Abstract: An optical transceiver comprises a transmitter configured to transmit a first signal, and a receiver coupled to the transmitter and configured to receive a first compensation, wherein the first compensation is based on a pattern-dependent analysis of the first signal, and provide the first compensation to the transmitter, wherein the transmitter is further configured to compensate a second signal based on the first compensation to form a first compensated signal, and transmit the first compensated signal. An optical transmitter comprises a digital signal processor (DSP) comprising a compensator, a digital-to-analog converter (DAC) coupled to the DSP, a radio frequency amplifier (RFA) coupled to the DAC, and an electrical-to-optical converter (EOC) coupled to the RFA. An optical receiver comprises an optical-to-electrical converter (OEC), an analog-to-digital converter (ADC) coupled to the OEC, and a digital signal processor (DSP) coupled to the ADC and comprising a calibrator.

Abstract: An additive manufacturing apparatus with assembled and dissembled feature includes a base having a cavity, a control circuit is installed in the cavity. An upper surface of the base defines a through hole for an electrical socket extending through the base and being exposed on the upper surface. A stand connecting member is provided on the upper surface. A material deposition device for depositing material is provided with a beam connecting member. A movable platform capable of moving along a Y axis direction for carrying the deposited material is provided with a column connecting member. A stand having a column, a beam is provided on a top of the column. The beam is provided with a material, deposition device connecting member. The column is provided with a movable platform connecting member. A bottom of the column is provided with at least one base connecting member corresponding to the base.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A first optical transceiver node comprises: a laser configured to emit an input optical signal; a first splitter coupled to the laser and configured to split the input optical signal into a local oscillator (LO) optical signal and an unmodulated optical signal; and a receiver coupled to the first splitter and configured to: receive the LO optical signal from the first splitter; receive a modulated optical signal from a second optical transceiver node, wherein the modulated optical signal is a modulated version of the unmodulated optical signal; and perform phase noise cancellation of the modulated optical signal using the LO optical signal.

Abstract: An optical transceiver comprises a transmitter configured to transmit a first signal, and a receiver coupled to the transmitter and configured to receive a first compensation, wherein the first compensation is based on a pattern-dependent analysis of the first signal, and provide the first compensation to the transmitter, wherein the transmitter is further configured to compensate a second signal based on the first compensation to form a first compensated signal, and transmit the first compensated signal. An optical transmitter comprises a digital signal processor (DSP) comprising a compensator, a digital-to-analog converter (DAC) coupled to the DSP, a radio frequency amplifier (REA) coupled to the DAC, and an electrical-to-optical converter (EOC) coupled to the REA. An optical receiver comprises an optical-to-electrical converter (OEC), an analog-to-digital converter (ADC) coupled to the OEC, and a digital signal processor (DSP) coupled to the ADC and comprising a calibrator.

Abstract: The disclosure provides an electrolyte supplement system in an aluminum electrolysis process, which includes low-molecular-ratio cryolite, wherein the low-molecular-ratio cryolite is selected from mKF.AlF3, nNaF.AlF3 or mixture thereof, where m=1˜1.5 and n=1˜1.5. When the electrolyte supplement system provided by the disclosure is applied to the aluminum electrolytic industry, electrolytic temperature can be reduced obviously in the aluminum electrolysis process without changing the existing electrolytic process; thus, power consumption is reduced, volatilization loss of fluoride is reduced and the comprehensive cost of production is reduced.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The disclosure relates to an arm holder for a pole-handled tool such as a broom, a mop, a squeegee, etc. that allows effective use of the pole-handled tool with only one hand. The arm holder comprises an arm grip having an arm-holding structure; and an attachment portion capable of attaching the arm grip to the pole-handled tool; wherein the arm-holding structure is capable of receiving an arm positioned within the arm-holding structure while a corresponding hand of the same arm grasps the pole handle, the pole handle acting as a lever where the corresponding hand forms a fulcrum of the lever.

