Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: An ultraviolet curing pipeline repair robot is provided. The ultraviolet radiation lamp comprises a lamp panel distributed at the circumference of frame body and ultraviolet LED lamps uniformly distributed on the lamp panel. Each frame body is provided with a spring sleeve circumferentially rotating around frame body. Each driving arm is formed by cross connection of two supporting arms. One end of the first supporting arm is fixedly arranged on frame body, one end of the second supporting arm is connected with a driving arm nut, and the driving arm nut is sleeved the spring sleeve and matched with the screw thread on the outer surface of the spring sleeve. The inside of a tail section of frame body is provided with a network transmission module and a first power carrier module connected with a second aviation plug. A cable is a power cable.

Abstract: Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: A pipeline robot, a pipeline video signal acquisition and transmission device, and a pipeline detection system and method. The pipeline robot comprises a camera module and a crawler, wherein the camera module comprises a front-view digital camera, a first microprocessor and a rotation motor; the crawler comprises a frame body, wheels on the both sides of the frame body, a driving motor, a sensor group, a second microprocessor, a network transmission module and a first power carrier module; a cable reel comprises a power line, a second power carrier module, a fourth microprocessor and a network communication module; and an acquisition control terminal is a mobile terminal provided with a detection module.

Abstract: Disclosed is a door-and-window system, in which a handle component (121) is assembled via a transmission component (123) with a force receiving portion (12231) of a movable door-and-window assembly component (122). When the handle component (121) is operated, the force receiving portion (12231) moves along a first guide groove (12211) thanks to the force transmission effect of the transmission component (123), and at the same time a driving portion (12232) moves along a second guide groove (12221). Due to an assembly relationship between a guide member (1224) and a third guide groove (12212), a first base seat (1221) translates relative to a second base seat (1222) along a direction of the third guide groove (12212), such that a movable door-and-window (11) can abut tightly against or move away from a sealing member (24) on a door-and-window mounting profile (2).

Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Provided are an auxiliary spring, a new-belted diaphragm and an air spring. The air spring comprises an auxiliary spring and a new-belted diaphragm arranged above the auxiliary spring, the auxiliary spring comprises a rim (1), which has a reversed convex structure and has a downward support column on a bottom surface thereof; a rubber piece (2), a center of which has a concave hole for enclosing the whole support column and a top of which contacts with a concave bottom surface of the rim (1); and a base plate (3); the new-belted diaphragm comprises a top cover (41) and a diaphragm body (42) that has a hollow structure and is installed below the top cover (41); a top of the diaphragm body (42) is an annular opening and is connected with the top cover (41), and a middle vertical portion thereof is a girdle portion.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variablesRA, RAA, subscipt n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: An optical device for focusing synchrotron radiation light source is disclosed according to the present invention, so as to improve the uniformity of the light intensity of the emergent light, to increase the divergence the emergent light, and to restrain the synchrotron radiation higher harmonics. An outline generatrix of the optical device is a quadratic curve segment or a combination of a plurality of quadratic curve segments, the opening orientations of which are the same, and the optical device includes: a plurality of capillary bodies made of transparent material, wherein the capillary bodies in a center region have a solid construe; the capillary bodies in a periphery region located outside of the center region have a hollow structure.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: An endoscopic device with cleaning function includes an image display, an operating handle, an air pressure tube coupler, a snake tube assembly, a liquid-guiding container, a spray switch, and a liquid-guiding tube; and the snake tube assembly is mounted on the operating handle and wired connected with the image display; the operating handle is provided with a signal transmitting terminal, and the snake tube assembly is wired connected with the signal transmitting terminal; the image display is provided with a signal receiving terminal for wireless signal transmission with the signal transmitting terminal. Under the premise of guaranteeing the acquisition of image functions, the images can be acquired by a wired way of snake tube assembly and image display, or by wireless transmission via the signal transmitting terminal and signal receiving terminal of the snake tube assembly, which can facilitate the cleaning and can check and inspect the surface of objects.

Abstract: An optical device for focusing synchrotron radiation light source is disclosed according to the present invention, so as to improve the uniformity of the light intensity of the emergent light, to increase the divergence the emergent light, and to restrain the synchrotron radiation higher harmonics. An outline generatrix of the optical device is a quadratic curve segment or a combination of a plurality of quadratic curve segments, the opening orientations of which are the same, and the optical device includes: a plurality of capillary bodies made of transparent material, wherein the capillary bodies in a center region have a solid construe; the capillary bodies in a periphery region located outside of the center region have a hollow structure.