Patents by Inventor Zhigang Hao

Zhigang Hao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250129141
    Abstract: Provided are a bispecific antibody and a monoclonal antibody for a tetanus toxin, and uses of the antibodies. The bispecific antibody contains a first antigen-binding fragment and a second antigen-binding fragment which bind to different epitopes of the tetanus toxin, and has activity of neutralizing the tetanus toxin. The monoclonal antibody binds to the tetanus toxin, and has activity of neutralizing the tetanus toxin.
    Type: Application
    Filed: November 19, 2020
    Publication date: April 24, 2025
    Applicants: BEIJING WISDOMAB BIOTECHNOLOGY CO., LTD, GENRIX (SHANGHAI) BIOPHARMACEUTICAL CO. LTD., CHONGQING GENRIX BIOPHARMACEUTICAL CO., LTD.
    Inventors: Zhigang LIU, Xiaowei ZHOU, Yulan LIU, Xiaobo HAO, Junjie HU
  • Publication number: 20250064697
    Abstract: Described herein are—inter alia—complexes comprising a curcuminoid; and an anionic surfactant. Methods of making and using same are also described.
    Type: Application
    Filed: November 13, 2024
    Publication date: February 27, 2025
    Applicant: Colgate-Palmolive Company
    Inventors: Payal ARORA, Harsh Mahendra TRIVEDI, Zhigang HAO, Paul THOMSON, Manish MANDHARE, Yu WANG, Chi-Yuan CHENG, Long PAN
  • Publication number: 20250057740
    Abstract: Disclosed herein are high water oral care compositions comprising a stannous ion source. which compositions have improved stability. Methods of making and using the compositions are also provided.
    Type: Application
    Filed: October 16, 2024
    Publication date: February 20, 2025
    Applicant: Colgate-Palmolive Company
    Inventors: Carl MYERS, Iraklis Pappas, Zhigang Hao, Saide Tang
  • Patent number: 12161743
    Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: December 10, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Long Pan, Ravi Subramanyam
  • Publication number: 20240277583
    Abstract: The present disclosure relates to a mouthwash composition containing an amine fluoride or amine base plus fluoride and an alkyl glucoside, as well as related methods for use of said compositions.
    Type: Application
    Filed: November 17, 2023
    Publication date: August 22, 2024
    Inventors: Changlong CHEN, Chi-Yuan Cheng, Hongwei Shen, Zhigang Hao, Svenia Schmid, Thomas Schollbach, Cornelia Scheffel
  • Publication number: 20240199538
    Abstract: This application relates to a novel chlorhexidine lauryl sulfate salt, which provides enhanced chlorhexidine stability and enhanced anti-bacterial activity, and to formulations and methods utilizing the novel salt.
    Type: Application
    Filed: December 6, 2023
    Publication date: June 20, 2024
    Inventors: Viktor DUBOVOY, Dailin Chen, Zhigang Hao, Xing He, Long Pan, Chi-Yuan Cheng, Yu Wang, Jake Salerno, Tatiana Brinzari
  • Publication number: 20240199295
    Abstract: A coated packaging article may include a packaging article and a coating. The packaging article may include a body having an interior surface, and the coating may be disposed over at least one portion of the interior surface of the body. The coating may include an edible oil and a surfactant. The coating may be in a liquid state on the interior surface inside the packaging article. The coating may be in direct contact with the at least one portion of the interior surface of the body.
    Type: Application
    Filed: December 15, 2022
    Publication date: June 20, 2024
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang HAO, Long Pan, Shiyou Xu
  • Publication number: 20240180800
    Abstract: Oral care compositions comprising a stannous ion source, tetrasodium pyrophosphate and an antioxidant, as well as to methods of using these compositions are disclosed herein. In some embodiments, the antioxidant is selected from ascorbyl phosphate and ascorbate.
    Type: Application
    Filed: December 5, 2023
    Publication date: June 6, 2024
    Applicant: Colgate-Palmolive Company
    Inventors: Tatiana BRINZARI, Chi-Yuan CHENG, Zhigang HAO, Long PAN, Cristina CASTRO, Robert D'AMBROGIO, Jean DENIS
  • Publication number: 20240180799
    Abstract: Oral care compositions comprising (i) a stannous ion source and (ii) a chelator or an antioxidant, as well as to methods of using these compositions are disclosed herein.
