Patents by Inventor Zhigang Guo

Zhigang Guo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10028458
    Abstract: Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: July 24, 2018
    Assignee: Syngenta Participations AG
    Inventors: Venkata Krishna Kishore, Andres Gutierrez-Rojas, Zhigang Guo, Joseph Byrum
  • Publication number: 20180134712
    Abstract: The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypo-function or basal ganglia dysfunction.
    Type: Application
    Filed: May 24, 2016
    Publication date: May 17, 2018
    Applicants: Merck Sharp & Dohme Corp., MSD R & D (China) Co. LTD.
    Inventors: Dong-Ming Shen, Michael P. Dwyer, Christopher J. Sinz, Deping Wang, Shawn J. Stachel, Daniel V. Paone, Ashley Forster, Richard Berger, Yilli Chen, Yimin Qian, Shimin Xu, Chunmel Hu, William D. Shipe, Jianmin Fu, Zhigang Guo, HAITANG LI, Yingjian Bo
  • Publication number: 20150256487
    Abstract: A method for managing a connection apparatus and a connection apparatus are disclosed. In an embodiment the connection apparatus includes a first connector configured to be connected to a service processing unit, a second connector configured to be connected to a first switching unit, a third connector configured to be connected to a second switching unit, wherein the third connector is further configured to be disconnected from the second switching unit and connected to the first switching unit. The apparatus further comprises a first transmission medium, a second transmission medium, one end of the first transmission medium being directly connected to the first connector, one end of the second transmission medium being directly connected to the first connector, another end of the first transmission medium being directly connected to the second connector, and another end of the second transmission medium being directly connected to the third connector.
    Type: Application
    Filed: May 22, 2015
    Publication date: September 10, 2015
    Inventors: Chongyang Wang, Zhigang Guo
  • Publication number: 20150089691
    Abstract: Methods for method for increasing genetic gain in a breeding process are provided.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 26, 2015
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Zhigang GUO, Venkata Krishna VENKATA
  • Patent number: 8874420
    Abstract: Methods for method for increasing genetic gain in a breeding process are provided. Also provided are methods for choosing breeding pairs predicted to produce progeny having desired phenotypes, methods for increasing the likelihood of producing progeny individual having desired phenotypes, methods for generating progeny individual having desired genotypes and/or phenotypes, progeny produced thereby, and cells, seeds, parts, and tissues cultures thereof.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: October 28, 2014
    Assignee: Syngenta Participations AG
    Inventors: Zhigang Guo, Venkata Krishna Kishore
  • Publication number: 20140317773
    Abstract: Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Venkata Krishna KISHORE, Andres Gutierrez-Rojas, Zhigang Guo, Joseph Byrum
  • Patent number: 8809621
    Abstract: Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: August 19, 2014
    Assignee: Syngenta Participations AG
    Inventors: Venkata Krishna Kishore, Libardo Andres Gutierrez Rojas, Zhigang Guo, Joseph Byrum
  • Publication number: 20140170660
    Abstract: Methods for predicting unobserved phenotypes are provided. In some embodiments, the methods include (a) determining marker effects for a plurality of markers in a genotyped and phenotyped reference population with respect to a phenotype, wherein the reference population includes an F2 generation, an F3 generation, or a subsequent generation; (b) genotyping one or more plants of a predicted population with respect to the plurality of markers, wherein each of the one or more plants of the predicted population is a descendant of two parents and each parent has at least 80% genetic identity to at least one of the two parental plants employed to generate the reference population; (c) summing the marker effects determined in step (a) for each of the one or more plants of the predicted population based on the genotyping of step (b); and (d) predicting a phenotype of the one or more plants of the predicted population based on the sum of the marker effects from step (c).
    Type: Application
    Filed: February 21, 2014
    Publication date: June 19, 2014
    Inventors: Zhigang GUO, Venkata Krishna KISHORE
  • Publication number: 20140108622
    Abstract: Embodiments of the present invention relate to the field of streaming media technology and provide a streaming media transmission method, device, and system, so that a streaming media transmission manner is dynamically adjusted to adapt to the change of a terminal usage state, thereby avoiding a waste of bandwidth resources and network traffic, and improving user experience. The method includes: receiving a playback state parameter reported by a terminal; obtaining streaming media information according to the playback state parameter; and sending the obtained streaming media information to the terminal. The embodiments of the present invention are applied to streaming media transmission.
