Patents by Inventor Zhi Xiang

Zhi Xiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11167036
    Abstract: The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: November 9, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: James L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo
  • Publication number: 20210205954
    Abstract: A burr trimming device includes a removing assembly and a directed spraying assembly disposed on a carrier, wherein the directed spraying assembly has a nozzle facing the removing assembly. The directed spraying assembly rapidly freezes objects such as burrs and then the removing assembly removes the hardened objects by coming into rigid contact therewith, thereby ensuring complete removal of the fine flexible burrs.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 8, 2021
    Inventors: Zhi-Xiang Chen, Chia-Chung Sung, Cheng-Yu Chu, Jao-Hao Chen
  • Patent number: 10847785
    Abstract: An electrode for use in a lithium-ion battery. The electrode comprises a group IV-VI compound and a transition metal group VI compound on a three-dimensional graphene network. A major portion of the transition metal group VI compound is provided on top of the group IV-VI compound or in close proximity to it, whereby the molybdenum group VI compound contributes to the decomposition of a lithium group VI compound at the surface of the group IV-VI compound.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: November 24, 2020
    Assignees: Airbus Singapore Private Limited, Singapore University of Technology and Design
    Inventors: Zhi-Xiang Huang, Hui-Ying Yang, Ye Wang
  • Publication number: 20200164088
    Abstract: Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.
    Type: Application
    Filed: November 28, 2018
    Publication date: May 28, 2020
    Inventors: James L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo, Jeremy Tan
  • Publication number: 20200164080
    Abstract: The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 28, 2020
    Inventors: James L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo
  • Publication number: 20200155686
    Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 21, 2020
    Inventors: Mareva B. Fevre, James L. Hedrick, Ashlynn Lee, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang, Zhi Xiang Voo
  • Publication number: 20200146296
    Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
    Type: Application
    Filed: January 9, 2020
    Publication date: May 14, 2020
    Inventors: Victoria A. Piunova, Noah Frederick Fine Nathel, James L. Hedrick, Yi Yan Yang, Willy Chin, Zhi Xiang Voo
  • Patent number: 10561146
    Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: February 18, 2020
    Assignee: International Business Machines Corporation
    Inventors: Willy Chin, James L. Hedrick, Noah Frederick Fine Nathel, Victoria A. Piunova, Zhi Xiang Voo, Yi Yan Yang
  • Publication number: 20190388460
    Abstract: Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 26, 2019
    Inventors: James L. Hedrick, Yi Yan Yang, Nathaniel H. Park, Victoria A. Piunova, Zhi Xiang Voo
  • Patent number: 10457772
    Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 29, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Willy Chin, Jeannette M. Garcia, James L. Hedrick, Eunice Leong Jiayu, Shrinivas Venkataraman, Zhi Xiang Voo, Rudy J. Wojtecki, Yi Yan Yang
  • Publication number: 20190159456
    Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
    Type: Application
    Filed: November 28, 2017
    Publication date: May 30, 2019
    Inventors: Willy Chin, James L. Hedrick, Noah Frederick Fine Nathel, Victoria A. Piunova, Zhi Xiang Voo, Yi Yan Yang
  • Publication number: 20190077909
    Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
    Type: Application
    Filed: September 8, 2017
    Publication date: March 14, 2019
    Inventors: Dylan J. BODAY, Willy CHIN, Jeannette M. GARCIA, James L. HEDRICK, Eunice Leong JIAYU, Shrinivas VENKATARAMAN, Zhi Xiang VOO, Rudy J. WOJTECKI, Yi Yan YANG
  • Publication number: 20190020017
    Abstract: An electrode for use in a lithium-ion battery. The electrode comprises a group IV-VI compound and a transition metal group VI compound on a three-dimensional graphene network. A major portion of the transition metal group VI compound is provided on top of the group IV-VI compound or in close proximity to it, whereby the molybdenum group VI compound contributes to the decomposition of a lithium group VI compound at the surface of the group IV-VI compound.
