction.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: May 11, 2021
    Assignee: SHANGHAI ZHAOXIN SEMICONDUCTOR CO., LTD.
    Inventors: Jing Chen, Xiaoyang Li, Juanli Song, Zhenhua Huang, Weilin Wang, Jiin Lai
  • Publication number: 20200392096
    Abstract: The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.
    Type: Application
    Filed: August 15, 2019
    Publication date: December 17, 2020
    Inventors: Zhenhua Huang, Li Li, Min Zhang
  • Publication number: 20200382289
    Abstract: A data processing method includes the following steps: a processor receives a symmetric wrapping key, and when an application needs to use a user private key, the processor executes an encryption and decryption instruction in a hardware-acceleration instruction-set. The encryption and decryption instruction is configured to apply the symmetric wrapping key to decrypt a wrapped private key that corresponds to the application to obtain the user private key. In addition, the symmetric wrapping key is stored in a model specific register of the processor.
    Type: Application
    Filed: March 16, 2020
    Publication date: December 3, 2020
    Inventors: Gangru XUE, Zhenhua HUANG, Yun SHEN
  • Patent number: 10776109
    Abstract: A microprocessor with dynamically adjustable bit width is provided, which has a bit width register, a datapath, a statistical register, and a bit width adjuster. The bit width register stores at least one bit width. The datapath operates according to the bit width stored in the bit width register to acquire input operands from received data and process input operands. The statistical register collects calculation results of the datapath. The bit width adjuster adjusts the bit width stored in the bit width register based on the calculation results collected in the statistical register.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: September 15, 2020
    Assignee: SHANGHAI ZHAOXIN SEMICONDUCTOR CO., LTD.
    Inventors: Jing Chen, Xiaoyang Li, Juanli Song, Zhenhua Huang, Weilin Wang, Jiin Lai
  • Patent number: D964271
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: September 20, 2022
    Assignee: LUXSHARE PRECISION INDUSTRY CO., LTD.
    Inventors: Yun Feng, ZhenHua Liu, Yong Huang