Abstract: A driving tool, including a driver assembly and a lifting assembly. The driver assembly includes a drivable driver member and a base arranged on the driver member, where the driver member extends longitudinally in a first axis, and a plurality of engagement holes arranged in the first axis are provided on the driver member. The lifting assembly includes a driving wheel that is driven by a power output portion to rotate and a plurality of fitting portions arranged on a periphery of the driving wheel at intervals, where the plurality of fitting portions can be alternately engaged with the corresponding engagement holes, to drive the driver member to move along the first axis, so as to drive the base to move from a starting position to a driven position.

Abstract: This disclosure provides compounds containing 7-(pyrimidin-4-yl)quinolin-4(1H)-one structure, the use thereof for selectively inhibiting the activity of CDK4, and pharmaceutical compositions comprising the compounds as treatment of various diseases including cancer.

Abstract: Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

Abstract: Disclosed herein are compounds used as inhibitors of KAT6, or a pharmaceutically acceptable salt, deuterated analog, N-oxide, or tautomer thereof. Also disclosed is a pharmaceutical composition comprising a compound disclosed herein, and a method for treating or preventing a disorder or a disease responsive to the inhibition of KAT6 activity in a subject using the same. In some embodiments, the compounds are of formula (I): wherein values for the variables are disclosed herein.

Abstract: An electronic device includes a transceiver and processing circuitry that is operatively coupled to the transceiver. The processing circuitry is configured to transmit, via the transceiver and to a second electronic device, a request for a wireless communication session with the second electronic device. The processing circuitry is also configured to communicate, via the transceiver, one or more first wireless signals during the wireless communication session with the second electronic device. Additionally, the processing circuitry is configured, after communicating the one or more first wireless signals, to extend the wireless communication session by transmitting, via the transceiver and to the second electronic device, one or more second wireless signals based on no wireless signals being communicated via the wireless communication session for a duration of time.

Abstract: Provided herein are compounds having the following structure: wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of KRAS G12D and/or G12V.

Abstract: The present invention relates to a target-oriented seismic acquisition method and apparatus, a medium and a device. The target-oriented seismic acquisition method comprises the steps of: giving parameters of an initial velocity model and a three-dimensional seismic layout aiming to an underground target position; conducting wave field continuation and focusing analysis on the three-dimensional seismic layout, and calculating distribution of seismic energy on the ground in an underground target region; conducting normalization processing on distribution of the seismic energy on the ground, and then conducting level partitioning to obtain a primary energy region and a secondary energy region; adding the number of shot points in the primary energy region to achieve target-oriented acquisition, and obtaining a target-oriented inhomogeneous laying acquired data imaging result.

Abstract: The present invention discloses an inner packaging structure for a network distribution frame, used to package a distribution frame body and a bracket, including an isolated protection board. A packaging box for a network distribution frame further includes a cover body and a box body with an open top, and the inner packaging structure is located in the box body. A packaging method for a network distribution frame includes the following steps: placing the distribution frame body and the bracket in the box body, and separating the distribution frame body from the bracket by the isolated protection board; and limiting the distribution frame body and the bracket to complete packaging by using fastening of a top cover of the cover body and the box body. The present invention ensures no abrasion in the transportation process while realizing deplasticization packaging of products, and saves logistics costs for enterprises and customers.

Abstract: Systems, methods, and apparatuses disclosed herein can compensate for imbalances between multiple transport streams of an uplink (UL)-multiple-input and multiple-output (MIMO) transmission. These systems, methods, and apparatuses can adjust one or more signal metrics of multiple recovered transport streams of the UL-MIMO transmission that are received in the presence of imbalances between the multiple transport streams of the UL-MIMO transmission. As an example, these systems, methods, and apparatuses can inject noise into one or more of the multiple recovered transport streams to adjust the one or more signal metrics of the multiple recovered transmission streams to lessen the imbalances between the multiple transmission streams.

