Patents by Inventor Zhihong Li

Zhihong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160167215
    Abstract: The disclosure relates to an arm holder for a pole-handled tool such as a broom, a mop, a squeegee, etc. that allows effective use of the pole-handled tool with only one hand. The arm holder comprises an arm grip having an arm-holding structure; and an attachment portion capable of attaching the arm grip to the pole-handled tool; wherein the arm-holding structure is capable of receiving an arm positioned within the arm-holding structure while a corresponding hand of the same arm grasps the pole handle, the pole handle acting as a lever where the corresponding hand forms a fulcrum of the lever.
    Type: Application
    Filed: December 11, 2014
    Publication date: June 16, 2016
    Inventor: Zhihong Li
  • Patent number: 9359355
    Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: June 7, 2016
    Assignee: AMGEN INC.
    Inventors: Xiaoqi Chen, Kang Dai, Jason Duquette, Michael W. Gribble, Jr., Justin N. Huard, Kathleen S. Keegan, Zhihong Li, Sarah E. Lively, Lawrence R. McGee, Mark L. Ragains, Xianghong Wang, Margaret F. Weidner, Jian Zhang
  • Publication number: 20160137667
    Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
    Type: Application
    Filed: January 27, 2016
    Publication date: May 19, 2016
    Applicant: AMGEN INC.
    Inventors: Michael D. BARTBERGER, Ana GONZALEZ BUENROSTRO, Hilary Plake BECK, Xiaoqi CHEN, Richard Victor CONNORS, Jeffrey DEIGNAN, Jason A. DUQUETTE, John EKSTEROWICZ, Benjamin FISHER, Brian M. FOX, Jiasheng FU, Zice FU, Felix GONZALEZ LOPEZ DE TURISO, Michael W. GRIBBLE, JR., Darin J. GUSTIN, Julie A. HEATH, Xin HUANG, XianYun JIAO, Michael G. JOHNSON, Frank KAYSER, David John KOPECKY, SuJen LAI, Yihong LI, Zhihong LI, Jiwen LIU, Jonathan D. LOW, Brian S. LUCAS, Zhihua MA, Lawrence R. MCGEE, Joel MCINTOSH, Dustin L. MCMINN, Julio C. MEDINA, Jeffrey Thomas MIHALIC, Steven H. OLSON, Yosup REW, Phillip M. ROVETO, Daqing SUN, Xiaodong WANG, Yingcai WANG, Xuelei YAN, Ming YU, Jiang ZHU
  • Patent number: 9296736
    Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: March 29, 2016
    Assignee: Amgen INC.
    Inventors: Michael D. Bartberger, Ana Gonzalez Buenrostro, Hilary Plake Beck, Xiaoqi Chen, Richard Victor Connors, Jeffrey Deignan, Jason A. Duquette, John Eksterowicz, Benjamin Fisher, Brian M. Fox, Jiasheng Fu, Zice Fu, Felix Gonzalez Lopez De Turiso, Michael W. Gribble, Darin J. Gustin, Julie A. Heath, Xin Huang, XianYun Jiao, Michael G. Johnson, Frank Kayser, David John Kopecky, SuJen Lai, Yihong Li, Zhihong Li, Jiwen Liu, Jonathan D. Low, Brian S. Lucas, Zhihua Ma, Lawrence R. McGee, Joel McIntosh, Dustin L. McMinn, Julio C. Medina, Jeffrey Thomas Mihalic, Steven H. Olson, Yosup Rew, Philip M. Roveto, Daqing Sun, Xiaodong Wang, Yingcai Wang, Xuelei Yan, Ming Yu, Jiang Zhu
  • Publication number: 20160068545
    Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 10, 2016
    Applicant: AMGEN INC.