Abstract: An optical transceiver comprises a transmitter configured to transmit a first signal, and a receiver coupled to the transmitter and configured to receive a first compensation, wherein the first compensation is based on a pattern-dependent analysis of the first signal, and provide the first compensation to the transmitter, wherein the transmitter is further configured to compensate a second signal based on the first compensation to form a first compensated signal, and transmit the first compensated signal. An optical transmitter comprises a digital signal processor (DSP) comprising a compensator, a digital-to-analog converter (DAC) coupled to the DSP, a radio frequency amplifier (RFA) coupled to the DAC, and an electrical-to-optical converter (EOC) coupled to the RFA. An optical receiver comprises an optical-to-electrical converter (OEC), an analog-to-digital converter (ADC) coupled to the OEC, and a digital signal processor (DSP) coupled to the ADC and comprising a calibrator.

Abstract: A method for preparing an aluminum-zirconium-boron alloy and synchronously preparing a cryolite is provided. The method includes the following steps: Step A: placing aluminum in a reactor, heating the reactor to 700-850 degrees centigrade, and adding a mixture consisting of fluorozirconate and fluoborate in a molar ratio of x: y into the reactor; Step B: stirring the reactants for 4-6 hours and extracting the upper molten liquid to obtain a cryolite, wherein the lower substance is an aluminum-zirconium-boron alloy, and aluminum is added in an excess amount. The method provided herein for preparing an aluminum-zirconium-boron alloy which is mild in reaction condition, easy to control and simple in technical flow can prepare a high-quality product through a complete reaction, besides, the use of the synchronously prepared low molecular ratio cryolites (KF.AlF3 and NaF.AlF3) in the aluminum electrolysis industry can achieve a proper electrical conductivity.

Abstract: The invention provides a preparation process of transition metal boride, comprising the following steps: A) aluminum is put in a reactor, inert gas is fed into the reactor after evacuation, the reactor is heated up to 700 to 800° C. and then added with dry potassium fluoborate or sodium fluoborate, monomer boron and cryolite are generated by rapid stirring and reaction for 4 to 6 hours, and the molten liquid at the upper layer is sucked out and the monomer boron is obtained by means of separation; and B) the obtained monomer boron is added with transition metal for reaction at the temperature from 1800 to 2200° C. in order to generate corresponding transition metal boride.

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract: A first optical transceiver node comprises: a laser configured to emit an input optical signal; a first splitter coupled to the laser and configured to split the input optical signal into a local oscillator (LO) optical signal and an unmodulated optical signal; and a receiver coupled to the first splitter and configured to: receive the LO optical signal from the first splitter; receive a modulated optical signal from a second optical transceiver node, wherein the modulated optical signal is a modulated version of the unmodulated optical signal; and perform phase noise cancellation of the modulated optical signal using the LO optical signal.

Abstract: An additive manufacturing apparatus with assembled and dissembled feature includes a base having a cavity, a control circuit is installed in the cavity. An upper surface of the base defines a through hole for an electrical socket extending through the base and being exposed on the upper surface. A stand connecting member is provided on the upper surface. A material deposition device for depositing material is provided with a beam connecting member. A movable platform capable of moving along a Y axis direction for carrying the deposited material is provided with a column connecting member. A stand having a column, a beam is provided on a top of the column. The beam is provided with a material, deposition device connecting member. The column is provided with a movable platform connecting member.

Abstract: An apparatus comprises an uncooled laser; a splitter coupled to the laser; a first wavelength component coupled to the splitter; a local oscillator (LO) port coupled to the first wavelength component; a modulator coupled to the splitter; a second wavelength component coupled to the modulator; and a signal port coupled to the second wavelength component. A method comprises emitting an input light; splitting the input light into a first local oscillator (LO) optical signal and a first unmodulated optical signal; modulating the first unmodulated optical signal using polarization-multiplexed, high-order modulation to produce a first modulated optical signal; transmitting the first LO optical signal to a first duplex fiber; and transmitting the first modulated optical signal to a second duplex fiber.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The disclosure relates to an arm holder for a pole-handled tool such as a broom, a mop, a squeegee, etc. that allows effective use of the pole-handled tool with only one hand. The arm holder comprises an arm grip having an arm-holding structure; and an attachment portion capable of attaching the arm grip to the pole-handled tool; wherein the arm-holding structure is capable of receiving an arm positioned within the arm-holding structure while a corresponding hand of the same arm grasps the pole handle, the pole handle acting as a lever where the corresponding hand forms a fulcrum of the lever.

Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.