Abstract: A heterodyne interferometer and a measurement method based on multi-target opposite displacement measurement are provided, technical points including: An output path of the laser source is sequentially arranged with a first beam splitter and a second beam splitter arranged in parallel on left and right sides, and both of which are polarization beam splitters; a first reflector is arranged above the first beam splitter, a third reflector is arranged on a right side of the second beam splitter, a second plane reflector is arranged in front of the second beam splitter, and a first plane reflector is arranged behind the second beam splitter; the first plane reflector and the second plane reflector jointly constitute a second reflector group; a left side of the first beam splitter is provided with a first photodetector and a second photodetector. The present invention realizes the measurement of relative displacement between opposing objects.

Abstract: Provided herein are methods of treating systemic lupus erythematosus including lupus nephritis, in particularly active proliferative lupus nephritis in a subject with (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are compounds having the following structure: or a pharmaceutically acceptable salt, tautomer, stereoisomer, or enantiomer thereof, wherein the substituents are as defined herein compositions comprising an effective amount of a compound, and methods for inhibiting activity of cyclin-dependent kinases.

Abstract: Disclosed herein are a solid Form of a TYK2 inhibitor N-(5-(2,2-dimethyl-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-6-yl)-4-((6-(methylsulfonyl)-4-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl)amino)pyridin-2-yl)acetamide per se and the pharmaceutically acceptable salts of the TYK2 inhibitor or crystalline Forms of the salts, pharmaceutical compositions comprising the crystalline Form or the salts or the salts in crystalline Forms, the processes for preparing the crystalline Form or the salts or the salts in crystalline Forms, and methods of use therefor.

Abstract: The present invention relates to salts of a HPK1 inhibitor (referred to as “Compound A” hereinafter), preferably citrate, and the crystalline forms thereof. The present invention also relates to the process of preparation and uses of the salts and crystalline forms of Compound A.

Abstract: Devices and associated methods for operating a dual-subscriber identity module (SIM) dual-standby (DSDS) user equipment device (UE) configured with a first SIM and a second SIM. The UE performs communications with a first cellular network using the first SIM and a first radio resource control (RRC) connection, and receives a request to perform a higher priority communication using the second SIM. In response to the request to perform the higher priority communication, the UE transmits a request to the first network to suspend the first RRC connection. After transmission of the request to suspend the first RRC connection, the UE receives a message from the first network to place the first RRC connection in an inactive state, and initiates a timer, wherein the timer is used to determine whether the first RRC connection remains in the inactive state or transitions to an idle state.

Abstract: Disclosed herein is a compound of Formula (I) for inhibiting Bcl-xL and treating a disease associated with the undesirable Bcl-xL activity (Bcl-xL related diseases), a method of using the compounds disclosed herein for treating tumor or cancer, and a pharmaceutical composition comprising the same.

Abstract: This disclosure relates to techniques for multi-RAT and DSDA capable wireless devices to handle frame blanking in a wireless communication system. A wireless device may establish wireless links according to a first radio access technology and a second radio access technology. The wireless device may determine to perform transmit and receive blanking for one or more antennas of the wireless device for the first radio access technology to perform sounding reference signal transmissions for the second radio access technology based at least in part on a band combination for the wireless links. The wireless device may determine a modification to channel state feedback reporting for the first radio access technology based at least in part on the transmit and receive blanking. The wireless device may perform channel state feedback reporting using the determined modification.

Abstract: The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

Abstract: A power module is disclosed and includes an upper surface for receiving multiple input signals, a lower surface for outputting multiple output signals, a top layer circuit board, a bottom layer circuit board and a middle layer. The top layer circuit board includes a first surface and a second surface disposed opposite to each other, and multiple electronic devices. The first surface forms the upper surface, and multiple first signal connection parts are disposed on the first surface for receiving the multiple input signals. The bottom layer circuit board includes a third surface and a fourth surface disposed oppositely. The fourth surface forms the lower surface, and multiple second signal connection parts are disposed on the fourth surface for outputting the multiple output signals. The middle layer is disposed between the top layer circuit board and the bottom layer circuit board.