    Inventors: Sean P. BROWN, Yunxiao LI, Mike Elias LIZARZABURU, Brian S. Lucas, Nick A. Paras, Joshua Taygerly, Marc VIMOLRATANA, Xianghong Wang, Ming Yu, Manuel ZANCANELLA, Liusheng Zhu, Ana GONZALEZ BUENROSTRO, Zhihong LI
  • Patent number: 9266897
    Abstract: Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberine alkaloids, a preparation method for same and pharmaceutical uses thereof. The derivatives of protoberberine biological alkaloids or the physiologically acceptable salts thereof show activity inhibiting ulcerative colitis and can be used in the preparation of drugs for same.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: February 23, 2016
    Assignee: Institute of Materia Medica, Chinese Academy of Medical Sciences
    Inventors: Hailin Qin, Wenjie Wang, Zhihui Zhang, Lianqiu Wu, Anjun Deng, Jinqian Yu, Zhihong Li
  • Publication number: 20160028487
    Abstract: An optical transceiver comprises a transmitter configured to transmit a first signal, and a receiver coupled to the transmitter and configured to receive a first compensation, wherein the first compensation is based on a pattern-dependent analysis of the first signal, and provide the first compensation to the transmitter, wherein the transmitter is further configured to compensate a second signal based on the first compensation to form a first compensated signal, and transmit the first compensated signal. An optical transmitter comprises a digital signal processor (DSP) comprising a compensator, a digital-to-analog converter (DAC) coupled to the DSP, a radio frequency amplifier (RFA) coupled to the DAC, and an electrical-to-optical converter (EOC) coupled to the RFA. An optical receiver comprises an optical-to-electrical converter (OEC), an analog-to-digital converter (ADC) coupled to the OEC, and a digital signal processor (DSP) coupled to the ADC and comprising a calibrator.
    Type: Application
    Filed: July 25, 2014
    Publication date: January 28, 2016
    Inventors: Clarence Kan, Fei Zhu, Zhihong Li
  • Publication number: 20150353542
    Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.
    Type: Application
    Filed: December 11, 2013
    Publication date: December 10, 2015
    Applicant: AMGEN INC.
    Inventors: Zhimei DU, John Douglas MCCARTER, Pranhitha REDDY, Andrew William SNOWDEN, Lawrence R. MCGEE, John Gordon ALLEN, David Lawrence TREIBER, Kathleen KEEGAN, Zhihong LI
  • Publication number: 20150211096
    Abstract: The present invention provides an alloy for magnesium and magnesium alloy grain refinement, and a preparation method thereof, the alloy as a grain refiner being an aluminum-zirconium-boron intermediate alloy comprising the following chemical compositions by weight percent: 5-20% of Zr, 0.5-4% of B, and the balance being Al. The invention can achieve the following technical effect: an intermediate alloy with strong nucleation capability and excellent capability of magnesium and magnesium alloy grain refinement is invented and its preparation method is provided. This kind of grain refiner can be applied to casting deformation plastic processing of magnesium and magnesium alloy profiles, with high degree of refinement, to promote the extensive industrial applications of magnesium.
    Type: Application
    Filed: November 21, 2012
    Publication date: July 30, 2015
    Inventors: Xuemin Chen, JUN Yang, Zhihong Li, Weiping Wu, Shiming Wei
  • Publication number: 20150203978
    Abstract: The disclosure provides a method for preparing an electrolyte and an electrolyte replenishment system during an electrolytic process. The method includes the following steps: Step A: placing aluminum in a reactor, vacuumizing the reactor and feeding an inert gas, heating the reactor to 700-850 degrees centigrade, and adding one or more of potassium fluozirconate, potassium fluoborate, sodium hexafluorozirconate and sodium fluoroborate; and Step B: stirring the reactants for 4-6 hours and extracting the upper molten liquid to obtain an electrolyte replenishment system during an aluminum electrolysis process. The disclosure has the following beneficial effects: when used in the aluminum electrolysis industry, the electrolyte system provided herein can be directly used as an aluminum electrolyte or a replenishment system in an electrolyte without changing existing electrolysis technology to significantly reduce an electrolysis temperature during an aluminum electrolysis process.
