Patents by Inventor Zhigang Hao

Zhigang Hao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240132581
    Abstract: A bispecific antibody and a monoclonal antibody against human thymic stromal lymphopoietin (TSLP), and a use thereof.
    Type: Application
    Filed: June 16, 2021
    Publication date: April 25, 2024
    Inventors: Xueping ZHANG, Zhigang LIU, Xiaowei ZHOU, Junjie HU, Xiaobo HAO, Yulan LIU
  • Publication number: 20240101869
    Abstract: A protective film sequentially includes a release film, a low-viscosity silica gel layer, a high-viscosity silica gel layer and a substrate from top to bottom. A high-viscosity organosilicon adhesive, a hydroxyl-terminated polydimethylsiloxane, a curing agent, an additive and a solvent are coated on a polyester film. A low-viscosity organosilicon adhesive, the hydroxyl-terminated polydimethylsiloxane, the curing agent, the additive and the solvent are mixed and costed on the polyester film complex, which is pressed with the release film to obtain a silica gel protective film for fuel cells. A proton exchange membrane is coated with a catalyst to form a first catalyst layer, the protective film is adhered to the surface of the first catalyst layer, the second side of the proton exchange membrane is coated, and the silica gel protective film is peeled off after the coating is finished to obtain a CCM for a fuel cell.
    Type: Application
    Filed: September 22, 2021
    Publication date: March 28, 2024
    Inventors: Jinkai HAO, Hongjie ZHANG, Zhigang SHAO
  • Patent number: 11904040
    Abstract: Described herein are zinc-amino acid-lauryl sulfate complexes and oral care compositions comprising the same; and methods of making and using the same are also described.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: February 20, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Tatiana Brinzari, Michael Stranick, Chi-Yuan Cheng, Zhigang Hao, Iraklis Pappas, Greggory Marron, Viktor Dubovoy, Long Pan
  • Patent number: 11892435
    Abstract: Methods for measuring pH of gel, paste, colloid, and aqueous solutions, such as a consumer product, a food product, a pet food product, a beverage product, a pharmaceutical product, and/or a medical product, are provided. The method may include preparing a calibration curve of a chemical species including or having an acid dissociation constant. Preparing the calibration curve may include plotting a chemical shift of the chemical species relative to pH. The method may also include determining a chemical shift of a gel, paste, and colloid, aqueous solutions, such as a consumer product, a food product, a pet food product, a beverage product, a pharmaceutical product, and/or a medical product, including the chemical species.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: February 6, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Chi-Yuan Cheng, Zhigang Hao, Long Pan, Zolijargal Balsandorj
  • Publication number: 20240024219
    Abstract: The disclosure provides a natural sweetener system and oral care compositions comprising the same. In one aspect the natural sweetener system comprises a combination of a Rebaudioside A extract and enzymatically glucosylated steviol glycosides extract obtained from Stevia Rebaudiana Bertoni. The natural sweetener system of the disclosure unexpectedly improves the taste of oral care compositions masking the bitterness and metallic notes of Stevia Rebaudiana Bertoni.
    Type: Application
    Filed: December 9, 2021
    Publication date: January 25, 2024
    Applicant: Colgate-Palmolive Company
    Inventors: Michelle MIGUELINO, Fusong SUN, Zhigang HAO
  • Patent number: 11826448
    Abstract: The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: November 28, 2023
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Tatiana Brinzari, Long Pan, Ravi Subramanyam
  • Publication number: 20230060978
    Abstract: Described herein are zinc-amino acid-lauryl sulfate complexes and oral care compositions comprising the same; and methods of making and using the same are also described.
    Type: Application
    Filed: June 29, 2022
    Publication date: March 2, 2023
    Applicant: Colgate-Palmolive Company
    Inventors: Tatiana BRINZARI, Michael STRANICK, Chi-Yuan CHENG, Zhigang HAO, Iraklis PAPPAS, Greggory MARRON, Viktor DUBOVOY, Long PAN
  • Publication number: 20220395441
    Abstract: Described herein are methods for improving or maintaining the barrier integrity of gingival tissue comprising administering an oral care composition comprising a curcurninoid, to the oral cavity of a subject in need thereof.
