Abstract: Methods and systems are disclosed for managing performance states of a data fabric of a system on chip (SoC). Techniques disclosed include determining a performance state of the data fabric based on data fabric bandwidth utilizations of respective components of the SoC. A metric, characteristic of a workload centric to cores of the SoC, is derived from hardware counters, and, based on the metric, it is determined whether to alter the performance state.

Abstract: A technique for varying firmware for different virtual functions in a virtualized device is provided. The virtualized device includes a hardware accelerator and a microcontroller that executes firmware. The virtualized device is virtualized in that the virtualized device performs work for different virtual functions (with different virtual functions associated with different virtual machines), each function getting a “time-slice” during which work is performed for that function. To vary the firmware, each time the virtualized device switches from performing work for a current virtual function to work for a subsequent virtual function, one or more microcontrollers of the virtualized device examines memory storing addresses for firmware for the subsequent virtual function and begins executing the firmware for that subsequent virtual function. The addresses for the firmware are provided by a corresponding virtual machine at configuration time.

Abstract: A technique for varying firmware for different virtual functions in a virtualized device is provided. The virtualized device includes a hardware accelerator and a microcontroller that executes firmware. The virtualized device is virtualized in that the virtualized device performs work for different virtual functions (with different virtual functions associated with different virtual machines), each function getting a “time-slice” during which work is performed for that function. To vary the firmware, each time the virtualized device switches from performing work for a current virtual function to work for a subsequent virtual function, one or more microcontrollers of the virtualized device examines memory storing addresses for firmware for the subsequent virtual function and begins executing the firmware for that subsequent virtual function. The addresses for the firmware are provided by a corresponding virtual machine at configuration time.

Abstract: A technique for varying firmware for different virtual functions in a virtualized device is provided. The virtualized device includes a hardware accelerator and a microcontroller that executes firmware. The virtualized device is virtualized in that the virtualized device performs work for different virtual functions (with different virtual functions associated with different virtual machines), each function getting a “time-slice” during which work is performed for that function. To vary the firmware, each time the virtualized device switches from performing work for a current virtual function to work for a subsequent virtual function, one or more microcontrollers of the virtualized device examines memory storing addresses for firmware for the subsequent virtual function and begins executing the firmware for that subsequent virtual function. The addresses for the firmware are provided by a corresponding virtual machine at configuration time.

Abstract: A technique for varying firmware for different virtual functions in a virtualized device is provided. The virtualized device includes a hardware accelerator and a microcontroller that executes firmware. The virtualized device is virtualized in that the virtualized device performs work for different virtual functions (with different virtual functions associated with different virtual machines), each function getting a “time-slice” during which work is performed for that function. To vary the firmware, each time the virtualized device switches from performing work for a current virtual function to work for a subsequent virtual function, one or more microcontrollers of the virtualized device examines memory storing addresses for firmware for the subsequent virtual function and begins executing the firmware for that subsequent virtual function. The addresses for the firmware are provided by a corresponding virtual machine at configuration time.

Abstract: A technique for varying firmware for different virtual functions in a virtualized device is provided. The virtualized device includes a hardware accelerator and a microcontroller that executes firmware. The virtualized device is virtualized in that the virtualized device performs work for different virtual functions (with different virtual functions associated with different virtual machines), each function getting a “time-slice” during which work is performed for that function. To vary the firmware, each time the virtualized device switches from performing work for a current virtual function to work for a subsequent virtual function, one or more microcontrollers of the virtualized device examines memory storing addresses for firmware for the subsequent virtual function and begins executing the firmware for that subsequent virtual function. The addresses for the firmware are provided by a corresponding virtual machine at configuration time.

Abstract: The present disclosure provides methods and compositions for diagnosis and for providing a prognosis of a cancer patient by assessing CK2 alpha 1 pseudogene (CSNK2A1P) status. The present disclosure also provides polypeptide, polynucleotide, host cell, and transgenic animal compositions associated with CSNK2A1P.

Abstract: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.

Abstract: The present disclosure provides methods and compositions for diagnosis and for providing a prognosis of a cancer patient by assessing CK2 alpha 1 pseudogene (CSNK2A1P) status. The present disclosure also provides polypeptide, polynucleotide, host cell, and transgenic animal compositions associated with CSNK2A1P.

Abstract: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.

Abstract: The present disclosure provides compositions, pharmaceutical preparations, kits and methods for inhibiting cell proliferation by contacting a cell expressing Fzd8 with a truncated Wnt2 polypeptide which acts as a dominant negative inhibitor of Fzd8 signaling. The present disclosure provides compositions, kits and methods for the detection of cancer by determining the level of Fzd8 and/or Wnt2 expression in a cell.

Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.

Abstract: This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression.

Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.

Abstract: This invention relates to methods of inhibiting the growth of cancer cells that overexpress a Wnt protein. The methods comprise contacting the cell with an agent that inhibits binding of the Wnt protein to a Frizzled receptor.

Abstract: This invention provides compositions, methods and kits for the diagnosis and treatment of cancers wherein Wnt Inhibitory Factor-1 (WIF-1) is underexpressed.

Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.

Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.

Abstract: This invention relates to methods of inhibiting the growth of cells, in particular cancer cells that over express Wnt16 protein. The methods comprise contacting the cell with an agent that binds to Wnt16 mRNA or Wnt16 protein, interferes with Wnt16 signaling or inhibits binding of the Wnt16 protein to another protein, such as a Frizzled receptor.

Abstract: Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein and other proteins such as the Frizzled (Fz) protein, have the general formula The invention also includes combinatorial libraries, arrays and methods for screening and studying proteins using such compounds. Compounds of the invention have produced apoptosis in certain cell lines that overexpress the Dishevelled protein (Dvl); inhibiting Wnt signaling.