    Type: Application
    Filed: December 28, 2016
    Publication date: January 17, 2019
    Inventors: Zhi-Xiang HUANG, Hui-Ying YANG, Ye WANG
  • Publication number: 20180120560
    Abstract: A projector includes a projection lens, an image capture module and a processor. The projection lens projects a projection image onto a display surface. The image capture module is disposed on one side of the projection lens and captures an image frame covering the projection image and defines a plurality of zones on the image frame. The zones correspond to parts of the image frame and cover at least the projection image and do not cover the entire image frame. The image capture module analyzes the parts of the image frame to obtain image data including a plurality of respective zone values. The processor is electrically connected to the image capture module and receives the image data and adjusts a focal length of the projection lens according to at least two of these zone values selected based on the image data. A focal length adjusting method is also provided.
    Type: Application
    Filed: October 25, 2017
    Publication date: May 3, 2018
    Inventors: CHUN-CHIEH WANG, ZHI-XIANG LI, JUI-TA LIU, YU-CHI WU
  • Publication number: 20170238547
    Abstract: The present disclosure provides a copolymer comprising monomer units represented by formulas (I) and/or (II) as disclosed and defined herein which are useful in antibacterial and/or antifouling coatings. The present disclosure further provides methods of synthesizing said copolymers.
    Type: Application
    Filed: October 14, 2015
    Publication date: August 24, 2017
    Inventors: Yi Yan YANG, Zhi Xiang VOO
  • Patent number: 9624191
    Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: April 18, 2017
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
  • Patent number: 9518329
    Abstract: A method for electrochemically converting a carbon dioxide gas into expected products includes using a member reactor. In the method, a membrane reactor includes a cavity, a solid electrolyte membrane separator, a cathode, an anode, and a fuel cell is provided. A cathode electrolyte and the carbon dioxide gas are passed through the cathode, and an anode electrolyte and an anode active material are passed through the anode chamber at the same time. An electrolytic voltage is applied to decompose the carbon dioxide gas into expected products. The expected products include a hydrogen gas and an oxygen gas which are fed back to the fuel cell to generate electric power.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: December 13, 2016
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Cheng Wang, Chen-Chen Zhao, Zhi-Xiang Liu, Jian-Wei Guo, Xiang-Ming He
  • Publication number: 20160207669
    Abstract: A circular plastic container locking mechanism includes a barrel body and a barrel cover; when the barrel body is stationary, the gear handle drives the gear to rotate towards a counter-clockwise direction, and with the rotating function of the gear, the rack on the barrel cover and the whole barrel cover are driven to move towards a clockwise direction, ten times the force for locking the barrel body and the barrel cover up and down can be produced with only a small amount of force by utilizing the lever effect of the gear handle and the effect of thread slope movement on the gear to lock the barrel cover and the barrel body; when the gear handle swings towards the clockwise direction, the barrel cover moves towards the counter-clockwise direction, and then the barrel cover is unlocked; and therefore locking and unlocking are very convenient.
    Type: Application
    Filed: January 15, 2016
    Publication date: July 21, 2016
    Inventors: Ao-qi Li, Zhi-Xiang Dai
  • Publication number: 20160009860
    Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.
    Type: Application
    Filed: September 23, 2015
    Publication date: January 14, 2016
    Inventors: Mareva B. Fevre, James L. Hedrick, Victor W.L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
  • Patent number: 9217202
    Abstract: A membrane reactor used for electrochemically converting a carbon dioxide gas into an expected product includes a cavity, a solid electrolyte membrane separator, a cathode, an anode, and a power source. The solid electrolyte membrane separator is disposed in the cavity and divides the cavity into two chambers defined as a cathode chamber and an anode chamber. The cathode is disposed in the cathode chamber, and the anode is disposed in the anode chamber. The cathode is a trickle bed structure including a porous conductive layer and cathode particles disposed on the porous conductive layer. The power source is disposed outside the cavity to provide an electrolytic voltage.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: December 22, 2015
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Cheng Wang, Chen-Chen Zhao, Zhi-Xiang Liu, Jian-Wei Guo, Xiang-Ming He