    Type: Application
    Filed: November 21, 2012
    Publication date: July 23, 2015
    Inventors: Xuemin Chen, Jun Yang, Zhihong Li, Weiping Wu, Shiming Wei
  • Patent number: 9083570
    Abstract: A method comprising receiving digital samples from an optical communication system, assigning the samples into bins based on signal levels of the samples, computing an average signal level for each bin, determining a level adjustment transformation function for the samples based on the average signal levels of the bins, and applying the level adjustment transformation function to the samples. Also, disclosed is an optical receiver comprising a frontend configured to receive an optical signal over an optical channel, and convert the optical signal into a plurality of sequences of digital samples, and a processor coupled to the frontend and configured to perform a channel equalization on the samples of the sequences, assign the channel equalized samples of each sequence into bins based on signal levels of the channel equalized samples, determine a level adjustment transformation function for each sequence, and apply the level adjustment transformation function to each sequence.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: July 14, 2015
    Assignee: Futurewei Technologies, Inc.
    Inventors: Clarence Kan, Zhihong Li, Fei Zhu
  • Publication number: 20150183645
    Abstract: A method for preparing zirconium boride and synchronously preparing a cryolite is provided which includes the following steps: Step A: placing aluminum in a reactor, heating the reactor to 700-850 degrees centigrade, and adding the mixture of fluorozirconate and fluoborate; and Step B: stirring the reactants for 4-6 hours and extracting the upper molten liquid to obtain a cryolite, wherein the lower substance is zirconium boride. The disclosure has the following beneficial effects: the new zirconium boride preparation method provided herein is simple in preparation flow and the device used, short in preparation period and high in reaction efficiency, the prepared zirconium boride with many contact angles has a large specific surface area and contains a controllable amount of aluminum.
    Type: Application
    Filed: November 26, 2012
    Publication date: July 2, 2015
    Inventors: Xuemin Chen, Jun Yang, Zhihong Li, Weiping Wu, Shiming Wei
  • Publication number: 20150175436
    Abstract: A method for preparing an aluminum-zirconium-boron alloy and synchronously preparing a cryolite is provided. The method includes the following steps: Step A: placing aluminum in a reactor, heating the reactor to 700-850 degrees centigrade, and adding a mixture consisting of fluorozirconate and fluoborate in a molar ratio of x: y into the reactor; Step B: stirring the reactants for 4-6 hours and extracting the upper molten liquid to obtain a cryolite, wherein the lower substance is an aluminum-zirconium-boron alloy, and aluminum is added in an excess amount. The method provided herein for preparing an aluminum-zirconium-boron alloy which is mild in reaction condition, easy to control and simple in technical flow can prepare a high-quality product through a complete reaction, besides, the use of the synchronously prepared low molecular ratio cryolites (KF.AlF3 and NaF.AlF3) in the aluminum electrolysis industry can achieve a proper electrical conductivity.
    Type: Application
    Filed: November 26, 2012
    Publication date: June 25, 2015
    Inventors: Xuemin Chen, Jun Yang, Zhihong Li, Weiping Wu, Shiming Wei
  • Patent number: 8980903
    Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: March 17, 2015
    Assignee: Amgen Inc.
    Inventors: Richard V. Connors, Kang Dai, John Eksterowicz, Pingchen Fan, Benjamin Fisher, Jiasheng Fu, Kexue Li, Zhihong Li, Lawrence R. McGee, Rajiv Sharma, Xiaodong Wang, Dustin L. McMinn, Jeffrey T. Mihalic, Jeffrey Deignan
  • Publication number: 20150031717
    Abstract: Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberine alkaloids, a preparation method for same and pharmaceutical uses thereof. The derivatives of protoberberine biological alkaloids or the physiologically acceptable salts thereof show activity inhibiting ulcerative colitis and can be used in the preparation of drugs for same.