    Type: Application
    Filed: December 5, 2023
    Publication date: June 6, 2024
    Applicant: Colgate-Palmolive Company
    Inventors: Tatiana BRINZARI, Chi-Yuan CHENG, Zhigang HAO, Long PAN, Cristina CASTRO, Viktor DUBOVOY
  • Publication number: 20240165001
    Abstract: The present disclosure relates to oral care compositions containing amines, fluoride ion sources, zinc-containing compounds and one or more stilbenoids (e.g., resveratrol), as well as related methods for use of said compositions.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 23, 2024
    Inventors: Payal ARORA, Norbert HUBER, Zhigang HAO, Jeannine LOETSCHER, Damien ROGALLE
  • Patent number: 11904040
    Abstract: Described herein are zinc-amino acid-lauryl sulfate complexes and oral care compositions comprising the same; and methods of making and using the same are also described.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: February 20, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Tatiana Brinzari, Michael Stranick, Chi-Yuan Cheng, Zhigang Hao, Iraklis Pappas, Greggory Marron, Viktor Dubovoy, Long Pan
  • Patent number: 11892435
    Abstract: Methods for measuring pH of gel, paste, colloid, and aqueous solutions, such as a consumer product, a food product, a pet food product, a beverage product, a pharmaceutical product, and/or a medical product, are provided. The method may include preparing a calibration curve of a chemical species including or having an acid dissociation constant. Preparing the calibration curve may include plotting a chemical shift of the chemical species relative to pH. The method may also include determining a chemical shift of a gel, paste, and colloid, aqueous solutions, such as a consumer product, a food product, a pet food product, a beverage product, a pharmaceutical product, and/or a medical product, including the chemical species.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: February 6, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Chi-Yuan Cheng, Zhigang Hao, Long Pan, Zolijargal Balsandorj
  • Publication number: 20240024219
    Abstract: The disclosure provides a natural sweetener system and oral care compositions comprising the same. In one aspect the natural sweetener system comprises a combination of a Rebaudioside A extract and enzymatically glucosylated steviol glycosides extract obtained from Stevia Rebaudiana Bertoni. The natural sweetener system of the disclosure unexpectedly improves the taste of oral care compositions masking the bitterness and metallic notes of Stevia Rebaudiana Bertoni.
    Type: Application
    Filed: December 9, 2021
    Publication date: January 25, 2024
    Applicant: Colgate-Palmolive Company
    Inventors: Michelle MIGUELINO, Fusong SUN, Zhigang HAO
  • Patent number: 11826448
    Abstract: The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: November 28, 2023
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Tatiana Brinzari, Long Pan, Ravi Subramanyam
  • Publication number: 20230060978
    Abstract: Described herein are zinc-amino acid-lauryl sulfate complexes and oral care compositions comprising the same; and methods of making and using the same are also described.
    Type: Application
    Filed: June 29, 2022
    Publication date: March 2, 2023
    Applicant: Colgate-Palmolive Company
    Inventors: Tatiana BRINZARI, Michael STRANICK, Chi-Yuan CHENG, Zhigang HAO, Iraklis PAPPAS, Greggory MARRON, Viktor DUBOVOY, Long PAN
  • Publication number: 20220395441
    Abstract: Described herein are methods for improving or maintaining the barrier integrity of gingival tissue comprising administering an oral care composition comprising a curcurninoid, to the oral cavity of a subject in need thereof.
    Type: Application
    Filed: December 17, 2020
    Publication date: December 15, 2022
    Applicants: Colgate-Palmolive Company, The University of North Carolina at Chapel Hill
    Inventors: Payal Arora, Zhigang HAO, Paul THOMSON, Manish MANDHARE, Yu WANG, Chi-Yuan CHENG, Harsh TRIVEDI, Long PAN, Silvana BARROS
  • Publication number: 20220241164
    Abstract: Described herein are—inter alia—complexes comprising a curcuminoid; and an anionic surfactant. Methods of making and using same are also described.
    Type: Application
    Filed: December 17, 2020
    Publication date: August 4, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Payal ARORA, Harsh Mahendra TRIVEDI, Zhigang HAO, Paul THOMSON, Manish MANDHARE, Yu WANG, Chi-Yuan CHENG, Long PAN
  • Patent number: 11395793
    Abstract: Described herein are zinc-amino acid-lauryl sulfate complexes and oral care compositions comprising the same; and methods of making and using the same are also described.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: July 26, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Tatiana Brinzari, Michael Stranick, Chi-Yuan Cheng, Zhigang Hao, Iraklis Pappas, Greggory Marron, Viktor Dubovoy, Long Pan
  • Publication number: 20220192940
    Abstract: A stabilized oral care composition comprises amino acids and traditionally incompatible flavor components. Methods of making and use are further provided.
    Type: Application
    Filed: April 25, 2019
    Publication date: June 23, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Erin LASKOWSKI, Victoria YEUNG, Mania BANKOVA, Long PAN, Yun XU, Peng YAN, Fusong SUN, Zheng YANG, Chi-Yuan CHENG, Tatiana BRINZARI
  • Publication number: 20220192952
    Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Application
    Filed: March 15, 2022
    Publication date: June 23, 2022
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang HAO, Chi-Yuan CHENG, Long PAN, Ravi SUBRAMANYAM