    Type: Application
    Filed: December 17, 2020
    Publication date: December 15, 2022
    Applicants: Colgate-Palmolive Company, The University of North Carolina at Chapel Hill
    Inventors: Payal Arora, Zhigang HAO, Paul THOMSON, Manish MANDHARE, Yu WANG, Chi-Yuan CHENG, Harsh TRIVEDI, Long PAN, Silvana BARROS
  • Publication number: 20220241164
    Abstract: Described herein are—inter alia—complexes comprising a curcuminoid; and an anionic surfactant. Methods of making and using same are also described.
    Type: Application
    Filed: December 17, 2020
    Publication date: August 4, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Payal ARORA, Harsh Mahendra TRIVEDI, Zhigang HAO, Paul THOMSON, Manish MANDHARE, Yu WANG, Chi-Yuan CHENG, Long PAN
  • Patent number: 11395793
    Abstract: Described herein are zinc-amino acid-lauryl sulfate complexes and oral care compositions comprising the same; and methods of making and using the same are also described.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: July 26, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Tatiana Brinzari, Michael Stranick, Chi-Yuan Cheng, Zhigang Hao, Iraklis Pappas, Greggory Marron, Viktor Dubovoy, Long Pan
  • Publication number: 20220192940
    Abstract: A stabilized oral care composition comprises amino acids and traditionally incompatible flavor components. Methods of making and use are further provided.
    Type: Application
    Filed: April 25, 2019
    Publication date: June 23, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Erin LASKOWSKI, Victoria YEUNG, Mania BANKOVA, Long PAN, Yun XU, Peng YAN, Fusong SUN, Zheng YANG, Chi-Yuan CHENG, Tatiana BRINZARI
  • Publication number: 20220192952
    Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Application
    Filed: March 15, 2022
    Publication date: June 23, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang HAO, Chi-Yuan CHENG, Long PAN, Ravi SUBRAMANYAM
  • Patent number: 11278481
    Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: March 22, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Long Pan, Ravi Subramanyam
  • Patent number: 11117906
    Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: September 14, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Tatiana Brinzari, Long Pan, Ravi Subramanyam, Lauren Evans, Sergio Leite
  • Patent number: 11116707
    Abstract: Disclosed herein are improved methods for the synthesis of stannous pyrophosphate, as well as improved methods for the manufacture of oral care compositions comprising stannous pyrophosphate.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: September 14, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Long Pan, Yu Wang
  • Publication number: 20210275416
    Abstract: The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.
    Type: Application
    Filed: March 4, 2021
    Publication date: September 9, 2021
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Tatiana Brinzari, Long Pan, Ravi Subramanyam
  • Patent number: 11110042
    Abstract: Disclosed herein are improved methods for the synthesis of stannous pyrophosphate, as well as improved methods for the manufacture of oral care compositions comprising stannous pyrophosphate.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: September 7, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Paul Thomson, Long Pan, Tatiana Brinzari, Guofeng Xu, Sergio Leite, Yu Wang
  • Patent number: 11091502
    Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: August 17, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Tatiana Brinzari, Long Pan, Ravi Subramanyam
  • Patent number: 11065186
    Abstract: Provided are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride or tin (II) chloride and a tripolyphosphate salt, e.g., sodium tripolyphosphate (Na5P3O10), and oral care compositions comprising the complex and uses thereof.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: July 20, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Shiri Nawrocki, Viktor Dubovoy, Long Pan, Zhigang Hao, Nihal Dogu
  • Publication number: 20210085583
    Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Application
    Filed: December 19, 2017
    Publication date: March 25, 2021
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang HAO, Chi-Yuan CHENG, Long PAN, Ravi SUBRAMANYAM