    Type: Application
    Filed: December 26, 2013
    Publication date: April 17, 2014
    Applicant: Huawei Device Co., Ltd.
    Inventor: Zhigang GUO
  • Publication number: 20120151625
    Abstract: Methods for method for increasing genetic gain in a breeding process are provided. Also provided are methods for choosing breeding pairs predicted to produce progeny having desired phenotypes, methods for increasing the likelihood of producing progeny individual having desired phenotypes, methods for generating progeny individual having desired genotypes and/or phenotypes, progeny produced thereby, and cells, seeds, parts, and tissues cultures thereof.
    Type: Application
    Filed: November 30, 2011
    Publication date: June 14, 2012
    Inventors: Zhigang Guo, Venkata Krishna Kishore
  • Patent number: 8170805
    Abstract: Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or more of nested association mapping (NAM), expression QTL analysis (eQTL), and allele epistastic analysis (AEA). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: May 1, 2012
    Assignee: Syngenta Participations AG
    Inventors: Venkata Krishna Kishore, Zhigang Guo, Min Li, Daolong Wang, Libardo Andres Gutierrez Rojas, Joseph Dallas Clarke, V, Joseph Byrum
  • Publication number: 20110296753
    Abstract: Methods for predicting unobserved phenotypes are provided. In some embodiments, the methods include (a) determining marker effects for a plurality of markers in a genotyped and phenotyped reference population with respect to a phenotype, wherein the reference population includes an F2 generation, an F3 generation, or a subsequent generation; (b) genotyping one or more plants of a predicted population with respect to the plurality of markers, wherein each of the one or more plants of the predicted population is a descendant of two parents and each parent has at least 80% genetic identity to at least one of the two parental plants employed to generate the reference population; (c) summing the marker effects determined in step (a) for each of the one or more plants of the predicted population based on the genotyping of step (b); and (d) predicting a phenotype of the one or more plants of the predicted population based on the sum of the marker effects from step (c).
    Type: Application
    Filed: June 3, 2010
    Publication date: December 8, 2011
    Inventors: Zhigang Guo, Venkata Krishna Kishore
  • Publication number: 20110035847
    Abstract: Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.
    Type: Application
    Filed: August 5, 2009
    Publication date: February 10, 2011
    Inventors: Venkata Krishna Kishore, Libardo Andres Gutierrez Rojas, Zhigang Guo, Joseph Byrum
  • Publication number: 20100269216
    Abstract: Provided herein are methods for mapping quantitative trait loci in a connected population of organisms. The invention includes evaluating associations between markers and a trait of interest using network population mapping (NPM). The methods include assembling a network of individual members for association mapping, wherein the members are connected at the allelic level. Members of the network are grouped according to a shared haplotype at one or more marker loci, and the network can be used to identify or validate QTL within the chromosomal region surrounding or flanked by the marker loci. The methods further include a means for estimating and ranking the effects of multiple alleles across the mapping population. Further provided is a novel simple interval mapping model as well as a novel composite interval mapping model for evaluating allele-specific associations across a connected mapping population.
    Type: Application
    Filed: April 16, 2009
    Publication date: October 21, 2010
    Applicant: Syngenta Participations AG
    Inventors: Zhigang Guo, Venkata Krishna Kishore, Suresh Babu Kadaru, Min Li, Todd Lee Warner, Homer Gene Caton
  • Publication number: 20100204921
    Abstract: Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or more of nested association mapping (NAM), expression QTL analysis (eQTL), and allele epistastic analysis (AEA). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait.
    Type: Application
    Filed: February 6, 2009
    Publication date: August 12, 2010
    Applicant: Syngenta Participitations AG
    Inventors: Venkata Krishna Kishore, Zhigang Guo, Min Li, Daolong Wang, Libardo Andres Gutierrez Rojas, Joseph Dallas Clarke, V, Joseph Byrum