    Type: Application
    Filed: October 24, 2012
    Publication date: January 29, 2015
    Applicant: Institute of Materia Medica, Chinese Academy of Medical Sciences
    Inventors: Hailin Qin, Wenjie Wang, Zhihui Zhang, Lianqiu Wu, Anjun Deng, Jinqian Yu, Zhihong Li
  • Patent number: 8936710
    Abstract: The disclosure provides low-molecular-ratio cryolite for aluminum electrolytic industry, which consists of potassium cryolite and sodium cryolite with a mole ratio of 1:1˜1:3, wherein the molecular formula of the potassium cryolite is mKF.AlF3 and the molecular formula of the sodium cryolite is nNaF.AlF3, where m=1˜1.5 and n=1˜1.5. When the low-molecular-ratio cryolite provided by the disclosure is applied to the aluminum electrolytic industry, electrolytic temperature and power consumption can be reduced and electrolytic efficiency is improved.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: January 20, 2015
    Assignee: Shenzhen Sunxing Light Alloys Materials Co., Ltd.
    Inventors: Xuemin Chen, Jun Yang, Zhihong Li, Weiping Wu
  • Patent number: 8930433
    Abstract: An embodiment of an apparatus performs a floating-point multiply-add process on a first multiplicand, a second multiplicand, and an addend. A leading 0 bit is added to a mantissa of the first multiplicand to form an expanded first mantissa, and a partial-product multiplication is performed on the expanded first mantissa and a mantissa of the second multiplicand to produce partial-product sum and a partial-product carry mantissas. Leading bits of the partial-product sum and carry mantissas are changed to 0 bits if they are both 1 bits, and the partial-product sum and the partial-product carry are shifted right according to an exponent difference of a product of the first multiplicand and the second multiplicand. Otherwise both the partial-product sum and carry mantissas are arithmetically shifted right according to the exponent difference. The first and second multiplicands and the addend can be complex numbers.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: January 6, 2015
    Assignee: Futurewei Technologies, Inc.
    Inventors: Zhihong Li, Tong Sun, Zhikun Cheng
  • Publication number: 20140350244
    Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: Richard V. Connors, Kang DAI, John EKSTEROWICZ, Pingchen FAN, Benjamin FISHER, Jiasheng FU, Kexue LI, Zhihong LI, Lawrence R. MCGEE, Rajiv SHARMA, Xiaodong WANG, Dustin L. MCMINN, Jeffrey T. MIHALIC, Jeffrey DEIGNAN
  • Patent number: 8883137
    Abstract: A nutritional composition comprising by weight: between 0.05 and 30% selenium-enriched yeast; between 1 and 90% yeast beta-glucan; between 0.5 and 60% Vitamin C; and between 0.5 and 40% Vitamin E. The composition features anti-oxidative, anti-aging, cancer-preventing, and immune-stimulating properties.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: November 11, 2014
    Assignee: Angel Yeast Co., Ltd.
    Inventors: Xuefeng Yu, Zhihong Li, Minghua Yu, Juan Yao, Yan Zhang, Yamin Zhu
  • Publication number: 20140315895
    Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 23, 2014
    Inventors: Michael D. Bartberger, Ana Gonzalez Buenrostro, Hilary Plake Beck, Xiaoqi Chen, Richard Victor Connors, Jeffrey Deignan, Jason A. Duquette, John Eksterowicz, Benjamin Fisher, Brian M. Fox, Jiasheng Fu, Zice Fu, Felix Gonzalez Lopez de Turiso, Michael W. Gribble, Darin J. Gustin, Julie A. Heath, Xin Huang, XianYun Jiao, Michael G. Johnson, Frank Kayser, David John Kopecky, SuJen Lai, Yihong Li, Zhihong Li, Jiwen Liu, Jonathan D. Low, Brian S. Lucas, Zhihua MA, Lawrence R. McGee, Joel Mcintosh, Dustin L. McMinn, Julio C. Medina, Jeffrey Thomas Mihalic, Steven H. Olson, Yosup Rew, Philip M. Roveto, Daqing Sun, Xiaodong Wang, Yingcai Wang, Xuelei Yan, Ming Yu, Jiang Zhu