Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.

Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.

Abstract: The present disclosure provides an online upgrade method and system for a multi-core embedded system. The system includes a service system and a multi-core embedded system. The service system is used to provide upgrade firmware files. The multi-core embedded system includes: a system on chip, including a multi-core embedded processor system and a programmable logic module, the programmable logic module maps the memory of the multi-core embedded processor system to the service system; a communication module, establishing the communication connection between the system on chip and the service system, receiving and caches the upgraded firmware files from the service system; a DMA module, used for fast data transfer between the communication module and the memory of the multi-core embedded processor system; an interrupt controller, executing interrupt processing, so that the multi-core embedded processor system can obtain the upgraded firmware files through the memory.

Abstract: A making device of ice balls comprises a refrigeration chamber unit; the refrigeration chamber unit comprises a lower half ball mold body, an upper half ball mold body and a water circulation unit; in addition, a cover plate is arranged above the refrigeration chamber unit, and a water injection hole is arranged on the cover plate; in addition, a plurality of low-temperature condensing tubes are arranged in the lower half ball mold body; in addition, the refrigeration chamber unit further comprises a thermo electric cooler, and a cold end face of the thermo electric cooler is attached to a bottom surface of the lower half ball mold body; the upper half ball mold body is arranged above the lower half ball mold body, a plurality of convection circulation holes are distributed on the upper half ball mold body, and a water inlet hole is arranged in the center of the upper half ball mold body; and the water circulation unit is arranged on the cover plate and comprises a pump, and the pump is respectively connected

Abstract: A portable electronic device and a plate antenna module thereof are provided. The plate antenna module includes an antenna carrying structure, an inner surrounding radiation structure, a first inner feeding structure, an outer surrounding radiation structure, and a first outer feeding structure. The first inner feeding structure is surrounded by the inner surrounding radiation structure. The inner surrounding radiation structure is surrounded by the outer surrounding radiation structure. The inner surrounding radiation structure and the outer surrounding radiation structure are respectively disposed on two different planes of the antenna carrying structure.

Abstract: A testkey structure for semiconductor device includes a substrate, a gate structure disposed on the substrate, and a plurality of first dummy gate structures disposed on the substrate and arranged around the gate structure. A bottom surface of the gate structure is lower than bottom surfaces of the first dummy gate structures. A top surface of the gate structure is flush with top surfaces of the first dummy gate structures.

Abstract: A burr trimming device includes a removing assembly and a directed spraying assembly disposed on a carrier, wherein the directed spraying assembly has a nozzle facing the removing assembly. The directed spraying assembly rapidly freezes objects such as burrs and then the removing assembly removes the hardened objects by coming into rigid contact therewith, thereby ensuring complete removal of the fine flexible burrs.

Abstract: An actuator includes a casing, an output disc, a transmission component, a cable, a power source, and a tension adjustment assembly. The output disc and the transmission component are rotatably disposed on the casing. The cable is disposed through the transmission component and connected to the output disc. The power source can drive the transmission component. The tension adjustment assembly includes a lever, an elastic component, and a slidable component. The lever has a first end and a second end opposite to each other. The first end is connected to the cable. The elastic component is connected to the casing and the second end of the lever. The slidable component is in contact with a portion of the lever located between the first end and the second end, and is slidable along the lever to change its position to adjust a tension of the cable.

Abstract: A portable electronic device and a plate antenna module thereof are provided. The plate antenna module includes an antenna carrying structure, an inner surrounding radiation structure, a first inner feeding structure, an outer surrounding radiation structure, and a first outer feeding structure. The first inner feeding structure is surrounded by the inner surrounding radiation structure. The inner surrounding radiation structure is surrounded by the outer surrounding radiation structure. The inner surrounding radiation structure and the outer surrounding radiation structure are respectively disposed on two different planes of the antenna carrying structure.

Abstract: The disclosure is directed to dual variable domain immunoglobulin double-stranded RNA conjugates that are advantageous for inhibition of target gene expression, as well as compositions suitable for therapeutic use. The dual variable domain immunoglobulin comprises a first variable domain that binds to a binding target, and a second variable domain that comprises a reactive residue, where the linker is covalently conjugated to the reactive residue. The dsRNA is linked to the linker and is capable of inhibiting the expression of the target gene by RNA interference. The disclosure also provides pharmaceutical compositions comprising these conjugate and methods of inhibiting the expression of a target gene by administering these conjugates, e.g., for the treatment of various disease conditions.

Abstract: An automated calibration system for the relation between a robot-arm coordinate frame and a profile-scanner coordinate frame includes a ball probe, a distance sensor module, a profile scanner and a control module. The ball probe is attached on a flange of a robot arm. The distance sensor module includes at least three distance sensors having respective axes sharing a common sensing plane and intersecting at a common point. The profile scanner is used for detecting a 2D cross-sectional profile of the ball probe. The control module is electrically connected with the distance sensor module, the profile scanner and the robot arm so as to control the robot arm to move the ball probe to obtain calibration information. In addition, an automated calibration method for the relation between the profile-scanner coordinate frame and the robot-arm coordinate frame is also provided.

Abstract: An actuator includes a casing, an output disc, a transmission component, a cable, a power source, and a tension adjustment assembly. The output disc and the transmission component are rotatably disposed on the casing. The cable is disposed through the transmission component and connected to the output disc. The power source can drive the transmission component. The tension adjustment assembly includes a lever, an elastic component, and a slidable component. The lever has a first end and a second end opposite to each other. The first end is connected to the cable. The elastic component is connected to the casing and the second end of the lever. The slidable component is in contact with a portion of the lever located between the first end and the second end, and is slidable along the lever to change its position to adjust a tension of the cable.

Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.

Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.

Abstract: The present disclosure provides an online upgrade method and system for a multi-core embedded system. The system includes a service system and a multi-core embedded system. The service system is used to provide upgrade firmware files. The multi-core embedded system includes: a system on chip, including a multi-core embedded processor system and a programmable logic module, the programmable logic module maps the memory of the multi-core embedded processor system to the service system; a communication module, establishing the communication connection between the system on chip and the service system, receiving and caches the upgraded firmware files from the service system; a DMA module, used for fast data transfer between the communication module and the memory of the multi-core embedded processor system; an interrupt controller, executing interrupt processing, so that the multi-core embedded processor system can obtain the upgraded firmware files through the memory.

Abstract: Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.

Abstract: Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.

Abstract: The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.

Abstract: Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.

Abstract: Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.