Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberine alkaloids, a preparation method for same and pharmaceutical uses thereof. The derivatives of protoberberine biological alkaloids or the physiologically acceptable salts thereof show activity inhibiting ulcerative colitis and can be used in the preparation of drugs for same.

Abstract: An optical transceiver comprises a transmitter configured to transmit a first signal, and a receiver coupled to the transmitter and configured to receive a first compensation, wherein the first compensation is based on a pattern-dependent analysis of the first signal, and provide the first compensation to the transmitter, wherein the transmitter is further configured to compensate a second signal based on the first compensation to form a first compensated signal, and transmit the first compensated signal. An optical transmitter comprises a digital signal processor (DSP) comprising a compensator, a digital-to-analog converter (DAC) coupled to the DSP, a radio frequency amplifier (RFA) coupled to the DAC, and an electrical-to-optical converter (EOC) coupled to the RFA. An optical receiver comprises an optical-to-electrical converter (OEC), an analog-to-digital converter (ADC) coupled to the OEC, and a digital signal processor (DSP) coupled to the ADC and comprising a calibrator.

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

Abstract: The present invention provides an alloy for magnesium and magnesium alloy grain refinement, and a preparation method thereof, the alloy as a grain refiner being an aluminum-zirconium-boron intermediate alloy comprising the following chemical compositions by weight percent: 5-20% of Zr, 0.5-4% of B, and the balance being Al. The invention can achieve the following technical effect: an intermediate alloy with strong nucleation capability and excellent capability of magnesium and magnesium alloy grain refinement is invented and its preparation method is provided. This kind of grain refiner can be applied to casting deformation plastic processing of magnesium and magnesium alloy profiles, with high degree of refinement, to promote the extensive industrial applications of magnesium.

Abstract: The disclosure provides a method for preparing an electrolyte and an electrolyte replenishment system during an electrolytic process. The method includes the following steps: Step A: placing aluminum in a reactor, vacuumizing the reactor and feeding an inert gas, heating the reactor to 700-850 degrees centigrade, and adding one or more of potassium fluozirconate, potassium fluoborate, sodium hexafluorozirconate and sodium fluoroborate; and Step B: stirring the reactants for 4-6 hours and extracting the upper molten liquid to obtain an electrolyte replenishment system during an aluminum electrolysis process. The disclosure has the following beneficial effects: when used in the aluminum electrolysis industry, the electrolyte system provided herein can be directly used as an aluminum electrolyte or a replenishment system in an electrolyte without changing existing electrolysis technology to significantly reduce an electrolysis temperature during an aluminum electrolysis process.

Abstract: A method comprising receiving digital samples from an optical communication system, assigning the samples into bins based on signal levels of the samples, computing an average signal level for each bin, determining a level adjustment transformation function for the samples based on the average signal levels of the bins, and applying the level adjustment transformation function to the samples. Also, disclosed is an optical receiver comprising a frontend configured to receive an optical signal over an optical channel, and convert the optical signal into a plurality of sequences of digital samples, and a processor coupled to the frontend and configured to perform a channel equalization on the samples of the sequences, assign the channel equalized samples of each sequence into bins based on signal levels of the channel equalized samples, determine a level adjustment transformation function for each sequence, and apply the level adjustment transformation function to each sequence.

Abstract: A method for preparing zirconium boride and synchronously preparing a cryolite is provided which includes the following steps: Step A: placing aluminum in a reactor, heating the reactor to 700-850 degrees centigrade, and adding the mixture of fluorozirconate and fluoborate; and Step B: stirring the reactants for 4-6 hours and extracting the upper molten liquid to obtain a cryolite, wherein the lower substance is zirconium boride. The disclosure has the following beneficial effects: the new zirconium boride preparation method provided herein is simple in preparation flow and the device used, short in preparation period and high in reaction efficiency, the prepared zirconium boride with many contact angles has a large specific surface area and contains a controllable amount of aluminum.

Abstract: A method for preparing an aluminum-zirconium-boron alloy and synchronously preparing a cryolite is provided. The method includes the following steps: Step A: placing aluminum in a reactor, heating the reactor to 700-850 degrees centigrade, and adding a mixture consisting of fluorozirconate and fluoborate in a molar ratio of x: y into the reactor; Step B: stirring the reactants for 4-6 hours and extracting the upper molten liquid to obtain a cryolite, wherein the lower substance is an aluminum-zirconium-boron alloy, and aluminum is added in an excess amount. The method provided herein for preparing an aluminum-zirconium-boron alloy which is mild in reaction condition, easy to control and simple in technical flow can prepare a high-quality product through a complete reaction, besides, the use of the synchronously prepared low molecular ratio cryolites (KF.AlF3 and NaF.AlF3) in the aluminum electrolysis industry can achieve a proper electrical conductivity.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

Abstract: Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberine alkaloids, a preparation method for same and pharmaceutical uses thereof. The derivatives of protoberberine biological alkaloids or the physiologically acceptable salts thereof show activity inhibiting ulcerative colitis and can be used in the preparation of drugs for same.

Abstract: The disclosure provides low-molecular-ratio cryolite for aluminum electrolytic industry, which consists of potassium cryolite and sodium cryolite with a mole ratio of 1:1˜1:3, wherein the molecular formula of the potassium cryolite is mKF.AlF3 and the molecular formula of the sodium cryolite is nNaF.AlF3, where m=1˜1.5 and n=1˜1.5. When the low-molecular-ratio cryolite provided by the disclosure is applied to the aluminum electrolytic industry, electrolytic temperature and power consumption can be reduced and electrolytic efficiency is improved.

Abstract: An embodiment of an apparatus performs a floating-point multiply-add process on a first multiplicand, a second multiplicand, and an addend. A leading 0 bit is added to a mantissa of the first multiplicand to form an expanded first mantissa, and a partial-product multiplication is performed on the expanded first mantissa and a mantissa of the second multiplicand to produce partial-product sum and a partial-product carry mantissas. Leading bits of the partial-product sum and carry mantissas are changed to 0 bits if they are both 1 bits, and the partial-product sum and the partial-product carry are shifted right according to an exponent difference of a product of the first multiplicand and the second multiplicand. Otherwise both the partial-product sum and carry mantissas are arithmetically shifted right according to the exponent difference. The first and second multiplicands and the addend can be complex numbers.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

Abstract: A nutritional composition comprising by weight: between 0.05 and 30% selenium-enriched yeast; between 1 and 90% yeast beta-glucan; between 0.5 and 60% Vitamin C; and between 0.5 and 40% Vitamin E. The composition features anti-oxidative, anti-aging, cancer-preventing, and immune-stimulating properties.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

Abstract: A method for processing a lignocellulose material, comprises the following steps: (1) crushing and sieving the lignocellulose material, and collecting granules with a particle size of between 0.08 and 0.1 mm; (2) mixing the granules obtained in step (1) with water, and dispersing through a colloid mill to yield a suspension with a particle size of 40-80 ?m; (3) homogenizing the suspension obtained in the step (2) under high pressure to have a particle size of between 10 and 40 ?m; and (4) buffering the suspension obtained in the step (3) with a buffer solution of sodium acetate and acetic-acid, adding cellulase, ?-glucosidase, and xylanase, and performing zymolysis for 36-72 hours.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.